Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization DOI Creative Commons
Alana Jones, Zsuzsanna Ament, Amit Patki

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 15, 2023

Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites aberrant DNA methylation in setting MetS. However, relationship between metabolome epigenome not been elucidated. In this study, we associated with MetS methylation, conducted bidirectional Mendelian randomization (MR) to assess causal relationships methylation. Methods: We leveraged metabolomic genomic data from a national United States cohort older adults (REGARDS), as well metabolomic, epigenomic, family-based study hypertension (HyperGEN). metabolite profiling for REGARDS using weighted logistic regression models validated them HyperGEN. Validated were selected which fit linear mixed six CpG sites previously linked Statistically significant metabolite-CpG pairs two-sample, MR. Results: Forward MR indicated that glucose serine on near CPT1A [B(SE): −0.003 (0.002), p = 0.028 B(SE): 0.029 (0.011), 0.030, respectively] ABCG1 −0.008(0.003), 0.006] SREBF1 −0.009(0.004), 0.018] , suggested protective effect serine. Reverse showed cg06500161 ( ) −1.534 (0.668), 0.023]. Discussion: The may contribute epigenetic modifications.

Language: Английский

Association between abnormal lipid metabolism and tumor DOI Creative Commons
Chunyu Li, Fei Wang, Lili Cui

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: May 25, 2023

Metabolic Reprogramming is a sign of tumor, and as one the three major substances metabolism, lipid has an obvious impact. Abnormal metabolism related to occurrence various diseases, proportion people with abnormal increasing year by year. Lipid involved in occurrence, development, invasion, metastasis tumors regulating oncogenic signal pathways. The differences among different are factors such tumor origin, regulation pathways, diet. This article reviews synthesis regulatory pathways lipids, well research progress on cholesterol, triglycerides, sphingolipids, rafts, adipocytes, droplets, lipid-lowering drugs relation their drug resistance. It also points out limitations current potential treatment targets pathway. Research intervention abnormalities may provide new ideas for survival prognosis tumors.

Language: Английский

Citations

24
Targeting Dysregulated Lipid Metabolism in Cancer with Pharmacological Inhibitors DOI Open Access

Amogh Gupta,

Dipanwita Das, Reshma Taneja

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(7), P. 1313 - 1313

Published: March 28, 2024

Metabolic plasticity is recognised as a hallmark of cancer cells, enabling adaptation to microenvironmental changes throughout tumour progression. A dysregulated lipid metabolism plays pivotal role in promoting oncogenesis. Oncogenic signalling pathways, such PI3K/AKT/mTOR, JAK/STAT, Hippo, and NF-kB, intersect with the drive Furthermore, altered microenvironment contributes immune dysfunction, exacerbating This review examines initiation, invasion, metastasis, stem cell maintenance. We highlight cybernetic networks uncover avenues for diagnostics, prognostics, therapeutics.

Language: Английский

Citations

16
Metabolic adaptations in prostate cancer DOI Creative Commons

Mikel Pujana-Vaquerizo,

Laura Bozal-Basterra, Arkaitz Carracedo

et al.

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 131(8), P. 1250 - 1262

Published: July 5, 2024

Prostate cancer is one of the most commonly diagnosed cancers in men and a major cause cancer-related deaths worldwide. Among molecular processes that contribute to this disease, weight metabolism has been placed under limelight recent years. Tumours exhibit metabolic adaptations comply with their biosynthetic needs. However, metabolites also play an important role supporting cell survival challenging environments or remodelling tumour microenvironment, thus being recognized as hallmark cancer. uniquely driven by androgen receptor signalling, knowledge influenced paths research. This review provides comprehensive perspective on support prostate progression beyond particular focus intrinsic extrinsic pathways.

Language: Английский

Citations

13
Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personalized immunotherapy strategies DOI Creative Commons

Zhongqiu Yang,

Yuquan Chen, Yaping Miao

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 15, 2025

The metabolism of stearoyl-GPE plays a key role in the liver metastasis gastric cancer. This investigation delves into mechanisms underlying intricate tumor microenvironment (TME) heterogeneity triggered by stearoyl cancer with (LMGC), offering novel perspectives for LMGC. Utilizing Mendelian randomization, we determined that significantly contributes to progression (GC). Following this, bulk transcriptome analyses and single-cell multiomics techniques investigate roles metabolism-related genes, particularly NCOA4, regulating LMGC TME. Our analysis highlights crucial modulating complex LMGC, impacting monocyte cells. Through sequencing spatial transcriptomics, have identified metabolic genes specific within cell population, including NCOA4. Regarding relationship between ferroptosis, metabolism, findings, it is plausible pathways intersect involved ferroptosis. Ferroptosis, characterized iron-dependent lipid peroxidation, represents regulated form death. activity Stearoyl-CoA desaturase (SCD), critical enzyme has been associated modulation composition susceptibility Furthermore, integral cellular processes related oxidative stress both which are significant factors context study enhances understanding ferroptosis promoting its regulation heterogeneity. In addition, this deeper dynamics provides basis development better interventions combat metastasis.

