The Impact of Smoking on Microbiota: A Narrative Review DOI Creative Commons
Sara Cicchinelli, Federico Rosa,

Federica Manca

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1144 - 1144

Published: April 10, 2023

Cigarette smoke is a classic risk factor for many diseases. The microbiota has been recently indicated as new, major player in human health. Its deregulation-dysbiosis-is considered new several illnesses. Some studies highlight cross-interaction between these two factors-smoke and dysbiosis-that may explain the pathogenesis of some We searched keywords "smoking OR AND microbiota" title articles on PubMed®, UptoDate®, Cochrane®. included published English over last 25 years. collected approximately 70 articles, grouped into four topics: oral cavity, airways, gut, other organs. Smoke impair homeostasis through same harmful mechanisms exerted host cells. Surprisingly, dysbiosis its consequences affect not only those organs that are direct contact with smoke, such cavity or but also involve distant organs, heart, vessels, genitourinary tract. These observations yield deeper insight implicated smoke-related diseases, suggesting role dysbiosis. speculate modulation help prevent treat

Language: Английский

Exploring the Links between Obesity and Psoriasis: A Comprehensive Review DOI Open Access
Ana Gabriela Barros Peláez, Pablo Durán, Ivana Vera

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7499 - 7499

Published: July 6, 2022

Obesity is a major public health issue worldwide since it associated with the development of chronic comorbidities such as type 2 diabetes, dyslipidemias, atherosclerosis, some cancer forms and skin diseases, including psoriasis. Scientific evidence has indicated that possible link between obesity psoriasis may be multifactorial, highlighting dietary habits, lifestyle, certain genetic factors microbiome leading in progress both pathologies because they are pro-inflammatory state. Thus, inflammation management plausible target for psoriasis, not only sick adipose tissue secretome profile but also due to relationship rest immune derangements initiation maintenance. Hence, this review will provide general molecular overview present recent therapeutic advances treating problem.

Language: Английский

Citations

72
Immune and inflammatory mechanisms of abdominal aortic aneurysm DOI Creative Commons
Ana Cristina Márquez-Sánchez, Ekaterina K. Koltsova

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 5, 2022

Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. Immune-mediated infiltration and destruction of the wall during AAA development plays significant role in pathogenesis this While various immune cells had been found AAA, mechanisms their activation function are still far from being understood. A better understanding regulating aberrant cell essential for novel preventive therapeutic approaches. In review we summarize current knowledge about discuss how pathogenic regulated

Language: Английский

Citations

72
The Implication of the Gut Microbiome in Heart Failure DOI Creative Commons
Vasile Valeriu Lupu, Anca Adam Răileanu, Cristina Maria Mihai

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(8), P. 1158 - 1158

Published: April 14, 2023

Heart failure is a worldwide health problem with important consequences for the overall wellbeing of affected individuals as well healthcare system. Over recent decades, numerous pieces evidence have demonstrated that associated gut microbiota represent an component human physiology and metabolic homeostasis, can affect one’s state or disease directly, through their derived metabolites. The advances in microbiome studies shed light on relationship between cardiovascular system, revealing its contribution to development heart failure-associated dysbiosis. HF has been linked dysbiosis, low bacterial diversity, intestinal overgrowth potentially pathogenic bacteria decrease short chain fatty acids-producing bacteria. An increased permeability allowing microbial translocation passage bacterial-derived metabolites into bloodstream progression. A more insightful understanding interactions microbiome, risk factors mandatory optimizing therapeutic strategies based modulation offering individualized treatment. purpose this review summarize available data regarding influence communities HF, order obtain better multi-layered complex relationship.

Language: Английский

Citations

46
Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review DOI Creative Commons

Xinyu Shen,

Aijun Xie,

Zijing Li

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(1), P. 151 - 151

Published: Jan. 2, 2024

Functional dyspepsia (FD) is a common functional gastrointestinal disorder. The pathophysiology remains poorly understood; however, alterations in the small intestinal microbiome have been observed. Current treatments for FD with drugs are limited, and there certain safety problems. A class of active probiotic bacteria can control homeostasis, nutritional digestion absorption, energy balance when taken dosages. Probiotics play many roles maintaining microecological balance, improving barrier function, regulating immune response. presence composition microorganisms vital role onset progression serve as critical factor both regulation potential intervention regarding management this condition. Thus, advantages to alleviating by flora using probiotics, targeting microorganisms. This review summarizes research progress probiotics provides reference basis improve FD.

