NAD+ Homeostasis and NAD+-Consuming Enzymes: Implications for Vascular Health

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 376 - 376

Published: Feb. 4, 2023

Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that takes part in many key redox reactions. NAD+ biosynthesis and NAD+-consuming enzymes have been attracting markedly increasing interest since they demonstrated to be involved several crucial biological pathways, impacting genes transcription, cellular signaling, cell cycle regulation. As consequence, pathological conditions are associated with an impairment of intracellular levels, directly or indirectly, which include cardiovascular diseases, obesity, neurodegenerative cancer, aging. In this review, we describe the general pathways starting from different precursors, analyzing actual state-of-art administration precursors blocking NAD+-dependent as strategies increase levels counteract decline ageing. Subsequently, focus on disease-related age-related alterations homeostasis endothelium consequent vascular dysfunction, significantly contributes wide group disorders.

Language: Английский

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The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update

Advances in Nutrition, Journal Year: 2023, Volume and Issue: 14(6), P. 1416 - 1435

Published: Aug. 23, 2023

The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well recognized. As the NAD+ concentration skin, blood, liver, muscle and brain are thought to decrease with age, finding ways increase status could possibly influence ageing process associated metabolic sequelae. Nicotinamide mononucleotide (NMN) a precursor for biosynthesis, vitro/in vivo studies have demonstrated that NMN supplementation increases mitigate ageing-related disorders such as oxidative stress, DNA damage, neurodegeneration inflammatory responses. promotion an anti-ageing health supplement has gained popularity due findings; however, since most evaluating effects been conducted cell or animal models, concern remains regarding safety physiological population. Nonetheless, dozen clinical trials currently underway. This review summarizes current progress these NMN/NAD+ biology clarify potential shed light on future study directions.

Language: Английский

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Roseburia hominis improves host metabolism in diet-induced obesity

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 20, 2025

Next-generation live biotherapeutics are promising to aid the treatment of obesity and metabolic diseases. Here, we reported a novel anti-obesity probiotic candidate, Roseburia hominis, that was depleted in stool samples obese subjects compared with lean controls, its abundance negatively correlated body mass index serum triglycerides. Supplementation R. hominis prevented weight gain disorders glucose lipid metabolism, fatty liver, inhibited white adipose tissue expansion brown whitening mice fed high-fat diet, boosted lean-related species. The effects could be partially attributed production nicotinamide riboside upregulation Sirtuin1/mTOR signaling pathway. These results indicated is candidate for development next-generation prevention

Language: Английский

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Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6078 - 6078

Published: Aug. 15, 2023

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is involved in an extensive spectrum human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes. Further, healthy aging longevity appear to be closely related NAD+ its metabolites, riboside (NR) mononucleotide (NMN). As a dietary supplement, NR appears well tolerated, having better pharmacodynamics greater potency. Unfortunately, reactive molecule, often unstable during manufacturing, transport, storage. Recently, work prebiotic chemistry discovered borate considerably more stable than itself. However, immediately upon consumption, dissociates from lost body through dilution binding other species, notably carbohydrates such as fructose glucose. The left behind expected behave pharmacologically ways identical This review provides comprehensive summary (through Q1 2023) literature makes case for consumption supplement. It then summarizes challenges delivering quality consumers using standard synthesis, manufacture, shipping, storage approaches. concludes by outlining advantages these processes.

Language: Английский

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A critical review of synthetic novel foods within the European regulation: proposed classification, toxicological concerns and potential health claims

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: Jan. 14, 2025

The NF concept was first established by Regulation (EC) 258/97 and includes any food that has not been used to a significant extent for human consumption in the EU before 15 May 1997. Synthetic novel foods (SNF) are currently undefined group of without universal definition. objectives this work perform an analysis those authorized EU, identify their potential adverse effects health benefits, claims. For that, extensive review available legislative documents scientific literature regarding SNF performed, market performed commercial availability. This considers as obtained chemical synthesis, excluding genetically modified foods. A total 29 were identified classified into 9 categories, risks benefits described. All considered safe different studied suggested various categories. Currently, 22 on market. characterizes previously unexplored expands knowledge new promising research area combining toxicological perspectives with legislation more optimal risk management EU.

Language: Английский

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Nicotinamide riboside alleviates sweeteners-induced brain and cognitive impairments in immature mice

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nicotinamide riboside alleviated cognitive impairment induced by sucrose/aspartame, which might be related to neuroinflammation, pyroptosis, oxidative stress, apoptosis and autophagy.

Language: Английский

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The Application of Nicotinamide Coenzyme Precursors in Health Food

Published: Jan. 1, 2025

Language: Английский

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Microalgae and exercise: from molecular mechanisms and brain health to clinical perspectives in the context of 3P medicine

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(2), P. 1291 - 1307

Published: Feb. 1, 2024

Changes in intracellular nicotinamide adenine dinucleotide (NAD+) levels have been observed various disease states. A decrease NAD+ has noted following spinal cord injury (SCI). Nicotinamide riboside (NR) serves as the precursor of NAD+. Previous research demonstrated anti-inflammatory and apoptosis-reducing effects NR supplements. However, it remains unclear whether exerts a similar role mice after SCI. The objective this study was to investigate impact on these changes mouse model Four groups were considered: (1) non-SCI without (Sham), (2) with (Sham +NR), (3) SCI (SCI), (4) (SCI + NR). Female C57BL/6J aged 6–8 weeks intraperitoneally administered 500 mg/kg/day for duration one week. supplementation resulted significant elevation tissue In comparison group, exhibited regulatory chemotaxis/recruitment leukocytes, leading reduced inflammatory factors such IL-1β, TNF-α, IL-22 injured area. Moreover, notably enhanced survival neurons synapses within area, ultimately resulting improved motor functions Therefore, our findings that had inhibitory leukocyte chemotaxis, effects, could significantly improve immune micro-environment SCI, thereby promoting neuronal enhancing recovery showed promise potential clinical treatment strategy

Language: Английский

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Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Nicotinamide adenine dinucleotide (NAD+) is essential in the proper function of many cellular processes human body. The purpose this review to investigate effect nicotinamide mononucleotide (NMN), a NAD+ precursor, on physical performance and evaluate safety profile supplementation. A systematic search criteria following guidelines from Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) was performed four databases randomized controlled trials NMN Study variables included title, author, publication date, study year, number patients, dosage, mean age, follow-up time, pre- post-intervention reported outcomes, rates complications. Ten studies, including 437 with age 58.0 years (35.1 81.1 years) time 9.6 weeks (4 12 weeks) were study. dosages ranged 150 1200 mg/day. Mean pre-intervention grip strength (two studies) skeletal mass index 29.9 kilograms (kg) (range: 21.4-40.1 kg) 7.4 kg/m2 6.9-7.65 kg/m2), respectively. 30.5 kg 21.7-41.9 (6.8-7.64 There no serious adverse effects observed. Moreover, side effects, they determined be independent Therefore, patients taking supplementation demonstrated non-significantly improved parameters. well tolerated

Language: Английский

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