Dietary nutrient intake and cancer presence: evidence from a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 1, 2025

Background While the role of specific nutrients in cancer is established, associations between comprehensive dietary nutrient intake and presence remain underexplored. This cross-sectional study investigates global profiles relation to solid blood cancers. Methods A total 42,732 mobile adults from National Health Nutrition Examination Survey (NHANES, 2001–2023) were enrolled this study. The potential intakes 34 4 common trace components with investigated by weighted logistic regression restricted cubic spline. Results Higher saturated fatty acid (OR = 1.1082, 95% CI: 1.0110–1.2146), β -carotene 1.0431, 1.0096–1.0777) vitamin K 1.0370, 1.0094–1.0654) was positively associated overall presence, while phosphorus 0.9016, 0.8218–0.9892) showed a protective association. For tumors, 1.1099), α 1.0353), 1.0484), 1.0405) exhibited positive associations. Retinol linked carcinoma 1.0935, 1.0222–1.1698). Dose–response analyses revealed linear relationships without non-linear thresholds. Conclusion Specific nutrients, notably fats, carotenoids, K, are increased whereas reduced presence. Due nature measurement after diagnosis, causal relationship could not be established. These findings underscore need for longitudinal studies establish causality inform interventions management.

Language: Английский

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Association between nutrition literacy and cognitive impairment among older adults in Bengbu, China

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: May 8, 2025

Background Cognitive impairment is a major public health concern. Nutrition literacy (NL) the capacity of an individual to make informed decisions about nutrition, which reflected in their eating behaviors and ultimately affects overall nutritional wellbeing. The association between NL cognitive unclear. Methods A cross-sectional study was conducted among individuals aged 60 years above. evaluated via validated NL-12 scale, identified simplified 30-item Chinese Mini-Mental State Examination scale. examined binary logistic regression. Results Of 1,344 participants, 30.3% had impairment. Compared with those lowest quartile, highest quartile lower likelihood experiencing [odds ratio (OR) = 0.12, 95% confidence interval (CI) 0.07–0.20]. This relationship extends dimensions knowledge, understanding, obtaining, interactive, critical skills. Moreover, negative Q4 group impairment, compared that corresponding Q1 group, significant regardless age, sex, exercise status, socioeconomic status. association, however, only evident older adults who exhibited healthy behavior. Additionally, behavior significantly moderated interaction p value 0.018. Conclusion Higher levels were associated odds adults, especially exhibiting healthier underscores importance enhancing as means mitigate adults. Future research should concentrate on examining interventions synergize lifestyle practices, ensuring seamless integration into daily routines address challenges effectively.

Language: Английский

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Vitamins in Gynecologic Malignancies

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1392 - 1392

Published: May 5, 2024

The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. use drug combinations, such as 9cUAB130 carboplatin cisplatin TAC-101, shows enhanced cytotoxic effects reductions ovarian tumor volume compared to single-drug treatments. Combining calcitriol progesterone increases VDR expression, potentially enhancing the effectiveness anticancer therapy cancer. treatment may vary depending on characteristics cell line from which it originated. An increase thiamine intake one unit is associated an 18% decrease HPV infection. Higher C by 50 mg/day linked a lower risk cervical neoplasia. Beta-carotene, C, E are 12%, 15%, 9% endometrial cancer, respectively. balanced daily vitamins important, both deficiency excess can influence cancer development. It has been observed that there U-shaped relationship between group B metabolic markers clinical

Language: Английский

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Review of the Potential Role of Ascorbate in the Prevention and Treatment of Gynecological Cancers

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 617 - 617

Published: May 19, 2024

Ascorbate (vitamin C) is an essential vitamin for the human body and participates in various physiological processes as important coenzyme antioxidant. Furthermore, role of ascorbate prevention treatment cancer including gynecological has gained much more interest recently. The bioavailability certain biological functions are distinct males versus females due to differences lean mass, sex hormones, lifestyle factors. Despite epidemiological evidence that ascorbate-rich foods plasma concentrations inversely related risk, not demonstrated a significant protective effect patients with cancers. Adequate intake may have potential reduce risk papillomavirus (HPV) infection high-risk HPV persistence status. High-dose exerts antitumor activity synergizes chemotherapeutic agents preclinical models cancer. In this review, we provide discuss ovarian, endometrial, cervical

Language: Английский

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Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(13), P. 2938 - 2938

Published: June 28, 2023

The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian and endometrial cancer. A wide spectrum their health-promoting properties such as antioxidant, anti-inflammatory, anticancer activities, been demonstrated. This paper analyzes the mechanisms action selected common flavonols, kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, morin, preclinical studies, with particular emphasis vitro studies gynecological cancers In future, these may find applications prevention treatment but this requires further, more advanced research.

