The Impact of Estimated Energy and Protein Balances on Extrauterine Growth in Preterm Infants DOI Open Access
Ioanna Lygerou, Stavroula Ilia, Panagiotis Briassoulis

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3556 - 3556

Published: Aug. 11, 2023

Background: Nutritional support of preterm infants remains a field debate in the literature and clinical practice varies significantly. Adequate nutrition should promote growth aim for optimal later neurodevelopment. However, it is often impaired by prematurity-associated morbidity physiologic immaturity infants. This study assessed impact energy macronutrient provision on velocity outcome explored differences attributed to heterogeneity population. Methods: We retrospectively collected nutritional data from neonates hospitalized two separate Neonatal Intensive Care Units (NICUs). Estimated protein balance were calculated based ESPGHAN guidelines their association with was explored. Growth assessment somatometry Delta (Δ) z-scores at discharge. Results: In total, 174 included study. By day 14, most exclusively enterally fed, whereas there <28 28–31+6 subgroups fed parenterally. Energy positive all gestational age (GA) except those born weeks. Protein consistently extremely premature but negative late preterms. Cumulative substrates provisions strong predictors or <34 weeks GA preterms days 14 (ROC analyses, p < 0.001) 7 (p 0.05). A higher = 0.013) enteral 0.005) additional balance. All had Δ z-score weight subcohorts, 0.009) short time regain birth (exp(B) 3.1 0.004)) independently associated Conclusions: Early achievement balance, guidelines, crucial ensure postnatal prevent extrauterine restriction, relatively common occurrence

Language: Английский

Anatomical and functional maturation of the mid-gestation human enteric nervous system DOI Creative Commons
Lori B. Dershowitz, Li Li, Anca M. Pașca

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 9, 2023

Abstract Immature gastrointestinal motility impedes preterm infant survival. The enteric nervous system controls motility, yet it is unknown when the human matures enough to carry out vital functions. Here we demonstrate that second trimester fetal takes on a striped organization akin embryonic mouse. Further, perform ex vivo functional assays of tissue and find in similar progression mouse motility. Together, this provides critical knowledge, which facilitates comparisons with common animal models advance translational disease investigations testing pharmacological agents enhance prematurity.

Language: Английский

Citations

9
Risk factors and clinical outcomes of extubation failure in very early preterm infants: a single-center cohort study DOI Creative Commons
Su Jeong Park,

Mi Hye Bae,

Mun Hui Jeong

et al.

BMC Pediatrics, Journal Year: 2023, Volume and Issue: 23(1)

Published: Jan. 21, 2023

Abstract Background Early extubation success (ES) in preterm infants may reduce various mechanical ventilation-associated complications; however, failure (EF) can cause adverse short- and long-term outcomes. Therefore, the present study aimed to identify differences risk factors clinical outcomes between ES EF very early infants. Methods This retrospective was conducted January 2017 December 2021. Premature born at 32 weeks’ gestational age whom had failed least once were assigned group. Successfully extubated patients with a similar birth weight as those group defined need for re-intubation within 120 h of extubation. Various variables compared groups. Results The rate this 18.6% (24/129), approximately 80% required 90.17 h. In group, there less use inotropes 7 days life (12 [63.2%] vs. 22 [91.7%], p = 0.022), lower respiratory severity score (RSS) 1 4 weeks (1.72 2.5, 0.026; 1.73 2.92, 0.010), faster time reach full feeding (18.7 29.7, 0.020). There higher bronchopulmonary dysplasia BPD (3 [15.8%] 14 [58.3%], 0.018), longer duration oxygen supply (66.5 92.9, 0.042), corrected discharge (39.6 42.5, 0.043) cutoff value, sensitivity, specificity week 1.98, 0.71, 0.42, respectively, RSS 2.22, 0.67, 0.47, respectively. Conclusions caused short-term such hospital stay. should be carefully evaluated. Using inotropes, feeding, help predict success.

