The importance of understanding why the Co²⁺‐binding ability of albumin is reduced in ischemia

International Journal of Gynecology & Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

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Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 807 - 807

Published: March 26, 2023

In the last few decades, our understanding of complex pathobiology uterine fibroid development has grown. While previously believed to be a purely neoplastic entity, we now understand that fibroids possess different and equally important aspects their genesis. An increasing body evidence suggests oxidative stress, imbalance between pro- antioxidants, is an factor in development. Oxidative stress controlled by multiple, interconnecting cascades, including angiogenesis, hypoxia, dietary factors. turn influences through genetic, epigenetic, profibrotic mechanisms. This unique aspect introduced several clinical implications, both diagnostic therapeutic, can aid us managing these debilitating tumors using biomarkers as well pharmaceutical antioxidants for diagnosis treatment. review strives summarize add current revealing relationship elucidating proposed mechanisms implications.

Language: Английский

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Free Fatty Acids and Free Fatty Acid Receptors: Role in Regulating Arterial Function

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7853 - 7853

Published: July 18, 2024

The metabolic network's primary sources of free fatty acids (FFAs) are long- and medium-chain triglyceride origin short-chain produced by intestinal microorganisms through dietary fibre fermentation. Recent studies have demonstrated that FFAs not only serve as an energy source for the body's metabolism but also participate in regulating arterial function. Excess been shown to lead endothelial dysfunction, vascular hypertrophy, vessel wall stiffness, which important triggers hypertension atherosclerosis. Nevertheless, acid receptors (FFARs) involved regulation functions, including proliferation, differentiation, migration, apoptosis, inflammation, angiogenesis cells (VECs) smooth muscle (VSMCs). They actively regulate hypertension, objective this review is examine roles heterogeneity FFARs function, with a view identifying points intersection between their actions providing new insights into prevention treatment diseases associated well development targeted drugs.

Language: Английский

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Prevention of uterine fibroids: Molecular mechanisms and potential clinical application

Journal of Endometriosis and Uterine Disorders, Journal Year: 2023, Volume and Issue: 1, P. 100018 - 100018

Published: Feb. 15, 2023

Uterine fibroids (UFs; leiomyoma) are the most common benign neoplastic threat to women worldwide, exacting an immense personal burden on female health and a monetary expense healthcare system estimated in hundreds of billions dollars every year globally. With no long-term non-invasive treatment option currently available treat UFs, deeper insights regarding tumor etiology key for developing newer therapies. Accordingly, this review, we discuss new mechanistic paradigm explain UF development through exquisite model involving developmental reprogramming myometrial stem cells due early life endocrine disruptors exposure, inflammation, fibrosis, DNA damage, eventually tissue stiffness. Further, propose utilize shear wave elastography as potential screening tool identification at risk UFs who can benefit from several simple preventive strategies, including consumption natural compounds such vitamin D green tea safe fertility friendly non-hormonal modality delay or even arrest reverse progression.

Language: Английский

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Free radical oxidation and antioxidant defense in uterine myoma and endometrioid adenocarcinoma depending on its degree of differentiation

South Russian Journal of Cancer, Journal Year: 2025, Volume and Issue: 6(1), P. 50 - 59

Published: Feb. 20, 2025

Purpose of the study . To evaluate features free radical oxidation (FRO) and principal enzymatic non-enzymatic links antioxidant defense in proliferating tissues benign myoma malignant endometrioid adenocarcinoma (EA) with varying degrees differentiation. Patients methods. who received surgical treatment for EA ( n = 42) uterine 14) were examined. stage Ia 26) Ib 16) disease selected. 16 patients had highly differentiated (G1) EA, 12 moderately (G2) 14 low-differentiated (G3) EA. The activity superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), transferase (GST), reduced (GSH), vitamins A E, lipid peroxidation products diene conjugates (DC) malondialdehyde (MDA) determined colorimetrically intact uterus. Results. Compared level tissue, SOD decreased by 3.2 times GST increased 2.7 p < 0.01). Similar changes noted G1 – on average 5.3 0.01) also DC 2.2 0.05). In G2 GPx activities lower than 5.7 4.5 times, respectively 0.05), GST, GSH G1, 4.9, 8.9 1.6 0.05 G3 there was an increase GSH, from 1.5 to 7.1 2.5 as well a decrease E 2.9 4.6 0.05) compared tissue. tissue minimal GSH-dependent system. Conclusion. results reflect differences mechanisms proliferation regulation FRO myomas its Knowledge characteristics individual can play certain role use therapy or tumors

Language: Английский

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Psychological distress and uterine fibroids: a bidirectional two-sample mendelian randomization study

