The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy DOI Open Access
Priscila Oliveira Barbosa, José E. Tanus‐Santos, Ricardo de Carvalho Cavalli

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1475 - 1475

Published: May 14, 2024

Hypertensive diseases of pregnancy (HDPs) represent a global clinical challenge, affecting 5-10% women and leading to complications for both maternal well-being fetal development. At the heart these is endothelial dysfunction, with oxidative stress emerging as pivotal causative factor. The reduction in nitric oxide (NO) bioavailability vital indicator this culminating blood pressure dysregulation. In therapeutic context, although antihypertensive medications are commonly used, they come inherent concerns related maternal-fetal safety, percentage do not respond therapies. Therefore, alternative strategies that directly address pathophysiology HDPs required. This article focuses on potential nitrate-nitrite-NO pathway, abundantly present dark leafy greens beetroot, an approach treating HDPs. objective review discuss prospective antioxidant role nitrate. We hope our discussion paves way using nitrate improve dysfunction control stress, offering therapy managing

Language: Английский

YTHDF1 mediates N‐methyl‐N‐nitrosourea‐induced gastric carcinogenesis by controlling HSPH1 translation DOI Creative Commons
Peng Song, Xiang Li, Shuai Chen

et al.

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(7)

Published: March 5, 2024

Abstract YT521‐B homology (YTH) domain family (YTHDF) proteins serve as readers that directly recognise m6A modifications. In this study, we aim to probe the role of YTHDF1 in environmental carcinogen‐induced malignant transformation gastric cells and cancer (GC) carcinogenesis. We established a long‐term low‐dose MNU‐induced model epithelial cells. vivo vitro experiments were conducted validate phenotype characterise roles its downstream genes Additionally, explored modification targets using RNA‐sequencing, RNA immunoprecipitation, proteomics analyses, validation cell clinical samples. Long‐term exposure MNU converted normal Gges‐1 into mRNA protein expression are increased ( p <0.001). Meanwhile, knockdown inhibits potential MNU‐treated <0.01). specifically suppresses HSPH1 protein, but not levels. RIP‐qPCR validates is target impairs transformed The key regulatory factor carcinogenesis affects tumorigenesis by regulating translation HSPH1. These findings provide new for preventing treating chemical‐induced

Language: Английский

Citations

6
Evaluation of some artificial food preservatives and natural plant extracts as antimicrobial agents for safety DOI Creative Commons

Jianrong Shi,

Jian‐Hong Xu, Xin Liu

et al.

Discover Food, Journal Year: 2024, Volume and Issue: 4(1)

Published: Sept. 6, 2024

Language: Английский

Citations

6
Dietary Nitrate from Plant Foods: A Conditionally Essential Nutrient for Cardiovascular Health DOI Creative Commons
Ana Clara da C. Pinaffi‐Langley,

Rosa M Dajani,

Mary C. Prater

et al.

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 15(1), P. 100158 - 100158

Published: Nov. 24, 2023

Under specific conditions, such as catabolic stress or systemic inflammation, endogenous nutrient production becomes insufficient and exogenous supplementation (for example, through dietary intake) is required. Herein, we propose consideration of a nitrate from plant foods conditionally essential for cardiovascular health based on its role in nitric oxide homeostasis. Nitrate derived may function nutrient, whereas obtained other sources, drinking water cured/processed meats, warrants separate because the associated risks. We have surveyed literature summarized epidemiological evidence regarding effect disease risk factors. Meta-analyses population-based observational studies consistently demonstrated an inverse association with blood pressure outcomes. Considering available evidence, suggest 2 different approaches to providing guidance plant-based sources nutrient: Dietary Reference Intakes developed by National Academies Sciences, Engineering, Medicine, guidelines evaluated Academy Nutrition Dietetics. Ultimately, this proposal underscores need food-based capture complex context-dependent relationships between nutrients, particularly nitrate, health.

Language: Английский

Citations

14
Highly Sensitive Graphene-Based Electrochemical Sensor for Nitrite Assay in Waters DOI Creative Commons
Florina Pogăcean, Codruţa Varodi, Lidia Măgeruşan

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(9), P. 1468 - 1468

Published: April 25, 2023

The importance of nitrite ions has long been recognized due to their extensive use in environmental chemistry and public health. growing nitrogen fertilizers additives containing processed food items increased exposure and, as a result, generated concerns about potential harmful health consequences. This work presents the development an electrochemical sensor based on graphene/glassy carbon electrode (EGr/GC) with applicability trace level detection water samples. According structural characterization exfoliated material, it appears mixture graphene oxide (GO; 21.53%), few-layers (FLG; 73.25%) multi-layers (MLG; 5.22%) exhibits remarkable enhanced sensing response towards compared bare (three orders magnitude higher). EGr/GC demonstrated linear range between 3 × 10-7 10-3 M for square wave voltammetry (SWV) 4 10-4 amperometry (AMP), low limit LOD (9.9 10-8 M). Excellent operational stability, repeatability interference-capability were displayed by modified electrode. Furthermore, practical was tested commercially available waters excellent results.

