Nutrients,
Journal Year:
2023,
Volume and Issue:
15(19), P. 4236 - 4236
Published: Sept. 30, 2023
Taurine,
a
naturally
occurring
sulfur-containing
amino
acid,
has
attracted
significant
attention
in
recent
years
due
to
its
potential
health
benefits.
Found
various
foods
and
often
used
energy
drinks
supplements,
taurine
been
studied
extensively
understand
impact
on
human
physiology.
Determining
exact
functional
roles
represents
complex
multifaceted
topic.
We
provide
an
overview
of
the
scientific
literature
present
analysis
effects
aspects
health,
focusing
aging
cardiovascular
pathophysiology,
but
also
including
athletic
performance,
metabolic
regulation,
neurological
function.
Additionally,
our
report
summarizes
current
recommendations
for
intake
addresses
safety
concerns.
Evidence
from
both
animal
studies
indicates
that
may
have
beneficial
effects,
blood
pressure
improved
cardiac
fitness,
enhanced
vascular
health.
Its
mechanisms
action
antioxidant
properties
make
it
intriguing
candidate
anti-aging
strategies.
Journal of Clinical Medicine,
Journal Year:
2021,
Volume and Issue:
10(15), P. 3239 - 3239
Published: July 22, 2021
Chronic
venous
disease
(CVD)
is
a
multifactorial
condition
affecting
an
important
percentage
of
the
global
population.
It
ranges
from
mild
clinical
signs,
such
as
telangiectasias
or
reticular
veins,
to
severe
manifestations,
ulcerations.
However,
varicose
veins
(VVs)
are
most
common
manifestation
CVD.
The
explicit
mechanisms
not
well-understood.
seems
that
genetics
and
plethora
environmental
agents
play
role
in
development
progression
exposure
these
factors
leads
altered
hemodynamics
system,
described
ambulatory
hypertension,
therefore
promoting
microcirculatory
changes,
inflammatory
responses,
hypoxia,
wall
remodeling,
epigenetic
variations,
even
with
systemic
implications.
Thus,
proper
management
patients
CVD
essential
prevent
potential
harms
disease,
which
also
entails
significant
loss
quality
life
individuals.
Hence,
aim
present
review
collect
current
knowledge
CVD,
including
its
epidemiology,
etiology,
risk
factors,
but
emphasizing
pathophysiology
medical
care
patients,
diagnosis,
treatments.
Furthermore,
future
directions
will
be
covered
this
work
order
provide
fields
explore
context
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(14), P. 2956 - 2956
Published: July 19, 2022
The
Mediterranean
Diet
(MedDiet)
is
a
term
used
to
identify
dietary
pattern
originating
from
the
unique
multi-millennial
interplay
between
natural
food
resources
and
eating
practices
of
people
living
in
basin.
Scientific
evidence
has
described
healthy
properties
MedDiet
its
beneficial
role
several
pathological
conditions.
Nevertheless,
current
socio-economic
trends
have
moved
away
this
lifestyle.
Thus,
clinical
biological
supporting
benefits
needed
overcome
these
limitations.
Clinical
nutrition
research
examines
effects
interventions
on
or
health-related
outcomes
determined
study
population.
produced
by
studies
useful
for
guidance
public
health
messaging.
We
provided
an
update
trials
registered
database
clinicaltrials.gov
evaluating
specific
diseases.
Our
findings
revealed
increased
number
last
decade
found
that
most
disease-related
focused
cardiovascular
diseases,
metabolic
cancer.
majority
MedDiet’s
could
be
primarily
related
anti-inflammatory
anti-oxidant
as
well
effectiveness
controlling
waist
circumference
obesity.
Moreover,
strict
long-lasting
adherence
components
(e.g.,
olive
oil
polyphenols)
seem
emerge
insights
interventional
improvements.
These
present
further
into
how
it
strengthen
overall
health.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 9, 2023
Th17
cells
play
an
important
role
in
the
abnormal
immune
response
inflammatory
bowel
disease
(IBD)
and
are
involved
development
progression
of
inflammation
fibrosis.
An
increasing
amount
data
has
shown
that
gut
microbes
parts
intestinal
immunity
regulators
cellular
immunity.
cell
differentiation
is
regulated
by
bacteria
cytokines,
regulate
mucosal
microenvironment
secreting
such
as
IL-17,
IL-21,
IL-26.
Solid
evidence
showed
that,
regarding
treatment
IBD
targeting
cells,
therapeutic
effect
different
biological
agents
varies
greatly.
Fecal
transplantation
(FMT)
been
a
popular
research
topic
recent
years
safe
effective
with
few
side
effects.
To
further
understand
associated
prospects,
this
review
will
discuss
progress
related
on
focusing
interaction
regulation
between
microbiota.