Language: Английский

Citations

8
Monitoring the Use of Human Milk, the Ideal Food for Very Low-Birth-Weight Infants—A Narrative Review DOI Creative Commons
Pasqua Anna Quitadamo,

Federica Zambianco,

Giuseppina Palumbo

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(5), P. 649 - 649

Published: Feb. 21, 2024

Aware of the utmost importance feeding premature babies—especially those lower weight—with human milk, as well need to monitor this important element neonatal care, we focused on four aspects in review. First all, reviewed beneficial effects infants with breast milk short and long term. Secondly, performed a quantitative evaluation rates breastfeeding Very-Low-Birth-Weight (VLBWs) during hospitalization Neonatal Intensive Care Unit (NICU) at discharge. Our aim was take snapshot current status milk-feeding care track its trends over time. Then analyzed, one hand, factors that have been proven facilitate use maternal and, other risk not milk. We also considered spread banking so assess availability donated for most vulnerable category babies. Finally, proposed protocol designed tool systematic monitoring actions could be planned implemented NICUs order achieve goal even more VLBWs

Language: Английский

Citations

3
The Prevalence of Small for Gestational Age and Extrauterine Growth Restriction among Extremely and Very Preterm Neonates, Using Different Growth Curves, and Its Association with Clinical and Nutritional Factors DOI Open Access
Ioanna Kakatsaki,

S Papanikolaou,

Theano Roumeliotaki

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3290 - 3290

Published: July 25, 2023

Monitoring the growth of neonates in Neonatal Intensive Care Unit (NICU) using charts constitutes an essential part preterm infant care. Preterm infants are at increased risk for extrauterine restriction (EUGR) due to energy needs and clinical complications. This retrospective study compares prevalence small gestational age (SGA) birth EUGR discharge extremely very hospitalized NICU a tertiary hospital Greece, different curves, it examines associated nutritional factors. Fenton2013 INTERGROWTH-21st curves were used calculate z-scores weight (BW) weight, length, head circumference discharge. The includes 462 newborns with mean BW 1341.5 g GA 29.6 weeks. At birth, 6.3% classified as SGA based on compared 9.3% curves. discharge, 45.9% characterized having 29.2% οn Nutritional factors such day initiation, attainment full enteral feeding, duration parenteral nutrition by both differs between two references. shows that further evaluation these is needed determine most appropriate way monitor growth.

Language: Английский

Citations

7
Effect of early total enteral feeding vs incremental feeding in small for gestational age very low birth weight infants: A randomized controlled trial DOI

Tanmesh Kumar Sahu,

Swati Manerkar,

Jayashree Mondkar

et al.

Journal of Neonatal-Perinatal Medicine, Journal Year: 2024, Volume and Issue: 17(2), P. 225 - 232

Published: April 16, 2024

Language: Английский

Citations

2
Impact of Early Nutrient Intake and First Year Growth on Neurodevelopment of Very Low Birth Weight Newborns DOI Open Access
Rasa Brinkis, Kerstin Albertsson‐Wikland,

Rasa Tamelienė

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(18), P. 3682 - 3682

Published: Sept. 6, 2022

Optimal nutrient intake ensuring better neurodevelopment for very low birth weight (VLBW) infants remains unknown. The aim of this study was to assess the relationship between early (first 28 days) nutritional intake, first year growth, and neurodevelopment. In total, 120 VLBW were included into study. A group 95 completed follow-up 12 months corrected gestational age (CGA). Nutrient assessed, weight, length, head circumference (HC) measured weekly until discharge at 3, 6, 9, CGA. Neurodevelopment assessed Two groups—extremely preterm (EP) very/moderately (VP)—were compared. Growth before slower in EP than VP group. At months, there no difference anthropometric characteristics or neurodevelopmental scores groups. Higher carbohydrate during days single significant predictor cognitive only (βs = 0.60, p 0.017). Other nutrients growth not motor either multivariable models, whereas post-discharge HC associated with both Monitoring all pre-discharge is essential gaining knowledge about individualized nutrition optimal

Language: Английский

Citations

11
Trend and Predictors of Breastmilk Feeding among Very-Low-Birth-Weight Infants in NICU and at Discharge DOI Open Access
Pasqua Anna Quitadamo,

