Effects of physical distancing by COVID-19 pandemic on diet quality, neurological and immunological markers, and fecal microbiota of Brazilian older women DOI Creative Commons
Priscila Larcher Longo, Rita de Cássia de Aquino, Sandra Regina Mota Ortiz

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 14, 2022

Physical distancing was used to prevent transmission of COVID-19, however there are concerns that this may promote harmful impacts on health, such as reduced levels physical practice and changes in food intake gut microbiota composition. This study evaluated the 6 months Brazilian older women upon body mass index (BMI), strength, activity level (IPAQ), eating habits, neurological markers (brain-derived neurotrophic factor-BDNF cortisol), cytokines (IL-2, IL-5, IL-6, IL-10, interferon-IFN-γ, tumor necrosis factor-TNF-α), aging-associated (vascular endothelial growth factor-VEGF, insulin-like factor-IGF-1, klotho thymic stromal lymphopoietin-TSLP), besides specific groups fecal microbiota. Fifteen women, over 60 years old, residents São Paulo state (Brazil), were March September 2020. The adult with a mean age 66 ± 6.2 presented significantly increased BMI high effect size for non-protective foods consumption, light strength following distancing. Furthermore, serum concentration IFN-γ, IGF-1, IFN-γ/IL-5 higher, while lower IL-2 IL-5 observed after Significant increase noted only Blautia spp. abundance Several correlations at both before distancing, however, interestingly, many them lost or inverted following, new ones emerged. Taken together, these results showed lifestyle stress conditions addressed by from COVID-19 pandemic impacted health included present study. Therefore, future follow-up studies essential propose interventions order restore period, thus maintain quality life adults different socioeconomic contexts.

Language: Английский

The PCOS puzzle: putting the pieces together for optimal care DOI
Mohd Altaf Dar, Mudasir Maqbool,

Irfat Ara

et al.

International Journal of Adolescent Medicine and Health, Journal Year: 2023, Volume and Issue: 35(4), P. 299 - 311

Published: Aug. 1, 2023

Abstract Polycystic ovary syndrome (PCOS) is a multifaceted hormonal disorder that has significant ramifications for both women’s reproductive and metabolic well-being. This analysis aims to offer thorough comprehension of PCOS by investigating the various contributing factors are crucial its effective management. We delve into topic imbalances, such as elevated androgens disrupted estrogen-progesterone dynamics, their effects on health. Furthermore, we explore intricate connection between insulin resistance, hyperinsulinemia, PCOS, highlighting pivotal role in dysfunction. Additionally, examine fertility challenges, irregular menstrual patterns, complications while also reviewing current treatment methodologies. Moreover, address latest research concerning genetic, environmental, epigenetic influences PCOS. By piecing together these essential elements, healthcare professionals can attain comprehensive understanding deliver optimal care those affected condition.

Language: Английский

Citations

2
May the SSRIs play a role in the onset of peri- and post-menopausal cervical cancer? DOI Creative Commons

Ciro Gargiulo Isacco,

Raffaele Del Prete,

Pietro Distratis

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 6(7)

Published: June 25, 2024

Abstract The emergence of cancer-causing bacteria and viruses that have become resistant to either antibiotics or viral treatment is often attributed their overuse in people livestock. Intriguingly, the class antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRIs), may also contribute generating microorganisms with a profound disturbing role local cervix-vagina homeostasis. Therefore, we proposed possible involvement SSRIs onset growth cervical cancer (CC), which based on some empirical considerations, (i) number women diagnosed post-menopausal CC almost equivalent depressive problems, (ii) proven affection both vaginal intestinal microbiota, (iii) essential microbiota immune response against oncogenic pathogens, including human papillomavirus Chlamydia trachomatis ( C. ), (IV) favoring rise antibiotic-resistant microorganisms, (V) inhibitory effect estradiol-serotonin-prolactin axis. These features are important overproduction reactive oxygen species, responsible for different harmful activities higher cell membrane permeability porosity, hyperstimulation transcription, translational activities, overall stress check-point genes involved ATP synthesis, DNA breaks, abnormal mutations. This paper's results suggested reconsidering efficacy long-term use since increase prescriptions mainly due rather than diagnoses per se, secondly little known about consequences use. evidence supports drugs increasing risk was searched discussed.

Language: Английский

Citations

0
The mechanism and potential therapeutic target of piezo channels in pain DOI Creative Commons
Yi Xu,

Yuheng Wang,

Shuchong Mei

et al.

Frontiers in Pain Research, Journal Year: 2024, Volume and Issue: 5

Published: Sept. 27, 2024

Pain is a common symptom of many clinical diseases; it adversely affects patients’ physical and mental health, reduces their quality life, heavily burdens patients society. treatment one the most difficult problems today. There an urgent need to explore potential factors involved in pathogenesis pain improve its diagnosis rate. Piezo 1/2, newly identified mechanosensitive ion channel opens response mechanical stimuli plays critical role regulating pain-related diseases. Inhibition or downregulation 1/2 alleviates disease-induced pain. Therefore, this study, we comprehensively discussed biology gene, focusing on relevance diseases, explored pharmacological effects drugs using gene for

Language: Английский

Citations

0
Dietitians’ knowledge and practice regarding inflammaging and related interventions: a pilot survey DOI Creative Commons

Cato Wiegers,

Sofia el Sarraf,

Olaf F. A. Larsen

et al.

PharmaNutrition, Journal Year: 2024, Volume and Issue: 30, P. 100420 - 100420

Published: Nov. 8, 2024

Language: Английский

Citations

0
Effects of physical distancing by COVID-19 pandemic on diet quality, neurological and immunological markers, and fecal microbiota of Brazilian older women DOI Creative Commons
Priscila Larcher Longo, Rita de Cássia de Aquino, Sandra Regina Mota Ortiz

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 14, 2022

Physical distancing was used to prevent transmission of COVID-19, however there are concerns that this may promote harmful impacts on health, such as reduced levels physical practice and changes in food intake gut microbiota composition. This study evaluated the 6 months Brazilian older women upon body mass index (BMI), strength, activity level (IPAQ), eating habits, neurological markers (brain-derived neurotrophic factor-BDNF cortisol), cytokines (IL-2, IL-5, IL-6, IL-10, interferon-IFN-γ, tumor necrosis factor-TNF-α), aging-associated (vascular endothelial growth factor-VEGF, insulin-like factor-IGF-1, klotho thymic stromal lymphopoietin-TSLP), besides specific groups fecal microbiota. Fifteen women, over 60 years old, residents São Paulo state (Brazil), were March September 2020. The adult with a mean age 66 ± 6.2 presented significantly increased BMI high effect size for non-protective foods consumption, light strength following distancing. Furthermore, serum concentration IFN-γ, IGF-1, IFN-γ/IL-5 higher, while lower IL-2 IL-5 observed after Significant increase noted only Blautia spp. abundance Several correlations at both before distancing, however, interestingly, many them lost or inverted following, new ones emerged. Taken together, these results showed lifestyle stress conditions addressed by from COVID-19 pandemic impacted health included present study. Therefore, future follow-up studies essential propose interventions order restore period, thus maintain quality life adults different socioeconomic contexts.

Language: Английский

Citations

2