Vitamin D Deficiency in COVID-19 Patients and Role of Calcifediol Supplementation

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3392 - 3392

Published: July 30, 2023

Hypovitaminosis D has been associated with worse outcome in respiratory tract infections, conflicting opinions regarding its role Coronavirus-19 disease (COVID-19). Our study aimed to evaluate the possible relationship between 25-OH vitamin (25OHD) values and following conditions patients hospitalized for COVID-19: prognosis, mortality, invasive (IV) non-invasive (NIV) mechanical ventilation, orotracheal intubation (OTI). A further objective was analysis of a positive effect supplementation calcifediol on COVID-19 severity prognosis. We analyzed 288 at San Giovanni di Dio Hospital Florence Santa Maria alle Scotte Siena, from November 2020 February 2021. The 25OHD levels correlated positively partial pressure oxygen FiO2 (PaO2/FiO2) ratio (r = 0.17; p < 0.05). Furthermore, when we according type support, found that were markedly reduced who underwent ventilation evaluation length hospitalization our population evidenced longer duration severe deficiency (<10 ng/mL). Moreover, statistically significant difference mortality rate had below 10 ng/mL those above this threshold total (50.8% vs. 25.5%, 0.005), as well 20 (38.4% 24.6%, 0.04). supplemented presented significantly (p Interestingly, effects COVID-19, percentage deaths higher did not receive any than treated 0.05) In conclusion, have demonstrated best prognosis adequate supplementation.

Language: Английский

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Calcifediol or Corticosteroids in the Treatment of COVID-19: An Observational Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1910 - 1910

Published: June 17, 2024

Medical treatment of coronavirus 19 disease (COVID-19) is a therapeutic challenge. The available data strongly suggest that calcifediol may reduce the severity COVID-19, and corticosteroids are choice worldwide for severe COVID-19. Both have very similar action profile, their combined use in patients modify contribution each administered compound. Objective: To evaluate how with and/or medical practice modified need ICU admission, death, or poor prognosis hospitalized COVID-19 during first outbreaks. Design, setting: A retrospective observational cohort study admitted to Pneumology Unit Hospital Universitario Reina Sofía (Córdoba, Spain). Interventions: Patients were treated or/and best therapy standard care, according clinical guidelines. Measurements: Admission intensive care unit (ICU) death hospitalization prognosis. Results: Seven hundred twenty-eight included. According received, they included four groups: (n = 68), glucocorticoids 112), both 510), neither 38). Of 578 calcifediol, 88 (15%), while 150 not 39 required admission (26%) (p < 0.01). Among taking without glucocorticoids, only 4 68 (5.8%) compared 84 510 (16.5%) 0.022). 595 who had good prognosis, 568 (82.01%) received versus 133 whom 90 (67.66%) 0.001). This difference was found corticosteroids. Interpretation: moderate mild could be administering corticosteroids, until natural history reaches stage hyperinflammation.

Language: Английский

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Construction of microgravity biological knowledge graph and its applications in anti-osteoporosis drug prediction

Life Sciences in Space Research, Journal Year: 2024, Volume and Issue: 41, P. 64 - 73

Published: Jan. 29, 2024

Language: Английский

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SARS-CoV-2 Infection and Multiple Sclerosis: Proactive Approach in a Vulnerable Patient Group through Daily Vitamin D Supplementation?

