Seminars in Oncology Nursing, Journal Year: 2024, Volume and Issue: unknown, P. 151793 - 151793
Published: Dec. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: March 11, 2024
Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies
Language: Английский
Citations
66
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(3)
Published: March 13, 2024
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer have unique ability to reprogram their by deviating reliance from primarily oxidative phosphorylation (OXPHOS) glycolysis, in order support survival. This metabolic phenotype is referred as the “Warburg effect” associated with an increase glucose uptake, diversion of glycolytic intermediates alternative pathways that anabolic processes. These processes include synthesis nucleic acids, lipids, proteins, necessary for rapidly dividing cells, sustaining growth, proliferation, capacity successful metastasis. Triple-negative breast (TNBC) one most aggressive subtypes cancer, poorest patient outcome due its high rate TNBC characterized elevated glycolysis certain instances, low OXPHOS. dysregulation linked chemotherapeutic resistance research models samples. There more than single mechanism which this switch occurs here, we review current knowledge relevant molecular mechanisms involved advanced metabolism, focusing on TNBC. Warburg effect, adaptations, microRNA regulation, mitochondrial involvement, calcium signaling, recent player JAK/STAT signaling. In addition, explore some drugs compounds targeting reprogramming. Research these highly promising could ultimately offer new opportunities development innovative therapies treat dysregulated metabolism.
Language: Английский
Citations
10
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 188984 - 188984
Published: Sept. 16, 2023
Language: Английский
Citations
11
Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 396 - 396
Published: Jan. 30, 2024
Cancer etiology involves complex interactions between genetic and non-genetic factors, with epigenetic mechanisms serving as key regulators at multiple stages of pathogenesis. Poor dietary habits contribute to cancer predisposition by impacting DNA methylation patterns, non-coding RNA expression, histone landscapes. Histone post-translational modifications (PTMs), including acyl marks, act a molecular code play crucial role in translating changes cellular metabolism into enduring patterns gene expression. As cells undergo metabolic reprogramming support rapid growth proliferation, nuanced roles have emerged for dietary- metabolism-derived acylation progression. Specific types acylation, beyond the standard acetylation shed light on how metabolites reshape gut microbiome, influencing dynamics repertoires. Given reversible nature PTMs, corresponding readers, writers, erasers are discussed this review context prevention treatment. The evolving ‘acyl code’ provides improved biomarker assessment clinical validation diagnosis prognosis.
Language: Английский
Citations
4
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 201, P. 104438 - 104438
Published: July 6, 2024
Language: Английский
Citations
4
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317502 - e0317502
Published: Jan. 16, 2025
Objectives Epithelial ovarian cancer is a significant contributor to cancer-related mortality in women, frequently recurring post-treatment, often accompanied by chemotherapy resistance. Dietary interventions have demonstrated influence on progression; for instance, caloric restriction has exhibited tumor growth reduction and enhanced survival animal models. In this study, we calculated transcriptomic signature based caloric-restriction patients explored its correlation with progression. Methods We conducted literature search identify proteins modulated fasting, intermittent fasting or prolonged human females. Based the gene expression of these proteins, Non-Fasting Genomic Signature score each sample sourced from Cancer Genome Atlas (TCGA) database. Subsequently, examined association between genomic profile various clinical characteristics. Results The non-fasting signature, comprising eight genes, higher prevalence primary tumors compared normal tissue. Patients elevated reduced overall increased lymphatic invasion. mesenchymal subtype, associated resistance, displayed highest expression. Multivariate analysis suggested as potential independent prognostic factor. Conclusions Ovarian expressing “non-fasting” transcriptional correlate poorer outcomes, emphasizing impact improving patient treatment response. Further investigations, including trials, are warranted validate findings explore broader applicability signatures other types.
Language: Английский
Citations
0
Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
0
Interdisciplinary cancer research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 324 - 324
Published: March 22, 2025
High-fat diets (HFDs) have become increasingly prevalent in modern societies, driving rising rates of obesity and metabolic syndrome. Concurrently, radiation exposure from medical treatments environmental sources poses health risks shaped by both biological factors. This review explores the intersection between HFDs sensitivity/susceptibility, focusing on how diet-induced alterations influence body’s response to radiation. Evidence preclinical clinical studies indicates that significantly alter metabolism, leading increased oxidative stress immune system dysregulation. These changes can exacerbate radiation-induced stress, inflammation, DNA damage, potentially increasing sensitivity normal tissues. Conversely, HFD-induced disruptions may activate cellular pathways involved repair, cell survival, inflammatory responses, fostering tumor resistance modifying microenvironment, which impair efficacy therapy cancer treatment. Understanding interplay diet is critical for optimizing public guidelines improving therapeutic outcomes. findings underscore need further research into dietary interventions mitigate radiation-associated risks.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 27, 2025
Nutraceuticals-including resveratrol (RSV), curcumin (CUR), piperine (PPR), and quercetin (QUE)-exhibit dual therapeutic toxicological profiles, are necessitating balanced risk–benefit evaluation. This review synthesizes evidence from about 120 preclinical/clinical studies sourced PubMed, Scopus, Web of Science using keywords (e.g., nutraceutical-drug interactions, bioavailability, CYP/P-gp modulation), prioritizing recent advances (2015–2024) alongside seminal works to contextualize mechanisms. Studies were selected based on methodological rigor, clinical relevance, mechanistic insights into protective effects (antioxidant, anti-inflammatory, anticancer) risks (organ toxicity, pro-oxidant activity, drug interactions). Key findings highlight PPR’s bioavailability-enhancing neuroprotective properties, yet its inhibition CYP3A4/P-gp elevates toxicity for carbamazepine (68.7% ↑ plasma concentration) warfarin. CUR demonstrates hepatoprotective benefits but alters cardiovascular pharmacokinetics amlodipine) induces oxidative stress at high doses. RSV QUE improve cardiovascular/neurological outcomes interact with chemotherapeutics (RSV ↓ resistance via apoptosis; methotrexate efficacy anti-inflammatory synergy). Critical include reproductive (PPR >10 mg/kg), neurocognitive deficits (high-dose CUR), CYP3A4-mediated interactions (QUE + cyclosporine). Nanotechnology-driven formulations CUR/PPR nanoemulsions) mitigate by enhancing stability enabling targeted delivery, though rigorous safety validation remains essential. underscores the need evidence-based guidelines optimize nutraceutical use in polypharmacy populations, emphasizing interdisciplinary collaboration manage interactions. Innovations like nanoencapsulation could transition nutraceuticals supplements precision medicine adjuvants, pending resolution dose–response ambiguities long-term gaps through research.
Language: Английский
Citations
0