Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

BioFactors, Journal Year: 2022, Volume and Issue: 48(2), P. 307 - 314

Published: March 1, 2022

Abstract Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of human body, their deficiencies can have dramatic short‐ long‐term health consequences. Among underlying causes, certainly a reduced dietary intake and/or poor absorption in gastrointestinal tract play key role decreasing bioavailability. Recent evidence from clinical vivo studies suggests an increasingly important contribution gut microbiome. Commensal microorganisms fact regulate levels micronutrients, both by intervening biosynthetic processes modulating absorption. This short narrative review addresses pivotal microbiome influencing bioavailability (such as A, B, C, D, E, K) minerals (calcium, iron, zinc, magnesium, phosphorous), well impact these micronutrients on composition functionality. Personalized microbiome‐based intervention strategies could therefore constitute innovative tool to counteract micronutrient toward eubiotic configuration capable satisfying needs our organism, while promoting general health.

Language: Английский

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Encapsulation of multiple probiotics, synbiotics, or nutrabiotics for improved health effects: A review

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 309, P. 102781 - 102781

Published: Sept. 25, 2022

Language: Английский

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Bioactive compounds for human and planetary health

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 17, 2023

Bioactive compounds found in edible plants and foods are vital for human planetary health, yet their significance remains underappreciated. These natural bioactives, as part of whole diets, ingredients, or supplements, can modulate multiple aspects health wellness. Recent advancements omic sciences computational biology, combined with the development Precision Nutrition, have contributed to convergence nutrition medicine, well more efficient affordable healthcare solutions that harness power food prevention therapy. Innovation this field is crucial feed a growing global population sustainably healthily. This requires significant changes our system, spanning agriculture, production, distribution consumption. As we facing pressing challenges, investing bioactive-based an opportunity protect biodiversity soils, waters, atmosphere, while also creating value consumers, patients, communities, stakeholders. Such research innovation targets include alternative proteins, such cellular agriculture plant-derived protein; extracts improve shelf-life preservatives; upcycling agricultural by-products reduce waste; alternatives synthetic fertilizers pesticides. Translational bioactives currently being developed at two levels, using systems-oriented approach. First, biological level, interplay between these host microbiome elucidated through omics research, big data artificial intelligence, accelerate both discovery validation. Second, ecosystem efforts focused on producing diverse nutrient-rich, flavorful, resilient, high-yield crops, educating consumers make informed choices benefit planet. Adopting system-oriented perspective helps: unravel intricate dynamic relationships nutrition, sustainability outcomes, harnessing nature promote wellbeing; foster sustainable ecosystem. Interdisciplinary collaboration needed new era practical food-based some most challenges humanity planet today.

Language: Английский

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Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1228 - 1228

Published: Jan. 19, 2024

The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in body. Existing evidence suggests that nutrients can influence modulation gut microbiota. However, there still limited regarding effects vitamin mineral supplementation on through epigenetic modification. It plausible maintaining an adequate dietary intake D, iron, fibre, zinc magnesium may have beneficial effect alleviating inflammation body, reducing oxidative stress, improving condition various mechanisms. Moreover, epigenetics involves alterations phenotype cell without changing its fundamental DNA sequence. appears by lead to regulation. correlations between are interdependent. Therefore, primary objective this review identify complex relationships diet, microbiota, These interactions could play crucial role systemic health.

Language: Английский

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Small intestinal microbiota: from taxonomic composition to metabolism

Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(10), P. 970 - 983

Published: March 19, 2024

The small intestinal microbiota (SIM) is essential for gastrointestinal health, influencing digestion, immune modulation, and nutrient metabolism. Unlike the colonic microbiota, SIM has been poorly characterized due to sampling challenges ethical considerations. Current evidence suggests that consists of five core genera additional segment-specific taxa. These bacteria closely interact with human host, regulating absorption Recent work presence two forms bacterial overgrowth, one dominated by oral (SIOBO) a second coliform bacteria. Less invasive techniques, omics approaches, mechanistic studies will allow more comprehensive understanding SIM, paving way interventions engineering towards better health.

Language: Английский

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Microbes Saving Lives and Reducing Suffering

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

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Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living

Human Genomics, Journal Year: 2023, Volume and Issue: 17(1)

Published: Dec. 8, 2023

Abstract The unique physiological and genetic characteristics of individuals influence their reactions to different dietary constituents nutrients. This notion is the foundation personalized nutrition. field nutrigenetics has witnessed significant progress in understanding impact variants on macronutrient micronutrient levels individual's responsiveness intake. These hold value facilitating development nutritional interventions, thereby enabling effective translation from conventional guidelines genome-guided Nevertheless, certain obstacles could impede extensive implementation individualized nutrition, which still its infancy, such as polygenic nature nutrition-related pathologies. Consequently, many disorders are susceptible collective multiple genes environmental interplay, wherein each gene exerts a moderate modest effect. Furthermore, it widely accepted that diseases emerge because intricate interplay between predisposition external influences. In context this specific paradigm, utilization advanced "omic" technologies, including epigenomics, transcriptomics, proteomics, metabolomics, microbiome analysis, conjunction with comprehensive phenotyping, potential unveil hitherto undisclosed hereditary elements interactions environment. review aims provide up-to-date information regarding fundamentals specifically emphasizing complex triangulation among microbiota, metabolites, genes. highlights intestinal microbiota's makeup, nutrigenomics, tailoring suggestions. Finally, article provides an overview genotyping versus microbiomics, focusing investigating applications knowledge tailored plans aim improve human well-being overall health.

Language: Английский

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Diet-microbiota associations in gastrointestinal research: a systematic review

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 9, 2024

Interactions between diet and gastrointestinal microbiota influence health status outcomes. Evaluating these relationships requires accurate quantification of dietary variables relevant to microbial metabolism, however current assessment methods focus on components human digestion only. The aim this study was synthesize research foods nutrients that gut thereby identify knowledge gaps inform advancements toward better understanding diet-microbiota interactions. Thirty-eight systematic reviews 106 primary studies reported associations. Dietary factors altering colonic included patterns, macronutrients, micronutrients, bioactive compounds, food additives. Reported associations were dominated by routinely analyzed nutrients, which are absorbed from the small intestine but for correlation stool microbiota. derived microbiota-relevant more challenging quantify underrepresented in studies. This evidence synthesis highlights needed, including opportunities expansion composition databases include data, particularly intervention These advances methodology will facilitate translation microbiota-specific nutrition therapy practice.

Language: Английский

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Effects of Deep Ocean-Derived Magnesium-Enhanced Water on Metabolic Diseases with Microbiome Changes

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103203 - 103203

Published: Feb. 1, 2025

Language: Английский

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Exploring the interaction and impact of probiotic and commensal bacteria on vitamins, minerals and short chain fatty acids metabolism

Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 12, 2024

Abstract There is increasing evidence that probiotic and commensal bacteria play a role in substrate metabolism, energy harvesting intestinal homeostasis, may exert immunomodulatory activities on human health. In addition, recent research suggests these microorganisms interact with vitamins minerals, promoting metabolic well-being while producing vital microbial metabolites such as short-chain fatty acids (SCFAs). this regard, there flourishing field exploring the intricate dynamics between vitamins, SCFAs, commensal/probiotic interactions. review, we summarize some of major hypotheses beyond mechanisms by which commensals/probiotics impact gut health their additional effects absorption metabolism SCFAs. Our analysis includes comprehensive review existing from preclinical clinical studies, particular focus potential interaction micronutrients. Finally, highlight knowledge gaps outline directions for future evolving field.

Language: Английский

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