Association between dried fruit intake and kidney function: research from univariate and multivariate Mendelian randomized studies DOI Creative Commons

Yuhang Gao,

Xinghai Yue,

Wei Zhao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 23, 2024

Objectives Observational studies have identified an association between dried fruit intake and kidney function. However, these limitations such as vulnerability to confounders reverse causality bias. Therefore, this study aimed explore the potential causal relationship Methods A two-sample Mendelian randomization (MR) was conducted using a large-scale genome-wide dataset investigate function markers (blood urea nitrogen (BUN), creatinine (CR), uric acid (UA), cystatin C (CyC), hematuria, microalbuminuria). The main analytical method inverse variance weighting. In addition, we applied MR Egger weighted median assess robustness of results. Finally, Multivariate (MVMR) used estimate direct effect on markers. Results univariate analysis showed that increased associated with lower markers, including BUN ( β : −0.171, 95% confidence interval (CI): −0.239 −0.102, p = 1.063 × 10 −6 ), CR −0.205, CI: −0.311 −0.099, 1.455 −4 UA −0.317, −0.384 −0.249, 4.439 −20 CysC −0.323, 1.074 −11 ); however, it unrelated hematuria microalbuminuria. Causality persisted after performing MVMR analysis; addition alcohol consumption smoking exposure factors, for −0.296, −0.523 −0.068, 1.094 −2 ) −0.238, −0.465 −0.011, 4.024× weakened, while −0.038, −0.215 0.138, 6.698 −1 −0.431 0.046, 1.347 disappeared. Conclusion Increased (BUN, CR, UA, CysC) in absence consumption; disappeared presence consumption. These results provide promising avenue delaying course chronic disease.

Language: Английский

Health Outcomes Associated with Olive Oil Intake: An Umbrella Review of Meta-Analyses DOI Creative Commons
Manuela Chiavarini, Patrizia Rosignoli, Irene Giacchetta

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(16), P. 2619 - 2619

Published: Aug. 21, 2024

Several studies suggested a negative association between olive oil (OO) consumption and the risk of several chronic diseases. However, an attempt to systematically search, organize, evaluate existing evidence on all health outcomes associated with OO is lacking. The objective this review describe multiple consumption. Medline, Scopus, Web Science databases were searched through 5 April 2024. selected met following criteria: (1) meta-analysis both observational (case–control cohort studies) interventional (trials), (2) evaluation consumption, mortality, and/or incidence non-communicable/chronic degenerative diseases, (3) study population ≥18 years old. Two independent reviewers extracted relevant data assessed bias individual studies. PRISMA statement guidelines for Integration Evidence from Multiple Meta-Analyses followed. literature search identified 723 articles. After selection, 31 articles included in umbrella review. primary benefits observed cardiovascular diseases factors, cancer, diabetes, specific biomarkers related anthropometric status inflammation. As key component Mediterranean diet, can be considered healthy dietary choice improving positive outcomes.

Language: Английский

Citations

5
The role of the Mediterranean diet in prediabetes management and prevention: a review of molecular mechanisms and clinical outcomes DOI Creative Commons
Viviana A. Ruiz‐Pozo, Patricia Guevara-Ramí­rez, Elius Paz‐Cruz

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Sept. 10, 2024

Language: Английский

Citations

4
Gut Microbiota Disruption in Hematologic Cancer Therapy: Molecular Insights and Implications for Treatment Efficacy DOI Open Access
Patricia Guevara-Ramí­rez, Santiago Cadena-Ullauri, Elius Paz‐Cruz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10255 - 10255

Published: Sept. 24, 2024

Hematologic malignancies (HMs), including leukemia, lymphoma, and multiple myeloma, involve the uncontrolled proliferation of abnormal blood cells, posing significant clinical challenges due to their heterogeneity varied treatment responses. Despite recent advancements in therapies that have improved survival rates, particularly chronic lymphocytic leukemia acute lymphoblastic treatments like chemotherapy stem cell transplantation often disrupt gut microbiota, which can negatively impact outcomes increase infection risks. This review explores complex, bidirectional interactions between microbiota cancer patients with HMs. Gut influence drug metabolism through mechanisms such as production enzymes bacterial β-glucuronidases, alter efficacy toxicity. Moreover, microbial metabolites short-chain fatty acids modulate host immune response, enhancing effectiveness. However, therapy reduces diversity beneficial bacteria, Bifidobacterium Faecalibacterium, while increasing pathogenic bacteria Enterococcus Escherichia coli. These findings highlight critical need preserve during treatment. Future research should focus on personalized microbiome-based therapies, probiotics, prebiotics, fecal transplantation, improve quality life for hematologic malignancies.

Language: Английский

Citations

4
Obesity and nutritional strategies: advancing prevention and management through evidence-based approaches DOI Creative Commons
Rosario Suárez, Estefanía Bautista-Valarezo, Andri Matos

et al.

