The botanical details, pharmacological activities and industrial applications of date seed (Phoenix dactylifera L.)

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: May 17, 2024

Language: Английский

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The anti-toxic effect of the date palm fruit extract loaded on chitosan nanoparticles against CCl4-induced liver fibrosis in a mouse model

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 235, P. 123804 - 123804

Published: Feb. 24, 2023

Language: Английский

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Assessing the ability of polysaccharides extracted from date palm fruit to salvage Wistar rats from cisplatin-linked hepatic damage

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 11, P. 100400 - 100400

Published: Feb. 24, 2024

Cisplatin is a platinum-based chemotherapeutic drug utilized in the treatment of many solid-tissue cancers; it associated with several organ toxicities. For ages, Phoenix Dactylifera, known as " large jujube or dà zǎo," Chinese traditional medicine, has been employed for medicinal applications. The present study assesses role Date Fruit Polysaccharides (DFP) cisplatin-induced liver injury Rats were intraperitoneally treated single therapeutic dose cisplatin (5 mg/kg body weight) and then orally daily without 50/100 weight DFP 7 successive days. salvaging effects assessed on Cisplatin-induced hepatic damage, by investigating function markers, oxidative stress, pro-inflammatory biomarkers, histopathological assessment morphology hematoxylin/eosin stain. To elucidate contents, functional groups, antioxidative potentials DFP, chromatographic, spectroscopic, vitro assays analysed. Exposure to led considerable escalation tested biomarkers (ALP ALT), an upsurge levels/activities malondialdehyde, cytokines, myeloperoxidase significant drop level GSH (P < 0.05) compared control. Moreover, there also obvious decline antioxidant enzymes (catalase, SOD GPx) activities. Contrarily, post-treatment significantly inhibited heightened lipid peroxidation, inflammation, stress dose-dependently. Analysis chemical constituents, activities demonstrated important monosaccharides properties DFP. This shows ability serve probable agent damage treatment.

Language: Английский

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Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1249 - 1249

Published: June 25, 2022

This study presents a comparison between two mistletoe plants-P. acacia and P. curviflorus-regarding their total phenolic contents antioxidant anticancer activities. curviflorus exhibited higher phenolics content (340.62 ± 19.46 mg GAE/g extract), demonstrated DPPH free radical scavenging activity (IC50 = 48.28 3.41µg/mL), stronger reducing power (1.43 0.54 mMol Fe+2/g) for ferric ions, greater capacity (41.89 3.15 GAE/g) compared to acacia. The cytotoxic effects of methanol extracts were examined on lung (A549), prostate (PC-3), ovarian (A2780) breast (MDA-MB-231) cancer cells. highest potential the was observed PC-3 cells, where more pronounced antiproliferative 25.83 μg/mL) than 34.12 μg/mL). In addition, both tested arrested cell cycle at Pre-G1 G1 phases, induced apoptosis. However, extract possessed apoptotic effect, mediated by upregulation p53, Bax, caspase-3, 8 9, downregulation Bcl-2 expression. pursuit link chemical diversity with bioactivities, its metabolomic profiling achieved LC-ESI-TOF-MS/MS technique. permitted tentative identification several phenolics-chiefly flavonoid derivatives, beside some triterpenes sterols-in extract. Furthermore, all metabolites in inspected binding modes towards CDK-2 EGFR proteins using molecular docking studies an attempt understand superiority over regarding effect Docking supported our experimental results; this taken together, could be regarded as prospect development chemotherapeutics cancer.

