Coffee or tea: Anti-inflammatory properties in the context of atherosclerotic cardiovascular disease prevention

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106596 - 106596

Published: Dec. 5, 2022

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflammation and its biomarkers, like C-reactive protein (CRP), among risk factors, such as hypertension, lipid disorders, diabetes, may be also responsible for residual (CVD) risk. Modern lipid-lowering treatment with statins, ezetimibe, PCSK9 inhibitors, or bempedoic acid does not fully protect against inflammation. The recommendations International Lipid Expert Panel (ILEP) indicate selected nutraceuticals anti-inflammatory properties. Diet have a significant impact on Especially interesting in context inflammation consumption coffee tea. These drinks many observational studies significantly reduced mortality. question whether effects these contribute to observed clinical effects. Thus, this narrative review, we primarily discuss properties consuming tea coffee. Based comprehensive analysis their meta-analyses, inconsistent results were obtained, which makes it impossible conclusively state how clinically potential black green are. A number confounding factors can inconsistency available results. Consumption appears increase adiponectin concentrations, decrease reactive oxygen species, low density lipoprotein (LDL) cholesterol concentrations (effect tea, etc.). Despite still uncertain effect coffee, recommend part healthy diet.

Language: Английский

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Biological potential and mechanisms of Tea’s bioactive compounds: An Updated review

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 65, P. 345 - 363

Published: Dec. 5, 2023

Tea (Camellia sinensis) has a rich history and is widely consumed across many countries, categorized into green tea, white oolong yellow black dark tea based on the level of fermentation. Based review previous literature, commonly recognized bioactive substances in include polyphenols, amino acids, polysaccharides, alkaloids, terpenoids, macro minerals, trace elements, vitamins, which have been known to various potential health benefits, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, anti-obesity properties, cardiovascular protection, immune regulation, control intestinal microbiota. Most studies only pointed out characteristics tea's bioactivities, so comprehensive summary pharmacological mechanisms bioactivities their use risks are vital. Review The aim this paper summarize mechanisms, providing scientific basis for application outlining future research directions study tea. Key Scientific Concepts This summarizes main biologically active substances, effects, discusses risks. It may help researchers grasp more progress further promote natural substance medical field.

Language: Английский

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The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

Nutrients, Journal Year: 2022, Volume and Issue: 14(12), P. 2498 - 2498

Published: June 16, 2022

Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in alleviation stress inflammation as well strengthening immunity, thus its’ possible involvement pathogenesis T1DM highlighted. goal present study analyze information on relationship between structure intestinal microbiome occurrence T1DM. modification can increase proportion SCFA-producing bacteria, which could turn effective prevention and/or treatment increased daily intake soluble non-soluble fibers, inclusion pro-biotics, prebiotics, herbs, spices, teas that are sources phytobiotics, diet, important improving composition activity metabolic disorders. Understanding how interacts with immune cells create tolerance enable development new therapeutic strategies for improve quality life people

Language: Английский

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Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6703 - 6703

Published: June 16, 2022

Endometrial cancer (EC) is second only to cervical carcinoma among the most commonly diagnosed malignant tumours of female reproductive system. The available literature provides evidence for involvement 32 genes in hereditary incidence EC. physiological markers EC and coexisting diet-dependent maladies include antioxidative system disorders but also progressing inflammation; hence, main forms prophylaxis pharmacotherapy ought a diet rich substances aiding organism’s response this type disorder, with particular focus on ones suitable lifelong consumption. Tea polyphenols satisfy those requirements due their proven antioxidative, anti-inflammatory, anti-obesogenic, antidiabetic properties. Practitioners consider promoting tea consumption individuals genetically predisposed EC, particularly given its low cost, accessibility, confirmed health benefits, above all, suitability long-term regardless patient’s age. aim paper analyse potential usability as an element support patients. analysis based information from worldwide published last 15 years.

Language: Английский

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The Effect of Brewing Time on the Antioxidant Activity of Tea Infusions

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(5), P. 2014 - 2014

Published: Feb. 29, 2024

Many studies have found that tea has an antioxidant, anti-inflammatory, anti-cancer, anti-obesogenic and anti-diabetic effect, mostly associated with the content of anti-oxidant compounds. Polyphenols, being main secondary metabolites in tea, are often considered physiological markers determining a tea’s quality. Apart from production process components, brewing conditions can also influence levels antioxidants tea. This study aimed to verify whether time various types (5, 10 15 min) affects level extraction antioxidant compounds into infusions their activity. We examined 11 tea: green leaf bags, white black red yerba mate, raspberry butterfly pea flower (Clitoria ternatea) lychee plum hibiscus Total polyphenol (TPC), flavonoids anthocyanins content, as well determination antiradical capacity DPPH radical ABTS cation, were determined using spectrophotometric assays. Due activity infusions, optimum for (leaf bags), mate is min. Red should be ten minutes, it five minutes. The results refer temperature recommended by manufacturers.

