Salt-Tolerant Plants, Halophytes, as Renewable Natural Resources for Cancer Prevention and Treatment: Roles of Phenolics and Flavonoids in Immunomodulation and Suppression of Oxidative Stress towards Cancer Management

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5171 - 5171

Published: March 8, 2023

Halophytes and xerophytes, plants with adequate tolerance to high salinity strong ability survive in drought ecosystem, have been recognized for their nutritional medicinal values owing comparatively higher productions of secondary metabolites, primarily the phenolics, flavonoids, as compared normal vegetation other climatic regions. Given consistent increases desertification around world, which are associated increasing salinity, temperature, water scarcity, survival halophytes due metabolic contents has prioritized these plant species, now become increasingly important environmental protection, land reclamation, food animal-feed security, primary utility traditional societies sources drugs. On herbs front, because fight against cancer is still ongoing, there an urgent need development more efficient, safe, novel chemotherapeutic agents, than those currently available. The current review describes secondary-metabolite-based chemical products promising candidates developing newer therapeutics. It further discusses prophylactic roles plants, constituents prevention management cancers, through exploration phytochemical pharmacological properties, a view on immunomodulation. various phenolics structurally diverse flavonoids major suppressing oxidative stress, immunomodulation, anti-cancer effects subject matter this aspects outlined details.

Language: Английский

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Phyllanthus emblica: a comprehensive review of its phytochemical composition and pharmacological properties

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 26, 2023

Phyllanthus emblica Linn, a prominent member of the euphorbiaceae family, exhibits extensive distribution across multitude tropical and subtropical nations. Referred to as “Balakka” in Indonesia, this plant assumes various names regions, such “kimalaka,” “balakka,” “metengo,” “malaka,” “kemloko” North Sumatra, Ternate, Sundanese, Java respectively. thrives locales like Malaysia, Thailand, while also making its presence felt regions India, China, Uzbekistan, Sri Lanka. The fruits Balakka are enriched with bioactive constituents recognized for their wide-ranging benefits, including antioxidant, anti-aging, anti-cholesterol, anti-diabetic, immunomodulatory, antipyretic, analgesic, anti-inflammatory, chemoprotective, hepatoprotective, cardioprotective, antimutagenic, antimicrobial properties. Comprising spectrum phenolic compounds (such tannins, acids, flavonoids), alkaloids, phytosterols, terpenoids, organic amino vitamins, components Malacca fruit offer diverse array health-promoting attributes. In light these insights, review aims comprehensively examine pharmacological activities associated P. delve into intricate composition phytochemical constituents.

Language: Английский

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An updated review of functional ingredients of Manuka honey and their value-added innovations

Food Chemistry, Journal Year: 2023, Volume and Issue: 440, P. 138060 - 138060

Published: Nov. 24, 2023

Manuka honey (MH) is a highly prized natural product from the nectar of Leptospermum scoparium flowers. Increased competition on global market drives MH innovations. This review updates comparative and non-comparative studies to highlight nutritional, therapeutic, bioengineering, cosmetic values MH. good source phenolics unique chemical compounds, such as methylglyoxal, dihydroxyacetone, leptosperin glyoxal, methylsyringate leptosin. Based evidence in vitro, vivo clinical studies, multifunctional bioactive compounds have exhibited anti-oxidative, anti-inflammatory, immunomodulatory, anti-microbial, anti-cancer activities. There are controversial topics related MH, grading, safety/efficacy, implied benefits, maximum levels contaminants concerned. Artificial intelligence can optimize analysis, toxicity prediction, multi-functional mechanism exploration innovation.

Language: Английский

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Oral administration of Manuka honey induces IFNγ-dependent resistance to tumor growth that correlates with beneficial modulation of gut microbiota composition

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 20, 2024

Background To investigate the potential of Manuka honey (MH) as an immunomodulatory agent in colorectal cancer (CRC) and dissect underlying molecular cellular mechanisms. Methods MH was administered orally over a 4 week-period. The effect treatment on microbiota composition studied using 16S rRNA sequencing fecal pellets collected before after treatment. Pretreated mice were implanted with CRC cells followed for tumor growth. Tumors lymphoid organs analyzed by flow cytometry (FACS), immunohistochemistry qRT-PCR. Efficacy also assessed therapeutic setting, oral initiated implantation. We utilized IFNγ-deficient to determine importance interferon signaling MH-induced immunomodulation. Results Pretreatment enhanced anti-tumor responses leading suppression Evidence immunogenicity included upregulated MHC class-II intratumoral macrophages, class-I expression increased infiltration effector T into microenvironment. Importantly, effective retarding growth when given therapeutically. Transcriptomic analysis tissue highlighted changes various chemokines inflammatory cytokines that drive observed immunogenicity. capacity abrogated mice. Finally, bacterial demonstrated induced unique gut may well underlie IFN-dependent enhancement Conclusion Our findings highlight immunostimulatory properties demonstrate its utilization prevention

Language: Английский

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Integrative metabolomic and transcriptomic analyses reveals the accumulation patterns of key metabolites associated with flavonoids and terpenoids of Gynostemma pentaphyllum (Thunb.) Makino

