Indian Pediatrics, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Language: Английский
Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1766 - 1766
Published: April 23, 2022
Food allergies are an increasing health problem worldwide. They multifactorial diseases, in which the genome alone does not explain development of disease, but a genetic predisposition and various environmental factors contribute to their onset. Environmental factors, particular nutritional early stages life recognized as key elements etiology food allergies. There is growing evidence advising that nutrition can affect risk developing through epigenetic mechanisms elicited by themselves or modulating gut microbiota its functional products. Gut postbiotics turn influence allergy mechanisms. Epigenetic programming accounts only for short-term effects on individual’s status, also those observed adulthood. The first thousand days represent important window susceptibility including ones, From this point view, it represents interesting opportunity intervention. This review reports main immune oral tolerance modulation
Language: Английский
Citations
23
Diagnostics, Journal Year: 2023, Volume and Issue: 13(5), P. 979 - 979
Published: March 4, 2023
Circulating fatty acids (FA) have an endogenous or exogenous origin and are metabolized under the effect of many enzymes. They play crucial roles in mechanisms: cell signaling, modulation gene expression, etc., which leads to hypothesis that their perturbation could be cause disease development. FA erythrocytes plasma rather than dietary used as a biomarker for diseases. Cardiovascular was associated with elevated trans decreased DHA EPA. Increased arachidonic acid Docosahexaenoic Acids (DHA) were Alzheimer’s disease. Low Arachidonic neonatal morbidities mortality. Decreased saturated (SFA), increased monounsaturated (MUFA) polyunsaturated (PUFA) (C18:2 n-6 C20:3 n-6) cancer. Additionally, genetic polymorphisms genes coding enzymes implicated metabolism desaturase (FADS1 FADS2) disease, Acute Coronary Syndrome, Autism spectrum disorder obesity. Polymorphisms elongase (ELOVL2) FA-binding protein polymorphism is dyslipidemia, type 2 diabetes, metabolic syndrome, obesity, hypertension, non-alcoholic liver peripheral atherosclerosis combined diabetes polycystic ovary syndrome. Acetyl-coenzyme A carboxylase obesity diabetic nephropathy. profile variants proteins considered biomarkers may help prevention management
Language: Английский
Citations
16
Frontiers in Allergy, Journal Year: 2023, Volume and Issue: 4
Published: Jan. 30, 2023
The “epithelial barrier hypothesis” states that a dysfunction can result in allergy development due to tolerance breakdown. This alteration may come from the direct contact of epithelial and immune cells with allergens, indirectly, through deleterious effects caused by environmental changes triggered industrialization, pollution, lifestyle. Apart their protective role, respond external factors secreting IL-25 IL-33, TSLP, provoking activation ILC2 Th2-biased response. Several agents influence function, such as allergenic proteases, food additives or certain xenobiotics are reviewed this paper. In addition, dietary response positive negative way will be also described here. Finally, we discuss how gut microbiota, its composition, microbe-derived metabolites, short-chain fatty acids, alter not only but integrity distant barriers, focusing review on gut-lung axis.
Language: Английский
Citations
13
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: Jan. 8, 2024
Long-chain fatty acids (LCFAs) are involved in regulating multiple physiological processes as signalling molecules. Gas chromatography-mass spectrometry (GC-MS) is widely used to quantify LCFAs. However, current quantitative methods for LCFAs using GC-MS have demonstrated complicated issues. Psoriasis a chronic inflammatory skin disease, and its pathogenesis may be related the overproduction of interleukin-17A (IL-17A). Clinical efficacy anti-IL-17A monoclonal antibody (mAb) treatment psoriasis patients has been demonstrated. Recent studies suggest that play varying roles psoriasis. more comprehensive research needed illuminate mechanism
Language: Английский
Citations
5
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: May 15, 2023
The immune function of normal T cells partially depends on the maneuvering lipid metabolism through various stages and subsets. Interestingly, T-cell malignancies also reprogram their to fulfill bioenergetic demand for rapid division. rewiring in not only provides survival benefits but contributes stemness, invasion, metastasis, angiogenesis. Owing distinctive metabolic programming cancer, quantitative, qualitative, spatial enrichment specific molecules occur. formation rafts rich cholesterol confers physical strength sustains signals. accumulation lipids de novo synthesis uptake free contribute reserve required robust during migration metastasis. Lipid storage leads specialized structures known as droplets. inimitable changes fatty acid (FAS) oxidation (FAO) are dynamic balance malignancies. FAO fuels molecular pumps causing chemoresistance, while FAS offers structural signaling cancer having immunosuppressive abilities. Moreover, composition membrane has implications evasion by malignant origin. droplets contributors maintaining hallmarks cells. In preclinical settings, targeting potentiates antitumor immunity chemotherapeutic response. Thus, direct adjunct benefit is expected improve clinical management
Language: Английский
Citations
11
Current Nutrition Reports, Journal Year: 2023, Volume and Issue: 12(4), P. 813 - 829
Published: Nov. 23, 2023
Language: Английский
Citations
11
Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(5), P. 1162 - 1170
Published: April 3, 2024
Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but molecular mechanisms underlying these are not fully elucidated. This study aimed determine associations between DHA, AA, proteins during neonatal period in extremely infants.
