Nutrients,
Journal Year:
2024,
Volume and Issue:
16(4), P. 481 - 481
Published: Feb. 7, 2024
Photoaging,
the
primary
cause
of
skin
aging
damage,
results
from
chronic
ultraviolet
(UV)
exposure,
leading
to
dryness
and
wrinkle
formation.
Nutritional
intervention
has
emerged
as
a
practical
approach
for
preventing
addressing
effect
photoaging.
The
aromatic
compound
isolated
clove
oil,
isoeugenol
(IE),
antibacterial,
anti-inflammatory,
antioxidant
qualities
that
work
effectively
restrict
cancer
cell
proliferation.
This
investigation
delved
into
advantages
IE
in
alleviating
photoaging
using
UVB-irradiated
fibroblasts
female
SKH-1
hairless
mouse
models.
alleviated
UVB-induced
photodamage
Hs68
dermal
by
inhibiting
matrix
metalloproteinase
secretion
promoting
extracellular
synthesis.
In
photoaged
mice,
dietary
reduced
wrinkles,
relieved
dryness,
inhibited
epidermal
thickening,
prevented
collagen
loss.
Additionally,
intestinal
dysbiosis
caused
prolonged
UVB
exposure
was
with
an
intervention.
Spearman’s
analysis
showed
strong
correlation
between
gut
microbiota.
Given
almost
unavoidable
contemporary
living,
this
research
demonstrated
efficacy
reversing
photoaging,
presenting
promising
tackle
concerns
related
extrinsic
aging.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 4, 2023
Diabetic
retinopathy
(DR)
is
a
microvascular
lesion
that
occurs
as
complication
of
diabetes
mellitus.
Many
studies
reveal
retinal
neurodegeneration
early
in
its
pathogenesis,
and
abnormal
function
can
occur
patients
without
any
signs
abnormalities.
The
gut
microbiota
large,
diverse
colony
microorganisms
colonize
the
human
intestine.
Studies
indicated
involved
pathophysiological
processes
DR
plays
an
important
role
development.
On
one
hand,
numerous
demonstrated
involvement
neurodegeneration.
other
alterations
bacteria
RD
cause
or
exacerbate
DR.
present
review
aims
to
underline
critical
relationship
between
After
brief
overview
composition,
function,
essential
ocular
health,
explores
concept
gut-retina
axis
conditions
crosstalk.
Because
dysbiosis
has
been
associated
with
DR,
intends
determine
changes
microbiome
hypothesized
mechanisms
linking
axis,
predictive
potential.
Biomedical Journal,
Journal Year:
2023,
Volume and Issue:
47(2), P. 100676 - 100676
Published: Nov. 3, 2023
Senescence
is
a
condition
of
cell
cycle
arrest
that
increases
inflammation
and
contributes
to
the
development
chronic
diseases
in
aging
human
body.
While
several
compounds
described
as
senolytics
senomorphics
produce
health
benefits
by
reducing
burden
senescence,
less
attention
has
been
devoted
lifestyle
interventions
similar
effects.
We
describe
here
effects
exercise,
nutrition,
caloric
restriction,
intermittent
fasting,
phytochemicals
from
natural
products,
prebiotics
probiotics,
adequate
sleep
on
senescence
model
organisms
humans.
These
can
be
integrated
within
healthy
reduce
delay
consequences
aging.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(2), P. 348 - 348
Published: Feb. 1, 2024
Our
current
understanding
of
skin
cell
senescence
involves
the
role
environmental
stressors
(UV,
O3,
cigarette
smoke,
particulate
matter,
etc.),
lifestyle
(diet,
exercise,
etc.)
as
well
genetic
factors
(metabolic
changes,
hormonal,
etc.).
The
common
mechanism
action
these
is
disturbance
cellular
redox
balance
characterized
by
increased
free
radicals
and
reactive
oxygen
species
(ROS),
when
overload
intrinsic
antioxidant
defense
system,
it
can
lead
to
an
oxidative
stress
condition.
main
mechanisms
that
activate
in
involve
(1)
damage
telomeres
causing
their
shortening;
(2)
oxidation
proteomes
DNA
damage;
(3)
a
lysosomal
mass
through
activity
resident
enzymes
such
senescence-associated
β-galactosidase
(SA-β-gal)
other
proteins
are
products
activity;
(4)
expression
SASP,
particular
pro-inflammatory
cytokines
transcriptionally
regulated
NF-κB.
However,
targets
ROS
on
proteome
(oxi-proteome),
followed
telomeres,
nucleic
acids
(DNAs),
lipids,
proteins,
cytoplasmic
organelles.
As
result,
cycle
arrest
pathways,
lipid
peroxidation,
content
dysfunctional
mitochondria,
SASP
synthesis
occur.
Furthermore,
cells
increases
p16INK4A
p53
inhibitors
Rb
CDks,
which
important
for
maintaining
cycle.
also
promotes
inactivation
mTOR-mediated
autophagic
apoptotic
leading
senescence.
markers
alone
cannot
establish
state
senescence,
multiple
analyses
encouraged
confirmation.
An
updated
more
comprehensive
approach
investigating
should
include
further
assays
ox-inflammatory
molecular
pathways
consolidate
cutaneous
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(4), P. 481 - 481
Published: Feb. 7, 2024
Photoaging,
the
primary
cause
of
skin
aging
damage,
results
from
chronic
ultraviolet
(UV)
exposure,
leading
to
dryness
and
wrinkle
formation.
Nutritional
intervention
has
emerged
as
a
practical
approach
for
preventing
addressing
effect
photoaging.
The
aromatic
compound
isolated
clove
oil,
isoeugenol
(IE),
antibacterial,
anti-inflammatory,
antioxidant
qualities
that
work
effectively
restrict
cancer
cell
proliferation.
This
investigation
delved
into
advantages
IE
in
alleviating
photoaging
using
UVB-irradiated
fibroblasts
female
SKH-1
hairless
mouse
models.
alleviated
UVB-induced
photodamage
Hs68
dermal
by
inhibiting
matrix
metalloproteinase
secretion
promoting
extracellular
synthesis.
In
photoaged
mice,
dietary
reduced
wrinkles,
relieved
dryness,
inhibited
epidermal
thickening,
prevented
collagen
loss.
Additionally,
intestinal
dysbiosis
caused
prolonged
UVB
exposure
was
with
an
intervention.
Spearman’s
analysis
showed
strong
correlation
between
gut
microbiota.
Given
almost
unavoidable
contemporary
living,
this
research
demonstrated
efficacy
reversing
photoaging,
presenting
promising
tackle
concerns
related
extrinsic
aging.
