Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 130 - 130

Published: Jan. 16, 2023

Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin plays a crucial role in immune function inflammation. Recent data suggested protective health purpose this meta-analysis trial sequential analysis (TSA) was to better explain strength supplementation risk mortality admission intensive care units (ICUs) patients with COVID-19. Methods: We searched four databases on 20 September 2022. Two reviewers screened randomized clinical trials (RCTs) assessed bias, independently duplicate. pre-specified outcomes interest were ICU admission. Results: identified 78 bibliographic citations. After reviewers’ screening, only five RCTs be suitable our analysis. performed meta-analyses then TSAs. administration results decreased death (standardized mean difference (95% CI): 0.49 (0.34–0.72) 0.28 (0.20–0.39), respectively). TSA showed that, since pooling reached definite sample size, positive is conclusive. that z-curve inside alpha boundaries, indicating need further studies. Discussion: respective TSAs suggest definitive hospitalization.

Language: Английский

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Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D

Nutrients, Journal Year: 2022, Volume and Issue: 14(18), P. 3811 - 3811

Published: Sept. 15, 2022

Although observational studies of health outcomes generally suggest beneficial effects with, or following, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations, randomized controlled trials (RCTs) have not supported those findings. Here we review results from and RCTs regarding how vitamin status affects several nonskeletal outcomes, including Alzheimer's disease dementia, autoimmune diseases, cancers, cardiovascular disease, COVID-19, major depressive disorder, type 2 diabetes, arterial hypertension, all-cause mortality, respiratory tract infections, pregnancy outcomes. We also consider relevant findings ecological, Mendelian randomization, mechanistic studies. clear discrepancies exist between on human benefits these should be interpreted cautiously. Bias confounding are seen in limitations, largely due to being designed like therapeutic drugs, thereby neglecting D's a nutrient with unique metabolism that requires specific consideration trial design. Thus, can fail for reasons: few participants' having low baseline 25(OH)D relatively small doses, other sources D, analyzed without achieved concentrations. Vitamin its relevance usefully examined using Hill's criteria causality biological system types before further considered would useful developing medical public policy, as they were nonsmoking policies. A promising approach future RCT design is adjustable supplementation based interval concentrations achieve target levels suggested by

Language: Английский

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Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization

Endocrine, Journal Year: 2023, Volume and Issue: 80(3), P. 669 - 683

Published: March 1, 2023

Language: Английский

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Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19

Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(5), P. 265 - 287

Published: March 28, 2023

Language: Английский

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Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies

Journal of Bone and Mineral Research, Journal Year: 2023, Volume and Issue: 38(10), P. 1391 - 1403

Published: July 22, 2023

ABSTRACT Vitamin D plays an important role in calcium homeostasis and many cellular processes. Although vitamin supplements are widely recommended for community-dwelling adults, definitive data on whether these benefit clinically skeletal extraskeletal outcomes have been conflicting. observational studies effects of musculoskeletal may be confounded by reverse causation, randomized controlled (RCTs) Mendelian randomization (MR) can help to elucidate causation. In this review, we summarize the recent findings from large RCTs and/or MR bone health risk fractures, falls, cancer, cardiovascular disease, disorders immune system, multiple sclerosis, mortality adults. The primary analyses indicate that supplementation does not decrease loss, cancer incidence, hypertension, or generally healthy populations. Large meta-analyses suggest effect supplemental mortality. existence benefits supplementations best documented system especially people with poor status, autoimmune diseases, sclerosis. Accumulating evidence indicates reduce all-cause These findings, mostly D–replete populations, do apply older adults residential communities deficiency osteoporosis. focus should shift widespread use populations targeted select individuals, good nutritional approaches, elimination globally. © 2023 American Society Bone Mineral Research (ASBMR).

