The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

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A comprehensive examination of the evidence for whole of diet patterns in Parkinson's disease: a scoping review

Nutritional Neuroscience, Journal Year: 2023, Volume and Issue: 27(6), P. 547 - 565

Published: July 10, 2023

Both motor and non-motor symptoms of Parkinson's disease (PD), a progressive neurological condition, have broad-ranging impacts on nutritional intake dietary behaviour. Historically studies focused individual components, but evidence demonstrating ameliorative outcomes with whole-of-diet patterns such as Mediterranean Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) is emerging. These diets provide plenty antioxidant rich fruits, vegetables, nuts, wholegrains healthy fats. Paradoxically, the ketogenic diet, high fat very low carbohydrate, also proving to be beneficial. Within PD community, it well advertised that associated progression symptom severity understandably, messaging inconsistent. With projected prevalence estimated rise 1.6 million by 2037, more data regarding impact needed develop diet-behaviour change programmes clear advice management. Objectives Methods: this scoping review both peer-reviewed academic grey literatures are determine current evidence-based consensus best practice in ascertain whether literature aligns. Results Discussion: The from was MeDi/MIND whole diet pattern (fresh fruit, wholegrains, omega-3 fish olive oil) improving outcomes. Support KD emerging, further research long-term effects. Encouragingly, mostly aligned nutrition rarely forefront. importance needs greater emphasis literature, positive approaches management day-to-day symptoms.

Language: Английский

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The influence of gut microbiota on circulating inflammatory cytokines and host: A Mendelian randomization study with meta-analysis

Life Sciences, Journal Year: 2023, Volume and Issue: 332, P. 122105 - 122105

Published: Sept. 21, 2023

Language: Английский

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Gut-brain-crosstalk- the vagus nerve and the microbiota-gut-brain axis in depression. A narrative review

Journal of Affective Disorders Reports, Journal Year: 2023, Volume and Issue: 13, P. 100607 - 100607

Published: June 7, 2023

This narrative review summarizes key aspects of vagus nerve function as a main player in the microbiota-gut-brain axis depression. Gut microbes well their metabolites signal directly to via specialized enteroendocrine cells called "neuropods". Some gut microbes, such Lactobacillus rhamnosus, do not exhibit anti-anxiety effects animal models when is cut. Furthermore, correlates with microbiota diversity, and short-chain fatty acid producers, Lactobacillales Ruminococcaceae, are more abundant individuals better function. The activated by several neurotransmitters produced regulates cholinergic anti-inflammatory pathway (CAIP), which attenuates inflammation decreases intestinal permeability, may be relevant inflammatory subtype Psychobiotics, pre-, pro synbiotics, on behavior, work nerve, could used enhance its More research microbiome interactions necessary develop targeted psychobiotics improve for optimal mental health.

Language: Английский

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Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 4, 2024

Abstract The tetracycline transactivator (tTA) system provides controllable transgene expression through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment for control in mouse models disease might have undesirable systemic effects resulting from changes gut microbiome. Here we assessed impact doxycycline on microbiome diversity a tTA-controlled model Alzheimer’s and then examined neuroimmune these alterations following acute LPS challenge. We show that decreased both transgenic wild-type mice persisted long after drug withdrawal. Despite change composition, had minimal effect basal transcriptional signatures inflammation brain or response to Our findings suggest central responses may be less affected by at doses needed than cocktails used experimental disruption.

Language: Английский

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Milmed Yeast Alters the LPS-Induced M1 Microglia Cells to Form M2 Anti-Inflammatory Phenotype

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3116 - 3116

Published: Dec. 2, 2022

Microglial cells polarized towards a proinflammatory phenotype are considered the main cellular players of neuroinflammation, underlying several neurodegenerative diseases. Many studies have suggested that imbalance gut microbial composition is associated with an increase in pro-inflammatory cytokines and oxidative stress underlie chronic neuroinflammatory diseases, perturbations to microbiota were detected conditions such as Parkinson's disease Alzheimer's disease. The importance gut-brain axis has been uncovered relevance appropriate balance highlighted. Probiotic treatment, rebalancing microbioma, may reduce inflammation. We show Milmed yeast, obtained from S. cerevisiae after exposure electromagnetic millimeter wavelengths, induces reversal LPS-M1 microglia anti-inflammatory phenotype, demonstrated morphologically by recovery resting microglia, decrease mRNAs IL-1β, IL-6, TNF-α expression iNOS. Moreover, stimulated secretion IL-10 Arginase-1, cell markers M2 cells. present findings data suggest be probiotic diversified activity, capable directing polarization microglial

Language: Английский

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Psychobiotic potential of Lactiplantibacillus plantarum: Current perspective in neurodegeneration and geriatric therapies

Brain Behavior and Immunity Integrative, Journal Year: 2023, Volume and Issue: 5, P. 100038 - 100038

