Atlantis Highlights in Chemistry and Pharmaceutical Sciences/Atlantis highlights in chemistry and pharmaceutical sciences,
Journal Year:
2023,
Volume and Issue:
unknown, P. 151 - 160
Acta Histochemica,
Journal Year:
2023,
Volume and Issue:
125(3), P. 152028 - 152028
Published: April 1, 2023
Toll-like
receptors
(TLRs)
are
essential
for
identifying
and
detecting
pathogen-associated
molecular
patterns
(PAMPs)
produced
by
a
variety
of
pathogens,
including
viruses
bacteria.
Since
TLR2
is
the
only
TLR
capable
creating
functional
heterodimers
with
more
than
two
other
types,
it
very
important
vertebrate
immunity.
not
broadens
PAMPs
that
can
recognize
but
has
also
potential
to
diversify
subsequent
signaling
cascades.
ubiquitous,
which
consistent
wide
tasks
functions
serves.
Immune
cells,
endothelial
epithelial
cells
have
all
been
found
express
TLR2.
This
review
aims
gather
currently
available
information
about
preservation
this
intriguing
immunological
molecule
in
phylum
vertebrates.
Biology,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1045 - 1045
Published: July 12, 2022
Dendritic
cells
(DCs)
are
antigen-presenting
(APCs)
that
regulate
the
beginning
of
adaptive
immune
responses.
The
mechanisms
tolerance
to
antigens
moving
through
digestive
tract
known
be
regulated
by
intestinal
DCs.
Agnatha
and
Gnathostoma
descendants
a
common
ancestor.
Ostracoderms
gave
rise
Cyclostomes,
whereas
Placoderms
Chondrichthyes.
Zoological Letters,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: March 4, 2023
Abstract
Metazoans
have
several
mechanisms
of
internal
defense
for
their
survival.
The
system
evolved
alongside
the
organisms.
Annelidae
circulating
coelomocytes
that
perform
functions
comparable
to
phagocytic
immune
cells
vertebrates.
Several
studies
shown
these
are
involved
in
phagocytosis,
opsonization,
and
pathogen
recognition
processes.
Like
vertebrate
macrophages,
permeate
organs
from
coelomic
cavity
capture
or
encapsulate
pathogens,
reactive
oxygen
species
(ROS),
nitric
oxide
(NO).
Furthermore,
they
produce
a
range
bioactive
proteins
response
detoxification
through
lysosomal
system.
Coelomocytes
can
also
participate
lithic
reactions
against
target
release
antimicrobial
peptides.
Our
study
immunohistochemically
identify
Lumbricus
terrestris
scattered
epidermal
connective
layer
below,
both
longitudinal
smooth
muscle
layer,
immunoreactive
TLR2,
CD14
α-Tubulin
first
time.
TLR2
not
fully
colocalized
with
each
other,
suggesting
may
belong
two
distinct
families.
expression
molecules
on
confirms
crucial
role
Oligochaeta
protostomes,
phylogenetic
conservation
receptors.
These
data
could
provide
further
insights
into
understanding
Annelida
complex
Natural Product Research,
Journal Year:
2023,
Volume and Issue:
37(23), P. 4032 - 4037
Published: Jan. 4, 2023
Functional
experiments
indicated
that
curcumin
displayed
stronger
inhibitory
activity
on
the
proliferation
of
cervical
cancer
HeLa
cells,
while
resveratrol
had
a
better
inhibition
effect
migration.
Then,
we
compared
candidate
target
genes
and
in
treatment
through
network
pharmacology.
GO
enrichment
results
showed
exerted
its
anti-cervical
by
regulating
cell
cycle
mitosis,
whereas
affected
adhesion.
Furthermore,
were
verified
molecular
docking,
qRT-PCR,
Western
blot,
revealed
significantly
decreased
expression
CHEK1
MAPK3,
respectively.
In
conclusion,
inhibited
cells
specifically
targeting
CHEK1,
targeted
MAPK3
to
supress
migration,
combination
them
can
synergistically
restrain
migration
cells.
Zoological Journal of the Linnean Society,
Journal Year:
2023,
Volume and Issue:
200(4), P. 980 - 993
Published: Sept. 7, 2023
Abstract
The
shell
of
bivalves
acts
as
structural
support,
defence
against
predators,
stressors,
and
maintenance
homeostasis.
Haemocytes
mantle
epithelial
cells
participate
in
formation.
Mantle
produce
the
organic
matrix
are
associated
with
biomineralization
because
their
proximity
to
surface
ability
maintain
deposition
ex
vivo.
play
an
immunological
role
involved
Ca2+
CO32-
intracellular
transport
implicated
mineralization.
This
study
aims
evaluate
expression
molecules
that
key
roles
internal
nervous
system,
haemocytes
outer
margin
two
species
bivalves,
Polititapes
aureus
Gmelin,
1791
Cerastoderma
glaucum
Bruguière,
1789,
highlight
collaborative
Our
data
show
for
first
time
presence
serotonin/S100
protein,
TLR2/iNOS
colocalization
P.
