Advances in the research of comorbid insomnia and depression: mechanisms, impacts, and interventions DOI Creative Commons
Tao Gao,

Han Xiang,

Qian Wu

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Insomnia and depression, both significantly impacting public health, are common psychosomatic illnesses that frequently co-occur in the same individual. Not only do these two conditions commonly co-occur, but they also exhibit a bidirectional link, where existence of one may heighten risk for other. Latest research offers compelling evidence significant overlap biological, psychological, sociological aspects comorbidity insomnia depression. Building on this, we aim to examine pathophysiology along with their comorbid mechanisms, encompassing biological routes (like genetics, HPA axis, immune-inflammatory activation, neuroendocrine regulation, microbiome alterations, neural circuits integrating sleep emotion regulation), as well psychosocial routes. Consequently, proposing self-perpetuating mutually reinforcing “snowball effect” model examining corresponding preventative intervention strategies rectify associated imbalances. Finally, this article encapsulates challenges field study directions future research. paper points out limitations current (cross-sectional data being dominant, mechanism multi-omics dynamics unknown) direction (longitudinal cohort combined computational modeling resolve temporal interactions), which will provide theoretical basis precision interventions.

Language: Английский

Interactions between gut microbes and NLRP3 inflammasome in the gut-brain axis DOI
Yang Ding, Zixu Wang, Yaoxing Chen

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2023, Volume and Issue: 21, P. 2215 - 2227

Published: Jan. 1, 2023

Language: Английский

Citations

19
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time? DOI Creative Commons
Jing Ren, Huimin Li, Guixing Zeng

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 1, 2023

Chronic low-grade inflammation affects health and is associated with aging age-related diseases. Dysregulation of the gut flora an important trigger for chronic inflammation. Changes in composition exposure to related metabolites have effect on inflammatory system host. This results development crosstalk between barrier immune system, contributing impairment health. Probiotics can increase diversity microbiota, protect barrier, regulate immunity, thereby reducing Therefore, use probiotics a promising strategy beneficial immunomodulation protection through microbiota. These processes might positively influence diseases, which are common elderly.

Language: Английский

Citations

19
Gut Microbiota in Patients with Prediabetes DOI Open Access

Wei-Lin Chang,

Yu-En Chen,

Hsiang-Tung Tseng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1105 - 1105

Published: April 9, 2024

Prediabetes is characterized by abnormal glycemic levels below the type 2 diabetes threshold, and effective control of blood glucose may prevent progression to diabetes. While association between gut microbiota, metabolism, insulin resistance in diabetic patients has been established previous studies, there a lack research regarding these aspects prediabetic Asia. We aim investigate composition microbiota their differences compared healthy individuals. In total, 57 60 adult individuals aged 18 65 years old were included this study. Biochemistry data, fecal samples, 3 days food records collected. Deoxyribonucleic acid extraction next-generation sequencing via 16S ribosomal ribonucleic metagenomic conducted analyze relationship dietary habits. Prediabetic showed lower microbial diversity than individuals, with 9 bacterial genera being less abundant 14 others more abundant. who consumed low-carbohydrate (LC) diet exhibited higher those high-carbohydrate diet. A abundance Coprococcus was observed on an LC Compared significantly different, adopting high fiber consumption positively impact microbiota. Future studies should understand Asian population.

Language: Английский

Citations

7
Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions DOI Creative Commons
Xinyan Zou,

Xinfu Zou,

Longxia Gao

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 7, 2024

Psoriasis is one of the most common autoimmune skin diseases. Increasing evidence shows that alterations in diversity and function microbiota can participate pathogenesis psoriasis through various pathways mechanisms.

Language: Английский

Citations

5
Advances in the application and mechanism of bioactive peptides in the treatment of inflammation DOI Creative Commons
Haiyang Liu, Lulu Zhang, Jingmou Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 23, 2024

Inflammation is a normal immune response in organisms, but it often triggers chronic diseases such as colitis and arthritis. Currently, the most widely used anti-inflammatory drugs are non-steroidal drugs, albeit they accompanied by various adverse effects hypertension renal dysfunction. Bioactive peptides (BAPs) provide therapeutic benefits for inflammation mitigate side effects. Herein, this review focuses on of BAPs different body parts. Emphasis placed immunomodulatory mechanisms treating inflammation, regulating release inflammatory mediators, modulating MAPK NF-κB signaling pathways, reducing oxidative stress reactions immunomodulation. This aims to reference function, application, anti-inflammation BAPs.

Language: Английский

Citations

5
A review of research on the impact of E171/TiO2 NPs on the digestive tract DOI Creative Commons
Ewa Baranowska‐Wójcik, Dominik Szwajgier,

Anna Winiarska‐Mieczan

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2022, Volume and Issue: 72, P. 126988 - 126988

Published: April 28, 2022

Nanotechnology utilises particles of between 1 and 100 nm in size. In recent years, it has enjoyed widespread application a variety areas. However, this also raised increasing concerns regarding the effects that use nanoparticles may have on human health. The titanium dioxide (TiO2 NPs) are among most promising nanomaterials already found wide cosmetics, medicine and, food industry. A nano-sized (diameter < nm) fraction TiO2 is present, at certain percentage, E171 ( EU) pigment commonly used as an additive food, whose presence raises particular terms its potential negative health impact. consumption increasingly associated with disorders intestinal barrier, including dysbiosis. It disrupt normal functions gastrointestinal tract (GIT) including: enzymatic digestion primary nutrients (lipids, proteins, or carbohydrates). aim review to provide comprehensive reliable overview studies conducted years substance's potentially impact animal alimentary systems.

