Science and Faith to Understand Milk Bioactivity for Infants DOI Open Access
Per Torp Sangild

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1676 - 1676

Published: May 29, 2024

Milk bioactivity refers to the specific health effects of milk components beyond nutrition. The science involves systematic study these and their effects, as verified by empirical data, controlled experiments, logical arguments. Conversely, ’faith in bioactivity’ can be defined personal opinion, meaning, value, trust, hope for that are investigation natural, social, or human sciences. Faith strictly secular, but also influenced spirituality religion. aim this paper is show scientific knowledge frequently supplemented with faith convictions establish public understanding bioactivity. Mammalian an immensely complex fluid containing myriad proteins, carbohydrates, lipids, micronutrients multiple functions across species, genetics, ages, environments, cultures. Human includes not only physical health, mental, spiritual requiring widely different fields prove relevance, safety, efficacy interventions. These relationships between feeding outcomes prevent firm conclusions based on logic alone. Current beliefs value breast milk, colostrum, infant formula, isolated proteins (e.g., immunoglobulins, α-lactalbumin, lactoferrin, growth factors) both contribute understand, stimulate, restrict use benefits breastfeeding infants doubt, strong its rely science, mechanisms unclear. Likewise, fear of, trust in, formula may faith. Knowledge from safeguards individuals society against ‘milk superstition’. wisdom faith-based protect unrealistic scientism’. Honesty transparency about potentials limitations important when informing nutritious bioactive qualities milk.

Language: Английский

Human breast milk-derived exosomes and their positive role on neonatal intestinal health DOI

Gen Chen,

Xiangdong Ouyang,

Yue Mu

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Language: Английский

Citations

2
Bovine colostrum derived-exosomes prevent dextran sulfate sodium-induced intestinal colitis via suppression of inflammation and oxidative stress DOI

Geonhee Han,

Haeun Cho,

Hyo‐Suk Kim

et al.

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(8), P. 2076 - 2087

Published: Jan. 1, 2022

Despite the rise in global burden of inflammatory bowel disease, there is a lack safe and effective therapies that can meet needs clinical patients. In this study, we investigated beneficial effects bovine milk, especially colostrum-derived exosomes (Col-exo) murine model ulcerative colitis induced by dextran sodium sulfate (DSS). Col-exo activated proliferation colonic epithelial cells macrophages, created an environment to relieve inflammation effectively removing reactive oxygen species regulating expression immune cytokines. Besides, could pass through gastrointestinal tract intact efficiently deliver bioactive cargoes stomach, small intestine, colon. Our results showed oral gavage alleviate symptoms including weight loss, bleeding, chronic diarrhea modulating intestinal responses. Overall, with excellent structural functional stability may offer great potential as natural therapeutics for recovery colitis.

Language: Английский

Citations

40
Invited review: Bovine colostrum, a promising ingredient for humans and animals—Properties, processing technologies, and uses DOI Creative Commons
Angela Costa, NW Sneddon, Arianna Goi

et al.

Journal of Dairy Science, Journal Year: 2023, Volume and Issue: 106(8), P. 5197 - 5217

Published: June 1, 2023

Mammalian colostrum, known as "liquid gold," is considered a valuable source of essential nutrients, growth factors, probiotics, prebiotics, antibodies, and other bioactive compounds. Precisely for this reason, bovine colostrum (BC) an emerging ingredient the feed, food, pharmaceutical industries, being nowadays commercially available in variety forms several countries. Moreover, quite large number functional foods supplements athletes, human medicines, pet nutrition plans, complementary feed some livestock categories, such piglets calves, contain BC. The amount BC yielded by cow after calving represents approximately 0.5% yearly output dairy breeds. For its nutritional properties low availability, characterized greater market value increasing demand compared with by-products sector. However, information regarding size food well future developments perspectives, scarcely scientific literature. This lack can be attributed to industrial secrecy relatively small scale business when products, which makes limited, specific, intended restricted audience. From legal perspective, regulations assign family milk-derived powders; thus, collecting specific production data, import-export trend information, not straightforward result unprecise estimates. Given that interest different fields, it important have overview steps pros cons ingredient. present narrative review discloses why has started product rather than by-product industry. document aims summarize existing methodologies used assess quality terms immunoglobulin concentration, applications industry, processing technologies. Finally, panoramic view current international provided first time product.