C.
glaucum,
suggesting
perform
canonical
sensory
biomineralizing
activity,
while
typical
immune
function,
collaboration
formation,
providing
new
information
on
cellular
interactions
formation
giving
more
details
taxonomical
studies.
Fish & Shellfish Immunology,
Journal Year:
2023,
Volume and Issue:
137, P. 108791 - 108791
Published: May 3, 2023
The
internal
defense
system
of
mollusks
represents
an
efficient
protection
against
pathogens
and
parasites,
involving
several
biological
immune
processes,
such
as
phagocytosis,
encapsulation,
cytotoxicity,
antigenic
recognition
self/non-self.
Mollusks
possess
professional,
migratory,
circulating
cells
that
play
a
key
role
in
the
organism,
hemocytes.
Several
studies
have
been
performed
on
hemocytes
from
different
mollusks,
but,
to
date,
these
are
still
scarcely
explored.
Different
hemocyte
populations
found,
according
presence
or
absence
granules,
size,
species
studied.
Our
study
aims
deepen
knowledge
gastropod
Aplysia
depilans
using
morphological
techniques
light
confocal
microscopy,
testing
Toll-like
receptor
2,
inducible
nitric
oxide
synthetase,
nicotinic
acetylcholine
alpha
7
subunit.
results
show
two
distinguishable
by
presence/absence
granules
cytoplasm,
strongly
positive
for
antibodies
tested,
suggesting
first
time
receptors
surface
sea
hare
immunohistochemistry.
These
data
help
understanding
this
gastropod,
providing
additional
comprehending
evolution
response
metazoan
phylogenesis.
Psychological Thought,
Journal Year:
2024,
Volume and Issue:
17(1), P. 200 - 219
Published: April 30, 2024
The
health
profession
has
been
characterized
as
consisting
of
high
stressors
and
this
is
more
pervasive
in
sub-Saharan
Africa.
Although
various
interventions
aimed
at
managing
stress
have
investigated,
little
attention
devoted
to
the
contribution
emotional
intelligence
(EI)
resilience.
present
study
sought
examine
role
EI
resilience
perception
among
professionals
Ghana.
A
convenient
sample
150
workers
domiciled
Ghana
participated
by
completing
questionnaires
on
EI,
resilience,
stress.
results
showed
that
while
were
positively
related,
both
negatively
associated
with
work-related
Regression
analysis
further
was
a
significant
negative
predictor
These
findings
important
implications
for
management
professionals.
Toxics,
Journal Year:
2023,
Volume and Issue:
11(9), P. 731 - 731
Published: Aug. 25, 2023
The
introduction
of
pollutants,
such
as
thiacloprid
and
benzo[a]pyrene
(B[a]P),
into
the
waters
urbanized
coastal
estuarine
areas
through
fossil
fuel
spills,
domestic
industrial
waste
discharges,
atmospheric
inputs,
continental
runoff
poses
a
major
threat
to
fauna
flora
aquatic
environment
can
have
significant
impact
on
internal
defense
system
invertebrates
mussels.
Using
monoclonal
polyclonal
anti-Toll-like
receptor
2
(TLR2)
anti-inducible
nitric
oxide
synthetase
(iNOS)
antibodies
for
first
time,
this
work
aims
examine
hemocytes
in
mantle
gills
M.
galloprovincialis
biomarkers
B[a]P
pollution
analyze
their
potential
synergistic
effect.
To
pursue
objective,
samples
were
exposed
both
individually
simultaneously.
Subsequently,
oxidative
stress
evaluated
by
enzymatic
analysis,
while
tissue
changes
number
different
contaminated
groups
assessed
via
histomorphological
immunohistochemical
analyses.
Our
findings
revealed
that
comparison
single
exposure,
two
pollutants
together
significantly
elevated
stress.
Moreover,
our
data
may
potentially
enhance
knowledge
how
TLR2
iNOS
part
bivalves.
This
would
help
creating
new
technologies
strategies,
biosensors,
are
more
suitable
managing
water
pollution,
garnering
details
condition
marine
ecosystem.
Acta Zoologica,
Journal Year:
2024,
Volume and Issue:
106(1), P. 88 - 99
Published: March 18, 2024
Abstract
The
skin
of
snakes
acts
as
the
first
interface
between
these
reptiles
and
environment
they
live
in.
It
plays
an
important
role
in
ecology
organisms,
specialised
structures,
such
tactile
corpuscles,
are
crucial
sensing
a
wide
variety
stimuli.
This
study,
by
examining
presence,
localisation
colocalisation
serotonin,
substance
P,
PGP
9.5
tubulin,
wants
to
demonstrate
sensory
that
structures
play
Green
whip
snake
Hierophis
viridiflavus
(Lacépède,
1789).
study
presents
evaluation
nerve
immune
molecules
(TLR2)
corpuscles
H.
viridiflavius
ventral
skin,
indicating
potential
defence
structures.
These
findings
provide
valuable
information
on
snakes,
their
systems,
evolutionary
morphostructural
adaptations.
Additionally,
identification
could
support
for
taxonomic
recognition.
Furthermore,
this
expands
knowledge
about
stimuli
snakes.
