Impact of fundamental components of the Mediterranean diet on the microbiota composition in blood pressure regulation

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 3, 2024

Abstract Background The Mediterranean diet (MedDiet) is a widely studied dietary pattern reflecting the culinary traditions of regions. High adherence to MedDiet correlates with reduced blood pressure and lower cardiovascular disease (CVD) incidence mortality. Furthermore, microbiota, influenced by diet, plays crucial role in health, dysbiosis CVD patients suggests possible beneficial effects microbiota modulation on pressure. MedDiet, rich fiber polyphenols, shapes distinct associated higher biodiversity positive health effects. review aims describe how various components impact gut influencing dynamics. Main body promotes regulation through its components. For instance, whole grains promote healthy given that they act as substrates leading production short-chain fatty acids (SCFAs) can modulate immune response, preserve barrier integrity, regulate energy metabolism. Other including olive oil, fuits, vegetables, red wine, fish, lean proteins, have also been regulation. Conclusion approach offers several benefits terms management risk factors, hypertension. intake favorable environment, which, turn, has shown aids other physiological processes like

Language: Английский

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Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2878 - 2878

Published: Aug. 28, 2024

As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic diet showed promising effects aging, possibly mTORC1 AMPK, an insulin signaling pathway. By understanding intricate interplay between pathways, we develop personalized not only prevent age-related diseases, but also promote overall health well-being throughout process.

Language: Английский

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Editorial: Chrononutrition and MASLD—Its About Time (Restricted Feeding)!

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The global obesity epidemic and the widespread adoption of a Westernised diet high in sugar processed foods, alongside sedentary lifestyle, have fueled rise metabolic dysfunction-associated steatotic liver disease (MASLD) [1]. Since an unhealthy lifestyle is central to MASLD development, effective interventions remain essential for improving patient outcomes [2]. Mediterranean (MD), rich produce, whole grains healthy fats like olive oil, while limiting red meat widely recognized as key dietary intervention [3, 4]. Adherence MD has shown reduction hepatic fat, improved insulin sensitivity, slowed progression [5, 6]. However, barriers such cost, accessibility, cultural preferences hinder adoption. As result, alternative strategies, time-restricted feeding (TRF), gained attention. TRF limits food intake set daily window, typically 6 10 h, followed by fasting. Although demonstrated health benefits, particularly when paired with caloric restriction [7], its optimal implementation impact on unclear, it not yet considered standard care. In CHRONO-NAFLD study, Tsitsou et al. [8] explored efficacy + combination. 12-week trial randomized 71 adults overweight/obesity into three groups: hypocaloric (control), early (8 AM–6 PM), late (12 PM–10 PM). Dietary adherence was rigorously measured using self-reports verified study personnel reinforced via phone calls, > 90% each group. boasted completion rate 83%. All groups experienced significant reductions body weight, blood pressure, along improvements VCTE-measured fat modest trend toward reduced stiffness. Notably, only between-group differences emerged glycemic control, resistance hemoglobin A1c observed both groups. these changes, statistically significant, did reach clinically meaningful thresholds (Figure 1). Importantly, this several strengths, including well-characterized population, rigorous methodology, validated measures assessing multiple relevant outcomes. limitations include selection bias (84% participants had moderate at baseline) most were physically active (> 600 MET-min/week). This generalisability, cohort relatively homogenous inclined consumption. Key confounders, meal composition physical activity also fully controlled. design precluded distinguishing whether benefits stemmed from itself or restriction. summary, shows promise control. further studies are needed determine if independently improves histology long-term questions due fasting simply intake, sustainable over time. While appears safe feasible, remains unclear offers advantages other structured calorically matched. Hannah Mohr: writing – original draft, review editing. Jonathan G. Stine: conceptualization, content solely responsibility authors does necessarily represent official views National Institutes Health. AI-based software used grammatical stylistic editing various parts manuscript. Dr. Stine receives received research support Astra Zeneca, Galectin, Kowa Inc., Novo Nordisk, Regeneron Zydus Therapeutics. consults Nordisk Advisory Board Madrigal. declare no conflicts interest. article linked al papers. To view articles, visit https://doi.org/10.1111/apt.70044 https://doi.org/10.1111/apt.70107. Data sharing applicable datasets generated analysed during current study.

Language: Английский

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Is Probiotic Supplementation Useful for the Management of Body Weight and Other Anthropometric Measures in Adults Affected by Overweight and Obesity with Metabolic Related Diseases? A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 666 - 666

Published: Feb. 19, 2021

The aim of this systematic review and meta-analysis is to assess the effectiveness probiotics in inducing body weight loss patients with overweight or obesity related metabolic diseases. research was carried out on PubMed Scopus, focusing studies reporting effect anthropometric measures (weight, mass Index (BMI), waist circumference (WC), hip (HC) after administration various probiotic strains compared placebo. Twenty randomized controlled trials, that included 1411 patients, were considered. meta-analyzed mean differences (MD) for random effects showed no significant decrease supplementation (-0.26 kg [-075, 0.23], p = 0.30), while a BMI found (-0.73 kg/m2 [-1.31, -0.16], 0.01). For WC HC, MD (WC: -0.71 cm [-1.24; -0.19], 0.008 HC: -0.73 [-1.16; -0.30], 0.0008). risk bias also evaluated considering high low according PRISMA criteria. In conclusion, results highlight positive trend amelioration obese However, further needed before recommending use as therapeutic strategy these patients. focus future should be evaluate efficacy different strains, quantities administered, duration intervention.

Language: Английский

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Colonization Ability and Impact on Human Gut Microbiota of Foodborne Microbes From Traditional or Probiotic-Added Fermented Foods: A Systematic Review

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: July 29, 2021

A large subset of fermented foods act as vehicles live environmental microbes, which often contribute food quality assets to the overall diet, such health-associated microbial metabolites. Foodborne microorganisms also carry potential interact with human gut microbiome via chain. However, scientific results describing flow connecting different microbiomes well their impact on health, are still fragmented. The aim this systematic review is provide a knowledge-base about literature addressing connection between foodborne and microbiomes, identify gaps where more research needed clarify map originating from foods, either traditional or added probiotics, possible microbiota composition extent microbes might be able colonize environment. An additional was highlight experimental approaches study designs could better standardized improve comparative analysis published datasets. Overall, presented in suggest that complex interplay indeed occurring, although mechanisms for interaction, how it can remain puzzling picture. Further employing trans-disciplinary aimed at understanding tailored positively influence and, turn, host therefore pivotal importance.

Language: Английский

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