Language: Английский

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High-throughput screening, “protein–metabolite” interaction, and hypoglycemic effect investigations of α-amylase inhibitors in teas using an affinity selection-mass spectrometry method

LWT, Journal Year: 2024, Volume and Issue: 203, P. 116392 - 116392

Published: June 24, 2024

Tea is consumed worldwide and can reduce the risk of diabetes whereas hypoglycemic compounds in tea remain unclear. Herein, chemical compositions comparison inhibition assays indicated that inhibitory effect against α-amylase was positively related with enzyme-mediated oxidation degree black teas containing high contents theaflavins exhibited strongest vitro effect. Affinity selection-mass spectrometry-based high-throughput screening revealed four specifically bind to α-amylase. Compared other compounds, showed one order magnitude higher effects; thus, are possibly dominant inhibitors tea. A series "α-amylase–theaflavins" interaction studies jointly demonstrated noncompetitively inhibit activity by interacting amino acid residues then inducing changes secondary structure. Furthermore, (10 mg/kg/d) extracts (100 comparable effects as acarbose diabetic mice.

Language: Английский

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Exploring risk factors and antimicrobial susceptibility patterns associated with bacteriuria among Syrian refugees in makeshift camps

Journal of Hospital Infection, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Understanding the role of green tea and matcha consumption in cardiovascular health, obesity, and diabetes: Insights from a Saudi Arabian population

Human Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 200302 - 200302

Published: Feb. 1, 2025

Language: Английский

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Tea leaf exosome-like nanoparticles (TELNs) improve oleic acid-induced lipid metabolism by regulating miRNAs in HepG-2 cells

Bioresources and Bioprocessing, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 10, 2025

Abstract Tea is a widely consumed beverage globally, but the tea industry faces significant waste management challenge. In this study, we developed leaf exosome-like nanoparticles (TELNs) with an average size of 274 ± 24.7 nm and zeta potential -20.6 0.78 mV, using polyethylene glycol (PEG) 6000 precipitation followed by ultracentrifugation. Structural analysis confirmed that TELNs are composed lipids, proteins, RNAs. vitro assays on HepG-2 cells revealed non-toxic at concentrations up to 300 µg/mL can be efficiently internalized. exhibited antioxidant capacity were able significantly ameliorate H 2 O -induced oxidative stress, increase viability reduce accumulation ROS in Hepg-2 cells. Notably, alleviated OA-induced lipid metabolic disorders hepatocellular injury. Further molecular downregulated expression miR-21-5p, miR-17-3p, miR-107, leading upregulation their target genes PPARα, CYP7A1, CPT-1A, which contributed improvement metabolism. This study first demonstrate metabolism regulation TELNs, providing new insights into underlying mechanisms helping develop therapeutic strategies for metabolism-related diseases. Furthermore, it expands scope use helps reuse residues. Graphical

Language: Английский

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Short-term structured dietary and exercise interventions delay diabetes onset in prediabetic patients: a prospective quasi-experimental study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Prediabetes indicates an increased risk of developing diabetes mellitus. We hypothesized that structured anti-inflammatory and antioxidant dietary exercise interventions (SAIDEs) can reduce the onset in prediabetic patients. This study included 542 patients who met at least one three common criteria for prediabetes: fasting blood glucose (FBG), 2-h oral tolerance (2h OGTT), or hemoglobin A1c (HbA1C). Patients were randomly assigned to four groups using block randomization method: routine community intervention, SAIDEs 6 months. Follow-up assessments conducted months 7.5 years, monitoring diabetes-related outcomes, inflammatory markers, progression. At baseline, most tested variables, including age, gender, body weight, lipids, sugar, β-cell function, immunological energy intake, did not differ among groups. After short-term (diet, exercise, SAIDEs) follow-up, all intervention exhibited reduced total pressure, cholesterol, levels, along with improved functions (all p < 0.001). Regardless time considerations, consistently physical activity (p Short-term also IgE, high-sensitivity C-reactive protein, IL-6, TNF-α, while increasing IL-4 IL-10 The prevalence abnormal markers-FBG, 2h OGTT, HbA1C-significantly decreased within each group after follow-up. time-dependent Cox regression test indicate a significant effect on incidence over 8-year follow-up period. However, log-rank revealed differences "survival" distribution (χ 2 = 15.63, mean survival before was significantly longer received than those other markers. These benefits persisted even period, intensive but delay its onset. https://www.chictr.org.cn/searchproj.html, identifier ChiCTR-IOR-16008445.

Language: Английский

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