Metabolic Disorders and Psoriasis: Exploring the Role of Nutritional Interventions

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3876 - 3876

Published: Sept. 6, 2023

(1) Background: Psoriasis is a chronic autoimmune disease with close relationship metabolic diseases such as obesity, diabetes, and dyslipidemia. The aim of this review was to identify the between psoriasis, diseases, dietetic therapies. According recent findings, there strong association psoriasis obesity well vitamin D micronutrient deficiencies. (2) Methods: This conducted via PubMed, aiming search for studies involving linked disorders or nutritional treatments. (3) Results: Our shows that healthy lifestyle can positively influence course disease. maintaining proper body weight together physical activity good choices are associated an improvement in severity. A Mediterranean diet rich fiber, vitamins, polyphenols may indeed be strategy controlling symptoms. effectiveness lies not only its anti-inflammatory power, but also ability favorably intestinal microbiota counteract dysbiosis, which risk factor many diseases. (4) Conclusions: In synergy standard therapy, adoption appropriate recommended improve clinical expression reduce incidence comorbidities.

Language: Английский

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Phenolic Profile and In Vitro Antioxidant Activity of Different Corn and Rice Varieties

Plants, Journal Year: 2023, Volume and Issue: 12(3), P. 448 - 448

Published: Jan. 18, 2023

Celiac disease (CD) is an autoimmune disease. To date, the only universally recognized treatment for CD gluten-free diet (GFD). Despite GFD, a state of inflammation and oxidative stress could remain at intestinal level celiac patients. Several components diet, such as phenolic compounds with known antioxidant properties, play protective role in inflammatory patients CD. The objective this study was characterization profile capacity pigmented cereals (rice corn) from Italian market farms. Different vitro methods were applied: Folin–Ciocalteu assay, pH differential method, DPPH TEAC High-Performance Thin Layer Chromatography technique. According to results, varieties are possible valuable sources anthocyanins high activity. They be used alternative ingredients formulation products.

Language: Английский

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Gut Microbiota Alteration and Its Modulation with Probiotics in Celiac Disease

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2638 - 2638

Published: Sept. 26, 2023

Celiac disease (CD) is a chronic inflammation of the small intestine triggered by gluten ingestion in genetically predisposed people. Recent literature studies highlight possible role gut microbiota pathogenesis this disease. The complex community microorganisms that can interact with innate and adaptative immune systems. A condition dysbiosis, which refers to an alteration composition function human microbiota, lead dysregulated response. This may contribute triggering intolerance, favoring development and/or progression CD susceptible patients. Interestingly, on children adults showed different microbiome profile fecal samples, degree “activity” for From point view, our review aimed collect discuss modern evidence about its modulation probiotics, future indications management patients affected CD.

Language: Английский

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Popular diets and nutritional assessment in the management of irritable bowel syndrome in inflammatory bowel disease: an overview of current evidence

Polskie Archiwum Medycyny Wewnętrznej, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 9, 2024

There is increasing interest in using popular diets to manage inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn's disease (CD).These conditions are often associated with nutritional deficiencies, protein-energy malnutrition, micronutrient altered body composition, sarcopenia.While dietary interventions can be supportive treating intestinal symptoms of adult IBD patients, it's important note that current guidelines from major scientific societies do not recommend any specific for this purpose.This review aims provide a summary the evidence on dietary-nutritional management patients IBD, specifically cases where appears remission, but patient continues experience irritable syndrome (IBS) or functional gastrointestinal symptoms.We focus vital aspects regard, malnutrition sarcopenia definitions, screening assessment.We then discuss detail most used over years, characterizing each one terms effects gut inflammation, IBS-like symptoms, potential risks malnutrition.These include Low-FODMAP diet, Gluten-free diet well Mediterranean plant-based diet.To date, does conclusively establish optimal topic review, suggesting personalized approaches may best strategy.

Language: Английский

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Vulnerability in Children with Celiac Disease: Findings from a Scoping Review

Children, Journal Year: 2024, Volume and Issue: 11(6), P. 729 - 729

Published: June 14, 2024

(1) Background: The scientific literature highlights that children diagnosed with celiac disease (CD) are at a heightened risk of experiencing physical, psychological, and social challenges, impacting their overall healthy childhood development. However, there remains lack clear understanding regarding the factors contribute to this vulnerability. purpose study is analyze map evidence on sociopsychosomatic vulnerability these identify gaps in topic. (2) Methods: Following Joanna Briggs Institute's guidelines for scoping reviews, we executed detailed search key electronic databases explored grey capture broad spectrum studies. Our focus was identifying research looked into multiple dimensions vulnerability-physical, social-in CD. We included diverse range designs as well systematic ensuring comprehensive analysis. selection process stringent, utilizing clearly defined inclusion exclusion criteria. (3) Results: identified 61 studies met our review highlighted significant adverse health outcomes CD elucidated various individual environmental determinants influenced vulnerabilities. It also underscored assessment tools evaluate problems population. (4) Conclusions: findings underscore critical need further deepen vulnerabilities associated children. Developing targeted will be crucial stratifying risks enhancing care strategies vulnerable

Language: Английский

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Living, Heat-Killed Limosilactobacillus mucosae and Its Cell-Free Supernatant Differentially Regulate Colonic Serotonin Receptors and Immune Response in Experimental Colitis

