Unlocking the therapeutic potential of edible mushrooms: Ganoderma and their secondary metabolites as novel antiviral agents for combating COVID-19 DOI
Samantha C. Karunarathna, Wenhua Lu,

Nimesha Patabedige

et al.

New Zealand Journal of Botany, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 59

Published: Aug. 8, 2024

The global COVID-19 pandemic, caused by SARS-CoV-2, has created an urgent need for novel antiviral agents, as it led to a devastating loss of lives worldwide. In response, numerous vaccines were developed in 2022, with ongoing efforts more candidates. Despite significant progress, reports vaccine-related issues and side effects have emerged. effectiveness been challenged new viral variants, lack well-designed vivo experiments, randomised controlled trials. Currently, no clinically approved medications exist treating COVID-19. However, few broad-spectrum drugs shown promising outcomes clinical studies. Many scientists believe that natural compounds derived from herbal medicines mushrooms could offer substantial benefits patients. Ganoderma, known its traditional use promoting health longevity, rich history therapeutic applications dietary supplementation. Numerous epidemiological studies demonstrated Ganoderma derivatives can enhance innate adaptive immune responses against various pathogens, including viruses, laboratory settings living organisms. Therefore, the secondary metabolites such triterpenoids, polysaccharides, glycoproteins, hold potential developing drugs. These mechanisms, inhibition replication, modulation responses, direct virucidal effects. Given search effective treatments COVID-19, bioactive stand out candidates further research development. Their multifaceted mechanisms make them suitable exploration agents potentially contributing enhancing existing treatments.

Language: Английский

A Look at the Importance of Chirality in Drug Activity: Some Significative Examples DOI Creative Commons
Jessica Ceramella, Domenico Iacopetta,

Angelica Franchini

et al.

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(21), P. 10909 - 10909

Published: Oct. 27, 2022

Chirality plays an important role in the development of many pharmaceuticals, being a general property ‘handedness’; nevertheless, large number pharmaceuticals are still marketed and administered as racemates. is all around even within us; indeed, receptors enzymes chiral entities interact specific manner with drugs. Consequently, controlling enantiomeric purity isolating enantiomers from drugs remains crucial subject for analytical, clinical, regulatory purposes, thus, improving drug safety profile. The classical examples spontaneous enantiomerization severe toxicity related to chirality represented by ibuprofen thalidomide, respectively, but numerous other cases have been reported literature. This review intends offer brief overview on most common used therapy treatment various diseases.

Language: Английский

Citations

71
Neuroprotective Effects of Curcumin in Neurodegenerative Diseases DOI Creative Commons
Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1774 - 1774

Published: June 5, 2024

Curcumin, a hydrophobic polyphenol extracted from the rhizome of Curcuma longa, is now considered candidate drug for treatment neurological diseases, including Parkinson’s Disease (PD), Alzheimer’s (AD), Huntington’s (HD), Multiple Sclerosis (MS), Amyotrophic Lateral (ALS), and prion disease, due to its potent anti-inflammatory, antioxidant potential, anticancerous, immunomodulatory, neuroprotective, antiproliferative, antibacterial activities. Traditionally, curcumin has been used medicinal dietary purposes in Asia, India, China. However, low water solubility, poor stability blood, high rate metabolism, limited bioavailability, little capability cross blood–brain barrier (BBB) have clinical application curcumin, despite important pharmacological activities this drug. A variety nanocarriers, liposomes, micelles, dendrimers, cubosome nanoparticles, polymer solid lipid nanoparticles developed with great success effectively deliver active brain cells. Functionalization on surface brain-specific ligands makes them target-specific, which should significantly improve bioavailability reduce harmful effects. The aim review summarize studies and/or containing most common neurodegenerative highlighting neuroprotective potential nutraceutical.

Language: Английский

Citations

18
Pharmacodynamics, pharmacokinetics, and cell signaling pathways of pomegranate peel extract DOI
Hashem Andishmand, Behzad Masoumi, Mohammad Yousefi

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

2
Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases DOI Creative Commons
Syed A. A. Rizvi,

George P Einstein,

Orien L. Tulp

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1442 - 1442

Published: Oct. 9, 2022

Infectious diseases have been a threat to human health globally. The relentless efforts and research enabled us overcome most of the through use antiviral antibiotic agents discovered employed. Unfortunately, microorganisms capability adapt mutate over time resistance ensues. There are many challenges in treating infections such as failure respond therapeutic agents, which has led more chronic infections, complications, preventable loss life. Thus, multidisciplinary approach collaboration is warranted create potent, effective, versatile therapies prevent eradicate old newly emerging diseases. In recent past, natural medicine proven its effectiveness against various illnesses. Most pharmaceutical currently used can trace their origin products one way, shape, or form. full potential yet be realized, numerous resources not explored analyzed. This merits continuous support analysis ancient treatment systems explore employ them an alternative principal therapy.

