International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1379 - 1379
Published: Feb. 6, 2025
Atherosclerosis,
a
chronic
inflammatory
disease
characterized
by
the
accumulation
of
lipids
and
immune
cells
within
arterial
walls,
remains
leading
cause
cardiovascular
morbidity
mortality
worldwide.
Oxidative
stress
inflammation
are
central
to
its
pathogenesis,
driving
endothelial
dysfunction,
foam
cell
formation,
plaque
instability.
Emerging
evidence
highlights
potential
bioactive
compounds
with
antioxidant
anti-inflammatory
properties
mitigate
these
processes
promote
vascular
health.
This
review
explores
mechanisms
through
which
compounds-such
as
polyphenols,
carotenoids,
flavonoids,
omega-3
fatty
acids,
coenzyme
Q10,
other
natural
compounds-modulate
oxidative
in
atherosclerosis.
It
examines
their
effects
on
key
molecular
pathways,
including
inhibition
reactive
oxygen
species
(ROS)
production,
suppression
nuclear
factor-κB
(NF-κB),
modulation
cytokines.
By
integrating
current
knowledge,
this
underscores
therapeutic
dietary
supplemental
complementary
strategies
for
managing
atherosclerosis,
paving
way
future
research
clinical
applications.
Annual Review of Nutrition,
Journal Year:
2024,
Volume and Issue:
44(1), P. 179 - 204
Published: April 18, 2024
Recent
advances
in
human
genetics,
together
with
a
substantial
body
of
epidemiological,
preclinical
and
clinical
trial
evidence,
strongly
support
causal
relationship
between
triglyceride-rich
lipoproteins
(TRLs)
atherosclerotic
cardiovascular
disease.
Consequently,
the
secretion
metabolism
TRLs
have
significant
impact
on
health.
This
knowledge
underscores
importance
understanding
molecular
mechanisms
regulation
very-low-density
lipoprotein
(VLDL)
chylomicron
biogenesis.
Fortunately,
there
has
been
resurgence
interest
intracellular
assembly,
trafficking,
degradation,
VLDL,
leading
to
many
ground-breaking
insights.
Furthermore,
identification
control
related
triglyceride
greatly
advanced
our
complex
TRLs.
In
this
review,
we
explore
recent
secretion,
We
also
discuss
available
treatment
strategies
for
hypertriglyceridemia.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1749 - 1749
Published: June 2, 2024
Background:
The
purpose
of
our
systematic
review
was
to
examine
the
effects
any
physical
activity/exercise
intervention
combined
with
diet/nutrition
on
biological/biochemical
index,
quality
life
(QoL),
and
depression
in
breast,
lung,
colon
rectum,
prostate,
stomach,
liver
cancer
patients
and/or
survivors.
Methods:
A
meta-analysis
were
undertaken,
using
PRISMA
guidelines
Cochrane
Handbook.
protocol
can
be
found
PROSPERO
database;
registration
number:
CRD42023481429.
Results:
We
moderate-quality
evidence
that
a
nutrition/diet
reduced
body
mass
weight,
fat
mass,
insulin,
homeostatic
model
assessment
for
insulin
resistance,
C-reactive
protein,
triglycerides,
depression,
while
it
increased
high-density
lipoprotein,
component
QoL,
general
functional
therapy.
Conclusions:
conclude
may
decrease
levels,
inflammation,
improve
lipidemic
profile,
These
outcomes
indicate
lower
risk
carcinogenesis;
however,
their
applicability
depends
heterogeneity
population
interventions,
as
well
potential
medical
treatment
World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(30), P. 3584 - 3608
Published: Aug. 8, 2024
Fanlian
Huazhuo
Formula
(FLHZF)
has
the
functions
of
invigorating
spleen
and
resolving
phlegm,
clearing
heat
purging
turbidity.
It
been
identified
to
have
therapeutic
effects
on
type
2
diabetes
mellitus
(T2DM)
in
clinical
application.
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
frequently
diagnosed
patients
with
T2DM.
However,
potential
FLHZF
NAFLD
underlying
mechanisms
need
further
investigation.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2927 - 2927
Published: Sept. 1, 2024
Dyslipidemia
is
a
significant
risk
factor
for
atherosclerotic
cardiovascular
disease
(ASCVD).
During
pregnancy,
physiological
changes
elevate
cholesterol
and
triglyceride
levels
to
support
fetal
development,
which
can
exacerbate
pre-existing
conditions
lead
complications
such
as
pre-eclampsia,
gestational
diabetes,
increased
ASCVD
both
mother
child.
Effective
management
strategies
are
necessary,
especially
pregnant
women
with
inherited
forms
of
dyslipidemia
(i.e.,
familial
hypertriglyceridemia,
hyperchylomicronemia),
where
personalized
dietary
adjustments
crucial
successful
pregnancy
outcomes.
Pharmacological
interventions
lipoprotein
apheresis
may
be
necessary
severe
cases,
though
their
use
often
limited
by
factors
cost,
availability,
potential
risks.
Despite
the
promise
advanced
therapies,
widespread
application
remains
constrained
studies
high
costs.
Thus,
personalized,
multidisciplinary
approach
essential
optimizing
This
review
provides
comprehensive
overview
current
evidence-based
practices
managing
during
emphasizing
balance
maternal
health.
Additionally,
it
discusses
in
lipid
metabolism
implications,
particularly
dyslipidemia.
Lipids in Health and Disease,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Sept. 9, 2023
Abstract
Background
and
aims
This
study
aimed
to
investigate
the
association
between
Dietary
Inflammatory
Index
(DII)
dyslipidemia,
as
well
evaluate
mortality
risk
associated
with
DII
in
participants
dyslipidemia.
