Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder DOI Open Access

Mălina Visternicu,

Viorica Rarinca,

Vasile Burlui

et al.

Published: July 25, 2024

Attention deficit hyperactivity disorder (ADHD) is the most common childhood-onset neurodevelopmental characterized by difficulty maintaining attention, impulsivity and hyperactivity. Although cause of this still unclear, recent studies state that heredity important in development ADHD. This linked to a few comorbidities: depression, criminal behavior anxiety. genetic factors play major role pathogenesis ADHD, there are also non-genetic factors, one which would be oxidative stress (OS) associated with OS implicated through lower levels antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), well total status (TOS) compared control groups. Moreover, close bidirectional connection between nervous system intestinal microbiota, communication two systems carried out gut-brain axis (GBA). A thorough review diet, implications, mechanism action, pharmacokinetics, drug-drug interactions reviewed here, special focus on treatment adults comorbid conditions.

Language: Английский

Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study DOI Creative Commons
Meritxell Rojo-Marticella, Victoria Arija, Josefa Canals

et al.

Research on Child and Adolescent Psychopathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract The aim of this study is to investigate the impact using probiotics with strains related dopamine and gamma-aminobutyric acid production on clinical features autism spectrum disorder (ASD) and/or attention deficit/hyperactivity (ADHD). This randomized, controlled trial involved 38 children ADHD 42 ASD, aged 5–16 years, who received ( Lactiplantibacillus plantarum Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed Conners' 3rd-Ed Social Responsiveness Scale Test, 2nd-Ed (SRS-2), completed Conners Continuous Performance (CPT 3) Kiddie CPT, (K-CPT 2). Executive functions, quality life sleep patterns also parent-assessed. Intention-to-treat analyses, controlling sociodemographic nutritional covariates, revealed no significant inter-group differences in parent-reported neuropsychological data after probiotic intervention. However, age-stratified analyses showed improved hyperactivity-impulsivity younger ASD (Cohen’s d = 1.245) 0.692). Intra-group supported these findings aforementioned age intervention group both diagnoses. An improvement impulsivity was observed intra-group analysis CPT commissions scores (probiotic: p 0.001, Cohen’s -1.216; placebo: 0.013, -0.721). A better comfort score (quality life) shown 0.010, 0.722; 0.099, 0.456). used, may improve or/and ASD. Further research warranted explore as an adjunctive therapeutic NDs. Trial registration: clinicaltrials.gov Identifier: NCT05167110.

Language: Английский

Citations

1
Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review DOI Creative Commons

Federica Cernigliaro,

Andrea Santangelo, Rosaria Nardello

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1084 - 1084

Published: Aug. 29, 2024

According to the DSM-5, neurodevelopmental disorders represent a group of heterogeneous conditions, with onset during developmental period, characterized by an alteration communication and social skills, learning, adaptive behavior, executive functions, psychomotor skills. These deficits determine impairment personal, social, scholastic, or occupational functioning. Neurodevelopmental are increased incidence multifactorial etiology, including genetic environmental components. Data largely explain role factors, also through epigenetic modifications such as DNA methylation miRNA. Despite nutritional factors play significant in pathophysiology these disorders, both prenatal postnatal underscoring that control modifiable could decrease disorders. The preventive nutrition is widely studied regards many chronic diseases, diabetes, hypertension, cancer, but actually we know effects on embryonic brain development influence preconceptional predisposition various pathologies. not limited only correct caloric intake good BMI, rather adequate balanced macro micronutrients, type diet, other elements exposure heavy metals. This review represents analysis literature physiopathological mechanisms which food influences our state health, especially age (from birth adolescence), changes, underlying how controlling should improve mothers' significantly reduce risk offspring. We searched key words "maternal disorders" Pubmed Google Scholar, selecting main reviews excluding individual cases. Therefore, nutrigenetics nutrigenomics teach us importance personalized for health. So future perspectives may include well-established reference values order mothers integration.