Language: Английский

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Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Cisplatin (CP), a widely used antineoplastic drug, could induce hepatotoxicity and is also one of the most common reasons for drug-induced liver injury (DILI). Licorice (Chinese name GanCao, GC) commonly herbal drug in traditional Chinese medicine (TCM) that has been shown to treat diseases DILI. CP documented apoptosis through promotion endoplasmic reticulum (ER) stress. However, exact role ER stress pathogenesis CP-induced remains unclear. A rat DILI model was constructed intraperitoneal injection CP, anti-DILI effect GC detected by coefficients, function tests, pathological staining, oxidative indices. Additionally, indices were investigated quantitative real-time PCR (qRT-PCR), Western blotting, immunofluorescence (IF) on toxicity tissues LO2 cells. In group, indicators significantly elevated, lesions more pronounced, reactive oxygen species (ROS) level increased, expression markers, factors, related protein kinase RNA-like kinase/activating transcription factor 4/C/EBP homologous (PERK/ATF4/CHOP) pathway elevated. Treatment with improved function, reduced lesions, decreased ROS. addition, inhibited PERK/ATF4/CHOP pathway, demonstrating anti-CP-induced GC. this study, we verified protective rats clarified its mechanisms apoptosis.

Language: Английский

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Modulating Effects of L-Arginine and Tribulus terrestris Extract on Fipronil-Induced Interference in the Male Reproductive System of Rats: Antioxidant Potential, Androgen Receptors, and Nitric Oxide Synthase Interplay

Toxics, Journal Year: 2025, Volume and Issue: 13(5), P. 371 - 371

Published: May 2, 2025

The protective potentials of Tribulus terrestris (TT) and L-arginine (L-Arg) against reproductive toxicity induced by fipronil (FPN) in male rats were investigated. A total 36 allocated into six groups: control, TT, L-Arg, FPN, FPN + L-Arg groups. body sex organ weights, semen criteria, serum testosterone levels, testicular oxidative stress determined. Sexual behavior, penile androgen receptor (AR), nitric oxide synthase (NOS), immunohistochemistry proliferating cell nuclear antigen (PCNA), histopathology also assessed. disrupted health influencing the expression activity NOS AR, leading to compromised erectile function, sexual dysfunction, hormonal imbalance. Significant improvements weight, levels observed TT- L-Arg-treated Behavioral assessments indicated improved performance Histopathological studies testes penis tissue, immunohistochemical PCNA tissues, biochemical analyses further confirmed effects TT L-Arg. Collectively, these findings highlighted potential counteracting FPN-induced impairments.

Language: Английский

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C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota—metabolites axis in mice

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 20, 2022

C-phycocyanin is a natural protein extracted from Spirulina platensis. We aim to investigate the preventive effect of on cisplatin chemotherapy-induced oxidative damage and inflammation. The result showed that treatment reduced cisplatin-induced mortality inflammation including decreased levels serum IL6, kidney MCP1, liver IL1β. Furthermore, also exerted antioxidant effects mice, increased GSH-Px, GGT, GSH in CAT SOD kidney. HepG2 cells experiments exhibited none prevention injury. Faecalibaculum greatest reduction among genera after treatment, which was related enrichment Romboutsia Lactobacillus genera. populations harmful bacteria Enterococcus faecalis, positively correlated with induced by cisplatin. contents 23-nordeoxycholic acid β-muricholic acid. Moreover, amino acid-related metabolites, Nα-acetyl-arginine trimethyl-lysine contents, fatty esters hydroxy acids (FAHFAs) contents. In conclusion, inhibited via acid-Enterococcus faecalis-inflammation axis, enhanced capacity Lactobacillus-NRF2 pathway. alleviated injury modulation gut microbiota, especially Enterococcus, as well regulation bile FAHFAs, highlight provide new strategy prevent

Language: Английский

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Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways

Stem Cells International, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 18

