I Am the 1 in 10—What Should I Eat? A Research Review of Nutrition in Endometriosis

Nutrients, Journal Year: 2022, Volume and Issue: 14(24), P. 5283 - 5283

Published: Dec. 11, 2022

Endometriosis is a chronic, painful, estrogen-related inflammatory disease that affects approximately 10% of the female population. has significant negative impact on quality life. Nutrition may be involved in development and severity endometriosis. The purpose this paper to discuss detail nutritional recommendations for patients with This article discusses importance nutrients such as polyphenols, vitamins C, D E, PUFAs, iron Alternative diets, Mediterranean, anti-inflammatory, vegetarian, low-nickel low-FODMAP have also been presented context their potential beneficial effects course

Language: Английский

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Association between nutrient intake and female infertility: a study based on NHANES database

Journal of Obstetrics and Gynaecology, Journal Year: 2023, Volume and Issue: 43(2)

Published: Nov. 27, 2023

This study was designed to investigate the association between nutrients and female infertility.A cross-sectional on 18-45 years of age reproductive-age women conducted using data from National Health Nutrition Examination Surveys (NHANES) for periods 2013-2014 2015-2016. Multivariate logistic regression analysis performed evaluate infertility. Subgroup applied body mass index (BMI). Results were summarised an odds ratio (OR) with a 95% confidence interval (CI).Of total 1713 women, 204 (11.91%) infertile. The result demonstrated that higher intake carbohydrate (OR: 0.46, CI: 0.24-0.86, p = 0.018), vitamin A 0.44, 0.24-0.80, 0.009), C 0.48, 0.26-0.88, 0.020), magnesium 0.36, 0.17-0.76, iron 0.43, 0.23-0.82, 0.012), lycopene 0.55, 0.33-0.91, 0.022), folate 0.38, 0.20-0.70, 0.003) associated lower risk subgroup also reported intakes A, C, related infertility among BMI being 18.5-24.9 kg/m2. Among > 24.9 kg/m2, high magnesium, decreased infertility.The several is These findings provide insight into potentially modifiable lifestyle factors infertility.Infertility becoming global challenge in both medical social aspects. There growing evidence importance nutrition reproduction animal human studies, suggesting correlation fertility. We observed carbohydrates, iron, helped increase awareness health professionals patients about important link infertility, educate significance healthy diet.

Language: Английский

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Reconsidering evidence-based management of endometriosis

Facts Views and Vision in ObGyn, Journal Year: 2022, Volume and Issue: 14(3), P. 225 - 233

Published: Sept. 1, 2022

Without an adequate animal model permitting experiments the pathophysiology of endometriosis remains unclear and without a non-invasive diagnosis, information is limited to symptomatic women. Lesions are macroscopically biochemically variable. Hormonal medical therapy cannot be blinded since recognised by patient evidence extensive surgery because combination low numbers interventions variable difficulty with surgical skills. Experience spread among specialists in imaging, therapy, infertility, pain surgery. In addition, limitations traditional statistics p-values interpret results complementarity Bayesian inference should realised.To review discuss management.A PubMed search for randomised controlled trials endometriosis.Good-quality endometriosis.Clinical experience undervalued especially surgery.Evidence-based medicine integrate statistical analysis P-values, complementary which predictive sequential more like clinical medicine. Since important grading evidence, specific different disciplines used judge trial designs results. Finally, can considered as series outcome. Therefore, opinion many has value than opinion.

Language: Английский

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Leptin induces leiomyoma cell proliferation and extracellular matrix deposition via JAK2/STAT3 and MAPK/ERK pathways

F&S Science, Journal Year: 2022, Volume and Issue: 3(4), P. 383 - 391

Published: May 19, 2022

To investigate the molecular effects of leptin on uterine leiomyoma cells.Experimental study using in vitro culture immortalized human (HuLM) cells.Academic university center.Women with fibroids who underwent a hysterectomy or myomectomy.Administration recombinant to media cultured HuLM cells separately combination pharmacologic Janus kinase 2 (JAK2)/signal transducer and activator transcription 3 (STAT3) mitogen-activated protein (MAPK)/extracellular signal-regulated (ERK) inhibitors.We examined tissues for expression receptor, termed OB-R. Cellular proliferation was measured at 6, 24, 48 hours 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Protein levels proliferating cell nuclear antigen, collagen 1, phosphorylated STAT3/total STAT3, ERK1/2 total were quantified immunoblotting. Pharmacologic inhibitors employed further assess role JAK2/STAT3 MAPK/ERK pathways proliferative response.The presence OB-R confirmed clinical myometrial tissue obtained from separate subjects immunofluorescence staining, identified There no significant difference receptor myometrium compared that tissue. Leptin stimulated extracellular matrix (ECM) deposition 24 after treatment. Pretreatment inhibitor attenuated ECM deposition, pretreatment significantly decreased leptin's stimulatory effect deposition.Leptin induces response cells. These findings suggest leptin, acting through pathways, is involved development leiomyomas, which may partly explain their increased incidence obese women.

Language: Английский

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Adipocyte coculture induces a pro-inflammatory, fibrotic, angiogenic, and proliferative microenvironment in uterine leiomyoma cells

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2022, Volume and Issue: 1869(1), P. 166564 - 166564

Published: Sept. 29, 2022

Language: Английский

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