Published: Dec. 9, 2023

Management of neurodegenerative disease can be challenging when there is limited access to effective treatment options. Recent studies indicate that human gut microbiota may influence diseases and the aging process. Gut dysbiosis one exacerbating factors associated with interrupted gut-brain axis diseases. According preclinical evidence, targeting by probiotic Lactiplantibacillus plantarum (LBP) a promising approach improve altered several hallmarks. LBP has been popular model but its psychobiotic potential little understood so far. modulate maintain intestinal homeostasis, resulting in induced levels SCFAs, GABA, other neurotransmitter. LBP-associated signaling agents induce (GBA) stimulate intracellular antioxidant anti-inflammatory pathways nerve cells. LBP-based supplements reduce various hallmarks such as β-amyloid formation, tau phosphorylation, microgliosis, infiltrated blood-brain barrier, neuroinflammation, morphology grey matter animal models Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease. This review suggests an important agent perturbed administration enhance existed treatment, especially geriatric conditions.

Language: Английский

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The gut metabolome in a cohort of pregnant and lactating women from Antioquia-Colombia

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: May 13, 2024

Nutrition during the perinatal period is an essential component of health and one that can severely impact correct development a human being its overall condition, in all subsequent stages life. The availability several compounds, mainly macronutrients micronutrients, plays key role balanced nutrition both mother baby process with direct relation to gut microbiome. Thus, we hereby refer set small molecules derived from microbiome metabolism as metabolome. These continuous processes occurring gestating or lactating related microbial communities nutrients, be revealed by metabolomics. In this study, explore for first time metabolome pregnant women, our region Antioquia-Colombia, applying untargeted metabolomics LC-QTOF-MS, molecular networking. Regarding composition cohort, found, metabolites used biomarkers function, metabolic health, dietary intake, pharmacology, lifestyle. women evidenced significantly higher abundance prostaglandins, alkaloids, corticosteroids, organosilicons, natural toxins, while lipids stand out. Our results suggest unveiling phenotype individual, metabolomics, allows broad visualization chemical space present important niche enables recognition influential indicators host’s status habits, especially significant period. This study constitutes evidence use LC-QTOF-MS coupled networking analysis, Colombian cohort establishes methodology finding relative abundances metabolites, potential nutritional physiological state assessments, future personalized practices.

Language: Английский

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Microbiome Dysbiosis Shows Strong Association of Gut-Derived Altered Metabolomic Profile in Gulf War Chronic Multisymptom Illness Symptom Persistence Following Western Diet Feeding and Development of Obesity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4245 - 4245

Published: Feb. 20, 2023

The pathophysiology of Gulf War Illness (GWI) remains elusive even after three decades. persistence multiple complex symptoms along with metabolic disorders such as obesity worsens the health present (GW) Veterans often by interactions host gut microbiome and inflammatory mediators. In this study, we hypothesized that administration a Western diet might alter metabolomic profile, which is likely associated altered bacterial species. Using five-month symptom GWI model in mice whole-genome sequencing, characterized species-level dysbiosis global metabolomics, heterogenous co-occurrence network analysis, to study bacteriome-metabolomic association. Microbial analysis at species level showed significant alteration beneficial beta diversity profile distinct clustering due diet, metabolites lipid, amino acid, nucleotide, vitamin, xenobiotic metabolism pathways. Network novel associations biochemical pathways could be used biomarkers or therapeutic targets ameliorate GW Veterans.

Language: Английский

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Emerging trends and focus of research on the relationship between traumatic brain injury and gut microbiota: a visualized study

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 3, 2023

Background Traumatic brain injury (TBI) is one of the most serious types trauma and imposes a heavy social economic burden on healthcare systems worldwide. The development emerging biotechnologies uncovering relationship between TBI gut flora, flora as potential intervention target increasing interest to researchers. Nevertheless, there paucity research employing bibliometric methodologies scrutinize interrelation these two. Therefore, this study visualized based methods reveal trends hotspots in field. ultimate objective catalyze progress preclinical clinical evolution strategies for treating managing TBI. Methods Terms related microbiota were combined search Scopus database relevant documents from inception February 2023. Visual analysis was performed using CiteSpace VOSviewer. Results From September 1972 2023, 2,957 published 98 countries or regions analyzed. number studies has risen exponentially, with United States, China, Kingdom being representative publishing fields. Research formed strong collaborations around highly productive authors, but relative lack international cooperation. area mainly high-impact journals field neurology. “intestinal its metabolites,” “interventions,” “mechanism action” “other diseases associated traumatic injury” are promising valuable sites. Targeting elucidate mechanisms course develop precisely targeted interventions management comorbidities great significant direction Conclusion findings suggest that close attention should be paid TBI, especially interaction, mechanisms, interventions, treatment comorbidities. Further investigation needed understand causal specific “brain-gut microbial axis.”

Language: Английский

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