Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6803 - 6803

Published: June 24, 2021

Adequate amounts of a wide range micronutrients are needed by body tissues to maintain health. Dietary intake must be sufficient meet these micronutrient requirements. Mineral deficiency does not seem the result physically active life or athletic training but is more likely arise from disturbances in quality and quantity ingested food. The lack some minerals appears symbolic modern era reflecting either excessive empty calories negative energy balance drastic weight-loss diets. Several animal studies provide convincing evidence for an association between dietary availability microbial composition gut. However, influence human gut microbiota on bioaccessibility bioavailability trace elements food has rarely been studied. Bacteria play role effecting mineral bioaccessibility, which further increased through fermentation cereals soaking germination crops. Moreover, probiotics have positive effect iron, calcium, selenium, zinc relation microbiome metabolism. current literature reveals beneficial effects bacteria supporting both overall This review focuses interactions several sport nutrition, as related lifestyle.

Language: Английский

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The Role of Magnesium in the Pathogenesis of Metabolic Disorders

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1714 - 1714

Published: April 20, 2022

Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It involved in many fundamental processes, and Mg deficiency often correlated with negative health outcomes. On the one hand, most western civilizations consume less than recommended daily allowance of Mg. other a growing body evidence has indicated that chronic hypomagnesemia may be implicated pathogenesis various metabolic disorders such as overweight obesity, insulin resistance (IR) type 2 diabetes mellitus (T2DM), hypertension (HTN), changes lipid metabolism, low-grade inflammation. High intake diet and/or supplementation seems to prevent complications. The protective action include limiting adipose tissue accumulation, improving glucose enhancing endothelium-dependent vasodilation, normalizing profile, attenuating inflammatory processes. Thus, it currently plays important role developing associated although more randomized controlled trials (RCTs) evaluating strategies are needed. This work represents review synthesis recent data on disorders.

Language: Английский

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Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

BioFactors, Journal Year: 2022, Volume and Issue: 48(2), P. 307 - 314

Published: March 1, 2022

Abstract Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of human body, their deficiencies can have dramatic short‐ long‐term health consequences. Among underlying causes, certainly a reduced dietary intake and/or poor absorption in gastrointestinal tract play key role decreasing bioavailability. Recent evidence from clinical vivo studies suggests an increasingly important contribution gut microbiome. Commensal microorganisms fact regulate levels micronutrients, both by intervening biosynthetic processes modulating absorption. This short narrative review addresses pivotal microbiome influencing bioavailability (such as A, B, C, D, E, K) minerals (calcium, iron, zinc, magnesium, phosphorous), well impact these micronutrients on composition functionality. Personalized microbiome‐based intervention strategies could therefore constitute innovative tool to counteract micronutrient toward eubiotic configuration capable satisfying needs our organism, while promoting general health.

Language: Английский

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Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1228 - 1228

Published: Jan. 19, 2024

The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in body. Existing evidence suggests that nutrients can influence modulation gut microbiota. However, there still limited regarding effects vitamin mineral supplementation on through epigenetic modification. It plausible maintaining an adequate dietary intake D, iron, fibre, zinc magnesium may have beneficial effect alleviating inflammation body, reducing oxidative stress, improving condition various mechanisms. Moreover, epigenetics involves alterations phenotype cell without changing its fundamental DNA sequence. appears by lead to regulation. correlations between are interdependent. Therefore, primary objective this review identify complex relationships diet, microbiota, These interactions could play crucial role systemic health.

Language: Английский

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Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(12), P. e2324 - e2333

Published: Feb. 14, 2024

Abstract Context The association between magnesium status and metabolic syndrome (MetS) remains unclear. Objective This study aimed to examine the relationship kidney reabsorption-related depletion score (MDS) MetS among US adults. Methods We analyzed data from 15 565 adults participating in National Health Nutrition Examination Survey (NHANES) 2003 2018. was defined according Cholesterol Education Program's Adult Treatment Panel III report. MDS is a scoring system developed predict of deficiency that fully considers pathophysiological factors influencing kidneys' reabsorption capability. Weighted univariate multivariable logistic regression were used assess MetS. Restricted cubic spline (RCS) analysis conducted characterize dose-response relationships. Stratified analyses by sociodemographic lifestyle also performed. Results In both analyses, higher significantly associated with increased odds Each unit increase approximately 30% risk for MetS, even after adjusting confounding (odds ratio 1.31; 95% CI, 1.17-1.45). RCS graphs depicted linear across range. positive correlation remained consistent various population subgroups exhibited no significant interaction age, sex, race, adiposity, smoking status, or alcohol consumption. Conclusion Higher urinary loss as quantified may be an independent factor adults, irrespective behavioral factors. Optimizing nutritional could potentially confer benefits patients

Language: Английский

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The relevance of magnesium homeostasis in COVID-19

European Journal of Nutrition, Journal Year: 2021, Volume and Issue: 61(2), P. 625 - 636