Published: Feb. 10, 2024

VitD deficiency-risk factor pathologyHans-Klaus Goischke (2024) SARS-CoV-2 Infection and Multiple Sclerosis: Proactive Approach in a Vulnerable Patient Group through Daily Vitamin D Supplementation?rate was significantly lower than with values below or deficiency [17].Current data suggest protective role for VitD, particularly risk of intensive care unit admission reduced death [18,19].In addition, the occurrence Long-Covid is an aspect implementing this simple, effective, safe costeffective therapy broad therapeutic window prevention treatment .Although there still no indisputable evidence that Vit supplementation (VitD suppl.)reduces SARSCov-2 infection healthy individuals, collective it benefits vulnerable individuals [23].PwMS comorbidities, psychiatric illnesses, hypertension, obesity (an increased BMI may correlate severe course Covid-19), age > 50 years, disability methylprednisolone boost as well some DMTs (disease-modifying therapies) have higher COVID-19 courses [24-26].Infections (SARS-COV-2) can increase MS symptoms (pseudo-relapses) cause real relapses [27].In post-COVID syndrome (Long Covid), one eight patients presents such fatigue, shortness breath, cough, joint pain, chest muscle headache paresthesia limbs after at least 3 months.The latter also occur PwMS per se [28,29].If vitamin administration results infection, severity illness to people risk, occurs less frequently [18,19,21,22,30-33], not ethically justifiable withhold high dose vitamin-D from risk. Mechanisms Action COVID-19Barrea et al. list detail 14 mechanisms described by suppl. be sufficient Covid 19 vaccination supported [19,29,32,[34][35][36][37][38].Vit its metabolites inactivate viruses (increase antimicrobial peptide cathelicidin, defensins), lead reduction cytokine storm, reduce matrix metalloproteinase-9 concentration thereby host's metabolic tolerance damage, pneumonia myocarditis, pro-inflammatory cytokines, especially interleukin 6 (IL-6), which promotes permeability BBB, leads potentiation CNS damage PwMS, serious [29,[39][40][41][42]. enables neuroprotection reducing inflammation oxidative stress.Low 25(OH)D levels were inversely correlated IL-6 independent predictors mortality [43].1,25(OH)2D3 inhibits immunoglobulin synthesis, regulates B cell activity reduces auto-Ab production.It converts cells into plasma [18].Vit EBV [29].Current studies show chronic Long Covid-19 reactivation latent Epstein-Barr virus (EBV) worsening health status [44-48].In MS, level molecular mimicry between transcription EBNA-1 protein GlialCAM (glial adhesion molecule central nervous system [49].Bernal able detect detecting DNA antibodies against EBV-lytic genes [50].

Language: Английский

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Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19

Immunological Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

ABSTRACT The COVID‐19 pandemic caused by the SARS‐CoV‐2 virus was arguably one of worst public health disasters last 100 years. As many infectious disease experts were focused on influenza, MERS, ZIKA, or Ebola as potential pandemic‐causing agents, appeared to come from nowhere and spread rapidly. with any zoonotic agent, initial pathogen able transmit a new host (humans), but it poorly adapted immune environment resulted in maladapted response. host‐pathogen interaction evolved, subsequent variants became less pathogenic acquired immunity provided protection, at least partial variants. has changed since beginning pandemic, is possible clinical results discussed here may not be applicable today they start pandemic. With this caveat mind, we present an overview response severe research perspective examine trials utilizing immunomodulating agents further elucidate importance hyperinflammation factor contributing disease.

Language: Английский

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Structural diversification of vitamin D using microbial biotransformations

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: July 6, 2024

Abstract Vitamin D deficiencies are linked to multiple human diseases. Optimizing its synthesis, physicochemical properties, and delivery systems while minimizing side effects is of clinical relevance great medical industrial interest. Biotechnological techniques may render new modified forms vitamin that exhibit improved absorption, stability, or targeted physiological effects. Novel derivatives hold promise for developing future therapeutic approaches addressing specific health concerns related deficiency impaired metabolism, such as avoiding hypercalcemic Identifying engineering key enzymes biosynthetic pathways involved, well efficient cultures, therefore outmost importance subject intense research. Moreover, we elaborate on the critical role microbial bioconversions might play in a la carte design, production novel, more efficient, safer analogs. In summary, novelty this work resides detailed description physiological, medical, biochemical, epidemiological aspects supplementation steps towards enhanced simplified family bioactives relying enzymes. Key points • Liver kidney pathologies hamper biosynthesis Actinomycetes able carry out 1α- 25-hydroxylation precursors

Language: Английский

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The Impact of Withholding Cost-Effective Early Treatments, such as Vitamin D, on COVID-19: An Analysis Using an Innovative Logical ParadigmThe Impact of Withholding Cost-Effective Early Treatments, such as Vitamin D, on COVID-19: An Analysis Using an Inno

World Journal of Advanced Pharmaceutical and Life Sciences, Journal Year: 2023, Volume and Issue: 5(2), P. 013 - 034

