Translation, Cross-Cultural Adaptation, and Validation of the Kannada Version of the Exercise Adherence Rating Scale (EARS-Kn) Among Head and Neck Cancer (HNC) Survivors in a Tertiary Care Setup in India

Integrative Cancer Therapies, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Background: Adherence in rehabilitation services includes attending appointments, regularly performing prescribed exercises, and correct exercise execution. The Exercise Rating Scale (EARS) has been adapted into several languages, but there is lack of a standardized tool for various Indian languages cultural contexts, particularly use with cancer survivors. With the anticipated 57.7% rise cases by 2040, this study aims to address gap. Aims objectives: To cross-culturally adapt EARS Kannada (EARS-Kn) evaluate its validity reliability amongst HNC survivors enrolled Multimodal Oncology Rehabilitation Exercise—MORE © Program. Methodology: Following Beaton guidelines, was Kannada. 34 engaged MORE program. Internal consistency (Cronbach’s ⍺) construct (Exploratory Factor Analysis, EFA) were assessed. Receiver Operating Curve (ROC) determined cut-off scores, sensitivity specificity EARS-Kn. Results: EARS-Kn demonstrated Cronbach’s-⍺ value .93. EFA revealed one-factor solution eigenvalues exceeding one 70.1% loading. area under curve (AUC) 0.908. A score 17 established, 95.83% 80% specificity. Conclusion: version showed strong among Kannada-speaking survivors, indicating potential enhance understanding adherence them. Future studies could explore diverse populations regimes. Studies also further investigate psychometric properties different which would help improve survivorship outcomes.

Language: Английский

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Exercise, cancer, and the cardiovascular system: clinical effects and mechanistic insights

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 14, 2024

Abstract Cardiovascular diseases and cancer are the leading causes of death in Western world share common risk factors. Reduced cardiorespiratory fitness (CRF) is a major determinant cardiovascular morbidity survival. In this review we discuss cancer- induced disturbances parenchymal, cellular, mitochondrial function, which limit CRF may be antagonized attenuated through exercise training. We show impact on survival its attenuating effects cardiotoxicity cancer-related treatment. Tailored programs not yet available for each tumor entity as several trials were performed heterogeneous populations without adequate cardiopulmonary testing (CPET) prior to prescription with wide variation modalities. There emerging evidence that crucial pillar treatment tool mitigate cardiotoxic effects. modalities aerobic resistance training their potential improve patients provide an example periodization model cancer.

Language: Английский

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Anti-cancer management of head and neck cancers and oral microbiome—what can we clinically obtain?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 28, 2024

Head and neck squamous cell carcinoma (HNSCC) exhibits significant genetic heterogeneity primarily concerns the oral cavity oropharynx. These cancers occur more frequently in men with a 5-year survival rate below 50%. Major risk factors include human papilloma virus (HPV) (notably type 16), Epstein-Barr virus, tobacco, alcohol, poor hygiene approximately 4.5% of global linked to HPV. Notably, differences microbiome between healthy individuals patients head (HNCs) have been identified. Recent studies highlight significance certain microbes assessment potential as biomarker for HNCs. Additionally, role metastasis has acknowledged. Treatment HNCs includes local methods, such surgery radiotherapy, systemic approaches, immunotherapy. Numerous side effects accompany these treatments. Emerging research suggests beneficial preoperative immunonutrition probiotics patient outcomes, emphasizing influence on treatment efficacy. This review explores reciprocal HNC gut using brachytherapy, surgery, immunotherapy, chemotherapy.

Language: Английский

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State of Rehabilitation Research in the Head and Neck Cancer Population: Functional Impact vs. Impairment-Focused Outcomes

Current Oncology Reports, Journal Year: 2022, Volume and Issue: 24(4), P. 517 - 532

Published: Feb. 19, 2022

Language: Английский

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Exercise-based rehabilitation on functionality and quality of life in head and neck cancer survivors. A systematic review and meta-analysis

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 26, 2023

Abstract Head and Neck Cancer (HNC) is a globally rare cancer that includes variety of tumors affecting the upper aerodigestive tract. It presents with difficulty breathing or swallowing mainly treated radiation therapy, chemotherapy, surgery for have spread locally throughout body. Alternatively, exercise can be used during treatment to improve function, including pain relief, increase range motion muscle strength, reduce cancer-related fatigue, thereby enhancing quality life. Although existing evidence suggests adjunctive use in other types, no previous studies examined effects on HNC survivors. The aim this meta-analysis was quantify effect exercise-based rehabilitation functionality life survivors who underwent and/or chemoradiotherapy. A systematic review were carried out following PRISMA statement registered PROSPERO (CRD42023390300). search performed MEDLINE (PubMED), Cochrane Library, CINAHL Web Science (WOS) databases from inception 31st December 2022 using terms “ ”, head neck neoplasms complications contraction stretching exercises ” combining booleans “AND”/“OR”. PEDro scale, Risk Bias Tool GRADE assess methodological quality, risk bias grade recommendation included respectively. 18 (n = 1322) finally which 1039 (78.6%) men 283 (21.4%) women. In patients radio-chemotherapy, overall [SMD − 0.62 [− 4.07, 2.83] CI 95%, Z 0.35, p 0.72] OP 0.07 0.62, 0.48] 0.25, 0.81] slightly reduced comparison controls. Besides, lower limb strength 0.10 1.52, 1.32] 0.14, 0.89] fatigue 0.51 0.97, 0.057] 2.15, < 0.01] also improved those receive radio-chemoradiation. dissection surgery, superior controls 1.04 3.31, 1.23] 0.90, 0.37] and, mid-term, shoulder SMD 2.81 7.06, 1.43] 1.76, 0.08]. No differences found at any follow-up periods. There fair good low moderate bias, weak recommendations supporting functionality. However, favor modality improving chemoradiotherapy surgery.

