The potential of metformin in weight loss

Meditsinskiy sovet = Medical Council, Journal Year: 2025, Volume and Issue: 23, P. 130 - 136

Published: Jan. 22, 2025

Metformin, as a unique first-line antidiabetic drug, it may also be effective in the treatment of obesity and related metabolic disorders. In meta-analyses numerous RCTs obese persons with without type 2 diabetes mellitus metformin, decrease weight fat mass (≈ 3 kg), well blood lipids adiponectin was noted. Mechanisms metformin action for loss, dependent independent AMP-activated protein kinase (AMPK): enhancement mitochondrial biogenesis, reduction fatty acid uptake, due to suppression transforming growth factor-β1 (TGF-β1)/Smad3 signaling, modulation gut microbiota regulation number other signals – fructose-1.6-biphosphatase 1 (FBP1), phosphatase (PP2A), fibroblast factor 21 (FG F21), sirtuin (SIRT1), target rapamycin (mTOR), etc., lipogenic gene expression, which leads energy intake. However, there is conflicting evidence that has little effect on intake, body composition its varies depending gender, age, duration treatment, does not necessarily persist after stopped, significantly affect composition. Metformin worldwide Russian Federation yet been included list medications obesity. Comprehensive, adequately powered studies longer durations are needed further evaluate efficacy safety loss gain control.

Language: Английский

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Behavioral weight-loss interventions for patients with NAFLD: A systematic scoping review

Hepatology Communications, Journal Year: 2023, Volume and Issue: 7(8)

Published: Aug. 1, 2023

Background: Clinically significant weight loss—which requires sustained dietary and physical activity changes—is central to treating NAFLD. Although behavioral interventions have demonstrated effectiveness in promoting loss among primary prevention populations, the data are limited patients with NAFLD who need for treatment. We undertook this scoping review map existing on characteristics, weight-loss outcomes, determinants of success evaluated Methods: searched Medline, EMBASE, Cochrane, PsycINFO, Web Science from inception January 1, 2023 identify publications reporting adults interventions. summarized classified them as successful if there was an average ≥ 5% baseline across enrolled participants or achieved by 50% participants. Results: included 28 studies: 10 randomized control trials, ten quasi-experimental, 8 observational studies. Intervention delivery, duration, counseling frequency varied; 12 were successful. Retention highest telephone lowest “real-world” face-to-face Patients women, younger, and/or had multiple metabolic conditions most likely dropout. Successful biweekly counseling, specific activity, calorie targets, theory grounding, promoted goal-setting, self-monitoring, problem-solving. Conclusion: There Research is needed develop effective generalizable diverse patient populations that maximize adherence, particularly diabetic, younger.

Language: Английский

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Exploring the benefits and costs of a growth mindset in a digital app weight management program

Journal of Health Psychology, Journal Year: 2024, Volume and Issue: 29(11), P. 1181 - 1194

Published: Feb. 5, 2024

We explored the potential benefits and costs of believing one can change their weight (i.e. growth mindset) in context a digital management program. investigated mechanisms by which mindsets relate to loss achievement body shame. Among participants seeking lose ( N = 1626; 74.7% female; 77.9% White; M age 45.7), stronger indirectly predicted greater through positive offset expectations subsequent increased program engagement. Additionally, less shame but more onset responsibility, replicating double-edged sword model mindsets. conclude with applications that leverage for optimal behavior while mitigating such as

Language: Английский

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Influence of eHealth Literacy and Health Promotion Behavior on Body Mass Index of Workers in the Public Sector

SAGE Open Nursing, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 1, 2024

Adequate eHealth literacy and health promotion behavior (HPB) are important to achieve good health-related quality of life. There is limited information on the influence HPB body mass index (BMI) in our setting among public service workers.

Language: Английский

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The Effects of Providing a Connected Scale in an App-Based Digital Health Program: Cross-sectional Examination

JMIR mhealth and uhealth, Journal Year: 2023, Volume and Issue: 11, P. e40865 - e40865

Published: Jan. 19, 2023

Language: Английский

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Real-world evaluation of a digital Tier 2 Weight Management Service to residents of Cornwall living with obesity (Preprint)