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 15, 2024

Abstract Gynostemma pentaphyllum (Thunb.) Makino ( G. ) is a medicinal and edible plant with multiple functions of liver protection, anti-tumor, anti-inflammation, balancing blood sugar lipids. The nutritional value the mainly due to its rich variety biologically active substances, such as flavonoids, terpenes polysaccharides. In this study, we performed comprehensive analysis combining metabolomics root, stem leaf transcriptomic data . We used transcriptomics construct dynamic regulatory network diagram flavonoids terpenoids, screened transcription factors involved in including basic helix-loop-helix (bHLH), myb-related, WRKY, AP2/ERF. Transcriptome results showed that among DEGs related synthesis dihydroflavonol 4-reductase (DFR) geranylgeranyl diphosphate synthases (GGPPS) were core genes. This study presents image gene expression different tissues , elucidating key genes metabolites terpenoids. beneficial deeper understanding plants also provides scientific basis for further mechanisms natural product pathways drug development.

Language: Английский

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Incorporation of natural and synthetic polymers into honey hydrogel for wound healing: A review

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(7)

Published: July 1, 2024

The difficulty in treating chronic wounds due to the prolonged inflammation stage has affected a staggering 6.5 million people, accompanied by 25 billion USD annually United States alone. A 1.9% rise wound prevalence among Medicare beneficiaries was reported from 2014 2019. Besides, global care market values were anticipated increase 20.18 2022 30.52 2030, suggesting an expected financial burdens. lack of feasibility using traditional dry dressings sparks hydrogel development as alternative approach tackling wounds. Since ancient times, honey been used treat wounds, including burns, and ongoing studies have also demonstrated its wound-healing capabilities on cellular animal models. However, fluidity low mechanical strength necessitate incorporation other polymers. Therefore, this review aims unravel characteristics natural (chitosan gelatin) synthetic (polyvinyl alcohol polyethylene glycol) polymers be incorporated hydrogel.

Language: Английский

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7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development

Current Neuropharmacology, Journal Year: 2021, Volume and Issue: 20(8), P. 1479 - 1497

Published: Sept. 16, 2021

7,8-Dihydroxyflavone (7,8-DHF) is a kind of natural flavonoid with the potential to cross blood-brain barrier. 7,8-DHF effectively mimics effect brain-derived neurotrophic factor (BDNF) in brain selectively activate tyrosine kinase receptor B (TrkB) and downstream signaling pathways, thus playing neuroprotective role. The preclinical effects have been widely investigated neuropsychiatric disorders, including Alzheimer's disease (AD), Parkinson's (PD), depression, memory impairment. Besides on TrkB, could also function through fighting against oxidative stress, cooperating estrogen receptors, or regulating intestinal flora. This review focuses recent experimental studies neurodegenerative diseases, learning functions. Additionally, structural modification preparation were concluded proposed, hoping provide reference for follow-up research clinical drug development field disorders.

Language: Английский

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The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

Applied Sciences, Journal Year: 2021, Volume and Issue: 11(11), P. 5192 - 5192

Published: June 3, 2021

Honey is a honey-bee product obtained mainly by the enzymatic processing of nectar from variety plants, which leads to wide range colours and flavours available on market. These organoleptic nutritional features are influenced chemical composition, in turn depends botanical origin. Bioactive compounds account for honey beneficial activity medical applications, explains extensive use ethno-pharmacology since antiquity, cough remedies dermatological treatments. Wound healing one main therapeutic uses honey, various design options pharmaceutical technology such as smart delivery systems advanced dressings currently being developed potentiate honey’s valuable properties better performance improved final outcome. In this review, we will focus latest research that discloses crucial factors determining what most when considering medicinal product. We present recent updates possible mechanisms responsible exceptional effects ageless therapeutical remedy skin repair. Furthermore, state-of-the-art application techniques (incorporation into scaffolds an alternative direct administration) used enhance honey-mediated wound-healing explored.

Language: Английский

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Antimicrobial properties of honeys produced by stingless bees (Hymenoptera, Apidae, Meliponini) from different vegetation zones of Tanzania

International Journal of Tropical Insect Science, Journal Year: 2023, Volume and Issue: 43(5), P. 1563 - 1581

Published: Aug. 30, 2023

Language: Английский

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Trends, key contributors, and emerging issues in honey and breast cancer: A bibliometric analysis from 2014 to 2024

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 17 - 17

Published: Jan. 3, 2025

Background Honey, a natural product with diverse bioactive compounds, has been increasingly explored for its potential anticancer properties. This study aims to comprehensively analyze the scientific literature on relationship between honey and breast cancer. Methods A bibliometric analysis was conducted using ScienceDirect database identify publications from 2014 2024. Data publication trends, author collaboration, keyword were extracted gain insight into research landscape. Keyword identified nine distinct clusters, indicating directions regarding role of in cancer treatment. Results Key journals such as Journal Ethnopharmacology Food Chemistry have at forefront disseminating findings this domain, demonstrating strong interdisciplinary approach that bridges traditional medicine modern inquiry. The increasing interest properties honey, evidenced by growing number studies, underlines promising agent prevention Recent advances synthesis theranostic paradigms cerium oxide nanoparticles (CeONPs) highlighted, well selenium nanoconstructs. toxicity quality control Perillae Fructus also highlighted. Conclusions provides comprehensive overview current state knowledge uncovers emerging issues require further investigation.

Language: Английский

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