Language: Английский

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Effect of Sarcopenia on Swallowing in Patients With Head and Neck Cancer

Otolaryngology, Journal Year: 2024, Volume and Issue: 170(5), P. 1331 - 1337

Published: Feb. 5, 2024

Abstract Objective Sarcopenia, characterized by decreased skeletal muscle mass, is associated with poorer oncologic outcomes in head and neck cancer (HNC) patients. The effect of sarcopenia on swallowing following HNC treatment unknown. This study aims to investigate the association dysfunction patients treated for HNC. Study Design Retrospective cohort study. Setting Academic medical center. Methods Pretreatment was assessed using index calculated from cross‐sectional imaging at third cervical vertebra. Feeding tube dependence, patient‐reported dysphagia, safety were before after Functional Oral Intake Scale, Eating Assessment Tool‐10, Penetration Aspiration respectively. between evaluated. Results A total 112 included, 84 males (75%) 28 females (25%). 69 (61.6%) had prior initiating therapy. Sarcopenia significantly an elevated risk dysphagia (odds ratio [OR] = 2.71 [95% confidence interval, CI, 1.12‐6.79]; P < .05). Multivariate logistic regression demonstrated that (OR 15.18 1.50‐453.53]; .05) independent predictor aspiration Conclusion Patients pretreatment higher rates more likely develop completion readily measured may be useful identifying those most benefit prehabilitation efforts.

Language: Английский

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Effects of Exercise in Patients Undergoing Chemotherapy for Head and Neck Cancer: A Pilot Randomized Controlled Trial

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(3), P. 1291 - 1291

Published: Feb. 1, 2021

Background: Cisplatin administration may induce muscle atrophy, thereby reducing the fitness level of patients with head and neck cancer (HNC). To date, only animal studies have been conducted to test effectiveness exercise interventions in diminishing side effects cisplatin. Aim: determine whether training improves physical health-related quality life (HRQoL) receiving chemotherapy for Head & Neck (H&N). Material methods: This pilot-randomized controlled trial was on 57 participants HNC. The were randomized into an group a control group. received moderate-intensity combined aerobic, resistance flexibility exercises three times week eight weeks during chemotherapy. no specific information regarding exercise. outcome measures including body composition, strength, balance, flexibility, cardiovascular assessed at baseline following baseline. Results: composition (body fat percentage, p = 0.002; skeletal 0.008), dynamic balance (p 0.01), strength (upper extremity, 0.037; lower 0.025) HRQoL 0.001) showed significant difference between Significant deteriorations noted several domains scale Conclusions: study found that program improve (i.e., composition) alleviate deterioration Further research large sample sizes are warranted investigate long-term this population.

Language: Английский

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Global Trends of Nutrition in Cancer Research: A Bibliometric and Visualized Analysis Study over the Past 10 Years

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(7), P. 4165 - 4165

Published: March 31, 2022

The increasing application of nutrition in cancer management has attracted a great deal research interest recent decades. Nutritional therapies, interventions, and assessments were known to have positive effects on reducing side from therapy. In order identify the global output for research, bibliometric analysis during past 10 years was conducted evaluate current status trends, gaps, directions as no studies been regarding cancer. After data collection, total 1521 articles chosen this study. visualization performed with VOSviewer. number publications grown continuously since substantial spark identified 2019. majority authors' affiliations European countries. Four types recognized among top author keywords; they breast cancer, head neck colorectal gastric Nutrients journal most popular authors published 195 related topic. conclusion, providing evidence-based nutritional solutions various is essential research. Since it presumed growing patients worldwide aging population, vital generate finding effective therapies patients.

Language: Английский

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Dysphagia, nutritional status, and quality of life in patients with head and neck cancer undergoing radiotherapy alone or combined with chemotherapy: an observational study

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Radiotherapy (RT) is the most common nonsurgical treatment for head and neck cancer (HNC) may or not be combined with chemotherapy (CT). Dysphagia, characterized by impaired swallowing function, one of side effects RT, occurring during after persist long treatment. To compare evolution dysphagia, nutritional status, quality life (QoL) in periods immediately before RT HNC individuals who received only RT/CT. Prospective longitudinal observational study performed a hospital Brazilian public health system. The were allocated into two groups: RG (n = 20), consisting patients HNC, RCG 27), plus CT. evaluated to identify classify dysphagia (PARD protocol), anthropometric variables (BMI, triceps skinfold thickness, arm calf circumferences, manual dynamometry), QoL (QLC-30 H&N-35 questionnaires). groups homogeneous demographic characteristics tumor stage. showed higher proportion worsening severity (p < 0.01) assessment 0.05). A negative correlation was observed between initial–final change BMI total sample (rho=-0.379, p worsened domains evaluated, but additional global nausea vomiting leads early development which can adversely affect status QoL. Including CT regimen more accentuated parameters.

Language: Английский

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Novel Survivorship Paradigms in Head/Neck Cancer

Seminars in Radiation Oncology, Journal Year: 2025, Volume and Issue: 35(2), P. 285 - 300

Published: March 14, 2025

Language: Английский

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