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 20, 2025

Language: Английский

Citations

0
Effect of diet on the microbiota and immune system in patients with systemic lupus erythematosus DOI Creative Commons
Viviana A. Ruiz‐Pozo,

Elius Paz-Cruz,

Santiago Cadena-Ullauri

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Nov. 30, 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and organ damage. Studies indicate that diet significantly influences the gut microbiota, which, in turn, affects immune system. This article explores microbiota dysbiosis SLE patients potential mechanisms related to dietary interventions function. It highlights specific patterns, such as high-fibre Mediterranean diet, may modulate diversity activity of microbiota. The interaction between altered responses, including regulation inflammatory cytokines, intestinal barrier permeability, autoantibody production examined. review importance personalized strategies enhancing response potentially mitigating progression.

Language: Английский

Citations

2
The Link between Salivary Amylase Activity, Overweight, and Glucose Homeostasis DOI Open Access
Gita Erta, Gita Gersone,

Antra Jurka

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9956 - 9956

Published: Sept. 15, 2024

Butyrate, a short-chain fatty acid (SCFA) produced by the fermentation of dietary fibers in colon, plays pivotal role regulating metabolic health, particularly enhancing insulin sensitivity. Given rising incidence disorders, understanding factors that influence butyrate production is significant interest. This study explores link between salivary amylase activity and levels overweight women reproductive age. Participants were categorized into low (LSA) high (HSA) groups further divided two subgroups: one followed low-starch diet (LS), other underwent caloric restriction (CR). We assessed measured serum concentrations to examine their associations. Our findings showed significant, though weak, positive correlation (ρ = 0.0486, p < 0.05), suggesting levels. The statistical significance, despite weak correlation, implies this relationship not random. Moreover, higher baseline observed with elevated activity. Also, on experienced more pronounced increase compared those restriction. These results suggest intake interact production, potential implications for improving sensitivity health. underscores promoting overall well-being. Further research necessary clarify mechanisms involved understand long-term effects health across different populations.

Language: Английский

Citations

1
A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases DOI Creative Commons
Can Gao,

Jiaxiao Wei,

Changxu Lu

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 21, 2024

Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, inflammation, have been identified with boosting morbidity mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies shown that variations in gut microbiota its own metabolites can influence occurrence CMDs. Intriguingly, composition function are susceptible exercise patterns, thus affecting inflammatory, immune, responses within host. this review, we introduce key mechanisms intestinal microecology involved onset development CMDs, discuss relationship between microecology, then analyze role beneficial effects on aiming at elucidating gut-heart axis mediated protective effect building avenues for application management

Language: Английский

Citations

1
Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk DOI Creative Commons
Patricia Guevara-Ramí­rez, Rafael Tamayo‐Trujillo, Santiago Cadena-Ullauri

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 3, 2024

Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual degeneration neurons within nervous system. Even though, each pathology presents diverse etiologies develops in different brain sites, they may share cellular molecular mechanisms, such as inflammation, protein aggregation, DNA RNA defects. Heavy metal contamination is global public health concern, given that anthropogenic activities like paint manufacturing, mining, oil refining contribute substantially heavy pollution. Consequently, studies have investigated its potential etiological factors neurodegenerative diseases. This review examines impact dietary exposure metals, specifically mercury, cadmium, lead, chromium, arsenic, zinc, on development progression Evidence from range indicates these metals play significant role advancing by disrupting essential functions, induction oxidative stress impairments mitochondrial function. findings underscore need for further research elucidate toxicological mechanisms develop preventive strategies, chelation therapies environmental remediation. Addressing risks especially critical protect neurocognitive health, particularly aging populations.

Language: Английский

Citations

1
Association between dried fruit intake and kidney function: research from univariate and multivariate Mendelian randomized studies DOI Creative Commons

Yuhang Gao,

Xinghai Yue,

Wei Zhao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 23, 2024

Objectives Observational studies have identified an association between dried fruit intake and kidney function. However, these limitations such as vulnerability to confounders reverse causality bias. Therefore, this study aimed explore the potential causal relationship Methods A two-sample Mendelian randomization (MR) was conducted using a large-scale genome-wide dataset investigate function markers (blood urea nitrogen (BUN), creatinine (CR), uric acid (UA), cystatin C (CyC), hematuria, microalbuminuria). The main analytical method inverse variance weighting. In addition, we applied MR Egger weighted median assess robustness of results. Finally, Multivariate (MVMR) used estimate direct effect on markers. Results univariate analysis showed that increased associated with lower markers, including BUN ( β : −0.171, 95% confidence interval (CI): −0.239 −0.102, p = 1.063 × 10 −6 ), CR −0.205, CI: −0.311 −0.099, 1.455 −4 UA −0.317, −0.384 −0.249, 4.439 −20 CysC −0.323, 1.074 −11 ); however, it unrelated hematuria microalbuminuria. Causality persisted after performing MVMR analysis; addition alcohol consumption smoking exposure factors, for −0.296, −0.523 −0.068, 1.094 −2 ) −0.238, −0.465 −0.011, 4.024× weakened, while −0.038, −0.215 0.138, 6.698 −1 −0.431 0.046, 1.347 disappeared. Conclusion Increased (BUN, CR, UA, CysC) in absence consumption; disappeared presence consumption. These results provide promising avenue delaying course chronic disease.

Language: Английский

Citations

0