The association between vitamin D deficiency and the clinical outcomes of hospitalized COVID-19 patients DOI Creative Commons
Andhika Rachman,

Rizky Rahmaniyah,

Andi Khomeini

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 12, P. 394 - 394

Published: Feb. 5, 2024

Background Vitamin D deficiency is an emerging public health problem that affects more than one billion people worldwide. has been shown to be effective in preventing and reducing the severity of viral respiratory diseases, including influenza. However, role vitamin COVID-19 infection remains controversial. This study aimed analyze association on clinical outcome hospitalized patients. Methods A prospective cohort was conducted among patients at two referral hospitals Indonesia from October 2021 until February 2022. Results The median serum 25(OH)D level 191 13.6 [IQR=10.98] ng/mL. levels were significantly lower with who had cardiovascular disease (p-value=0.04), use a ventilator (p-value=0.004), severe cases (p-value=0.047), mortality (p-value=0.002). Furthermore, different between mild (p-value=0.019). Serum moderate (p-value=0.031). Lower associated increased number comorbidities (p-value=0.03), (p-value=0.002), mechanical ventilation (p-value=0.032). Mortality found 7.3% deficient levels. either sufficient or insufficient did not develop mortality. Conclusions having disease, mortality, cases, used ventilation. comorbidities, severity, mechanical-ventilation. Thus, we suggest reach status improve disease.

Language: Английский

Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors DOI Creative Commons
Luigi di Filippo, Stefano Frara,

Fabrizio Nannipieri

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 108(10), P. e1106 - e1116

Published: April 13, 2023

Long COVID is an emerging syndrome affecting 50% to 70% of COVID-19 survivors that still lacks predicting factors.Due the extraskeletal effects vitamin D, we retrospectively assessed association between 25(OH) D levels and long in 6 months after hospitalization.Long was defined according NICE guidelines. Fifty 50 non-long-COVID subjects matched on a 1:1 basis were enrolled from outpatient clinic post-COVID cohort seen August November 2020. Therapies/comorbidities calcium/vitamin D/bone metabolism, and/or admission intensive care unit during hospitalization exclusion criteria. Vitamin measured at hospital discharge.We observed lower levels, evaluated follow-up, with than those without (20.1 vs 23.2 ng/mL, P = .03). Regarding affected health areas entire cohort, neurocognitive symptoms follow-up (n 7) 93) (14.6 20.6 .042). In patients presenting deficiency (<20 ng/mL), both 42), by 22) presented not 20) (12.7 15.2 .041). multiple regression analyses, only variable significantly associated our (P .008, OR 1.09, CI 1.01-1.16).COVID-19 have COVID. Our data suggest should be discharge. The role supplementation as preventive strategy sequelae tested randomized controlled trials.

Language: Английский

Citations

65
A view on vitamin D: a pleiotropic factor? DOI
Andrea Giustina, Marise Lazaretti‐Castro, Adrian R. Martineau

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(4), P. 202 - 208

Published: Jan. 22, 2024

Language: Английский

Citations

16
Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review DOI Open Access

Antonella Al Refaie,

Leonardo Baldassini,

Caterina Mondillo

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1144 - 1144

Published: April 12, 2024

Nowadays, the interest in extraskeletal effects of vitamin D is growing. In literature, its several possible actions have been confirmed. Vitamin seems to a regulatory role many different fields-inflammation, immunity, and endocrine system-and studies would demonstrate correlation between cardiovascular disease. this paper, we deepened relationship dyslipidemia by reviewing available literature. The results are not entirely clear-cut: on one hand, numerous observational suggest link higher serum levels beneficial lipid profile, while other interventional do significant effect. Understanding may represent turning point: another system.

Language: Английский

Citations

10
Long COVID and pituitary dysfunctions: a bidirectional relationship? DOI
Luigi di Filippo,

Vincenzo Franzese,

Simona Santoro

et al.

Pituitary, Journal Year: 2024, Volume and Issue: 27(6), P. 955 - 969

Published: Sept. 6, 2024

Language: Английский

Citations

7
Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study DOI Open Access
Marlene Fabiola Escobedo-Monge, M. Pilar Bahíllo‐Curieses,

Joaquín Parodi-Román

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1349 - 1349

Published: April 29, 2024

Chronic diseases may affect the nutritional status of children and adolescents. Calcium (Ca), phosphorus (P), vitamin D (Vit-D) are crucial nutrients for their growth development. Proper diagnosis treatment critical components personalized precision medicine. Hence, we conducted a cross-sectional comparative study to evaluate Ca, P, Vit-D levels in non-skeletal functions association with health biomarkers adolescents diverse chronic conditions. We performed anthropometric, body composition, clinical evaluation, biochemical analysis, dietary survey methods. A total 78 patients (1–19 years, 43 females, 42 children) took part this study. Overall, 24, 30, 24 participants were obese, undernourished, eutrophic, respectively. Results found that 74% 35% individuals had deficient Ca intake, Most cases normocalcemic. also 47% subjects deficiency (VDD), 37% insufficient, hypophosphatemia. Of 46% 31% VDD insufficient levels, 19% 11% hypophosphatemic, Calcium, associated anthropometric parameters, mass index, physical activity, diet, hormones, immune, liver, kidney systems. These results show coincident risk altered metabolism diseases.

