Pharmacological Properties of Honey

Published: Jan. 1, 2024

Language: Английский

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Differential in vitro cytotoxic effects and metabolomic insights into raw and powdered Manuka honey through UPLC-Q-TOF-MS

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 30, 2024

Abstract Manuka honey (MH) has garnered much attention due to its remarkable antimicrobial, anticancer, immunomodulatory and wound-healing properties. This study compared the antiproliferative effects of raw powdered MH (pMH) on various human murine cancer cell lines. A detailed metabolomics analysis was also carried out using untargeted ultrahigh-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry (UPLC-Q-TOF-MS) compare constituents in pMH. The results viability studies showed that both pMH caused a dose-dependent inhibition tumor growth at concentrations > 1% w/v (equivalent ~ 10 mg/ml). differential susceptibility observed among lines with MDA-MB-231 A549 cells B16.F10 being relatively resistant while MC38 colorectal adeno-carcinoma showing most sensitivity. effect validated 2 indepndent assays. Metabolomics detected 2440 compounds, which 833 were successfully identified. Among these, 90 phytochemical predominantly comprising terpenoids, flavonoids, coumarins derivatives, phenylpropanoic acids, 79 lipids identifiable. Significant differences 5 metabolite classes, including phenols, carbohydrates, organic acids between Moreover, several altered metabolic pathways identified MH, such as energy metabolism, amino acid other collectively influence biological functions associated cellular growth, signaling, stress response.

Language: Английский

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Pyrrole: An Essential Framework in the Development of Therapeutic Agents and Insightful Analysis of Structure‐Active Relationships

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(31)

Published: Aug. 16, 2024

Abstract Pyrrole is a heterocyclic structure with diverse pharmacophores, enabling the creation of an extensive lead molecule library. Its broad range pharmacological profiles has concerned significant global research interests. This review highlights recent advancements in pyrrole scaffolds, focusing on their active relationship and bioactivities. derivatives recognized for biological activities, are promising scaffolds developing antimicrobial, antimalarial, antiviral, antituberculosis, enzyme‐inhibiting properties. Their unique anti‐inflammatory antioxidant features have prompted development novel cardioprotective neuroprotective compounds. The aims to elucidate SAR mimics, aiding future therapeutic developments.

Language: Английский

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The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(3), P. 1109 - 1129

Published: Aug. 20, 2024

Within the domain of conventional oncochemotherapeutics, anticancer chemotherapy (AC) has emerged as a potent strategy for treatment cancers. AC is mainstay solid and non-solid cancer treatment. Its mechanistic action targets blockage DNA transcription dysregulation cell cycle machinery in cells, leading to activation death pathways. However, attendant side effect toxicity inflicted by on healthy tissues presents formidable challenge. The crucial culprit unknown, although oxidative stress, mitochondrial impairment, inflammatory cascades, autophagy dysregulation, apoptosis, certain aberrant signaling have been implicated. Honey natural bee product with significant health benefits pharmacological properties. Interestingly, literature reports that honey may proffer protection mechanism delicate tissue/organs against from AC. Thus, this review delves into prospective role an alleviator toxicity; it provides elucidation mechanisms honey’s molecular mitigation. endeavors unravel specific cascades which orchestrates its mitigating effects, overarching objective refining application adjuvant product. supplementation prevents via inhibition NF-κB-mediated inflammation, caspase-dependent apoptosis cascades. Although there need increased studies, could mitigate various toxicities induced

Language: Английский

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Lonicerae Japonicae Flos with the homology of medicine and food: a review of active ingredients, anticancer mechanisms, pharmacokinetics, quality control, toxicity and applications

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 9, 2024

Lonicerae Japonicae Flos (LJF, called Jinyinhua in China), comes from the dried flower buds or flowers to be opened of Lonicera japonica Thunb. family. It has a long history medicinal use and wide range application prospects. As modern research advances, an increasing number scientific experiments have demonstrated anticancer potential LJF. However, there is notable absence systematic reports detailing anti-tumor effects This review integrates principles Traditional Chinese Medicine (TCM) with contemporary pharmacological techniques, drawing upon literature authoritative databases such as PubMed, CNKI, WanFang conduct comprehensive study Notably, total 507 compounds been isolated characterized plant date, which include volatile oils, organic acids, flavonoids, iridoids, triterpenes triterpenoid saponins. Pharmacological studies that LJF extract, along components chlorogenic acid, luteolin, rutin, luteoloside, hyperoside isochlorogenic exhibits activities. Consequently, we conducted summary mechanisms action clinical applications these components. Furthermore, detailed pharmacokinetics, quality control, toxicity LJF, while also discussing its prospective fields biomedicine preventive healthcare. hoped will provide valuable reference for research, development,

Language: Английский

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