Exposure and Health,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 19, 2024
Abstract
Arsenic
(As)
is
a
toxic
metalloid
that
can
enter
the
food
chain
through
uptake
by
plants
from
soils
followed
production
of
plant-based
food.
While
soil–plant
transfer
As
in
crops,
especially
rice,
relatively
well
studied,
role
soil
microbes
translocation
maize
not
understood.
We
performed
greenhouse
pot
experiment
with
grown
at
different
levels
to
study
on
species
maize.
Three
treatments
varying
disturbance
(native
soil,
sterilized
and
reconditioned
indigenous
microbes)
were
intersected
three
(0,
100
200
mg
kg
−1
spiked
As,
aged
for
8
weeks)
experiment,
where
was
5
months.
Compared
uncontaminated
soils,
high-As
tended
accumulate
more
stems
less
leaves
grains,
proportionally.
increased
due
microbiome.
The
sterilization
effects
caused
phosphorus
manganese
deficiency,
leading
higher
plants,
rising
resulted
lower
total
dry
biomass
plants.
In
summary,
this
highlights
limiting
inorganic
into
cultivating
recommended.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6662 - 6662
Published: June 17, 2024
Humans
are
continuously
exposed
to
various
heavy
metals
including
copper,
iron,
cadmium,
and
arsenic,
which
were
specifically
selected
for
the
current
analysis
because
they
among
most
frequently
encountered
environmental
mankind
industrial
pollutants
potentially
causing
human
health
hazards
liver
injury.
So
far,
these
issues
poorly
assessed
remained
a
matter
of
debate,
also
due
inconsistent
results.
The
aim
actual
report
is
thoroughly
analyze
positive
as
well
negative
effects
four
on
health.
Copper
iron
correctly
viewed
pollutant
elements
essential
maintaining
part
important
enzymes
metabolic
pathways.
Healthy
individuals
prepared
through
genetically
based
mechanisms
maintain
cellular
copper
homeostasis,
thereby
circumventing
or
reducing
hazardous
organ
injury
excessive
amounts
entering
body.
In
few
humans
with
gene
aberration,
however,
may
develop
excessively
accumulated
can
lead
Wilson
disease
substantial
deposition
hemochromatosis.
At
molecular
level,
toxicities
some
traced
back
Haber
Weiss
Fenton
reactions
involving
reactive
oxygen
species
formed
in
course
oxidative
stress.
On
other
hand,
homeostasis
cadmium
arsenic
cannot
be
provided,
their
life-long
organs.
Consequently,
represent
leading
higher
disability-adjusted
life
years
increased
mortality
rates
cancer
non-cancer
diseases.
For
unknown
reasons,
rarely
observed.
sum,
good
except
those
hemochromatosis
at
risk
radical
formation,
while
lack
any
beneficial
but
rather
focus
disability
potential
cancer.
Primary
efforts
should
emission
metals.
Frontiers in Pediatrics,
Journal Year:
2023,
Volume and Issue:
11
Published: July 4, 2023
Background
Studies
have
found
that
toxic
heavy
metals
exposure
could
induce
the
generation
of
reactive
oxygen
species
(ROS),
and
is
epigenetic
effect,
which
might
be
associated
with
occurrence
Autistic
Disorder
(ASD).
This
systematic
review
meta-analysis
aims
to
elucidate
association
between
4
metals,
cadmium
(Cd),
lead
(Pb),
arsenic(As),
mercury
(Hg),
ASD
in
children.
Methods
We
searched
PubMed,
Web
Science,
Embase,
Cochrane
Library,
from
their
inception
October
2022,
for
epidemiological
investigations
explore
Cd,
Pb,
As,
or
Hg
child
ASD.
Results
A
total
53
studies
were
included,
involving
5,054
individuals
aged
less
than
18
(2,533
patients
2,521
healthy
controls).
Compared
controls,
hair
blood
tests,
concentrations
significantly
higher
group
control
group,
differences
arsenic
statistically
significant
(
P
<
0.05).
In
urine
test,
0.05),
while
results
Cd
Pb
opposite
those
>
Subgroup
analysis
geographic
regions
showed
Asia
Europe
had
compared
arsenic,
North
America,
controls
Conclusion
Hg.
These
play
different
roles
progression
Moreover,
there
heterogeneity
among
included
due
controversies
about
study
countries
sources
detection
materials.
The
this
firmly
support
policies
limit
exposure,
especially
pregnant
women
young
children,
so
as
help
reduce
incidence
Agriculture,
Journal Year:
2023,
Volume and Issue:
13(2), P. 401 - 401
Published: Feb. 8, 2023
Arsenic
contamination
in
soil
and
water
is
a
major
problem
worldwide.
Inorganic
arsenic
widely
present
as
arsenate
arsenite.
transferred
to
crops
through
the
irrigation
water.
It
reported
reduce
crop
production
plants
can
cause
wide
array
of
diseases
humans,
including
different
types
cancers,
premature
delivery,
stillbirth,
spontaneous
abortion.
methyltransferase
(AS3MT)
human
body
converts
inorganic
into
monomethylarsonic
acid
dimethylarsinic
acid,
which
are
later
excreted
from
body.
transfer
grains
rice
involves
transporters
such
Lsi1,
Lsi2,
Lsi6.
These
also
required
for
silicate,
makes
them
important
plant.
Different
mitigation
strategies
have
been
used
mitigate
crops,
plant
growth-promoting
bacteria,
fungi,
nanoparticles,
well
using
genotypes
extracts.
factors
nitric
oxide,
Fe,
jasmonate
affect
response
oxidative
stress
caused
by
arsenic.