Published: Oct. 23, 2021

Abstract Purpose In less than one and a half year, the COVID-19 pandemic has nearly brought to collapse our health care economic systems. The scientific research community concentrated all possible efforts understand pathogenesis of this complex disease, several groups have recently emphasized recommendations for nutritional support in patients. scoping review, we aim at encouraging deeper appreciation magnesium clinical nutrition, view vital role numerous links between pathophysiology SARS-CoV-2 infection magnesium-dependent functions. Methods By searching PubMed Google Scholar from 1990 date, review existing evidence experimental studies on chronic non-communicable diseases infectious diseases, focus recent reports alterations homeostasis patients their association with disease outcomes. Importantly, conduct census ongoing trials specifically dedicated disclosing COVID-19. Results Despite many methodological limitations, data seem corroborate an deranged COVID-19, call further better explore prophylactic or therapeutic potential supplementation. Conclusion We propose reconsider relevance magnesium, frequently overlooked practice. Therefore, magnesemia should be monitored and, case imbalanced homeostasis, appropriate regimen supplementation might contribute protect against infection, reduce severity symptoms facilitate recovery after acute phase.

Language: Английский

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Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 223 - 223

Published: Dec. 23, 2022

Magnesium (Mg) is involved in the regulation of metabolism and maintenance homeostasis all tissues, including brain, where it harmonizes nerve signal transmission preserves integrity blood–brain barrier. Mg deficiency contributes to systemic low-grade inflammation, common denominator most diseases. In particular, neuroinflammation hallmark neurodegenerative disorders. Starting from a rapid overview on role magnesium this narrative review provides evidences linking derangement balance with multiple sclerosis, Alzheimer’s, Parkinson’s

Language: Английский

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A weighted quantile sum regression with penalized weights and two indices

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: July 18, 2023

New statistical methodologies were developed in the last decade to face challenges of estimating effects exposure multiple chemicals. Weighted Quantile Sum (WQS) regression is a recent method that allows mixture effect associated with specific health and identifying components characterize effect.In this study, we propose an extension WQS estimates two chemicals on outcome same model through inclusion indices, one positive direction negative direction, introduction penalization term.To evaluate performance new performed both simulation study real case where assessed nutrients obesity among adults using National Health Nutrition Examination Survey (NHANES) data.The showed good parameter weights single elements when penalized term was set equal magnitude Akaike information criterion unpenalized regression. The indices further helped give better estimate parameters [Positive Median Error (PME): 0.022; Negative (NME): -0.044] compared standard without (PME: -0.227; NME: 0.215). In able find significant directions sodium magnesium as main actors association, respectively.Through work, introduced improved accuracy considering can have protective harmful outcome; advantage adding weights.

Language: Английский

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Association between dietary magnesium and 10-year risk of a first hard atherosclerotic cardiovascular disease event

The American Journal of the Medical Sciences, Journal Year: 2024, Volume and Issue: 368(4), P. 355 - 360

Published: May 26, 2024

Background To test whether dietary magnesium is associated with 10-year risk of a first hard atherosclerotic cardiovascular disease event. Method In this cross-sectional study, total 2980 participants, aged 40 to 79 years, from the National Health and Nutrition Examination Survey 1999-2018 were analyzed. The association between (ASCVD) event was assessed following adjustment for clinical factors, including sex, age, race, educational level, body mass index (BMI), alcohol drinking, smoking, systolic blood pressure (SBP), diastolic (DBP), hypertension treated or not, diabetes low density lipoprotein cholesterol (LDL-C), energy fiber. We performed multivariate linear regression models smooth curve fittings evaluate associations Result observed significant inverse predicted (β=-0.01, [95%CI: -0.01, -0.00], P=0.0256). divided into two categories, statistically reduction ASCVD when risk≥7.5% P=0.0440). Conclusion Dietary intake inversely

Language: Английский

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Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 13, 2024

Magnesium (Mg), an essential mineral abundantly present within the human body, is intricately involved in a multitude of biochemical processes vital for maintaining health and overall well-being. This review aims to delve into multifaceted impact Mg on health, exploring its physiological functions, dietary sources, potential implications deficiency or insufficiency. plays pivotal role various processes, including energy metabolism, muscle contraction, protein synthesis, DNA synthesis. It acts as cofactor more than 300 enzymatic reactions, facilitating conversion adenosine triphosphate (ATP) diphosphate (ADP) production. Moreover, proper functioning ion channels, particularly calcium influencing nerve transmission relaxation. naturally found wide array foods, with green leafy vegetables, whole grains, nuts, seeds, legumes being rich sources. Additionally, certain fortified foods supplements provide supplemental intake. Deficiency insufficiency mg can have profound health. Inadequate levels been associated increased risks chronic diseases, hypertension, type 2 diabetes, osteoporosis, cardiovascular diseases. Furthermore, may manifest symptoms such weakness, fatigue, tremors, irregular heartbeat. Numerous studies elucidated relationship between intake risk developing For instance, epidemiological evidence suggests that higher reduced possibly due vasodilatory effects influence blood pressure regulation mechanisms. Similarly, has implicated pathophysiology contributing insulin resistance impaired glucose metabolism. adequate crucial bone density reducing mineralization Understanding importance physiology underscores significance ensuring through diet supplementation. Healthcare professionals play critical educating individuals about incorporating mg-rich their diets considering supplementation when necessary, at those indispensable far-reaching Its involvement Ensuring preventing deficiency-related complications Further research warranted elucidate optimal strategies therapeutic applications disease prevention management.

Language: Английский

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