Language: Английский

Citations

69
Exploring the Potential of Postbiotics for Food Safety and Human Health Improvement DOI Creative Commons
Folayemi J. Isaac-Bamgboye, Chiamaka Linda Mgbechidinma, Helen Onyeaka

et al.

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Food safety is a global concern, with millions suffering from foodborne diseases annually. The World Health Organization (WHO) reports significant morbidity and mortality associated contaminated food consumption, this emphasizes the critical need for comprehensive measures. Recent attention has turned to postbiotics, metabolic byproducts of probiotics, as potential agents enhancing safety. Postbiotics, including organic acids, enzymes, bacteriocins, exhibit antimicrobial antioxidant properties that do not require live organisms, offers advantages over probiotics. This literature review critically examines role postbiotics in gut microbiome modulation applications industry. Through an extensive existing literature, study evaluates impact on composition their functional ingredients. Research indicates are effective inhibiting pathogens such

Language: Английский

Citations

13
Expanding the Role of Chiral Drugs and Chiral Nanomaterials as a Potential Therapeutic Tool DOI

Sourabh Satapathy,

Shivam Kumar,

Balak Das Kurmi

et al.

Chirality, Journal Year: 2024, Volume and Issue: 36(7)

Published: July 1, 2024

ABSTRACT Chirality, the property of molecules having mirror‐image forms, plays a crucial role in pharmaceutical and biomedical research. This review highlights its growing importance, emphasizing how chiral drugs nanomaterials impact drug effectiveness, safety, diagnostics. Chiral serve as precise diagnostic tools, aiding accurate disease detection through unique biomolecule interactions. The article extensively covers applications treating cardiovascular diseases, CNS disorders, local anesthesia, anti‐inflammatories, antimicrobials, anticancer drugs. Additionally, it explores emerging field nanomaterials, highlighting their suitability for diagnostics therapeutics, enhancing medical treatments.

Language: Английский

Citations

11
Aloe vera―An Extensive Review Focused on Recent Studies DOI Creative Commons
Alessia Catalano, Jessica Ceramella, Domenico Iacopetta

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2155 - 2155

Published: July 8, 2024

Since ancient times,

Language: Английский

Citations

10
Understanding chronic inflammation: couplings between cytokines, ROS, NO, Cai2+, HIF-1α, Nrf2 and autophagy DOI Creative Commons
Katarzyna Michalak,

Alicja Michalak

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Chronic inflammation is an important component of many diseases, including autoimmune intracellular infections, dysbiosis and degenerative diseases. An element this state the mainly positive feedback between inflammatory cytokines, reactive oxygen species (ROS), nitric oxide (NO), increased calcium, hypoxia-inducible factor 1-alpha (HIF-1α) stabilisation mitochondrial oxidative stress, which, under normal conditions, enhance response against pathogens. Autophagy nuclear erythroid 2-related 2 (Nrf2)-mediated antioxidant are negatively coupled with above-mentioned elements to maintain defence at a level appropriate severity infection. The current review first attempt build multidimensional model cellular self-regulation chronic inflammation. It describes feedbacks involved in explains possible pathways by which becomes chronic. multiplicity suggests that symptomatic treatment should focus on inhibiting multiple effectively suppress all dysregulated inflammation, calcium mito-stress other metabolic disturbances.

Language: Английский

Citations

1
Predictive models of long COVID DOI
Blessy Antony, Hannah Blau, Elena Casiraghi

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 96, P. 104777 - 104777

Published: Sept. 4, 2023

Language: Английский

Citations

22
Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries DOI Creative Commons
Domenico Iacopetta, Jessica Ceramella, Alessia Catalano

et al.

Antibiotics, Journal Year: 2023, Volume and Issue: 12(1), P. 112 - 112

Published: Jan. 7, 2023

Dental caries is a biofilm-mediated disease that represents worldwide oral health issue. Streptococcus mutans has been ascertained as the main cariogenic pathogen responsible for human dental caries, with high ability to form biofilms, regulated by quorum sensing. Diarylureas represent class of organic compounds show numerous biological activities, including antimicrobial one. Two small molecules belonging this class, specifically diphenylureas, BPU (1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea) and DMTU (1,3-di-m-tolyl-urea), showed interesting results in studies regarding activity against bacterium S. mutans. Since there are not many antimicrobials used prevention treatment further on these two other diarylureas may be useful design new effective agents generally low cytotoxicity.

Language: Английский

Citations

17