The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 1, 2023

Abstract There have been hundreds of millions cases coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). With the growing population recovered patients, it crucial to understand long-term consequences and management strategies. Although COVID-19 was initially considered an illness, recent evidence suggests that manifestations including but not limited those cardiovascular, respiratory, neuropsychiatric, gastrointestinal, reproductive, musculoskeletal systems may persist long after phase. These persistent manifestations, also referred as COVID, could impact all patients with across full spectrum illness severity. Herein, we comprehensively review current literature on highlighting its epidemiological understanding, vaccinations, organ-specific sequelae, pathophysiological mechanisms, multidisciplinary In addition, psychological psychosomatic factors underscored. Despite these findings diagnostic therapeutic strategies based previous experience pilot studies remain inadequate, well-designed clinical trials should be prioritized validate existing hypotheses. Thus, propose primary challenges concerning biological knowledge gaps efficient remedies well discuss corresponding recommendations.

Language: Английский

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Higher Serum Monolaurin Is Associated with a Lower Risk of COVID-19: Results from a Prospective Observational Cohort Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2452 - 2452

Published: March 10, 2025

The COVID-19 pandemic has stimulated the search for effective preventive and therapeutic agents. In recent years, many studies have considered effects of different nutrients. This study aimed to investigate association between serum monolaurin levels risk developing among healthcare workers. this prospective observational cohort study, 2712 workers from University Hospital “Maggiore della Carità” in Novara, Italy were enrolled. Participants underwent blood sampling followed up six months evaluate protective role against infection. Monolaurin quantified using targeted metabolomic analysis. consisted 1000 individuals with a mean age 46.4 predominantly female. Higher concentrations significantly associated lower SARS-CoV-2 infection at both 3- 6-month follow-ups. optimal cut-off value monolaurin, which provides efficacy, was identified as 0.45 µg/mL. appear be reduced COVID-19, suggesting its potential dietary supplement contributes growing body evidence supporting factors management prevention infectious diseases highlights metabolomics identifying prophylactic biomarkers.

Language: Английский

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Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Foods, Journal Year: 2022, Volume and Issue: 11(18), P. 2884 - 2884

Published: Sept. 17, 2022

The beginning of the end or beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. reduction severe cases and deaths from COVID-19 led to increasing importance new called post-COVID syndrome. term is used indicate permanency symptoms in patients who have recovered acute respiratory syndrome 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well ozone therapy been treat disease. Vaccines then become available administered worldwide prevent insurgence However, pandemic not over yet at all given emergence omicron variants. New therapeutic strategies urgently needed. In this view, great interest was found nutraceutical products, including vitamins (C, D, E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), curcumin. This review summarizes role nutraceuticals prevention and/or treatment

Language: Английский

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The effect of macronutrient and micronutrient supplements on COVID-19: an umbrella review

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 29, 2024

Abstract Background and aims A healthy diet play an important role in the prevention even treatment of various diseases. Proper nutrition plays boosting immune system. These include consumption macronutrients such as proteins, lipids, carbohydrates, also micronutrients including vitamins. Here, we aimed to systematically review effects on COVID-19. Methods We searched databases PubMed, Scopus, Embase, Web Science December 23, 2023. The records were downloaded into EndNote file, duplicates removed, studies underwent a two-phase screening process based their title/abstracts full texts. included articles screened inclusion exclusion criteria. English systematic reviews meta-analyses that concurred with aim our study. selected assessed by Cochrane's Risk Bias Systematic Reviews for quality check. data eligible extracted pre-designed word table used qualitative synthesis. Results total 28 this Most have shown are effective morbidity mortality controlling viral respiratory infections COVID-19 but some sometimes not severity. On other hand, calcifediol was far most successful agent reducing intensive care needs between studies. Conclusion Individuals without malnutrition had reduced risk SARS-CoV-2 infection severe disease. administration Vitamin D is patients. Patients vitamin deficiency more prone experience infection, they at higher morbidities mortality. Other A, B, Zinc showed benefits patients C no efficacy management intravenous form or high doses.

Language: Английский

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Resveratrol and Physical Activity: A Successful Combination for the Maintenance of Health and Wellbeing?

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 837 - 837

Published: Feb. 28, 2025

Physical exercise is an essential component of human health. In recent years, scientific research has focused on identifying natural compounds and formulating new supplements aimed at enhancing athletic performance, accelerating muscle recovery, minimizing the damage caused by physical exertion. The use antioxidants to counteract formation reactive oxygen species (ROS) following activity (PA) already a widely adopted practice. Resveratrol (RES), polyphenol belonging stilbene class, well known for its potent antioxidant anti-inflammatory effects primarily attributed activation sirtuins. RES possesses multiple nutraceutical properties used prevention treatment inflammatory, cardiovascular, neoplastic, infectious diseases, thus attracting attention study in combination with promote well-being. Animal trials combining PA have mainly reported improvements muscle, energy, cardiovascular functions. data presented discussed this narrative review are from Pubmed, Scopus, Human Gene Database (search limited 2011 2025 keywords RES, sirtuins, altogether or each other). This gathers several studies focusing properties, epigenetic activities via potential benefits maintaining health well-being based performed first animals later humans. been conducted various populations, including active adults, sedentary individuals, patients elderly individuals. Some confirmed observed animal experiments. However, some cases, no substantial differences were found between supplementation control group. conclusion, literature still not fully evident, given contrasting number trials, but both successful tools maintenance wellbeing.