Published: Oct. 23, 2023

Despite its clinical value, cisplatin (CISP) is complicated by marked hepatotoxicity via inducing oxidative stress, inflammatory, and apoptotic pathways. This study aims to explore the protective impact of azilsartan (AZIL), an antihypertensive drug, in addition adipose tissue-derived mesenchymal stem cells (AD-MSCs) on CISP-induced hepatotoxicity. After characterization labeling AD-MSCs PKH26 dye, 54 Wistar male albino rats were randomly divided into nine groups: I (CONT), II (AZIL.H), III (CISP), IV (CISP + AZIL.L), V AZIL.H), VI AD-MSCs), VII AZIL.L VIII AZIL.H IX VITA C). Serum alanine aminotransferase (ALT), (AST), albumin levels determined. Assessment reactive oxygen species, malondialdehyde, glutathione contents, superoxide dismutase activity histopathological evaluations done hepatic tissue. Quantitative real-time PCR was utilized estimate expression TNF-α IL-6 genes. Cell homing labeled liver tissues investigated. Hepatic JNK1/2, ERK1/2, p38, Bax, Bcl-2, cleaved caspase-3 proteins investigated western blot analysis. CISP elevated serum ALT AST activities, reduced level, remarkably changed architecture. It increased genes, raised proteins, diminished Bcl-2 protein. By contrast, treatment animals with either AZIL or dramatically effects injection. Moreover, combination therapy (AZIL.L H AD-MSCs) considerably mitigated all previously mentioned alterations superior alone, which might be attributed AZIL-enhanced ability injured In conclusion, present findings demonstrated that improves hepatoprotective potential against modulating mitogen-activated protein kinase,

Language: Английский

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The current status of old traditional medicine introduced from Persia to China

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 14, 2022

Traditional Chinese medicine (TCM) includes over ten thousand herbal medicines, some of which were introduced from outside countries and territories. The Silk Road enabled the exchange merchandise such as teas, silks, carpets, medicines between East West Eurasia continent. During this time, ‘Compendium Materia Medica’ (CMM) was composed by a traditional practitioner, Shizhen Li (1,518–1,593) Ming Dynasty. This epoch-making masterpiece collected knowledge medical materials treatments in China 16th century before utmost detail, including origin where material obtained. Of 1892 CMM, 46 came Persia (now Iran). In study, basic information these materials, time introduction, medicinal value TCM theory, together with current status Iran, are summarized. It is found that 20 herbs four stones out registered latest Pharmacopoeia. Now most distributed or replacements available but saffron, ferula, myrrh, olibanum still highly dependent on imports. study may contribute to further development, exchange, internationalization various backgrounds world, given barriers transportation language largely eased nowadays.

Language: Английский

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The Hepatoprotective Effect of Two Date Palm Fruit Cultivars’ Extracts: Green Optimization of the Extraction Process

Foods, Journal Year: 2023, Volume and Issue: 12(6), P. 1229 - 1229

Published: March 13, 2023

Date palm fruit (Phoenix dactylifera: Arecaceae) is rich in essential nutrients and possesses several pharmacological medicinal activities. The current study aimed to optimize a water bath-assisted extraction method for two cultivars of date fruits, Anbara (An) Reziz (Rz), investigated the protective effect optimized extract against CCl4-induced liver toxicity relation oxidative stress, inflammation, apoptosis, DNA integrity. optimization process was applied, using response surface methodology through adjusting three "factors"; time, temperature, rotation, allow maximum contents total phenolic (TPC), flavonoid (TFC), reducing power (FRAP) scavenging activity (ABTS) "responses". Extraction factors' application significantly enhanced TPC, TFC, FRAP, ABTS responses by 1.30, 1.23, 3.03, 2.06-fold, respectively An 2.18, 1.71, 1.11, 2.62-fold, Rz, convectional extraction. Furthermore, co-administered CCl4 with or Rz extracts body weight gain, amended hepatic architecture, diminished collagen fiber accumulation. reduced enzymes, hydroxyproline, alpha-fetoprotein (AFP), MDA, inflammatory cytokine (TNF-α, NF-κB) levels, fragmentation, while increasing deteriorated adiponectin (ADP) antioxidant enzyme (GSH, GPX, NO, IFN-γ) relative CCl4-administered animals. effects Rz-optimized were also evidenced suppressing fibrosis improving function structure via modulating damage. Hence, fruits resulted which are an elevated power. presence these could help explain their proven hepatoprotective toxicity.

Language: Английский

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