Federica Zambianco,

Giuseppina Palumbo

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3314 - 3314

Published: July 26, 2023

Mothers' own milk (MOM) for premature babies is considered a life-saving drug its proven protective action against the complications of prematurity and effects on outcome in short long term, especially neurological ones. We studied use MOM infants weighing <1500 g period 5 years, evaluating trend over time impact some variables human feeding performance. Statistical comparisons concerned rate with breast during stay an NICU at discharge respect to two types variables: (1) maternal neonatal characteristics (gestational age, birth weight, type pregnancy (whether single or twin), age) (2) (time start minimal enteral availability MOM, days until achievement full feeding). Group were performed using ANOVA

Language: Английский

Citations

5
Retinopathy of prematurity: risk stratification by gestational age DOI
Tiffany Wu, Rakesh Rao,

Hongjie Gu

et al.

Journal of Perinatology, Journal Year: 2023, Volume and Issue: 43(6), P. 694 - 701

Published: Jan. 18, 2023

Language: Английский

Citations

4
Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the “Connection Trial” DOI Creative Commons
Josef Neu,

Patricia L. Ashley,

Vikas Chowdhary

et al.

American Journal of Perinatology, Journal Year: 2023, Volume and Issue: 41(S 01), P. e2717 - e2726

Published: Sept. 8, 2023

Objective Investigate daily feeding volumes and their association with clinical variables in the early postnatal care of premature infants “Connection Trial.” Study Design A total 641 510 to 1,000-g birth weight (BW, mean: 847 g) mean 27 weeks' gestational age at (GA) were analyzed for enteral (TDE) 10, 20, 40, 80, 120 mL/kg/d 24 variables. Uni- multivariable Cox regression models used calculate hazard ratios (HR) 95% confidence intervals as a measure chance reaching each TDE volumes. Results Daily highly variable median advancement from 10 was 11 mL/kg/d. Univariable analyses showed lowest (HR, 0.22–0.81) gastrointestinal (GI) serious adverse events (SAEs), GI perforation, obstruction, necrotizing enterocolitis, well respiratory SAEs, persistent ductus arteriosus, hypotension. Each GA week, 100-g BW, point 5-minute Apgar score associated 8 20% increased Multivariable independent effects GA, score, abdominal symptoms/signs, days on antibiotics, Conclusion This observational analysis demonstrates cautious progression feedings contemporary extremely low BW extent which associate this progression. Key Points

Language: Английский

Citations

4
Predictors of extubation failure in newborns: a systematic review and meta-analysis DOI Creative Commons

Maoling Fu,

Zhenjing Hu,

Genzhen Yu

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2023, Volume and Issue: 49(1)

Published: Oct. 2, 2023

Abstract Extubation failure (EF) is a significant concern in mechanically ventilated newborns, and predicting its occurrence an ongoing area of research. To investigate the predictors EF newborns undergoing planned extubation, we conducted systematic review meta-analysis. A literature search was PubMed, Web Science, Embase, Cochrane Library for studies published English from inception each database to March 2023. The PRISMA guidelines were followed all phases this review. Risk Bias Assessment Nonrandomized Studies tool used assess methodological quality. Thirty-four included, 10 which overall low risk bias, 15 moderate 9 high bias. reported 43 possible six broad categories (intrinsic factors; maternal diseases adverse conditions newborn; treatment characteristics before after extubation; clinical scores composite indicators). Through qualitative synthesis quantitative meta-analysis 19 factors, identified five definite eight 22 unclear factors related EF. Definite included gestational age, sepsis, pre-extubation pH, FiO 2 , respiratory severity score. Possible age at anemia, inotropic use, mean airway pressure, PCO mechanical ventilation duration, Apgar score, spontaneous breathing trial. With only few high-quality currently available, well-designed more extensive prospective investigating affecting are still needed. In future, it will be important explore possibility combining multiple or assessment tools enhance accuracy extubation outcomes practice.

Language: Английский

Citations

4