Language: Английский

Citations

6
Lack of vitamin D predicts impaired long-term immune response to COVID-19 vaccination DOI Creative Commons
Luigi di Filippo, Stefano Frara,

Umberto Terenzi

et al.

Endocrine, Journal Year: 2023, Volume and Issue: 82(3), P. 536 - 541

Published: Aug. 17, 2023

Abstract Purpose Low vitamin D levels were reported to negatively influence the outcome of acute COVID-19, as well be linked Long-COVID. However, few studies have investigated, so far, its effects on humoral-response anti-SARS-CoV-2 vaccination, reporting conflicting results. We aimed evaluate impact baseline 25(OH)vitamin (25(OH)D) a two-dose cycle Pfizer-BioNTech-vaccine up 9–10 months after immunization. Methods retrospectively included 119 consecutive healthcare-workers (median age 53 years) without previous history COVID-19 or immunoglobulins presence immunized with two doses Comirnaty-vaccine from January February 2021. 25(OH)D was measured at time first-immunization. Immune response evaluated at: 0 (T0), before first-dose; T1, second-dose (21 days T0); T2, T3, T4 1, 5 and 9 respectively. Results Median 25.6 ng/mL, deficiency (25(OH)D <20 ng/mL) observed in 29 subjects (24.8%). In those deficiency, we found non-significant trend towards lower antibody-titers significantly titers compared not D-deficient, also observing more pronounced negative drop peak-T2 deficiency. A positive correlation between ( p = 0.043) found. multiple linear-regression analysis, older-age resulted independent factors associated antibody titer 0.026, 0.004; respectively). Conclusion our relatively young cohort presenting low prevalence hypovitaminosis D, long-term humoral vaccination influenced by 25(OH)D. Vitamin supplementation could tested strategy optimize campaigns prevent severe COVID-19.

Language: Английский

Citations

16
New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases DOI
Luigi di Filippo, John P. Bilezikian, Ernesto Canalis

et al.

Endocrine, Journal Year: 2024, Volume and Issue: 85(3), P. 1007 - 1019

Published: April 17, 2024

Language: Английский

Citations

5
The Association between Serum Vitamin D Levels and Urinary Tract Infection Risk in Children: A Systematic Review and Meta-Analysis DOI Open Access

Gan Yan,

Siyi You,

Junjie Ying

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2690 - 2690

Published: June 9, 2023

The association between serum vitamin D levels and urinary tract infection (UTI) in children is unclear. We undertook a systematic review meta-analysis to evaluate the relationships different likelihood of UTI children. Online databases, including Web Science, PubMed, Embase, Cochrane Library, were searched up 6 February 2023 for studies based on inclusion criteria. Weighted mean difference (WMD) Odds Ratios (ORs), along with their 95% confidence intervals (CI), calculated, random-effects model was used analysis. Twelve case–control one cross-sectional study (839 929 controls) included. found that had lower than healthy controls (WMD: −7.730, CI: −11.57, −3.89; p < 0.001). Low significantly associated (OR: 2.80; 1.55, 5.05; = having increased when level less 20 ng/mL 5.49, 1.12, 27.04; 0.036). Therefore, level, especially ng/mL, risk factor UTI.

Language: Английский

Citations

13
Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy DOI Creative Commons
Adel A. Gomaa,

Yasmin A. Abdel-Wadood,

Romany H. Thabet

et al.

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271

Published: Nov. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Language: Английский

Citations

12
COVID-19 Biomarkers Comparison: Children, Adults and Elders DOI Creative Commons
Ionuț Dragoș Căpraru, Dan Dumitru Vulcănescu, Iulia Cristina Bagiu

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(5), P. 877 - 877

Published: May 3, 2023

Background and Objectives: this study aimed to research links between C-reactive protein (CRP), lactate dehydrogenase (LDH), creatinekinase (CK), 25-OH vitamin D (25-OHD), ferritin (FER), high-density lipoprotein cholesterol (HDL)cholesterol clinical severity in patients from the western part of Romania, compare their potential use as biomarkers for intensive care units (ICU) admission death children, adults elders. Materials Methods: is a retrospective cohort study, performed on positively diagnosed with COVID-19. Available CRP, LDH, CK D, ferritin, HDL were recorded. The following assessed: median group differences, association, correlation receiver operating characteristic. Results: 381 614 elders studied 1 March 2021 2022. Most children presented mild symptomatology (53.28%, 35.02%, respectively), while most severe (30.04%). ICU was 3.67% 13.19% 46.09% elders, mortality 0.79% 8.63% 25.1% With exception CK, all other showed some significant associations severity, death. Conclusions: are important COVID-19 positive patients, especially pediatric population, mostly within normal ranges.

Language: Английский

Citations

11