Vitamin D Supplementation and COVID-19 Outcomes: Mounting Evidence and Fewer Doubts

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3584 - 3584

Published: Aug. 31, 2022

The coronavirus disease 2019 (COVID-19) has already killed more than 6 million people around the world. A growing body of epidemiological evidence suggests that low 25-hydroxy vitamin D (25-OH-vitamin D) plasma levels are associated with an increased risk developing COVID-19 and -most importantly-with a higher severe dying. On other hand, supplementation during early phases been related to decreased length hospital stay, less frequent need for oxygen, reduced mortality rate in inpatients. This seems be particularly true when high dosages used. In light this evidence, further studies needed define best timing most effective dosage schedule.

Language: Английский

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Targeting Calcitriol Metabolism in Acute Vitamin D Toxicity—A Comprehensive Review and Clinical Insight

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10003 - 10003

Published: Sept. 17, 2024

High-dose vitamin D supplementation is common in the general population, but unsupervised high-dose D-replete individuals poses a risk of severe toxicity. Susceptibility to toxicity shows significant inter-individual variability that may part be explained by genetic predispositions (i.e., CYP24A1 polymorphism). The classic manifestation hypercalcemia, which refractory conventional therapy. Its causes include endogenous overaction 1α-hydroxylase, monogenic alterations affecting metabolizing enzymes and exogenous intoxication. In this manuscript, we literature review potential pharmacological interventions targeting calcitriol metabolism treat intoxication present case severe, responding systemic corticosteroids after failure Systemic glucocorticoids alleviate acute hypercalcemia inhibiting enteric calcium absorption increasing degradation metabolites cause adverse effects. Inhibitors 1α-hydroxylase (keto/fluconazole) inducers CYP3A4 (rifampicin) considered steroid-sparing alternatives for treatment

Language: Английский

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Anti-inflammatory and Nutritional Interventions Against SARS-CoV-2: A Comprehensive Review

Journal of Agriculture and Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 101422 - 101422

Published: Sept. 1, 2024

Language: Английский

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Contributions of Small Grains Grown in Zimbabwe’s Dryland Regions in Boosting Immunity and Combating COVID-19

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 59 - 75

Published: Jan. 1, 2023

Language: Английский

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