Language: Английский
Citations
4
Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1471 - 1471
Published: July 19, 2024
Asthma is, worldwide, the most frequent non-communicable disease affecting both children and adults, with high morbidity relatively low mortality, compared to other chronic diseases. In recent decades, prevalence of asthma has increased in pediatric population, and, general, risk developing asthma-like symptoms is higher during first years life. The "gut-lung axis" concept explains how gut microbiota influences lung immune function, acting directly, by stimulating innate system, indirectly, through metabolites it generates. Thus, process intestinal microbial colonization newborn crucial for his/her future health, alterations that might generate dysbiosis 100 days life are influential promoting hypersensitivity That why this period termed "critical window". This paper reviews published evidence on numerous factors can act modifying profile infant, thereby or inhibiting later following specifically addressed depth here: diet pregnancy, maternal adherence a Mediterranean diet, mode delivery, exposure antibiotics, type infant feeding three months
Language: Английский
Citations
4
Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1362 - 1362
Published: Oct. 26, 2024
Aging induces complex changes in the lipid profiles across different areas of brain. These can affect function brain cells and may contribute to neurodegenerative diseases such as Alzheimer's disease. Research shows that while overall profile human remains quite steady throughout adulthood, specific occur with age, especially after age 50. include a slow decline total content shifts composition fatty acids, particularly glycerophospholipids cholesterol levels, which vary depending on region. Lipid rafts play crucial role maintaining membrane integrity facilitating cellular signaling. In context disease, have been associated development For example, alterations raft lead increased accumulation amyloid β (Aβ) peptides, contributing neurotoxic effects. droplets store neutral lipids are key for energy metabolism. As organisms dynamics change, evidence suggesting metabolic activity over time. This reduced an imbalance synthesis mobilization, processes. model like Drosophila, studies shown metabolism be influenced by diet insulin signaling pathways, balance. The interplay between metabolism, oxidative stress, inflammation is critical aging peroxidation, consequence formation reactive aldehydes further damage neurons. Inflammatory processes also disrupt pathology AD. Consequently, oxidized integrity, influencing pathways involved neuronal survival function.
Language: Английский
Citations
4
Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 6, 2025
Breast milk is the primary source of nutrition during early life, and existing research indicates that development jaundice in breastfed newborns may be linked to specific nutrients or bioactive substances present breast milk. However, association between microbiota small-molecule metabolites neonatal remains unproven. This study aimed investigate neonates relation metabolites. Based on conditions exclusive breastfeeding, we selected healthy without significant their mothers day 4 (96-120 h after birth) as control group, jaundiced group. samples were collected from both groups postnatal analyzed for using 16S rRNA gene sequencing an liquid chromatography-tandem mass spectrometry techniques. A total 104 mother-child pairs included study, which 51 group other 53 Our results demonstrated there was no difference species composition diversity flora groups. At genus level, abundance Lactobacillus, Ackermannia, Bifidobacterium significantly higher than Metabolomics analysis revealed a 27 different two Notably, had elevated levels 24 metabolites, predominantly lipids family, including sphingolipids, phospholipids, fatty acid derivatives. suggests link contains beneficial bacteria lipid family compared with jaundice. offers new insights into relationship breastfeeding
Language: Английский
Citations
0