Metabolites,
Journal Year:
2022,
Volume and Issue:
12(1), P. 50 - 50
Published: Jan. 8, 2022
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
essential
for
the
proper
functioning
of
organism,
affecting
health
disease
status
individuals.
There
continuous
bidirectional
communication
between
host,
conforming
to
unique
entity
known
as
“holobiont”.
Among
these
crosstalk
mechanisms,
synthesizes
broad
spectrum
bioactive
compounds
or
metabolites
which
exert
pleiotropic
effects
on
human
organism.
Many
microbial
can
cross
blood–brain
barrier
(BBB)
have
significant
brain,
playing
key
role
in
so-called
microbiota-gut-brain
axis.
An
altered
(MGB)
axis
major
characteristic
many
neuropsychiatric
disorders,
including
depressive
disorder
(MDD).
Significative
differences
eubiosis
dysbiosis
mental
disorders
like
MDD
with
their
different
metabolite
composition
concentrations
are
being
discussed.
In
present
review,
main
(short-chain
fatty
acids
-SCFAs-,
bile
acids,
amino
tryptophan
-trp-
derivatives,
more),
signaling
pathways
functions
will
be
summarized
explain
part
pathophysiology.
Conclusions
from
promising
translational
approaches
related
metabolome
addressed
more
depth
discuss
possible
clinical
value
management
patients.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(7), P. 2645 - 2673
Published: Jan. 27, 2023
Abstract
Bipolar
disorders
(BD)
represent
a
severe
leading
disabling
mental
condition
worldwide
characterized
by
episodic
and
often
progressive
mood
fluctuations
with
manic
depressive
stages.
The
biological
mechanisms
underlying
the
pathophysiology
of
BD
remain
incompletely
understood,
but
it
seems
that
there
is
complex
picture
genetic
environmental
factors
implicated.
Nowadays,
gut
microbiota
in
spotlight
new
research
related
to
this
kind
psychiatric
disorder,
as
can
be
consistently
several
pathophysiological
events
observed
BD.
In
context
so-called
microbiota–gut–brain
(MGB)
axis,
shown
have
strong
influence
on
host
neuromodulation
endocrine
functions
(i.e.,
controlling
synthesis
neurotransmitters
like
serotonin
or
mediating
activation
hypothalamic–pituitary–adrenal
axis),
well
modulation
immune
responses,
critically
regulating
intestinal,
systemic
brain
inflammation
(neuroinflammation).
present
review
aims
elucidate
derived
from
MGB
axis
disruption
possible
therapeutic
approaches
mainly
focusing
network
Understanding
its
bidirectional
communication
other
systems
shed
light
discovery
therapies
for
improving
clinical
management
these
patients.
Besides,
effect
drugs
currently
used
patients,
together
therapeutical
targeting
ecosystem
(dietary
patterns,
probiotics,
prebiotics,
novelties)
will
also
contemplated.
Advances in Nutrition,
Journal Year:
2023,
Volume and Issue:
14(4), P. 858 - 869
Published: April 29, 2023
To
our
knowledge,
no
systematic
review
with
meta-analysis
has
separately
synthesized
the
effects
of
Mediterranean
diet-based
interventions
in
children
and
adolescents
relation
to
on
anthropometric
measures.
A
better
understanding
variables
could
facilitate
their
implementation
efforts
prevent
obesity
young
population.
The
aim
present
was
evaluate
indicators
among
adolescents.
Four
databases
were
systematically
searched
(PubMed,
Scopus,
Web
Science,
Cochrane
Database
Systematic
Reviews),
including
all
studies
up
until
15
March,
2023.
Eligible
articles
randomized
controlled
trials
measuring
effect
an
intervention
based
promotion
diet
obesity-associated
parameters.
size
each
study
estimated
by
Cohen's
d
for
continuous
or
risk
difference
categorical
variables.
Compared
control
group,
showed
small
significant
reductions
body
mass
index
(d
=
-0.14;
95%
CI:
-0.26,
-0.01;
I2
77.52%).
Participants
had
a
reduction
percentage
(risk
0.12;
0.01,
0.23;
84.56%)
comparison
group.
Interventions
greater
when
aiming
at
participants
excess
weight
(that
is,
overweight
obesity),
both
index,
waist
circumference,
waist-to-height
ratio,
obesity,
abdominal
obesity.
have
reducing
as
well
(aged
3-18
y).
This
trial
registered
PROSPERO
CRD42023386789.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1104 - 1104
Published: Feb. 22, 2023
Low
muscle
mass
combined
with
changes
in
physical
function
and
quality
is
defined
as
sarcopenia.
In
people
>
60
years,
sarcopenia
reaches
10%
tends
to
increase
age.