Language: Английский

Citations

31
Role of the microbiota–gut–heart axis between bile acids and cardiovascular disease DOI Creative Commons
Ziyi Zhang, Tingting Lv, Xiang Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116567 - 116567

Published: April 6, 2024

Bile acid (BA) receptors (e.g., farnesoid X-activated receptor, muscarinic receptor) are expressed in cardiomyocytes, endothelial cells, and vascular smooth muscle indicating the relevance of BAs to cardiovascular disease (CVD). Hydrophobic cardiotoxic, while hydrophilic cardioprotective. For example, fetal cardiac insufficiency maternal intrahepatic cholestasis during pregnancy, degree abnormality, is closely related level hydrophobic blood infant blood. However, ursodeoxycholic (the most BA) can reverse/prevent these detrimental effects increased levels on heart. The gut microbiota (GM) GM metabolites (especially secondary BAs) have crucial roles hypertension, atherosclerosis, unstable angina, heart failure. Herein, we describe relationship between CVD at BA level. We combine concept "microbiota-gut-heart axis" (MGHA) postulate role mechanism development. In addition, strategies for treating with under MGHA proposed.

Language: Английский

Citations

17
Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases DOI Creative Commons

Xiaopeng Ai,

Peiling Yu,

Li‐Xia Peng

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 3, 2021

Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular affecting vasculature heart, cerebrovascular disease, atherosclerosis, diabetic complications have compromised quality life affected individuals increase burden on health care services. Berberine, naturally occurring isoquinoline alkaloid form Rhizoma coptidis , is widely used China as folk its antibacterial anti-inflammatory properties. Promisingly, an number studies identified several cellular molecular targets berberine, indicating potential alternative therapeutic strategy vascular diseases, well providing novel evidence that supports berberine to combat diseases. The purpose this review comprehensively systematically describe agent including pharmacological effects, mechanisms, pharmacokinetics. According data published so far, shows remarkable anti-inflammatory, antioxidant, antiapoptotic, antiautophagic activity via regulation multiple signaling pathways, AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated silent information regulator 1 (SIRT-1), hypoxia-inducible 1α (HIF-1α), endothelial growth phosphoinositide 3-kinase (PI3K), B (Akt), janus 2 (JAK-2), Ca 2+ channels, endoplasmic reticulum stress. Moreover, we discuss existing limitations give corresponding measures. In addition, propose some research perspectives challenges, provide solid base from which further can excavate effective drugs monomers.

Language: Английский

Citations

96
Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine DOI Creative Commons
Hao Cheng, Juan Liu, Yuzhu Tan

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2021, Volume and Issue: 12(4), P. 541 - 555

Published: Oct. 22, 2021

Berberine (BBR), an isoquinoline alkaloid, has been found in many plants, such as

Language: Английский

Citations

95
The Role of Short-Chain Fatty Acids of Gut Microbiota Origin in Hypertension DOI Creative Commons

Yeshun Wu,

Hongqing Xu,

Xiaoming Tu

et al.

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 28, 2021

Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases, its development involves multiple mechanisms. Gut microbiota has been reported to be closely linked hypertension. Short-chain fatty acids (SCFAs)—the metabolites of gut microbiota—participate in hypertension through various pathways, including specific receptors, immune system, autonomic nervous metabolic regulation gene transcription. This article reviews the possible mechanisms SCFAs regulating blood pressure prospects as target prevent treat

Language: Английский

Citations

72
The role of the gut microbiota in health and cardiovascular diseases DOI Creative Commons
Lu Wang, Shiqi Wang, Qing Zhang

et al.

Molecular Biomedicine, Journal Year: 2022, Volume and Issue: 3(1)

Published: Oct. 11, 2022

Abstract The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, metabolites interact with host. Meanwhile, increasing evidence indicates that has a strong correlation occurrence, progression treatment of cardiovascular diseases (CVDs). In patients CVDs corresponding risk factors, composition ratio have significant differences compared their healthy counterparts. Therefore, dysbiosis, microbiota-generated metabolites, related signaling pathway may serve explanations for some mechanisms about occurrence development CVDs. Several studies also demonstrated many traditional latest therapeutic treatments are associated its generated pathways. Given information, we summarized advances in current research regarding effect on main CVDs, highlighted roles several introduced promising microbiota. this review mainly focuses exploring role potential which eventually provide better solutions well prevention

Language: Английский

Citations

67
The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research DOI Creative Commons
Melanie Schächtle, Stephan P. Rosshart

Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: July 15, 2021

Over the past decades, microbiome research has evolved rapidly and became a hot topic in basic, preclinical clinical research, for pharmaceutical industry general public. With help of new high-throughput sequencing technologies tremendous progress been made characterization host-microbiota interactions identifying as major factor shaping mammalian physiology. This development also led to discovery gut-brain axis crucial connection between gut microbiota nervous system. Consequently, growing body evidence emerged suggesting that commensal plays vital role brain Moreover, it evident communication along this microbiota-gut-brain is bidirectional primarily mediated by biologically active microbial molecules metabolites. Further, intestinal dysbiosis leading changes relationship system was linked pathogenesis several psychiatric neurological disorders. Here, we discuss impact on health disease, specifically regards neuronal homeostasis, normal aging well their diseases highest socioeconomic burden such Alzheimer's disease stroke. Subsequently, utilize stroke examine translational value current mouse models spotlight research. Finally, propose future strategies how could conduct field neuroscience may lead identification novel treatments human diseases.

Language: Английский

Citations

66