Methods
Data
from
National
Health
Nutrition
Examination
Survey
database
were
divided
into
dyslipidemia
non-dyslipidemia
groups.
The
was
investigated
using
weighted
chi-square
test,
t-test,
logistic
regression.
Weighted
Cox
proportional
hazards
models
used
estimate
hazard
ratios
95%
confidence
intervals
for
all-cause
cardiovascular
disease-related
within
group.
Results
A
total
of
17,820
participants,
including
4,839
without
12,981
analyzed
this
study.
results
showed
that
higher
group
compared
(1.42
±
0.03
vs.
1.23
0.04,
P
<
0.01).
However,
energy,
protein,
carbohydrates,
fat,
saturated
iron,
lower
Logistic
regression
analysis
revealed
a
strong
positive
odds
Q1
Q4
1.00
(reference),
1.12
(0.96–1.31),
(1.04–1.44),
1.33
(1.11–1.59),
respectively.
In
high
mortality.
Conclusion
closely
pro-inflammatory
diet
may
play
role
unfavorable
consequences
is
linked
both
death
patients
Participants
should
pay
attention
their
anti-inflammatory
dietary
patterns.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 21
Published: Jan. 19, 2025
The
so-called
Mediterranean
diet,
with
olive
oil
as
a
key
component,
is
effective
in
reducing
cardiometabolic
disease
risk.
Olive
consumption
improves
blood
pressure,
insulin
levels
and
resistance,
supporting
heart
health
glycemic
control.
Its
phenolic
compounds,
including
oleuropein
(OLE),
hydroxytyrosol
(HT),
tyrosol
(TYR)
are
hypothesized
to
likely
contribute
these
benefits.
Thus,
this
meta-analysis
evaluated
the
clinical
effects
of
dietary
supplementation
OLE,
HT,
TYR
on
outcomes.
Fourteen
human
intervention
studies
594
participants
were
included.
analysis
using
random-effects
model
showed
that
significantly
reduced
total
cholesterol
(SMD
=
−0.19,
CI:
−0.37
−0.01,
p
0.04,
I2
35%),
triacylglycerol
−0.32,
−0.60
−0.03,
0.03,
73%),
−0.42,
−0.82
78%).
Subgroup
that,
certain
contexts,
interventions
may
be
more
beneficial
for
BMI
<30,
non-Mediterranean,
individuals,
while
compound,
type
intervention,
duration
might
have
differential
regarding
considered
Overall,
suggests
beneficially
impact
some
parameters,
though
further
needed
confirm
findings.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 501 - 501
Published: Jan. 23, 2025
Obesity,
which
is
characterized
by
excessive
body
fat
accumulation
and
energy
imbalance,
a
major
risk
factor
for
type
2
diabetes
mellitus.
Boesenbergia
rotunda
rhizomes
(known
as
fingerroots)
exhibit
variety
of
pharmacological
activities
are
used
in
traditional
medicine.
Pinostrobin
was
identified
constituent
rhizome
(BR)
extract
suppressed
nitric
oxide
production
interleukin
1β-treated
hepatocytes.
Next,
we
investigated
the
anti-obesity
effects
BR
ob/ob
mice,
mellitus
model.
The
mice
were
treated
with
or
without
1%
14
days
then
analyzed
serum
insulin
triglyceride
levels,
liver
histology,
mRNA
expression.
administration
significantly
decreased
blood
glucose
concentrations
increased
mice.
In
addition,
this
treatment
reduced
levels
both
lipid
Microarray
analysis
revealed
that
hepatic
affected
expression
genes
involved
inflammation,
metabolism,
synthesis,
signaling,
leading
to
improvements
obesity.
Because
has
hypoglycemic
antidiabetic
on
it
might
be
promising
candidate
addressing
obesity
related
metabolic
disorders.
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 27, 2025
Background/Objectives
To
evaluate
the
impact
of
maximal
fat
oxidation
intensity
exercise
combined
with
calorie
restriction
intervention
on
lipid-related
parameters
in
a
hypercholesterolemic
population,
and
to
determine
if
an
optimal
range
exists
for
effectively
enhancing
blood
lipid
profiles.
Methods
A
4-week
study
64
patients
aged
18–60
secondary
hypercholesterolemia.
Ultimately,
43
participants
completed
study.
The
dietary
adhered
principles
balanced
diet,
meal
plans
designed
provide
three
meals
per
day
duration
Each
subject’s
daily
intake
was
set
match
their
individual
resting
energy
expenditure
(REE)
plus
varying
proportions
physical
activity
(PA)
calories.
Participants
were
divided
into
four
groups
based
these
proportions:
REE
only,
+
PA33%,
PA67%,
PA100%.
FATmax
exercises
conducted
5
times
week,
lasting
1
h
each.
Results
1)
Compared
baseline,
subjects’
body
weight,
mass
rate
decreased
significantly;
fat-free
also
significantly
REE,
PA67%
groups.
2)
Subjects’
serum
TC
LDL-C
ApoB
groups;
there
no
significant
changes
HDL-C
ApoA1.
3)
Serum
PCSK9
PA
67%
LDLR
all
subjects.
4)
Between
groups,
change
different.
Conclusion
proper
can
decrease
cholesterol
levels
patients.
Nevertheless,
it
is
misleading
assume
that
drastic
reduction
invariably
results
superior
outcomes.
Optimal
cost-effectiveness
may
be
achieved
within
PA33-67%.