Language: Английский

Citations

6
Role of Vitamins and Nutrients in the Management of Attention-Deficit Hyperactivity Disorder (ADHD): A Narrative Review DOI Creative Commons
Rehab El-Sayed, Eman Alamri, Mohamed H. El‐Sayed

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 1, 2025

Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric that affects individuals across all age groups, including children, adolescents, and adults. The ADHD etiology encompasses lack of several nutrients food compositions. Some applied strategies, such as increased intake specific nutrients, were proposed additional therapy for this condition. In our narrative review, we explored the relationship between dietary patterns by searching through “Google Scholar, Scopus, PubMed” relevant studies. This review sheds light on connection provides concise summary about practicing these therapies. Several studies reported unhealthy eating habits positively correlated with ADHD, while healthy showed negative correlation. Furthermore, there potential association deficiency in certain magnesium, iron, zinc, polyunsaturated fatty acids, vitamin D. However, despite promising nature modifications strategies managing need more robust scientific evidence to validate their effectiveness highly recommended.

Language: Английский

Citations

0
The Multidimensional Dynamic Feedback Model: A Comprehensive Framework for Understanding and Managing Attention-Deficit/Hyperactivity Disorder DOI Creative Commons
Yuying Wang, Yuan Zhao, Luming Hu

et al.

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 303 - 303

Published: Feb. 27, 2025

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental characterized by persistent inattention, hyperactivity, and impulsivity. These symptoms can significantly impact academic performance, social interactions, daily activities, often creating cycles that worsen long-term challenges. This review introduces the Multidimensional Dynamic Feedback Model (MDFM), which aids in understanding ADHD’s development guiding intervention strategies. The model emphasizes dynamic interactions among genetic, environmental, cognitive, behavioral factors. MDFM consists of three key aspects: (1) interplay between genetic environmental factors shaping biological basis, (2) role cognitive neural processes driving core symptoms, (3) influence feedback loops reinforce negative behaviors hinder adaptation. highlights importance personalized interventions effective systems, including early prevention, supportive family school environments, cultural backgrounds on treatment outcomes. As comprehensive framework, offers holistic perspective for clinicians, aiming to enhance outcomes promote health well-being individuals with ADHD across lifespan. By addressing implementation challenges, seeks improve prevention management, ultimately supporting their communities.

Language: Английский

Citations

0
Behandlung der ADHS bei Erwachsenen DOI

Alexandra Philipsen,

Marie-Christin Atzor

DNP – Die Neurologie & Psychiatrie, Journal Year: 2025, Volume and Issue: 26(2), P. 27 - 31

Published: April 1, 2025

Citations

0
Plant-based fat supply is associated with reduced ADHD disease burden DOI Creative Commons
Duan Ni, Alistair M. Senior, David Raubenheimer

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 2, 2024

Abstract Objectives Attention-Deficit/Hyperactivity Disorder (ADHD) is emerging as a major neurodevelopmental disorder on global scale, affecting both children and increasingly adult population. Its aetiology unclear but seems to involve genetic environmental factors, particularly diets nutrients. However, most studies so far only focused specific nutrients or dietary patterns, lacking systematic perspectives of their potential interactions, also neglecting other confounding factors like socioeconomic status. Thus, we aim systematically interrogate the association between nutrient supply, reflecting food exposure environment, status ADHD disease burden at level over time. Methods burden, macronutrient supply gross domestic product (GDP) were collated from more than 150 countries 1990 2018 analyzed with nutritional geometry generalized additive mixed models (GAMMs). Results Modelling results suggested interactive effects ADHD. Fat, especially plant-based fat associated decreased burden. These associations conserved across sexes ages not confounded by total energy supply. Conclusions Globally, far, seemed drive reduction which supported previous reports about amelioration ketogenic diets. Further in-depth are needed elucidate underlying mechanistic may inform future targeted interventions for prevention and/or treatment.