Language: Английский

Citations

1
Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications DOI Creative Commons
Xiaowen Xie, Weici Liu, Zhiyuan Yuan

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 8, 2025

Epigenomic modifications—such as DNA methylation, histone acetylation, and methylation—and their implications in tumorigenesis, progression, treatment have emerged a pivotal field cancer research. Tumors undergo metabolic reprogramming to sustain proliferation metastasis nutrient-deficient conditions, while suppressing anti-tumor immunity the tumor microenvironment (TME). Concurrently, immune cells within immunosuppressive TME adaptations, leading alterations function. The complicated interplay between metabolites epigenomic modulation has spotlighted significance of regulation immunometabolism. In this review, characteristics modification associated with tumors are systematically summarized alongside regulatory roles Classical emerging approaches delineated broaden boundaries research on crosstalk immunometabolism epigenomics. Furthermore, we discuss potential therapeutic strategies that target modulate modifications, highlighting burgeoning synergy therapies immunotherapy promising avenue for treatment.

Language: Английский

Citations

1
Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer DOI
Mengjun Huang, Qiliang Teng, Fei Cao

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1617 - 1629

Published: Jan. 1, 2024

Incidence and mortality of prostate cancer (PCa) rank in the top five among male tumors. However, single treatment modalities are often restricted due to biochemical recurrence drug resistance, necessitating development new approaches for combination castration-resistant neuroendocrine PCa. Ferroptosis is characterized by accumulation iron-overload-mediated lipid peroxidation has shown promising outcomes anticancer treatment, prompting us present a review reporting application ferroptosis First, process mechanism briefly reviewed. Second, research advances combining ferroptosis-inducing agents clinical regimens, which exhibit "two-pronged approach" effect, further summarized. Finally, recent progress on nanomaterials therapy presented. This expected provide novel insights into ferroptosis-based drug-resistant

Language: Английский

Citations

6
Aberrant Lipid Metabolism in Cancer: Current Status and Emerging Therapeutic Perspectives DOI
Rasha Irshad,

Sazi Tabassum,

Mohammad Husain

et al.

Current Topics in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 23(12), P. 1090 - 1103

Published: May 1, 2023

Abstract: It is now an undisputed fact that cancer cells undergo metabolic reprogramming to support their malignant phenotype, and it one of the crucial hallmarks which enables facilitate survival under variable conditions ranging from lack nutrients conditions, such as hypoxia. Recent developments in technologies, lipidomics machine learning, have underlined critical effects altered lipid metabolism tumorigenesis. The show elevated de novo fatty acid synthesis, increased capacity scavenge lipids environment, enhanced oxidation fulfill need for uncontrolled cellular proliferation, immune evasion, tumor formation, angiogenesis, metastasis, invasion. Besides, important genes/ proteins involved been proposed prognostic indicators a variety types linked and/or recurrence. Consequently, several approaches are being explored regulate this dysregulation subvert its tumorigenic properties different cancers. present review details significance progression, enzymes therein, regulation. : Moreover, current findings interplay between oncogenic pathways elucidated briefly. therapeutic implications modulating these aberrations advancement anti-cancer therapies also discussed. Although understanding initiation progression still infancy somewhat obscure, in-depth comprehension will open promising opportunities development novel strategies treatment management.

Language: Английский

Citations

15
Epigenetics and environmental health DOI
Min Zhang, Ting Hu,

Tianyu Ma

et al.

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: 18(4), P. 571 - 596

Published: May 28, 2024

Language: Английский

Citations

5
Targeting lipid metabolism in cancer metastasis DOI
Gloria Pascual, Blanca Majem, Salvador Aznar Benitah

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1879(1), P. 189051 - 189051

Published: Dec. 13, 2023

Language: Английский

Citations

13
Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial Disparities DOI Open Access
Kunwar Somesh Vikramdeo,

Amod Sharma,

Shashi Anand

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4482 - 4482

Published: Feb. 24, 2023

Prostate cancer (PCa) affects millions of men worldwide and is a major cause cancer-related mortality. Race-associated PCa health disparities are also common both social clinical concern. Most diagnosed early due to PSA-based screening, but it fails discern between indolent aggressive PCa. Androgen or androgen receptor-targeted therapies standard care treatment for locally advanced metastatic disease, therapy resistance common. Mitochondria, the powerhouse cells, unique subcellular organelles that have their own genome. A large majority mitochondrial proteins are, however, nuclear-encoded imported after cytoplasmic translation. Mitochondrial alterations in cancer, including PCa, leading altered functions. Aberrant function nuclear gene expression retrograde signaling promotes tumor-supportive stromal remodeling. In this article, we discuss been reported review literature related roles pathobiology, resistance, racial disparities. We translational potential as prognostic biomarkers effective targets therapy.

Language: Английский

Citations

11