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 468 - 468

Published: Feb. 6, 2024

Lactobacillus species have been shown to alleviate gut inflammation and oxidative stress. However, the effect of different lactobacilli components on has not well studied. This study aims identify differences in mechanisms forms Limosilactobacillus mucosae (LM) treatment alleviation using a colitis mouse model that is induced by dextran sodium sulfate (DSS). Seventy-two C57BL/6 mice were divided into six groups: control, DSS, live LM+DSS (LM+DSS), heat-killed (HKLM+DSS), LM cell-free supernatant + DSS (LMCS+DSS), MRS medium (MRS+DSS). The treated with for two weeks before treatment. After that, sacrificed an assessment their levels inflammatory cytokines, serotonin (5-HT) receptors (HTRs), tryptophan metabolites. results showed compared other treatments, LMCS was more effective (p < 0.05) DSS-induced body weight loss led increase disease activity index score. All three increased indole-3-acetic acid but reduced 5-HT colon. HKLM or percentages CD3+CD8+ cytotoxic T cells CD3+CD4+ helper spleen. abundances CD4+Foxp3+ regulatory treatments expression pro-inflammatory cytokines Il6 Il17a. HKLM+DSS group had higher mRNA anti-inflammatory cytokine Il10, cell differentiation proliferation markers Lgr5 Ki67, degradation enzyme Maoa, HTRs (Htr1a, Htr2a, Htr2b) phosphorylation STAT3. above findings can help optimize functionality probiotics develop new dietary strategies aid maintenance healthy gut.

Language: Английский

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Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis

BMC Pediatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 16, 2024

Abstract Background The relationship between Vitamin D levels and pediatric celiac disease (CD) remains controversial. In this study, we conducted a systematic review meta-analysis to examine the CD. Methods: We screened relevant studies from PubMed, EMBASE, Web of Science published in English January 1, 2000, August 2023. included were assessed according STROBE checklist. Heterogeneity was quantified by Cochran’s Q test I 2 statistic. Publication bias estimated Begg’s Egger’s test. Meta‐regression used detect potential sources heterogeneity. Results: A total 26 meta-analysis. Nineteen articles compared 25(OH)D3 CD patients control groups, average 25-hydroxyvitamin 3 [25(OH)D or calcidiol], 1,25-dihydroxyvitamin [1,25(OH) calcitriol] levels, as main forms D, there significant difference healthy controls (weighted mean (WMD) = − 5.77, 95% confidence interval (CI) [− 10.86, 0.69] nmol/L). Meanwhile, eleven reported numbers with deficiency, incidence 25(OH)D deficiency (odds ratio 2.20, CI= [1.19, 4.08]). Nine changes before after administering GFD CD, result study revealed increase gluten-free diet (GFD) (WMD 6.74, CI 9.78, 3.70] Conclusions: lower than controls, more prevalent patients. found that elevated GFD, which is consistent previous research. Further well-designed, longitudinal, prospective cohort focusing on role pathogenesis are therefore needed.

Language: Английский

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Celiac Disease, Gluten-Free Diet and Metabolic Dysfunction-Associated Steatotic Liver Disease

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2008 - 2008

Published: June 25, 2024

Celiac disease (CD) is a chronic autoimmune disorder triggered by the ingestion of gluten-containing food genetically predisposed individuals. Hence, treatment CD consists permanent avoidance wheat, rye, barley, and other foods. Lifelong adherence to gluten-free diet (GFD) improves symptoms CD, but recent evidence suggests it also associated with higher risk for hepatic steatosis coexistence or emergence cardiometabolic factors. Moreover, liver reported some authors as potential extraintestinal complication itself. Recent nomenclature changes designate association between at least one five factors metabolic dysfunction-associated steatotic (MASLD). An extended network potentially causative underlying MAFLD before after dietary therapy implemented, was recently described. The individualized these patients less supported evidence, most current recommendations relying on empiric clinical judgment. This review focuses associations injury, either an manifestation side effect GFD, referring therapeutic strategies

Language: Английский

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Uma análise acerca dos aspectos clínicos da Doença Celíaca

Revista Eletrônica Acervo Médico, Journal Year: 2025, Volume and Issue: 25, P. e18506 - e18506

Published: Jan. 6, 2025

Objetivo: Examinar as características da Doença Celíaca (DC). Revisão bibliográfica: A DC é uma doença autoimune desencadeada após a ingesta proteína glúten por pessoas geneticamente suscetíveis. As principais manifestações são gastrointestinais como diarreia, dor abdominal, náuseas, vômitos e constipação crônica. Fadiga crônica, anemias carenciais sintomas neuropsiquiátricos também comuns. O diagnóstico deve ser feito maneira mais precoce possível, para melhorar qualidade de vida dos celíacos impedir que haja complicações. tratamento eficaz eliminação total do alimentação. Existem outras terapias, mas elas utilizadas em casos acidental glúten. Considerações finais: Conclui-se não tratada causa muitos prejuízos pacientes pode proporcionar complicações graves. É extrema importância o seja implementada quanto antes. Além disso, suporte psicológico acompanhamento nutricional especializado essenciais promover adesão dieta bem-estar emocional indivíduos vivem com celíaca.

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Non-Celiac Gluten/Wheat Sensitivity—State of the Art: A Five-Year Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 220 - 220

Published: Jan. 8, 2025

Background: Non-celiac gluten/wheat sensitivity (NCGWS) is a syndrome for which pathogenesis and management remain debated. It described as condition characterized by gastrointestinal extra-intestinal symptoms rapidly occurring after gluten ingestion in subjects who have had celiac disease or wheat allergy excluded. To date, the diagnosis of NCGWS challenging no universally recognized biomarkers been yet identified, nor has predisposing genetic profile described. However, research moving fast, new data regarding pathogenic pathways, patients' classification, potential candidate biomarkers, dietary interventions are emerging. Methods: This literature review aims to address state art summarize latest updates this field from 2019 date. Results Conclusions: Clinical studies last five years reported shed light on complex guide specialists towards more in-depth, prompt, objective diagnosis.

Language: Английский

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