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 18, 2024

Abstract Background Observational data indicates a connection between emotional discomfort, such as anxiety and depression, uterine fibroids (UFs). However, additional investigation is required to establish the causal relationship them. Hence, we assessed reciprocal causality four psychological disorders UFs utilizing two-sample Mendelian randomization (MR). Methods To evaluate types of distress (depressive symptoms, severe or panic attacks, mood swings) UFs, bidirectional MR was employed, single nucleotide polymorphisms (SNPs) associated with these conditions. Both univariate (UVMR) multivariate (MVMR) primarily applied inverse variance weighted (IVW) method for estimating potential effects. Complementary approaches Egger, median, simple mode, mode were utilized validate findings. assess robustness our results, conducted sensitivity analyses using Cochran’s Q-test Egger intercept test. Results The results UVMR analysis suggest that genetic predispositions depressive symptoms (Odds Ratio [OR] = 1.563, 95% Confidence Interval [CI] 1.209–2.021, P 0.001) major disorder (MDD) (OR 1.176, CI 1.044–1.324, 0.007) are an increased risk UFs. Moreover, IVW model showed nominally significant positive correlation swings (OR: 1.578; CI: 1.062–2.345; 0.024) risk. did not distress. Even after adjusting confounders like body mass index (BMI), smoking, alcohol consumption, number live births in MVMR, link MDD remained 1.217, 1.039–1.425, 0.015). Conclusions Our study presents evidence supporting susceptibility incidence These findings highlight significance addressing health issues, particularly both prevention treatment

Language: Английский

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Adipocyte and Adipokines Promote a Uterine Leiomyoma Friendly Microenvironment

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 715 - 715

Published: Jan. 31, 2023

Uterine leiomyomas are the most common benign tumors of female reproductive system. Obese individuals have a higher burden uterine leiomyoma, yet mechanism relating obesity and leiomyoma development remains unknown. In this study, we observe effect adipocyte coculture leptin treatment on human myometrium cells. We isolated primary cells from hysterectomy or myomectomy patients. Protein expression levels phosphorylated ERK1/2/total ERK1/2, STAT3/total STAT3, AKT1/2/3/total AKT1/2/3 were quantified using immunoblotting in immortalized myometrial cocultured with adipocytes treated leptin. An enzyme-linked immunosorbent assay (ELISA) was used to assess pro-inflammatory, fibrotic, angiogenic factors The effects ERK, AKT inhibitors assessed cell lines additionally cultured adipocytes. Adipocyte increases JAK2/STAT3, MAPK/ERK, PI3K/AKT signaling while suppressed effect. Leptin induces tumor-friendly microenvironment through upregulation pro-inflammatory (IFNγ, IL-8, IL-6, GM-CSF, MCP-1, TNF-α), fibrotic (TGF-β1, TGF-β2, TGF-β3), (VEGF-A, HGF, Follistatin) Furthermore, growth activation PI3k/AKT pathways. Finally, inhibitor PCNA, TNF-α, TGF-β3, VEGF-A intracellular staining intensity both These findings suggest that, obese women, secreted hormone may contribute by activating receptor

Language: Английский

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Correlation between inflammatory marker and lipid metabolism in patients with uterine leiomyomas

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: May 3, 2023

Introduction Obesity is a risk factor for the development of uterine leiomyoma (UL), and inflammatory response plays key role in pathogenesis UL. Our objective was to assess whether there an independent relationship between markers triglycerides (TG) patients with Methods 1,477 UL participants who were hospitalized at Jining Medical University January 2016 December 2022 included this cross-sectional study. The dependent variables measured baseline TG levels, respectively. covariates age, body mass index (BMI), menstrual status. Based on number fibroids, study population divided into Single-group Multiple-group. Results Univariate multiple regression analyses stratified revealed significant positive correlations neutrophil-lymphocyte ratio systemic immune inflammation TG, negative monocyte-lymphocyte TG. Conclusion findings show correlation lipid metabolism levels patients. This provides direction further research pathophysiology also helps formulate hypotheses predictive models

Language: Английский

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Structural Characterization and Effects on Insulin Resistance of a Novel Chondroitin Sulfate from Halaelurus burgeri Skin

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(4), P. 221 - 221

Published: March 30, 2023

Several studies have isolated chondroitin sulphate (CHS) from sharks' jaws or cartilage. However, there has been little research on CHS shark skin. In the present study, we extracted a novel Halaelurus burgeri skin, which chemical structure and bioactivity improvement in insulin resistance. Results using Fourier transform-infrared spectroscopy (FT-IR), 1H-nuclear magnetic resonance (1H-NMR), methylation analysis showed that of was [4)-β-D-GlcpA-(1→3)-β-D-GlcpNAc-(1→]n with 17.40% sulfate group concentration. Its molecular weight 238.35 kDa, yield 17.81%. Experiments animals this could dramatically decrease body weight, reduce blood glucose levels, lower lipid concentrations both serum liver, improve tolerance sensitivity, regulate serum-inflammatory factors. These results demonstrated H. skin positive effect reducing resistance because its structure, provides significant implication for polysaccharide as functional food.

Language: Английский

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Common Beverage Consumption and Benign Gynecological Conditions

Beverages, Journal Year: 2024, Volume and Issue: 10(2), P. 33 - 33

Published: May 1, 2024

The purpose of this article is to review the effects four commonly consumed beverage types—sugar-sweetened beverages (SSBs), caffeinated beverages, green tea, and alcohol—on five common benign gynecological conditions: uterine fibroids, endometriosis, polycystic ovary syndrome (PCOS), anovulatory infertility, primary dysmenorrhea (PD). Here we outline a plethora research, highlighting studies that demonstrate possible associations between intake increased risk certain conditions—such as SSBs dysmenorrhea—as well protective effect against condition—such tea fibroids. This aims help inform diet choices those with aforementioned conditions give uteruses autonomy over their lifestyle decisions.

Language: Английский

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