Nutrients,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1359 - 1359
Published: March 10, 2023
The
beneficial
effects
of
L-carnitine
on
non-alcoholic
fatty
liver
disease
(NAFLD)
were
revealed
in
previous
reports.
However,
the
underlying
mechanisms
remain
unclear.
In
this
study,
we
established
a
high
fat
diet
(HFD)-induced
NAFLD
mice
model
and
systematically
explored
dietary
supplementation
(0.2%
to
4%)
NAFLD.
A
lipidomics
approach
was
conducted
identify
specific
lipid
species
involved
ameliorative
roles
Compared
with
normal
control
group,
body
weight,
concentrations
TG
serum
AST
ALT
levels
dramatically
increased
by
HFD
feeding
(p
<
0.05),
accompanied
obvious
damage
activation
hepatic
TLR4/NF-κB/NLRP3
inflammatory
pathway.
treatment
significantly
improved
these
phenomena
exhibited
clear
dose-response
relationship.
results
analysis
showed
that
total
12
classes
145
identified
livers.
Serious
disorders
profiles
noticed
livers
HFD-fed
mice,
such
as
an
relative
abundance
decreased
PC,
PE,
PI,
LPC,
LPE,
Cer
SM
0.05).
contents
PC
PI
DG
after
4%
intervention
Moreover,
47
important
differential
notably
separated
experimental
groups
based
VIP
≥
1
p
0.05.
pathway
inhibited
glycerolipid
metabolism
activated
pathways
alpha-linolenic
acid
metabolism,
glycerophospholipid
sphingolipid
Glycosylphosphatidylinositol
(GPI)-anchor
biosynthesis.
This
study
provides
novel
insights
into
attenuating
AJP Gastrointestinal and Liver Physiology,
Journal Year:
2025,
Volume and Issue:
328(2), P. G110 - G124
Published: Jan. 21, 2025
Patients
who
were
less
inclined
to
have
olanzapine-induced
fatty
liver
had
different
gut
microbiota
profiles
than
did
those
in
the
susceptible
cohort.
Lachnospiraceae,
Ruminococcaceae,
Oscillospiraceae,
Butyricicoccaceae,
and
Christensenellaceae
enriched
patients
prone
disease
caused
by
olanzapine.
Fecal
treatment
(FMT)
with
these
fecal
samples
promoted
short-chain
acid
(SCFA)
production,
which
attenuated
circulating
leptin
inhibited
FASN
ACC1,
thereby
suppressing
lipid
synthesis
liver,
ultimately
leading
alleviation
of
hepatic
steatosis.
International Journal of Food Sciences and Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 11
Published: March 2, 2025
Seaweed-derived
dietary
fibre
sodium
alginate
(SA)
has
been
shown
to
present
with
health
benefits
in
food-derived
disease
models.
To
determine
whether
SA
improves
the
rather
than
merely
suppressing
its
progression,
we
assessed
effects
using
farnesoid
X
receptor
(FXR)-deficient
mice
provide
a
model
of
advanced
hyperlipidaemia.
Fxr-null
were
fed
5%
SA-supplemented
diet
for
nine
weeks
and
showed
significant
decreases
levels
liver
triglycerides
(p
<
0.05),
total
cholesterol
serum
low-density
lipoprotein-cholesterol
0.001).
The
expression
fatty
acid-synthesizing
genes
(Fas
Scd1)
cholesterol-metabolizing
(Hmgcr,
Hmgcs,
Abca1),
significantly
reduced.
Furthermore,
supplementation
altered
gut
microbiota
increased
abundance
genus
Oscillospira
0.001)
Parabacteroides
0.01).
These
results
suggest
that
lipid
disruption
influences
composition
mice.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19046 - e19046
Published: March 24, 2025
Diabetic
peripheral
neuropathy
(DPN)
is
a
significant
complication
of
diabetes
with
limited
effective
therapeutic
options.
Sodium
alginate
(SA),
natural
polysaccharide
from
brown
algae,
has
demonstrated
health
benefits,
however,
whether
it
can
treat
streptozotocin
(STZ)-induced
DPN
remains
unclear.
The
present
experiment
aimed
to
test
the
preventive
role
SA
on
STZ-induced
in
rats
and
explored
possible
mechanisms.
rat
model
was
established
by
intraperitoneal
injection
single
dose
40
mg/kg
b.w.
