Free Zinc as a Predictive Marker for COVID-19 Mortality Risk

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1407 - 1407

Published: March 28, 2022

Free zinc is considered to be the exchangeable and biological active form of in serum, discussed a suitable biomarker for alterations body homeostasis related diseases. Given that coronavirus disease 2019 (COVID-19) characterized by marked decrease total serum zinc, clinical data indicate status impacts susceptibility severity infection, we hypothesized free might altered response SARS-CoV-2 infection may reflect severity. To test this hypothesis, concentrations samples survivors nonsurvivors COVID-19 were analyzed fluorometric microassay. Similar reported deficit measured reflection X-ray fluorescence, patients was considerably lower than control subjects, surviving displayed significantly higher levels those (mean ± SD; 0.4 0.2 nM vs. 0.1 nM; p = 0.0004). In contrast recovering (r 0.706, < 0.001) or declining copper−zinc ratio −0.646; 0.001), remained unaltered with time nonsurvivors. particularly low male as compared female 0.0003). This particular interest, sex described risk factor severe COVID-19. Overall, results depressed are associated increased death COVID-19, suggesting serve novel prognostic marker course

Language: Английский

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Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(23), P. 8279 - 8307

Published: April 19, 2023

Personalized nutrition (PN) has gained much attention as a tool for empowerment of consumers to promote changes in dietary behavior, optimizing health status and preventing diet related diseases. Generalized implementation PN faces different obstacles, one the most relevant being metabolic characterization individual. Although omics technologies allow assessment dynamics metabolism with unprecedented detail, its translatability affordable simple protocols is still difficult due complexity regulation technical economical constrains. In this work, we propose conceptual framework that considers dysregulation few overarching processes, namely Carbohydrate metabolism, lipid inflammation, oxidative stress microbiota-derived metabolites, basis onset several non-communicable These processes can be assessed characterized by specific sets proteomic, metabolomic genetic markers minimize operational constrains maximize information obtained at individual level. Current machine learning data analysis methodologies development algorithms integrate markers. Reduction dimensionality variables facilitates digital tools. This exemplified presenting EU-Funded project PREVENTOMICS use case.

Language: Английский

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Copper nutrition and biochemistry and human (patho)physiology

Advances in food and nutrition research, Journal Year: 2021, Volume and Issue: unknown, P. 311 - 364

Published: Jan. 1, 2021

Language: Английский

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The function of specialized pro-resolving endogenous lipid mediators, vitamins, and other micronutrients in the control of the inflammatory processes: Possible role in patients with SARS-CoV-2 related infection

Prostaglandins & Other Lipid Mediators, Journal Year: 2022, Volume and Issue: 159, P. 106619 - 106619

Published: Jan. 12, 2022

Language: Английский

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Nutritional deficiencies that may predispose to long COVID

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(2), P. 573 - 583

Published: March 15, 2023

Language: Английский

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