Published: Dec. 30, 2023

Purpose: While numerous widely accepted nutraceuticals lack randomized clinical trial (RCT) validation, regulatory bodies prioritize RCTs as the primary evidence for testing hypotheses drug approvals. Despite challenges in authorizing generic therapies SARS-CoV-2, promptly granted Emergency Use Authorization patented agents. This study evaluated whether data yielded adequate to justify approval of compounds, like vitamin D, adjunct therapy combat SARS-CoV-2. Methods: We employed an ancient logic system, seamlessly integrated with modern scientific principles and artificial intelligence principles, analyze empirical from 7 papers published 2020. Subsequently, we compared results over 200 (including 100 treatment studies) referenced a large (big)database. aimed determine if there was substantial 2020 support agents such D (and ivermectin) treating COVID-19. Results: The process undervalues well-designed observational studies, placing them subordinate position when assessing effectiveness, even nutrients. Our utilization Catuskoti, innovative logical method, highlights its potential catalyst progress, including big analysis integrating into nutrient pharmaceutical processes. Conclusions: Analyses conducted within this framework affirmed robust inverse correlation between levels positive outcomes COVID-19 cases. Emphasizing broader adoption Catuskoti logic, particularly analyzing Machine Learning paradigms, becomes crucial approach aims mitigate harm individuals future pandemics by providing more comprehensive understanding relationships variables.

Language: Английский

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Calcifediol for Use in Treatment of Respiratory Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(12), P. 2447 - 2447

Published: June 13, 2022

Calcifediol is the prohormone of vitamin D endocrine system (VDES). It requires hydroxylation to move 1,25(OH)2D3 or calcitriol, active form that exerts its functions by activating receptor (VDR) expressed in many organs, including lungs. Due rapid oral absorption and because it does not require first hepatic hydroxylation, a good option replace prevalent deficiency (25 hydroxyvitamin D; 25OHD), which patients with respiratory pathologies are no strangers. Correcting 25OHD can decrease risk upper infections thus improve asthma COPD control. The same happens other and, particular, COVID-19. may be for raising serum levels quickly profile inflammatory cytokines exhibited diseases, such as asthma, COVID-19, increase degradation metabolites VDES. aim this narrative revision report current evidence on role calcifediol main diseases. In conclusion, status have beneficial effects clinical course This hypothesis should confirmed large, randomized trials. Otherwise, correction 25(OH)D useful disease.

Language: Английский

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Can vitamin D status influence seroconversion to SARS-COV2 vaccines?

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 19, 2022

Existing data indicate an association between vitamin D deficiency and increased severity of respiratory distress due to COVID-19 infection, especially in high-risk populations. To date, the effect on immunogenicity SARS-CoV-2 vaccines has been investigated solely young healthcare workers a few studies, yielding conflicting findings, yet highlighting that response immunization is inversely related age. Vitamin status can potentially influence antibody titers people with previous (or naïve) infection vaccination, given its role immune regulatory functions. From this standpoint, supplementation help reduce risk severity/mortality rebalance immunological function, particularly subjects vigorous T lymphocyte responses COVID-19. However, more research needed establish correlation generation protective serological vaccination.

Language: Английский

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Preoperative vitamin D level is significantly associated with hypocalcemia after total thyroidectomy

BMC Musculoskeletal Disorders, Journal Year: 2022, Volume and Issue: 23(1)

Published: Dec. 22, 2022

To evaluate the association of preoperative vitamin D levels with postoperative hypocalcaemia after total thyroidectomy.The medical records patients who underwent thyroidectomy between May 2020 and January 2022 had a documented serum 25-hydroxyvitamin (25-OHD) concentration were retrospectively reviewed. Vitamin categorized into four groups: <10 ng/mL (severe deficiency), 10-20 (vitamin 20-30 insufficiency), > 30 sufficiency). Multivariate logistic regression was performed to analyse risk controlling for potential confounding factors.A 196 included in this study. Of these, 47 (24.0%) 25-OHD < 10 ng/mL, 62 (31.6%) 51 (26.0%) remaining 36 (18.4%) ng/mL. The incidence hypocalcemia highest group severe deficiency (42.6% 23.4% laboratory symptomatic hypocalcaemia, respectively), followed by (29.0% 16.1%), insufficiency (19.6% 5.9%) sufficiency (5.6% 2.8%). indicated that odds 13.20 times (95% CI: 2.69-64.79, P 0.01) 6.32 1.32-30.28, = 0.02) greater than those sufficiency, respectively; while 10.18 1.14-90.86, 0.04) sufficiency.Preoperative (< 20 ng/mL), especially is an independent predictive factor thyroidectomy.

Language: Английский

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