Language: Английский

Citations

27
Heat-Stress Impacts on Developing Bovine Oocytes: Unraveling Epigenetic Changes, Oxidative Stress, and Developmental Resilience DOI Open Access

Xiaoyi Feng,

Chong-Yang Li,

Hang Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4808 - 4808

Published: April 28, 2024

Extreme temperature during summer may lead to heat stress in cattle and compromise their productivity. It also poses detrimental impacts on the developmental capacity of bovine budding oocytes, which halt fertility. To mitigate adverse effects stress, it is necessary investigate mechanisms through affects oocytes. The primary goal this study was impact epigenetic modifications oocytes embryos, as well oocyte capacity, reactive oxygen species, mitochondrial membrane potential, apoptosis, transzonal projections, gene expression levels. Our results showed that significantly reduced levels from histone H1, H2A, H2B, H4, DNA methylation, hydroxymethylation at all stages embryo. Similarly, cleavage rate, blastocyst mitochondrial-membrane potential level, adenosine-triphosphate (ATP) copy number, projection level. found affected distribution increased apoptosis autophagy findings suggest genes related ability, cytoskeleton, function, modification, lowering competence season.

Language: Английский

Citations

11
Role of Bovine Colostrum Against Various Diseases DOI
Yalçın Mert Yalçıntaş, Hatice Duman, João Miguel Rocha

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104818 - 104818

Published: Aug. 2, 2024

Language: Английский

Citations

11
Untargeted Metabolomics Reveals Key Differences Between Yak, Buffalo, and Cow Colostrum Based on UHPLC-ESI-MS/MS DOI Creative Commons

Yuzhuo Wang,

Changhui Li,

Jiaxiang Huang

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 232 - 232

Published: Jan. 13, 2025

Background: Colostrum, abundant in immunoglobulins and growth factors, plays a vital role supporting immunity. Both yak buffalo milk are characterized by their high protein fat content. However, the metabolomic profiles of colostrum (YC), (BC), bovine (CC) remain largely unexplored. The objective this study is to identify unique metabolites that may impact nutritional value colostrum. Methods: This employed ultra-high performance liquid chromatography-electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) for untargeted metabolomics analysis YC, BC, CC. Results: revealed 97, 70, 75 differentially expressed YC-CC, BC-CC, YC-BC comparisons, respectively. In comparison CC, both YC BC shared common features, including reduced choline levels elevated O-acetylcarnitine. Moreover, such as 2-hydroxy-6-pentadecylbenzoic acid, DL-glycerol-1-phosphate, thiamine, L-carnitine, methyl β-D-galactoside, uridine diphosphate (UDP) were identified potential biomarkers while 21-deoxycortisol, D-synephrine, uridine, mannitol-1-phosphate, nonadecanoic perillic acid specific BC. Conclusions: has greater advantages energy supply, antioxidant activity, immune regulation, cell homeostasis, holds significance physical development balance regulation. These findings provide valuable insights, enabling selection bioactive develop targeted functional foods from colostrum, catering diverse needs.

Language: Английский

Citations

1
Bovine colostrum as a fortifier to human milk in very preterm infants – A randomized controlled trial (FortiColos) DOI Creative Commons
Agnethe May Ahnfeldt, Lise Aunsholt, Bo Mølholm Hansen

et al.