Language: Английский

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Serum vitamin D levels and COVID-19 during pregnancy: A systematic review and meta-analysis

Clinical Nutrition ESPEN, Journal Year: 2022, Volume and Issue: 51, P. 120 - 127

Published: Sept. 9, 2022

Language: Английский

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Consensus and Controversial Aspects of Vitamin D and COVID-19

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2022, Volume and Issue: 108(5), P. 1034 - 1042

Published: Dec. 8, 2022

Abstract Objective This work aims to review and discuss controversial topics in the field of vitamin D, SARS-CoV-2 infection, COVID-19. Methods The International Conferences “Controversies Vitamin D” are a series workshops that started 2017 featuring international experts leaders D research clinical practice. fifth annual conference was held Stresa, Italy, September 15 18, 2021. Evidence Before event, participants reviewed available studies on their assigned topic, drafted related abstract, presented findings at time conference. Relevant literature became since also discussed within panel updated accordingly. Consensus abstracts had been merged prepare preliminary document. After presentations, in-depth discussions open sessions led consensus. document subsequently modified according up-to-date inclusion. Conclusions There is quite consistent evidence for an association between low 25 OH (25(OH)D) levels poor COVID-19 outcomes, despite heterogeneous publications variable quality. However, status patients might reflect reverse causality. supplementation have positive role prevention. supporting beneficial effect treatment decreasing risk complications conflicting. Conclusive statements regarding this context await high-quality, randomized controlled trials.

Language: Английский

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The Effect of Vitamin D Supplementation on the Length of Hospitalisation, Intensive Care Unit Admission, and Mortality in COVID-19—A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3470 - 3470

Published: Aug. 5, 2023

The coronavirus disease 2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has become a global health crisis and pushed researchers physicians to discover possible treatments improve outcome of their patients. Vitamin D, known for its role in immune system function, been hypothesized play COVID-19 treatment. A systematic review meta-analysis were conducted evaluate efficacy vitamin D supplementation COVID-19, focusing on length hospital stay (LOS), admission intensive care unit (ICU), mortality. Thirteen randomized controlled trials (RCTs) included, revealed that high-dose showed potential benefits reducing ICU rates patients with COVID-19. However, overall effect mortality did not reach statistical significance. While this suggests stays patients, caution is warranted due high heterogeneity limitations included studies. Further large-scale consistent study characteristics are needed provide more robust evidence regarding therapeutic outcomes.

Language: Английский

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Vitamin D3 and COVID-19 Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 247 - 247

Published: Jan. 22, 2023

Background: The immune system (innate and adaptive) is influenced by vitamin D3, which affects gene expression inflammatory pathways. An umbrella review was conducted to evaluate the power accuracy of data connecting D3 outcomes COVID-19 infection appraise proof provided published meta-analyses. Methods: MEDLINE, Embase, Cochrane Library were searched from database inception 31 May 2022. Meta-analyses prospective or retrospective observational studies randomized trials included. Evidence association graded according established criteria: strong, highly suggestive, weak, not significant. Results: From 74 publications, 27 meta-analyses described five associations between levels supplementation outcomes. Low significantly associated with severity (highly suggestive evidence; OR = 1.97 [95% CI, 1.55–2.51], p < 0.01; I2 77%, 0.01) mortality risk due disease (OR 1.83 1.55–2.16], 50%, 0.01). Vitamin supplementation, after a diagnosis infection, reduced (e.g., ICU admission) mortality. Conclusions: This available evidence suggests that insufficient may increase risk, severity, mortality, in addition showing among infected patients.

Language: Английский

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Association of vitamin B12, folate, and homocysteine with COVID-19 severity and mortality: A systematic review and meta-analysis

SAGE Open Medicine, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Objective: We aimed to review the available evidence on association between vitamin B12, folate, and homocysteine levels with worse outcomes among COVID-19 patients. Methods: The search was carried out in ten databases simultaneously run 10 May 2023, without language restrictions. included cross-sectional, case-control, cohort studies. random-effects meta-analysis performed using Sidik-Jonkman method corrected 95% confidence intervals truncated Knapp-Hartung standard errors. Standardized mean difference CI used as measure effect size. Results: Thirteen articles were this ( n = 2134). Patients who did not survive had highest serum B12 values (SMD: 1.05; CI: 0.31–1.78; p 0.01, I 2 91.22%). In contrast, low folate associated patients severe −0.77; −1.35 −0.19; 0.02, 59.09%). remaining tested differences yield significant results. Conclusion: Elevated of higher mortality COVID-19. Severe cases levels. Future studies should incorporate a larger sample

Language: Английский

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