Individual
nutrients,
such
protein,
may
have
a
protective
role
against
sarcopenia,
but
recent
evidence
suggests
that
protein
alone
has
been
ineffective
increasing
strength.
Dietary
patterns,
instead,
high
"anti-inflammatory"
potential,
the
Mediterranean
dietary
pattern,
considered
an
emerging
remedy
The
aim
of
this
systematic
review
was
summarize
diet
prevention
and/or
improvement,
including
data,
healthy
elders.
We
searched
published
studies
about
until
December
2022
Pubmed,
Cochrane,
Scopus
search
engine
grey
literature.
total,
ten
articles
were
identified
relevant:
four
cross-sectional
six
prospective.
No
clinical
trial
identified.
Only
three
assessed
presence
measured
mass,
which
essential
criterion
diagnosis.
adherence
had,
general,
positive
function,
while
results
less
clear
regard
Additionally,
there
no
effect
on
There
need
for
conduction
trials
order
reach
cause-effects
conclusions
regarding
importance
management
non-Mediterranean
populations.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(3), P. 412 - 412
Published: Jan. 31, 2024
Alzheimer’s
disease
(AD),
the
most
prevalent
form
of
dementia,
is
characterized
by
accumulation
amyloid-beta
(Aβ)
plaques
and
hyperphosphorylated
tau
tangles.
Currently,
(AD)
impacts
50
million
individuals,
with
projections
anticipating
an
increase
to
152
year
2050.
Despite
increasing
global
prevalence
AD,
its
underlying
pathology
remains
poorly
understood,
posing
challenges
for
early
diagnosis
treatment.
Recent
research
suggests
a
link
between
gut
dysbiosis
aggregation
Aβ,
development
proteins,
occurrence
neuroinflammation
oxidative
stress
are
associated
AD.
However,
investigations
into
gut–brain
axis
(GBA)
in
context
AD
progression
have
yielded
inconsistent
findings.
This
review
aims
enhance
our
understanding
microbial
diversity
at
species
level
role
these
pathology.
Additionally,
this
addresses
influence
confounding
elements,
including
diet,
probiotics,
prebiotics,
on
throughout
different
stages
(preclinical,
mild
cognitive
impairment
(MCI),
AD)
progression.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 15, 2024
Mounting
evidence
progressively
appreciates
the
vital
interplay
between
immunity
and
metabolism
in
a
wide
array
of
immunometabolic
chronic
disorders,
both
autoimmune
non-autoimmune
mediated.
The
immune
system
regulates
functioning
cellular
within
organs
like
brain,
pancreas
and/or
adipose
tissue
by
sensing
adapting
to
fluctuations
microenvironment’s
nutrients,
thereby
reshaping
metabolic
pathways
that
greatly
impact
pro-
or
anti-inflammatory
immunophenotype.
While
it
is
agreed
relies
on
an
adequate
nutritional
status
function
properly,
we
are
only
just
starting
understand
how
supply
single
combined
all
them
termed
immunonutrients,
can
steer
cells
towards
less
inflamed,
tolerogenic
Polyphenols,
class
secondary
metabolites
abundant
Mediterranean
foods,
pharmacologically
active
natural
products
with
outstanding
immunomodulatory
actions.
Upon
binding
range
receptors
highly
expressed
(e.g.
AhR,
RAR,
RLR),
they
act
through
mitochondria-centered
multi-modal
approach.
First
,
polyphenols
activate
nutrient
via
stress-response
pathways,
essential
for
responses.
Second
regulate
mammalian
target
rapamycin
(mTOR)/AMP-activated
protein
kinase
(AMPK)
balance
well-tolerated
caloric
restriction
mimetics.
Third
interfere
assembly
NLR
family
pyrin
domain
containing
3
(NLRP3)
endoplasmic
reticulum-mitochondria
contact
sites,
inhibiting
its
activation
while
improving
mitochondrial
biogenesis
autophagosome-lysosome
fusion.
Finally
chromatin
remodeling
coordinates
epigenetic
reprogramming.
This
work
moves
beyond
well-documented
antioxidant
properties
polyphenols,
offering
new
insights
into
multifaceted
nature
these
compounds.
It
proposes
mechanistical
appraisal
regulatory
which
modulate
response,
alleviating
low-grade
inflammation.
Furthermore,
draws
parallels
pharmacological
interventions
polyphenol-based
immunonutrition
their
modes
immunomodulation
across
spectrum
socioeconomically
impactful
diseases
such
as
Multiple
Sclerosis,
Diabetes
(type
1
2)
even
Alzheimer’s
disease.
Lastly,
discusses
existing
challenges
thwart
translation
polyphenols-based
immunonutritional
long-term
clinical
studies.
Overcoming
limitations
will
undoubtedly
pave
way
precision
nutrition
protocols
provide
personalized
guidance
tailored
plans.