Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1023 - 1023

Published: May 7, 2024

The synergic role of vitamin D and the intestinal microbiota in regulation immune system has been thoroughly described literature. Vitamin deficiency dysbiosis have shown a pathogenetic development numerous immune-mediated allergic diseases. physiological processes underlying aging sex proven to be capable having negative influence both on values biodiversity microbiome. This leads global increase levels systemic inflammatory markers, with potential implications for all diseases conditions. Our review aims collect analyze relationship between microbiome associated it, emphasizing effect mediated by sexual hormones aging.

Language: Английский

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Effectiveness of Vitamin D Supplementation on Disease Course in Inflammatory Bowel Disease Patients: Systematic Review With Meta-Analysis

Inflammatory Bowel Diseases, Journal Year: 2022, Volume and Issue: 30(2), P. 281 - 291

Published: Dec. 29, 2022

Abstract Background The vitamin D role in bone metabolism is well known; however, recent evidence suggests the impact of immune modulation and its implications immune-mediated diseases, including inflammatory bowel disease (IBD). Method We performed a systematic review with meta-analysis by specific protocol (PROSPERO: CRD42022311184; March 2022, https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=311184). Randomized clinical trials involving IBD patients treated supplementation, compared placebo, that evaluated risk relapse activity were included. Literature search was using Medline, Scopus, Cochrane CENTRAL through January 2022. Results Out 1448 articles, 12 (11 full-texts 1 abstract) Seven randomized reported data on as dichotomous outcome, while 7 studies expressed continuous variables. pooled ratio 0.64 (95% confidence interval, 0.46-0.89; I2 = 25%) among 458 patients. However, this seems to be solid only Crohn’s (CD) In fact, 2 studies, 67 ulcerative colitis, included analysis. CD remission had strong significant reduction (risk ratio, 0.47; 95% 0.27-0.82; 0%), suggesting it could subgroup maximum benefit supplementation. Conclusions This shows supplementation can reduce patients, especially remission. analysis, not (due small number low patients), well-powered are needed, particular for colitis

Language: Английский

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Correlation Between Vitamin D Deficiency (25(OH)D3) and the Severity of Purulent Oropharyngeal Infections

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2410 - 2410

Published: April 1, 2025

Background: Vitamin D plays a crucial role in immune system function, and its deficiency has been associated with an increased risk of infections. This study investigates the relationship between vitamin severity purulent oropharyngeal infections, considering need for surgical interventions duration hospitalization. Materials Methods: retrospective included patients diagnosed peritonsillar phlegmons, laterocervical abscesses, abscesses. Patients were categorized based on their levels: (<30 ng/mL) optimal levels (≥30 ng/mL). The clinical parameters, length hospitalization, type treatment analyzed. Statistical analyses Student's t-test, chi-square test, ANOVA to assess differences groups. Results: (25(OH)D3) had significantly longer hospital stay (8.50 days vs. 3.24 days, p = 0.001) required more frequent (55.6% 27.8%, 0.002) compared those levels. A trend toward complex regimens was also observed, although this not statistically significant (p > 0.05). Conclusions: These findings suggest that may contribute severe course increasing invasive treatments prolonging highlights importance monitoring potential benefits supplementation preventing managing upper respiratory tract

Language: Английский

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The effects of Vitamin D on Keratoconus progression

American Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: results from the InCHIANTI study

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Abstract Few studies have evaluated the association between circulating levels of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin (1,25(OH) 2 D), and endocrine disruptor bisphenol A (BPA), with risk cardiovascular (CV) disease in elderly individuals. This was a cross-sectional study subgroup people from InCHIANTI Biobank Italy. We examined serum vitamin metabolites, 1,25(OH) D, 25(OH)D, disrupting agent BPA, an arbitrary CV score European Society Cardiology-based 10-year (SCORE2/SCORE2-OP) using univariate multiple regression. In 299 individuals, blood samples were tested for values urinary BPA levels. One hundred eighty individuals (60.2%) deficient (< 20 ng/ml) 25(OH)D. Levels 25(OH)D negatively correlated ( p < 0.0001 both) as well SCORE2/SCORE2-OP while positively both scores both). logistic regression model, male gender (odds ratio; OR: 2.1, 95% CI:1.1–3.8, = 0.022), obesity (OR:2.8, CI:1.2–6.5, 0.016) ≥ 110 ng/dl (OR:20.9, CI:9.4–46.8, 0.0001) associated 1,25(OH)2D 41 ng/ml 3 (OR: 4.16, CI: 2.32–7.4, 1.86, 1.02–3.39, 0.044) respectively 20% (OR:2.98, 1.7–5.2, 0.0001). this analysis, exposure significantly reduced that turn increased risk.