Published: May 25, 2023

Obesity is a major global public health issue. In the United Kingdom, Cornwall considered one of most deprived areas with disproportionately higher rates overweight and obesity. This study examined demographics outcomes residents self-referred to precision digital app delivering Tier 2 Weight Management programme. The objective this was understand clinical characteristics living in (a remote area Kingdom mixed deprivation) who tool programme; evaluate effectiveness acceptability program reduce body weight single-arm intervention design, adults were or obese (Gro Health) that promotes accessible behaviour change self-management by providing evidence-based structured education, guided behavioural activities, weekly virtual meetups community support, tracking data-driven insights. Participant data collected at baseline follow-ups 12 26 weeks. 423 participants completed landing page, 408 (96.4%) eligible 404 (95.5%) downloaded Gro Health created an account. Overall had average age 49.1 years, BMI 36.3 kg/m2, 56% female 89% identifying as having white ethnicity. reported weeks loss 6.6 ± 0.1% (Week 0: 99.3 21.9 kg Week 26: 92.5 17.0). Participants high engagement acceptance app. A service provided care setting well accepted promoted clinically relevant loss.

Language: Английский

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The Impact of a Digital Weight Loss Intervention on Health Care Resource Utilization and Costs Compared Between Users and Nonusers With Overweight and Obesity: Retrospective Analysis Study

JMIR mhealth and uhealth, Journal Year: 2023, Volume and Issue: 11, P. e47473 - e47473

Published: July 12, 2023

The Noom Weight program is a smartphone-based weight management that uses cognitive behavioral therapy techniques to motivate users achieve loss through comprehensive lifestyle intervention.This retrospective database analysis aimed evaluate the impact of use on health care resource utilization (HRU) and costs among individuals with overweight obesity.Electronic record data, insurance claims data were used conduct analysis. study included 43,047 14,555 non-Noom aged between 18 80 years BMI ≥25 kg/m² residing in United States. index date was defined as first day 3-month treatment window during which at least once per week average. Inverse probability weighting balance sociodemographic covariates 2 cohorts. HRU for inpatient visits, outpatient telehealth surgeries, prescriptions analyzed.Within 12 months after date, had less (mean difference [MD] -US $20.10, 95% CI $30.08 $10.12), (MD $124.33, $159.76 $88.89), overall prescription $313.82, $565.42 $62.21), $450.39, $706.28 $194.50) user than users. In terms HRU, fewer visits -0.03, -0.04 -0.03), -0.78, -0.93 -0.62), surgeries -0.01, -0.01 0.00), -1.39, -1.76 -1.03) Among subset 24-month follow-up incurred lower $1139.52, $1972.21 $306.83) $1219.06, $2061.56 $376.55) key differences associated reduced use.Noom use, potential cost savings up US $1219.06 24 date. These findings suggest could be cost-effective obesity. This provides valuable evidence providers payers evaluating benefits digital interventions such Weight.

Language: Английский

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The Impact of a Digital Weight Loss Intervention on Health Care Resource Utilization and Costs Compared Between Users and Nonusers With Overweight and Obesity: Retrospective Analysis Study (Preprint)

Published: March 22, 2023

The Noom Weight program is a smartphone-based weight management that uses cognitive behavioral therapy techniques to motivate users achieve loss through comprehensive lifestyle intervention. This retrospective database analysis aimed evaluate the impact of use on health care resource utilization (HRU) and costs among individuals with overweight obesity. Electronic record data, insurance claims data were used conduct analysis. study included 43,047 14,555 non–Noom aged between 18 80 years BMI ≥25 kg/m² residing in United States. index date was defined as first day 3-month treatment window during which at least once per week average. Inverse probability weighting balance sociodemographic covariates 2 cohorts. HRU for inpatient visits, outpatient telehealth surgeries, prescriptions analyzed. Within 12 months after date, had less (mean difference [MD] −US $20.10, 95% CI $30.08 $10.12), (MD $124.33, $159.76 $88.89), overall prescription $313.82, $565.42 $62.21), $450.39, $706.28 $194.50) user than users. In terms HRU, fewer visits −0.03, −0.04 −0.03), −0.78, −0.93 −0.62), surgeries −0.01, −0.01 0.00), −1.39, −1.76 −1.03) Among subset 24-month follow-up incurred lower $1139.52, $1972.21 $306.83) $1219.06, $2061.56 $376.55) key differences associated reduced use. use, potential cost savings up US $1219.06 24 date. These findings suggest could be cost-effective provides valuable evidence providers payers evaluating benefits digital interventions such Weight.

Language: Английский

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Effects of a Digital Weight Management Service on adults with obesity living in Cornwall: a single-arm intervention trial (Preprint)

JMIR mhealth and uhealth, Journal Year: 2023, Volume and Issue: unknown

Published: May 25, 2023

Language: Английский

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