Language: Английский

Citations

12
Nitrate: “the source makes the poison” DOI Creative Commons

Eric Bowles,

Mia Burleigh, Álex Mira

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Aug. 30, 2024

Interest in the role of dietary nitrate human health and disease has grown exponentially recent years. However, consensus is yet to be reached as whether consuming from various food sources beneficial or harmful health. Global authorities continue recommend an acceptable daily intake (ADI) 3.7 mg/kg-bw/day due concerns over its carcinogenicity. This despite evidence showing that consumption vegetable sources, exceeding ADI, associated with decreased cancer prevalence improvements cardiovascular, oral, metabolic neurocognitive review examines paradox between highlights key source matrix moderating this interaction. We present mechanistic epidemiological support notion vegetable-derived promotes a increase nitric oxide generation limits toxic N-nitroso compound formation seen high intakes added during processing contaminated water. demonstrate need for more pragmatic approach nitrate-related nutritional research guidelines. Ultimately, we provide overview our knowledge field facilitate therapeutic applications nitrate, whilst maintaining population safety.

Language: Английский

Citations

4
Nongenetic risk factors for thyroid cancer: an umbrella review of evidence DOI

Ge Peng,

Xiaohui Pan,

Ziwei Ye

et al.

Endocrine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

0
Production of Smoked Sausage Using Monascus Pigments-Calcium Carbonate Colorant Lake with Nisin as a Nitrite Substitute DOI Creative Commons
Jiaqi Cui, Guohui Bai, Yang Fu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 477 - 477

Published: Feb. 2, 2025

This study explored the complete replacement of sodium nitrite with a combination Monascus pigments (MPs)-calcium carbonate colorant lake (MPs-CaCO3 lake) and nisin in smoked sausage production. The effects on color stability, total aerobic mesophilic bacteria count (TAMB), physicochemical properties sausages were assessed. results indicated that combining 0.26 g/kg 0.4 effectively replaced coloring preservative functions nitrite. Physicochemical analyses revealed addition pigment significantly increased pH calcium content reduced juice loss rates (at low concentrations) group compared to blank groups. Gas chromatography–mass spectrometry (GC-MS) based flavor compounds analysis demonstrated notable changes profile volatile MPs, marked by appearance paraldehyde disappearance butanediol Electronic nose confirmed MPs had similar odors, distinctly different from group. However, electronic tongue showed no significant differences among three Overall, MPs-CaCO3 nitrite, enhanced did not adversely affect quality sausage.

Language: Английский

Citations

0
Dietary Components Associated with the Risk of Gastric Cancer in the Latin American Population: A Systematic Review and Meta-Analysis DOI Creative Commons
Azalia Ávila-Nava, Ana Ligia Gutiérrez-Solís,

Oscar Daniel Pacheco-Can

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1052 - 1052

Published: March 19, 2025

Gastric cancer is one of the most frequent types in Latin American population, and its development related to multiple factors, including diet. The present systematic review meta-analysis, based on PRISMA, aims determine dietary components associated with gastric America. were divided into food micro- macronutrients. Meta-analyses performed for different groups foods, effects calculated using Odds Ratios. A total 483 studies identified; thirteen articles included after removing duplicates applying inclusion exclusion criteria. meta-analysis showed that daily consumption vegetables (OR 0.54; 95% CI [0.41, 071]) fruits 0.57; [0.45, 0.73]) protective factors cancer; fresh meat eggs 1.47; [1.12, 1.95]), salted, canned, pickled foods 2.30; [1.10, 4.80]) risk cancer. Consuming carotenoids, plant sterols, polyphenols, proteins, polyunsaturated fats was a factor regarding Therefore, nitrite nitrate products capsaicin considered

Language: Английский

Citations

0
Alternative Methods to Reduce the Formation of Nitrosamines in Cured Meats: A Review DOI Open Access

Haider K. Al‐Qutaifi,

Aum El-Bashar H.J. Al-Mossawi

IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1487(1), P. 012119 - 012119

Published: April 1, 2025

Abstract Since nitrites, nitrates append to cured meat products enhance colour, flavour, shelf life, and lower microbiological load. There has been a surge in the processing of these vital commodities. Nitrites are beneficial body nutritionally, but there hazards associated with their propensity create nitrosamines body. In addition, describing possible health risks chemical consumption, this review aims shed light on role nitrites used products. It also summarizes various strategies replace industrial order obtain healthy discusses impact potential risks. The most effective ways at moment alternative additives such phenolic compounds, vitamins, different plant extracts effect toxicities nitrosamines. Therefore, alternatives techniques reduce measure production processed should be sought ensure safety, quality life.

Language: Английский

Citations

0
Formation and prediction of heterocyclic amines and N‐nitrosamines in smoked sausages using back propagation artificial neural network DOI
Yajun Zhou,

Shimin Zhai,

Yao Guangming

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(7), P. 4083 - 4096

Published: Feb. 7, 2024

Abstract BACKGROUND Heterocyclic amines (HAs) and N ‐nitrosamines (NAs) are formed easily during the thermal processing of food, epidemiological studies have demonstrated that consuming HAs NAs increases risk cancer. However, there few on application back propagation artificial neural network (BP‐ANN) models to simultaneously predict content in sausages. This study aimed investigate effects cooking time temperature, smoking fat‐to‐lean ratio formation smoked sausages, their total based BP‐ANN model. RESULTS With an increase time, temperature fat ratio, sausages increased significantly, while HA precursors nitrite residues decreased significantly. The optimal topology model was 5–11–2, correlation coefficient values for training, validation, testing all datasets were 0.99228, 0.99785, 0.99520 0.99369, respectively, mean squared error value best validation performance 0.11326. bias factor accuracy within acceptable limits, predicted approximated true values, indicating has good predictive performance. CONCLUSION contents significantly influenced by conditions, conditions ratio. high predicting which provides a theoretical basis suppression carcinogen formation. © 2024 Society Chemical Industry.

Language: Английский

Citations

3