Language: Английский

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Unveiling the Interplay—Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 831 - 831

Published: Oct. 16, 2024

The interaction of the SARS-CoV-2 spike protein with membrane-bound angiotensin-converting enzyme-2 (ACE-2) receptors in epithelial cells facilitates viral entry into human cells. Despite this, ACE-2 exerts significant protective effects against coronaviruses by neutralizing viruses circulation and mitigating inflammation. While reduces expression, vitamin D increases it, counteracting virus's harmful effects. Vitamin D's beneficial actions are mediated through complex molecular mechanisms involving innate adaptive immune systems. Meanwhile, status [25(OH)D concentration] is inversely correlated severity, complications, mortality rates from COVID-19. This study explores which inhibits replication, including suppression transcription enzymes, reduced inflammation oxidative stress, increased expression antibodies antimicrobial peptides. Both hypovitaminosis elevate renin levels, rate-limiting step renin-angiotensin-aldosterone system (RAS); it ACE-1 but expression. imbalance leads to elevated levels pro-inflammatory, pro-coagulatory, vasoconstricting peptide angiotensin-II (Ang-II), leading widespread It also causes membrane permeability, allowing fluid infiltrate soft tissues, lungs, vascular system. In contrast, sufficient suppress reducing RAS activity, lowering ACE-1, increasing levels. cleaves Ang-II generate Ang

Language: Английский

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Association between vitamin D receptor polymorphisms, tight junction proteins and clinical features of adult patients with atopic dermatitis

Dermatology Practical & Conceptual, Journal Year: 2024, Volume and Issue: unknown, P. e2024214 - e2024214

Published: July 31, 2024

Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD).

Language: Английский

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Vitamin D Deficiency: Insights and Perspectives from a Five-Year Retrospective Analysis of Children from Northeastern Romania

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3808 - 3808

Published: Nov. 7, 2024

Vitamin D plays an important role in maintaining bone health with numerous benefits for extraskeletal as well.

Language: Английский

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Vitamin D: A Potential Mitigation Tool for the Endemic Stage of the COVID-19 Pandemic?

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: June 10, 2022

The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and associated development clinical symptoms COVID-19 have presented an enormous global on our health care systems, public economy. To date several observational epidemiological studies consistently found that vitamin D deficiency, measured as low levels circulating 25-hydroxyvitamin D, is with cardiovascular diseases, diabetes, certain cancers, autoimmune diseases many infectious including infections. Since not merely immunosuppressive but also acts immunomodulator in tolerance homeostasis, experts considered a role prevalence severity immune mediated inflammatory such SARS-CoV-2, adding to evidence importance response against viral infections reinforcing need for targeted supplementation, focus high-risk populations high-dose supplementation treatment hospitalized patients. expected transition endemicity SARS-CoV-2 even further corroborates potential mitigation tool prevention COVID-19. aim this paper analyse current regarding present hypothesis its future preventive measurement health.

Language: Английский

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Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 1993 - 1993

Published: Aug. 17, 2022

The use of micronutrients such as vitamin D could improve the response to viral vaccines, particularly in immunosuppressed and immunosenescent subjects. Here, we analysed association between serum 25-hydroxyvitamin (25OHD) levels immune elicited by BNT162b2 vaccine a cohort 101 healthcare workers naïve for SARS-CoV-2 infection. We observed no significant differences anti-spike (S) IgG T-cell responses according 25OHD status at baseline. However, correlations concentration baseline (i) anti-S (p < 0.020) (ii) neutralizing antibody (NT) titre = 0.040) six months after second dose were detected. concluded that adequate may mRNA vaccines BNT162b2, further larger studies are warranted order confirm these preliminary observations.

Language: Английский

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