This
review
highlights
various
effects
on
with
respect
their
biochemical,
molecular,
physiological
aspects
employment
classical
innovative
methods
mitigation.
The
current
expected
initiate
further
research
improve
As
remediation
effect
heavy
metal
pollution
environment.
Eco-Environment & Health,
Journal Year:
2024,
Volume and Issue:
3(3), P. 392 - 405
Published: March 7, 2024
Arsenic
(As)
is
a
naturally
occurring
chemical
element
widely
distributed
in
the
Earth's
crust.
Human
activities
have
significantly
altered
As
presence
environment,
posing
significant
threats
to
biota
as
well
human
health.
The
environmental
fates
and
adverse
outcomes
of
various
species
been
extensively
studied
past
few
decades.
It
imperative
summarize
these
advances
whole
provide
more
profound
insights
into
cycle
for
sustainable
development.
Embracing
One
Health
concept,
we
systematically
reviewed
previous
studies
this
work
explored
following
three
fundamental
questions,
i.e.,
what
trends
associated
changes
are
contamination,
how
living
organisms
interact
cope
with
most
importantly
do
achieve
future
As.
By
focusing
on
one
critical
question
each
section,
review
aims
full
picture
complexity
To
tackle
research
challenges
gaps
pollution
mitigation,
further
proposed
framework
potential
coping
strategies,
guiding
coordinated
agenda
dealing
legacy
environment
ensuring
future.
Plants,
Journal Year:
2023,
Volume and Issue:
12(22), P. 3829 - 3829
Published: Nov. 11, 2023
The
leading
cause
of
death
worldwide
has
been
identified
as
chronic
illnesses,
according
to
the
World
Health
Organization
(WHO).
Chronic
inflammatory
conditions
such
asthma,
cancer,
diabetes,
heart
disease,
and
obesity
account
for
three
out
every
five
deaths.
Although
many
people
benefit
from
using
nonsteroidal
anti-inflammatory
medicines
(NSAIDs)
pain
inflammation
relief,
there
are
significant
adverse
effects
these
medications.
Medicinal
plants
possess
properties
with
minimal
or
no
side
effects.
Nigella
sativa
(NS),
also
known
black
cumin,
is
one
used
in
traditional
medicine
most.
Many
studies
on
NS
have
shown
that
their
therapeutic
attributed
seed,
oil,
secondary
metabolites.
This
plant
studied
extensively
medical
uses,
anti-inflammatory.
its
phytochemical
compounds,
thymoquinone,
can
cell
apoptosis
via
oxidative
stress,
block
efflux
pumps,
enhance
membrane
permeability,
exert
potent
biocidal
Notwithstanding
documented
effectiveness
observed
experimental
model,
precise
mechanisms
underlying
diverse
diseases
multi-targeting
characteristics
remain
largely
unexplored.
review
examines
metabolites,
a
valuable
source
development
diseases.
Most
clinical
were
done
diabetes
cardiovascular
disease;
therefore,
more
required
examine
extracts
phytoconstituents
treat
obesity,
neurological
disorders,
COVID-19.
study
will
be
resource
clinicians
biologists
seeking
pharmaceutical
solution
Toxicology Letters,
Journal Year:
2024,
Volume and Issue:
398, P. 105 - 117
Published: June 18, 2024
Inorganic
arsenic
species
exist
in
the
environment
as
a
result
of
both
natural
sources,
such
volcanic
and
geothermal
activities,
geological
formations,
well
anthropogenic
including
smelting,
exploration
fossil
fuels,
coal
burning,
mining,
use
pesticides.
These
deposit
water,
rocks,
soil,
sediments,
atmosphere.
Arsenic-contaminated
drinking
water
is
global
public
health
issue
because
its
prevalence
toxicity.
Therefore,
chronic
exposure
to
can
have
deleterious
effect
on
humans,
cancer
other
diseases.
This
work
describes
mechanisms
environmental
arsenic,
molecular
regulatory
factors
involved
metabolism,
genetic
polymorphisms
affecting
individual
susceptibility
toxic
effects
human
(oxidative
stress,
DNA
damage
cancer).
We
conclude
that
role
single
nucleotide
variants
urinary
excretion
metabolites
are
highly
relevant
be
used
biomarkers
intracellular
retention
rates
showing
new
avenues
research
this
field.
Foods,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1890 - 1890
Published: June 16, 2024
Metals
are
integral
components
of
the
natural
environment,
and
their
presence
in
food
supply
is
inevitable
complex.
While
essential
metals
such
as
sodium,
potassium,
magnesium,
calcium,
iron,
zinc,
copper
crucial
for
various
physiological
functions
must
be
consumed
through
diet,
others,
like
lead,
mercury,
cadmium,
toxic
even
at
low
concentrations
pose
serious
health
risks.
This
study
comprehensively
analyzes
presence,
importance,
consequences
chain.
We
explore
pathways
which
enter
supply,
distribution
across
different
types,
associated
implications.
By
examining
current
regulatory
standards
maximum
allowable
levels
metals,
we
highlight
importance
ensuring
safety
protecting
public
health.
Furthermore,
this
research
underscores
need
continuous
monitoring
management
metal
content
food,
especially
global
agricultural
production
practices
evolve.
Our
findings
aim
to
inform
dietary
recommendations,
fortification
strategies,
policies,
ultimately
contributing
safer
more
nutritionally
balanced
diets.