Clinical Nutrition, Journal Year: 2023, Volume and Issue: 42(5), P. 773 - 783

Published: March 15, 2023

Language: Английский

Citations

18
Bovine colostrum and its potential contributions for treatment and prevention of COVID-19 DOI Creative Commons
Hatice Duman, Sercan Karav

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 16, 2023

Bovine colostrum (BC) is the initial milk an animal produces after giving birth, particularly in first few days. Numerous bioactive substances found BC, including proteins, enzymes, growth factors, immunoglobulins, etc., are beneficial to human health. BC has a significant role play as part of healthy diet, with well-documented health and nutritional advantages for people. Therefore, use its crucial derivatives development functional food pharmaceuticals prevention several diseases such gastrointestinal respiratory system disorders becoming increasingly popular around world. A novel coronavirus severe acute syndrome 2 (SARS-CoV-2) was identified cause cluster pneumonia cases that called Coronavirus Disease 2019 (COVID-19) China. After SARS-CoV-2 virus-related fatality announced, illness quickly spread throughout China other continents, causing pandemic. Since then, numerous studies have been initiated develop safe efficient treatments. To prevent viral infection potential lingering effects, it important investigate alternative treatments COVID-19. Due effective profile immunomodulatory roles biological processes, might be considered promising approach assist combating people affected by or from virus. effects because high concentration components lactoferrin, cytokines, which help control immunological responses, potentially fostering balanced immune response. Furthermore, cross-reactivity against SARS-CoV-2, aiding virus neutralization comprehensive also supplies vitamins, minerals, amino acids, system. Hence, possible contributions management COVID-19 were reviewed this article based on most recent research subject. Additionally, key influence modulation evaluated. These may serve mediators therapeutic

Language: Английский

Citations

18
Bovine colostrum: A source of bioactive compounds for prevention and treatment of gastrointestinal disorders DOI Creative Commons

Rhaabe D.S. Gomes,

Katya Anaya,

Alyne B. S. Galdino

et al.

NFS Journal, Journal Year: 2021, Volume and Issue: 25, P. 1 - 11

Published: Oct. 9, 2021

Bovine colostrum is a rich source of nutrients and biologically active molecules known to be able modulate the human immune system, such as lactoferrin, lysozyme, lactoperoxidase, immunoglobulins growth factors. This comprehensive review aimed gather evidence from animal experimentation clinical trials that investigated potential effects bovine in preventing treating diseases affect gastrointestinal tract. Considered safe for consumption, BC or its isolate components were used against range different disorders. Beneficial observed several conditions: infections, infectious diarrhoea, drug-induced lesions, gut-barrier malfunction, inflammatory bowel disease. Under proper processing maintain components' integrity, products are valuable supplements with high nutraceutical value, capable promoting restoring health.

Language: Английский

Citations

37
A Review: The Effect of Bovine Colostrum on Immunity in People of All Ages DOI Open Access

Hao Duan,

Qian Sun, Chao Chen

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2007 - 2007

Published: June 25, 2024

Bovine colostrum provides newborn calves with strong passive immunity, which will further affect the immunity of their offspring. Compared other commercial dairy products, bovine emphasizes limit aflatoxin M1, pathogenic bacteria, microorganisms, antibiotics, stimulants, and items, so it is safe to use. There are many reports that use as a breast milk fortifier for preterm infants necessary immune support premature infants, but selection products chosen must be free Bacillus cereus because they very dangerous infants. This also used in more clinical research needed. At same time, should emphasized composition BC different from human colostrum, particular, main protein casein, while whey protein, especially α-lactalbumin, together ovalbumin still reference best biological value, muscles. Therefore, currently not complete substitute milk. In recent years, addition studies have found has immunomodulatory promoting effects adolescents, adults, elderly. suggests potential provide appropriate people all ages. this study aimed evaluate quality nutritional characteristics on three dimensions. The ages narrative review identified several classes immunoactive substances including immunoglobulins, cytokines, enzymes, compared mature milk, full-term demonstrate rich range components. addition, influencing factors affecting (immunoglobulin) were reviewed, was individual differences, environmental factors, processing methods had great impact BC. More importantly, reviewed detail (with an emphasis immunocompromised children neonates) evidence hopes above make understand health role having effect, at when seeing value future, limitations its application deeply re-explored, such lactose intolerance, allergies, etc., effective solutions wide colostrum.

Language: Английский

Citations

6