Anti-Hyperlipidemia and Gut Microbiota Community Regulation Effects of Selenium-Rich Cordyceps militaris Polysaccharides on the High-Fat Diet-Fed Mice Model DOI Creative Commons

Minglei Yu,

Jin Yue, Nan Hui

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(10), P. 2252 - 2252

Published: Sept. 23, 2021

Supplementation of polysaccharides is a promising gut microbiota-targeted therapeutic method for obesity and metabolic diseases. Biological activities Cordyceps militaris have been well reported, but the effect selenium (Se)-rich C. (SeCMP) on associated disorder microbiota composition has rarely studied. This study aimed to investigate anti-obesity modulatory crude separated from Se-rich high-fat diet (HFD)-fed C57BL/6J mice model. Mice were treated with normal (CHOW), HFD alone, plus (CMP), or low/medium/high dosage SeCMP 8 weeks. Body weight, fat content, serum lipid, appetite hormone, lipid gene expression, inflammation cytokines, thermogenic protein, short-chain fatty acids (SCFAs), structure determined. Compared HFD-fed mice, triglyceride low-density lipoprotein cholesterol (LDL-C) in SeCMP-200 group decreased by 51.5% 44.1%, respectively. Furthermore, lipopolysaccharide-binding proteins (LBP), adiponectin level, pro-inflammation expression colon subcutaneous inhibited, whereas anti-inflammation was improved, reflecting might mitigate obese-induced inflammation. Meanwhile, promoted satiety thermogenesis obese mice. It also significantly bacteria, such as Dorea, Lactobacillus, Clostridium, Ruminococcus, that negatively correlated traits increased mucosal beneficial bacteria Akkermansia. There no significant difference between CMP SeCMP-100 groups. Our results revealed high dose could prevent HFD-induced dyslipidemia dysbiosis potential be used functional foods.

Language: Английский

Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet DOI

Xinhao Duan,

Lei Zhang, Yi Liao

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 969, P. 176440 - 176440

Published: Feb. 24, 2024

Language: Английский

Citations

9
The relationships between high-fat diet and metabolic syndrome: Potential mechanisms DOI
Chao Tang,

Yuxin Wang,

Zeyu Xu

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 104261 - 104261

Published: May 1, 2024

Language: Английский

Citations

9
Fecal bacteria transplantation replicates aerobic exercise to reshape the gut microbiota in mice to inhibit high-fat diet-induced atherosclerosis DOI Creative Commons

Jie Men,

Hao Li,

Chenbin Cui

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0314698 - e0314698

Published: Feb. 4, 2025

Aerobic exercise exerts a significant impact on the gut microbiota imbalance and atherosclerosis induced by high-fat diet. However, whether fecal transplantation, based aerobic exercise, can improve progression remains unexplored. In this study, we utilized male C57 mice to establish models of atherosclerosis, followed transplantation(Fig 1a). Firstly, analyzed body weight, somatotype, adipocyte area, aortic HE images model mice. Our findings revealed that diet -induced exhibited elevated lipid accumulation, larger more severe progression. Additionally, assessed plasma levels, inflammatory factors, composition in each group displayed dyslipidemia along with responses reduced diversity as well abundance beneficial bacteria. Subsequently performing transplantation demonstrated experienced weight loss accompanied accumulation while normalizing their profile; furthermore it significantly improved blood lipids inflammation markers thereby exhibiting notable anti- effects. The suggest modify diet-induced atherosclerosis(Fig 1b). Moreover, these effects be effectively transmitted through offering promising therapeutic approach for managing atherosclerosis.

Language: Английский

Citations

1
The gut microbiota during the progression of atherosclerosis in the perimenopausal period shows specific compositional changes and significant correlations with circulating lipid metabolites DOI Creative Commons
Qinghai Meng,

Meng-Hua Ma,

Weiwei Zhang

et al.

Gut Microbes, Journal Year: 2021, Volume and Issue: 13(1)

Published: Jan. 1, 2021

Atherosclerosis (AS) is exacerbated in the perimenopausal period, which significantly increases incidence rate of cardiovascular disease. The disruption gut microbiota has been associated with AS or menopause, but specific changes AS-associated period remain largely unknown. As lipid abnormalities are mainly responsible for AS, relationship between metabolism and disruptions during menopause rarely reported hitherto. In present study, ApoE-/- mice fed a high-fat diet (HFD) were subjected to ovariectomy supplemented estrogen. ovariectomized HFD-fed underwent significant damage, hepatic hyperlipidemia, metabolism- transport-related enzymes. There was higher abundance some metabolites plasma than non-ovariectomized ones, including cholesterol esters, triglycerides, phospholipids, other types lipids (free fatty acids, acylcarnitine, sphingomyelins, ceramides). administration estrogen reduced contents most metabolites. diversity composition evidently changed mice, compared without ovariectomy. contrast, supplementation, restored approach that relative abundances bacteria even like those C57BL/6 normal diet. On hand, transplantation feces from sufficient correct hyperlipidemia reverse characteristics changing metabolomics mice. These phenomena also observed after estrogen-treated Moreover, correlated, demonstrating serum may be period. conclusion, progression showed compositional correlations circulating Estrogen supplementation exert beneficial effects on metabolism.

Language: Английский

Citations

43
Anti-Hyperlipidemia and Gut Microbiota Community Regulation Effects of Selenium-Rich Cordyceps militaris Polysaccharides on the High-Fat Diet-Fed Mice Model DOI Creative Commons

Minglei Yu,

Jin Yue, Nan Hui

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(10), P. 2252 - 2252

Published: Sept. 23, 2021

Supplementation of polysaccharides is a promising gut microbiota-targeted therapeutic method for obesity and metabolic diseases. Biological activities Cordyceps militaris have been well reported, but the effect selenium (Se)-rich C. (SeCMP) on associated disorder microbiota composition has rarely studied. This study aimed to investigate anti-obesity modulatory crude separated from Se-rich high-fat diet (HFD)-fed C57BL/6J mice model. Mice were treated with normal (CHOW), HFD alone, plus (CMP), or low/medium/high dosage SeCMP 8 weeks. Body weight, fat content, serum lipid, appetite hormone, lipid gene expression, inflammation cytokines, thermogenic protein, short-chain fatty acids (SCFAs), structure determined. Compared HFD-fed mice, triglyceride low-density lipoprotein cholesterol (LDL-C) in SeCMP-200 group decreased by 51.5% 44.1%, respectively. Furthermore, lipopolysaccharide-binding proteins (LBP), adiponectin level, pro-inflammation expression colon subcutaneous inhibited, whereas anti-inflammation was improved, reflecting might mitigate obese-induced inflammation. Meanwhile, promoted satiety thermogenesis obese mice. It also significantly bacteria, such as Dorea, Lactobacillus, Clostridium, Ruminococcus, that negatively correlated traits increased mucosal beneficial bacteria Akkermansia. There no significant difference between CMP SeCMP-100 groups. Our results revealed high dose could prevent HFD-induced dyslipidemia dysbiosis potential be used functional foods.

Language: Английский

Citations

41