Secoiridoid-Enriched Extra Virgin Olive Oil Extracts Enhance Mitochondrial Activity and Antioxidant Response in Colorectal Cancer Cells: The role of Oleacein and Oleocanthal in PPARγ Interaction

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 235, P. 56 - 72

Published: April 23, 2025

Language: Английский

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Plant-Based Diet and Supplements Reduced COVID-19 Severity and Mortality in Elderly Patients with Multiple Comorbidities (Part 2: Exploring the Underlying Mechanisms of Successful Intervention)

Published: March 4, 2024

Abstract: The potential advantages of plant-based interventions in decreasing the incidence and lessening severity mortality COVID-19 are yet to be widely acknowledged. Nevertheless, recent investigations propose that these could effective. Our publication (part one) features an interventional study which we incorporated foods provided supplementation 3470 elderly patients with multiple comorbidities. We pay close attention precise selection food items, application appropriate processing methods, provision nourishing meals our patients. outcome was highly successful as achieved a zero rate, none experienced worsening conditions or required hospitalization. This second paper presents theoretical framework on mechanisms through supplement can mitigate disease mortality. However, only very recently have experts validated hypotheses. measures methods used address ongoing SARS-CoV-2 pandemic supplements effective may help prevent manage future pandemics.

Language: Английский

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Extra Virgin Olive Oil Phenolic Compounds: Modulating Mitochondrial Function and Protecting Against Chronic Diseases—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1443 - 1443

Published: April 25, 2025

Background: Extra virgin olive oil (EVOO), an essential element of the Mediterranean diet (MedDiet), has demonstrated considerable potential in improving mitochondrial health and protecting against chronic diseases. This narrative review aims to explore how main phenolic compounds found EVOO—hydroxytyrosol, oleuropein, oleocanthal—contribute by reducing oxidative stress inflammation. Methods: A search for scientific evidence was carried out between October 2024 March 2025 different bibliographic databases such as PubMed, Web Science, Embase, SciSpace, ResearchRabbit databases. The strategy included combinations terms “extra oil”, “EVOO polyphenols”, “mitochondrial function”, “oxidative stress”, “inflammation”, “mitophagy”, “chronic diseases”. Preclinical, clinical, mechanistic studies were included, giving priority peer-reviewed publications. Results: shows some bioactive components EVOO activate cellular pathways, mTOR, AMPK sirtuins, which promote biogenesis, improve efficiency electron transport chain, protect DNA integrity. Furthermore, improves membrane fluidity integrity, ensuring its functionality efficiency. On other hand, nutrition literacy, important component health, is a critical determinant people’s eating behaviors. Conclusions: Although recent supports metabolic benefits on metabolism function, further nutritional intervention with these are recommended confirm their clinical relevance dietary tool aimed at preventing and/or delaying age-related

Language: Английский

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Features of a Balanced Healthy Diet with Cardiovascular and Other Benefits

Current Vascular Pharmacology, Journal Year: 2023, Volume and Issue: 21(3), P. 163 - 184

Published: March 28, 2023

Cardiovascular (CV) disease (CVD) remains the leading cause of death globally. Besides lack exercise, obesity, smoking, and other risk factors, poor nutrition unhealthy/ unbalanced diets play an important role in CVD.This review examined data on all issues CV-health benefits a balanced diet, with tabulation nutritional health-authority recommendations pictorial illustration main features CV-healthy diet.PubMed Google Scholar were searched for relevant studies reviews diet CV health.For long time, there has been evidence, corroborated by recent findings, that pro-vegetarian have beneficial influence serum lipid levels, markers inflammation endothelial function, prooxidant-antioxidant balance, gut microbiome, probably contributing to reduced risk. Worries about adequacy vegetarian are circumvented obtaining certain nutrients lacking or found lower amounts plants than animal foods, consuming wide variety healthy plant foods through intake oral supplements fortified foods. Well-balanced diets, such as Mediterranean Dietary-Approaches-to-Stop-Hypertension provide benefits. Nevertheless, broad plant-based low/minimal food may allow personalized culturally adjusted application dietary maintenance health.Universal adoption can reduce global, mortality ~20%. This requires world-wide programs information education public, starting school children expanding groups, sectors, levels.

Language: Английский

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Cross‐sectional analysis of healthy individuals across decades: Aging signatures across multiple physiological compartments

Aging Cell, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 23, 2023

Abstract The study of age‐related biomarkers from different biofluids and tissues within the same individual might provide a more comprehensive understanding changes between compartments as these are likely highly interconnected. Understanding differences by may shed light on mechanism their reciprocal interactions, which contribute to phenotypic manifestations aging. To such possible we carried out targeted metabolomic analysis plasma, skeletal muscle, urine collected healthy participants, age 22–92 years, identified 92, 34, 35 age‐associated metabolites, respectively. metabolic pathways that were across included inflammation cellular senescence, microbial metabolism, mitochondrial health, sphingolipid lysosomal membrane permeabilization, vascular aging, kidney function.

Language: Английский

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