Language: Английский

Citations

3
The Role of Diet and the Gut Microbiota in Reactive Aggression and Adult ADHD—An Exploratory Analysis DOI Open Access
Babette Jakobi,

Chiara Cimetti,

Danique Mulder

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2174 - 2174

Published: July 9, 2024

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition, of-ten persistent into adulthood and accompanied by reactive aggression. Associations of diet the gut-microbiome with ADHD as well emotional behaviors suggest potential clinical rele-vance both. However, studies on in human aggression are lacking, should investigate interaction between leading to behavioral changes assess their relevance. In this study, we investigated gut-microbiota adult 77 adults 76 neurotypical individuals. We studied relationships ag-gression dietary patterns, bacterial community taxonomic differences 16S-sequenced fecal microbiome samples, mediating effects genus abundance signifi-cant diet-behavior associations. The key findings include: (1) An association high-energy intake aggeression scores (

Language: Английский

Citations

3
Serum Biomarker Analysis in Pediatric ADHD: Implications of Homocysteine, Vitamin B12, Vitamin D, Ferritin, and Iron Levels DOI Creative Commons
Tanja Lukovac,

Olivera Aleksić Hil,

Milka Popović

et al.

Children, Journal Year: 2024, Volume and Issue: 11(4), P. 497 - 497

Published: April 22, 2024

The current diagnosis of attention deficit hyperactivity disorder (ADHD) is based on history, clinical observation, and behavioral tests. There a high demand to find biomarkers for the ADHD. aim this study analyze serum profiles several biomarkers, including homocysteine (Hcy), vitamin B12, D, ferritin, iron, in cohort 133 male subjects (6.5–12.5 years), 67 individuals with an ADHD DSM-V criteria 66 age-matched healthy boys (healthy controls, HC). Assessments included Iowa Conners’ Teacher Rating Scale (CPRS) ADHDT test, as well cognitive assessments using Wechsler Intelligence Children-Revised (WISC-R) TROG-2 language comprehension test. Hcy iron were quantified spectrophotometry, while B12 total 25-hydroxy D levels determined electrochemiluminescence immunoassay (ECLIA) ferritin was measured particle-enhanced immunoturbidimetric assay. results showed significantly increased decreased patients compared HCs. Multiple logistic regression analysis indicated that potential prognostic indicator These suggest elevated may serve markers prognosis

Language: Английский

Citations

2
More than just a number: the gut microbiota and brain function across the extremes of life DOI Creative Commons
Nathan D. Nuzum, Clara Deady, Sarah Kittel‐Schneider

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 20, 2024

Understanding the interrelationship between gut microbiota and host physiology, although still in its relative infancy, has taken important steps forward over past decade. In context of brain disorders including those characterized by neurodevelopmental neurodegenerative changes there have been advances. However, initially research involved correlational analyses, had limited translational scope, lacked functional assessments. Thus, largescale longitudinal clinical investigations that assess causation underlying mechanisms via depth analysis methods are needed. neurodegeneration research, strong causal evidence now links microbiome to Alzheimer's (AD), Parkinson's Disease (PD), as supported human-to-animal transplantation studies. Longitudinal interventions being conducted AD, PD, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis. Neurodevelopmental also seen a boon microbiome-related autism, Attention-deficit/hyperactivity disorder, schizophrenia, which is confirming prior animal model work regarding key time-windows for infant cognition. While recent advances represent progress, fundamental knowledge gaps obstacles remain. Knowing how why at extremes life will develop our mechanistic understanding help build base we strive toward counteracting microbial missteps with precision therapeutic interventions.

Language: Английский

Citations

2
Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management DOI Open Access
Yaiza Tobajas, Marc Alemany-Fornés, Iris Samarra

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(14), P. 4666 - 4666

Published: July 13, 2023

Histamine intolerance occurs when there is an imbalance between histamine production and the capacity for degradation. Diamine oxidase (DAO) main enzyme catabolism of ingested degradation in gastrointestinal tract its deficiency has been linked to allergy-like symptoms. Psychostimulant drugs are commonly used treat Attention Deficit Hyperactivity Disorder (ADHD), but their interaction with DAO not well characterized. In this work, we evaluated effects psychostimulant (methylphenidate lisdexamfetamine) on vitro activity human cell line enterocytes (Caco-2), evaluating expression (mRNA protein) activity. Methylphenidate lisdexamfetamine did repress addition, Caco-2 cells, promoted a strong upregulation mRNA levels, whereas methylphenidate tended induce To sum up, treatments do reduce These findings could be useful physicians prescribing these two ADHD patients affected by deficiency.

Language: Английский

Citations

6