STZ,
(200
b.w./day)
orally
administered
for
28
days
after
type
2
mellitus
(T2DM)
induction.
obtained
findings
revealed
that
STZ
significantly
increased
serum
levels
FBG,
HOMA-IR,
TC,
TG,
VLDL-C,
LDL-C,
while
decreased
insulin,
incretin
GLP-1,
HDL-C,
lipase
activity.
In
sciatic
nerves,
proinflammatory
cytokine
(IL-1β,
IL-6,
TNF-α),
caspase-3
(a
pro-apoptotic
protein),
markers
oxidative
stress
(MDA
NO),
AGEs.
parallel,
induced
decline
activities
enzymatic
antioxidants,
viz.
,
SOD,
CAT,
GPx,
non-enzymatic
GSH.
These
changes
were
accompanied
low
expression
miR-146a
nerves
rats.
Except
treatment
injected
improved
these
parameters
helped
rescue
neurological
morphology
nerve
fibers.
conclusion,
mitigated
experimental
DPN,
this
might
be
due
its
ability
suppress
hyperglycemic-hyperlipidemic
effects,
counteract
overactivation
inflammatory
molecules,
increase
expression,
modulate
dysregulation,
reduce
cell
apoptosis.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 30, 2025
Fatty
acids
in
pork
are
involved
cellular
physiological
functions
and
related
to
meat
nutrition,
tenderness,
flavor.
Increasing
evidences
have
suggested
that
short-chain
fatty
produced
by
the
gut
microbiota
may
affect
host
metabolism
energy
utilization.
However,
association
between
long-chain
(LCFAs)
has
been
largely
unknown.
In
this
study,
microbial
compositions
of
243
cecum
content
samples
from
Erhualian
pigs
235
fecal
Bamaxiang
were
determined
high
throughput
16S
rRNA
gene
sequencing.
The
contents
12
LCFAs
longissimus
dorsi
(LD)
muscle
also
for
all
experimental
both
pig
populations.
We
systematically
evaluated
contribution
variations
acid
α
-diversity
microbiota,
co-abundance
groups
(CAGs)
Amplicon
Sequence
Variants
(ASVs),
acid-associated
bacterial
taxa.
identified
hundred
ASVs
>
40
taxa
significantly
associated
with
two
Different
numbers
specific
detected
luminal
samples,
suggesting
heterogeneity
LCFA-associated
locations.
uncovered
some
interesting
associations
contents.
strongest
was
observed
ASV
annotated
Akkermansia
n-6/n-3
polyunsaturated
ratio
(
p
=
6.45E-04,
Z
−9.65).
could
explain
1.47–4.62%
variation
twelve
acids.
functional
prediction
analysis
KEGG
pathways
metabolisms
carbohydrate
lipids,
fat
digestion
absorption
positively
adipocytokine
signaling
pathway
thermogenesis
negatively
results
study
provided
basic
knowledge
improving
regulating
microbiome.
Journal of Oleo Science,
Journal Year:
2024,
Volume and Issue:
73(5), P. 729 - 742
Published: Jan. 1, 2024
Astaxanthin
is
a
keto-based
carotenoid
mainly
obtained
from
marine
organisms,
like
Haematococcus
pluvialis
(H.
pluvialis).
Previous
studies
indicated
the
protective
effects
of
and
H.
on
aging
related
oxidative
injury
in
liver,
while
potential
mechanisms
are
largely
unknown.
In
addition,
residue
by-product
after
astaxanthin
extraction,
which
rarely
studied
utilized.
The
present
study
aimed
to
compare
astaxanthin,
oxidant
liver
D-galactose-induced
mice
explore
through
gut-liver
axis.
results
showed
that
all
three
supplements
prevented
tissue
injury,
stress
chronic
inflammation
improved
function.
Gut
microbiota
analysis
notably
increased
fecal
levels
Bacteroidetes,
unclassified_f__
Lachnospiraceae,
norank_f__Lachnospiraceae,
norank_f__norank_o__Clostridia_UCG-014,
Prevotellaceae_
UCG-001,
unclassified_f__Prevotellaceae
D-galactose-fed
(p
<
0.05).
Compared
mice,
group
had
higher
norank_f__Lachnospiraceae
Lachnospiraceae_UCG-006
displayed
relative
Streptococcus,
Rikenellaceae_RC9_gut_group
Moreover,
production
microbial
metabolites,
SCFAs
LPS
was
also
differently
restored
by
supplements.
Overall,
our
suggest
could
prevent
hepatic
gutliver
axis
provide
evidence
for
exploiting
as
functional
ingredient
treatment
diseases.
Future
needed
further
clarify
effect
mechanism
dominant
components
expected
reference
high-value
utilization
resources.