Language: Английский

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Exploring the Potential of Dietary Supplements to Alleviate Pain Due to Long COVID

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1287 - 1287

Published: April 7, 2025

Long COVID, characterized by persistent symptoms following COVID-19 infection, significantly impacts individuals' health and daily functioning due to fatigue pain. Focusing on pain, this review addresses nociplastic chronic pain conditions. Interventions designed reduce inflammation, oxidative stress, enhance vagal activity may offer a promising approach managing post-pandemic This presents individual components of food supplements with demonstrated efficacy in one or more conditions, focusing their proposed mechanisms clinical including use post-COVID-19 when available. Many these substances have long history safe an alternative long-term analgesic drug treatment, which is often associated potential side effects. also explores the for synergistic effects combining each other conventional analgesics, considering advantages both patients healthcare system using as adjunctive primary therapies related COVID. While preclinical scientific literature provides mechanistic basis action several control signaling pathways, experience, particularly field COVID-associated still limited. However, reviewed strongly suggests that attainable goal, provided rigorous trials are conducted.

Language: Английский

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Role of nutrient supplements in children with post-COVID condition: a retrospective preliminary observation and narrative review

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2025, Volume and Issue: 51(1)

Published: April 16, 2025

Abstract Background Post-COVID Condition (PCC), emerging as a significant long-term consequence of SARS-CoV-2 infection, affects not only adults but also the pediatric population. Despite ongoing research, precise pathophysiology PCC remains elusive. However, several putative mechanisms have been identified, leading to exploration various therapeutic strategies. Notably, in adult population, there has substantial interest potential efficacy nutritional supplements. Regrettably, information regarding use such supplements population is currently lacking. Methods The present study was conducted assess impact on alleviating long COVID symptoms children. To achieve this, we retrospective analysis nutrient administered by parents children with (PCC) between February 2020 and October 2022. Statistical analyses were employed determine associations categorical variables. Results A total 1243 enrolled following documented 940 (76.2%) diagnosed recovered 294 (23.8%) Long COVID. Among patients experiencing disabling symptoms, treatment oral lactoferrin and/or Multi-Element Product (MEP) antioxidant anti-inflammatory properties initiated. correlation persistence at next follow-up showed that MEP alone (OR 5.7, 95% CI 3.8–8.5), or combination 5.06, 3.3–7.6) three months after initial infection for months, associated lower risk having covid six when compared 7.6 5.1–11.4). Conclusions This proof-of-concept revealed lactoferrin, new diagnosis covid, may positive improving during evaluations. trend toward reducing exhibited suggested benefit worthy future randomized controlled trials.

Language: Английский

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Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production

Nutrients, Journal Year: 2022, Volume and Issue: 14(11), P. 2194 - 2194

Published: May 25, 2022

Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease has emerged in 2019. The COVID-19-associated pandemic considerably affected the way of life and economy world. It consequently crucial to find solutions allowing remedying or alleviating effects this disease. Natural products have been perpetual application from immemorial time given that they are attested be efficient towards several illnesses without major side effects. Various studies shown plant extracts purified molecules a promising inhibiting impact coronavirus. In addition, it substantial understand characteristics, susceptibility diet on patients infected with COVID-19. review, we recapitulate influence pure medicinal plants We approach possibilities treatment/co-treatment feeding applied also show complications associated nutrient deficiencies then discuss food groups COVID-19 pathogenesis. Then, covered emerging technologies using plant-based SARS-CoV-2 vaccine. conclude giving curative therapy recommendations which potential interest infection could pave for pharmacological treatments co-treatments

Language: Английский

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Did Household Income Loss Have an Immediate Impact on Animal-Source Foods Consumption during the Early Stage of the COVID-19 Pandemic?

Foods, Journal Year: 2023, Volume and Issue: 12(7), P. 1424 - 1424

Published: March 27, 2023

The outbreak of COVID-19 in 2020 caused extensive impact on household income and foods consumption. However, little attention has been paid to the immediate loss animal-source consumption early stage pandemic. This paper aims narrow this gap, a total 1301 valid samples food surveys Wuhan Nanjing were obtained through specially designed online questionnaires. show that there 69.6% (Wuhan) 42.2% (Nanjing) surveyed households whose affected, 47.4% 18.9% who suffered loss. Furthermore, makes an empirical study linkage between results pandemic affected income, resulting may have due combination price increases, insufficient savings, which led “perfect storm” for Moreover, various differently. For suffering losses, odds pork, beef mutton, poultry, aquatic products, eggs dairy products being increased by factor 1.894, 2.140, 2.773, 2.345, 1.802, 2.835, respectively, holding other variables constant. be related residents’ habits prices. During pandemic, reduction state tension concerning increase development nutrition intake health, security risks.

Language: Английский

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Potential of macronutrients and probiotics to boost immunity in patients with SARS-COV-2: a narrative review

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: May 15, 2023

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) may cause inflammation and increased cytokine secretion. Dietary factors play an important role in enhancing the immune responses against infectious diseases such as SARS-COV-2. This narrative review aims to determine effectiveness of macronutrients probiotics improve immunity SARS-COV-2 patients. proteins boost pulmonary function patients through inhibitory effects on Angiotensin-converting enzyme (ACE) reduce Angiotensin (ANG-II). Moreover, omega-3 fatty acids oxygenation, acidosis, renal function. fiber also produce anti-inflammatory by reducing level high-sensitivity C-Reactive Protein (hs-CRP), Interleukin (IL-6), Tumor necrosis factor (TNF-α). In addition, some evidence indicates that significantly oxygen saturation which enhance survival rate. conclusion, consumption a healthy diet including adequate probiotic intake decrease oxidative stress. Following this dietary practice is likely strengthen system have beneficial

Language: Английский

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