Language: Английский

Citations

22
The Nutrition-Microbiota-Physical Activity Triad: An Inspiring New Concept for Health and Sports Performance DOI Open Access
Nathalie Boisseau, Nicolas Barnich, Christelle Koechlin‐Ramonatxo

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(5), P. 924 - 924

Published: Feb. 22, 2022

The human gut microbiota is currently the focus of converging interest in many diseases and sports performance. This review presents as a real "orchestra conductor" host's physio(patho)logy due to its implications aspects health disease. Reciprocally, composition activity are influenced by different factors, such diet physical activity. Literature data have shown that macro- micro-nutrients influence composition. Cumulative indicate bacteria sensitive modulation activity, studies using training hypoactivity models. Sports performance also presented interesting promising results. Therefore, could be considered "pivotal" organ for performance, leading new concept: nutrition-microbiota-physical triad. next challenge scientific medical communities test this concept clinical studies. long-term aim find best combination three elements triad optimize treatments, delay disease onset, or enhance possibilities offered biotic supplementation modalities open avenues future research.

Language: Английский

Citations

19
The Gut–Brain Axis as a Therapeutic Target in Multiple Sclerosis DOI Creative Commons
Ana Maria Bugă, Vlad Pădureanu, Anca‐Lelia Riza

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(14), P. 1872 - 1872

Published: July 17, 2023

The CNS is very susceptible to oxidative stress; the gut microbiota plays an important role as a trigger of damage that promotes mitochondrial dysfunction, neuroinflammation, and neurodegeneration. In current review, we discuss recent findings on oxidative-stress-related inflammation mediated by gut–brain axis in multiple sclerosis (MS). Growing evidence suggests targeting can be promising strategy for MS management. Intricate interaction between factors leads increased intra- inter-individual heterogeneity, frequently painting different picture vivo from obtained under controlled conditions. Following evidence-based approach, all proposed interventions should validated clinical trials with cohorts large enough reach significance. Our review summarizes existing focused identifying suitable interventions, combinations, appropriate timings target microbiota-related stress. Most studies assessed relapsing–remitting (RRMS); only few limited were carried out other stages (e.g., secondary progressive MS–SPMS). Future must consider extended time frame, perhaps starting perinatal period lasting until young adult period, aiming capture many complex intersystem interactions possible.

Language: Английский

Citations

11
Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases DOI Open Access
Barbara Pala,

Laura Pennazzi,

Giulia Nardoianni

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3254 - 3254

Published: May 31, 2024

Background: Over the past decade, gut microbiome (GM) has progressively demonstrated to have a central role in human metabolism, immunity, and cardiometabolic risk. Likewise, sleep disorders showed an impact on individual health Recent studies seem suggest multi-directional relations among GM, diet, sleep, risk, though specific interactions are not fully elucidated. We conducted systematic review synthesize currently available evidence potential between GM their possible implications Methods: A was following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) statement reporting reviews meta-analyses, including articles from January 2016 until November 2022. Narrative syntheses were employed describe results. Results: total of 8 selected according these criteria. Our findings indicated that disorder and/or acute circadian rhythm disturbance caused by sleep–wake shifts affected mainly throughout microbial functionality. Conclusions: Sleep should be viewed as cardiovascular risk factors targeted preventive intervention. More research well-designed needed completely assess deprivation relationship

Language: Английский

Citations

4
Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics DOI Creative Commons
Georges P Schmartz, Jacqueline Rehner, Madline P. Gund

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 26, 2024

Abstract The human microbiome emerges as a promising reservoir for diagnostic markers and therapeutics. Since host-associated microbiomes at various body sites differ diseases do not occur in isolation, comprehensive analysis strategy highlighting the full potential of should include diverse specimen types diseases. To ensure robust data quality comparability across diseases, we employ standardized protocols to generate sequencing from 1931 prospectively collected specimens, including saliva, plaque, skin, throat, eye, stool, with an average depth 5.3 gigabases. Collected 515 patients, these samples yield 3.7 metagenomes per patient. Our results suggest significant microbial variations types, unexpected anatomical sites. We identify 583 unexplored species-level genome bins (SGBs) which 189 are significantly disease-associated. Of note, existence resistance genes one was indicative same other specimens Annotated previously undescribed SGBs collectively harbor 28,315 biosynthetic gene clusters (BGCs), 1050 correlations combinatorial approach identifies distinct BGCs, emphasizing value pan-body pan-disease microbiomics source therapeutic strategies.

Language: Английский

Citations

4