Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(7), P. 2532 - 2554

Published: Jan. 1, 2024

Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components.In this narrative review, we provide comprehensive overview autophagy's molecular basis, biological significance, pharmacological modulation, its relevance lifestyle medicine.We delve into intricate mechanisms that govern autophagy, including macroautophagy, microautophagy chaperone-mediated autophagy.Moreover, highlight significance autophagy aging, immunity, metabolism, apoptosis, tissue differentiation systemic diseases, such as neurodegenerative or cardiovascular diseases cancer.We also discuss latest advancements modulation their potential implications clinical settings.Finally, explore intimate connection between factors emphasizing how nutrition, exercise, sleep patterns environmental can significantly impact autophagic process.The integration medicine research opens new avenues for promoting health longevity through personalized interventions.

Language: Английский

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Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review

Cancers, Journal Year: 2022, Volume and Issue: 14(20), P. 5149 - 5149

Published: Oct. 20, 2022

Chemotherapy and radiotherapy are first-line treatments in the management of advanced solid tumors. Whereas these directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient’s quality life even life-threatening. Diet is modifiable risk factor has been shown affect risk, recurrence, treatment toxicity, but little information known how diet interacts with modalities. Although dietary interventions, such as intermittent fasting ketogenic diets, have promise pre-clinical studies by reducing toxicity increasing efficacy chemotherapeutics, there remains limited number clinical this space. This review surveys impact interventions (caloric restriction, short-term fasting, diet) on outcomes both studies. Early support complementary role for improving patient across multiple types perhaps benefit efficacy. Larger, phase III, randomized trials ultimately necessary evaluate oncologic or patients undergoing chemotherapy radiotherapy.

Language: Английский

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Does intermittent fasting impact mental disorders? A systematic review with meta-analysis

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(32), P. 11169 - 11184

Published: June 17, 2022

Accumulating evidence supports the benefits of intermittent fasting (IF) as a dietary strategy for cardiometabolic health and weight control. However, little is known about potential implications IF on mental disorders. The aim this review was to synthesize regarding effects disorders (depression, anxiety, mood state) in general population. We conducted systematic search five databases from inception January 2022. Randomized nonrandomized clinical trials (RCTs/nonRCTs) were included. A random method used pool standardized mean differences (SMDs) 95% CIs. total 14 studies involving 562 individuals included, which 8 RCTs 6 nonRCTs. showed moderate positive effect depression scores when compared control groups (SMD: 0.41; 95%CI: 0.05 0.76; I2=45%; n = 4). Conversely, within-group analyses did not show any significant anxiety 0.10; -0.09 0.30; I2=0%; 5) or state 0.14; 0.37; I2=59%; 7). modalities negatively impact In fact, influence diminishing scores, modify mood.

Language: Английский

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Intermittent Fasting and Its Effects on Weight, Glycemia, Lipids, and Blood Pressure: A Narrative Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3661 - 3661

Published: Aug. 21, 2023

Metabolic syndrome (MetS) has become a significant public health concern globally. Weight managementis crucial in controlling MetS risk factors, making energy balance and weight loss strategies important nutrition recommendations. Intermittent fasting (IF) gained traction as dietary approach for management cardiovascular reduction. However, the effects of IF on factors have been inconsistent previous studies. This review aims to summarize various types body mass index (BMI), glycemia, lipid profile, blood pressure, while providing insights into their clinical implications. A comprehensive search interventional studies meta-analyses was conducted, results were analyzed. The findings indicate that different lead mixed effects. Time-restricted eating (TRE) alternate-day (ADF) consistently showed decreases BMI, outcomes intermittent restriction (IER) more uncertain. glycemia profile also variable, with TRE ADF generally showing positive results. impact IER remained inconsistent. More research is needed understand long-term optimal implementation managing metabolic factors.

Language: Английский

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Intermittent fasting ameliorates neuronal ferroptosis and cognitive impairment in mice after traumatic brain injury

Nutrition, Journal Year: 2023, Volume and Issue: 109, P. 111992 - 111992

Published: Feb. 4, 2023

Language: Английский

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