Language: Английский

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Micro- and Macronutrients in Endometrial Cancer—From Metallomic Analysis to Improvements in Treatment Strategies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9918 - 9918

Published: Sept. 14, 2024

Endometrial cancer is reported to be one of the most prevalent cancers female reproductive organs worldwide, with increasing incidence and mortality rates over past decade. Early diagnosis critical for effective treatment. Recently, there has been a growing focus on role nutrition micronutrient macronutrient status in patients gynecologic cancers, including endometrial cancer. In following paper, we have conducted an in-depth narrative literature review aim evaluating results metallomic studies specifically concerning micro- The main objective paper was analyze regarding nutritional describe chosen elements onset progression carcinogenesis. Further, focused evaluation usage described potential treatment abovementioned cancer, as well possible prevention considering proper supplementation healthy individuals. Calcium proposed reduce risk although some offer conflicting evidence. Deficiencies phosphorus, selenium, zinc inversely associated risk, suggesting they may play protective role, whereas excessive levels iron, copper, cadmium positively correlated increased risk. However, molecular mechanisms by which these affect carcinogenesis are not fully understood, current findings often contradictory. Further research needed clarify relationships evaluate interventions

Language: Английский

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Folate intake and the risk of endometrial cancer: A dose–response meta-analysis

Medicine, Journal Year: 2024, Volume and Issue: 103(38), P. e39775 - e39775

Published: Sept. 20, 2024

The relationship between folate intake and risk of endometrial cancer (EC) is debatable. goal this study was to examine the consumption EC then conduct a dose-response analysis in accordance with this.

Language: Английский

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Environment and gynaecologic cancers

Oncology Reviews, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 8, 2024

In the current era, environmental factors are well established as major causative agents for all cancers especially lung and breast cancer. We sought to review available literature on topic pertaining gynaecologic cancers. Although a few in literature, others need more research conclude.

Language: Английский

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Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1567 - 1567

Published: Dec. 19, 2024

Background: Gynecological cancers, including ovarian, cervical, and endometrial significantly affect both survival reproductive health in women. Cancer treatments such as chemotherapy radiotherapy can impair ovarian function, reducing oocyte quality fertility potential. Objective: This review aims to evaluate how vitamins antioxidants enhance preservation outcomes for women diagnosed with gynecological particularly the context of assisted technologies (ART). Standard these hysterectomy, bilateral salpingo-oophorectomy, radiation, chemotherapy, often compromise function quality. focuses on potential role interventions improving quality, thereby supporting successful ART outcomes. Methods: A comprehensive narrative current literature was conducted, examining effects A, C, D3, E, Coenzyme Q10 oxidative stress inflammation induced by cancer its treatments. Results: The evidence suggests that certain may mitigate damage Vitamin supports cumulus–oocyte complex integrity, while C E act potent antioxidants, tissues. D3 enhances reserve markers modulates inflammatory cytokines. improves mitochondrial reduces DNA damage, increasing viability fertilization Conclusions: incorporation specific into strategies cancers. Although preliminary findings are promising, further research is needed determine optimal dosages establish standardized protocols clinical use.

Language: Английский

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Dietary vitamin D intake and the bladder cancer risk: A pooled analysis of prospective cohort studies

Clinical Nutrition, Journal Year: 2023, Volume and Issue: 42(8), P. 1462 - 1474

Published: May 23, 2023

Background & aimsDiet may play an essential role in the aetiology of bladder cancer (BC). Vitamin D is involved various biological functions which have potential to prevent BC development. Besides, vitamin also influences uptake calcium and phosphorus, thereby possibly indirectly influencing risk BC. The aim present study was investigate relation between intake risk.MethodsIndividual dietary data were pooled from ten cohort studies. Food item converted daily intakes D, phosphorus. Pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs) obtained using Cox-regression models. Analyses adjusted for gender, age smoking status (Model 1), additionally food groups fruit, vegetables meat 2). Dose–response relationships 1) examined a nonparametric test trend.ResultsIn total, 1994 cases 518,002 non-cases included analyses. showed no significant associations individual nutrient risk. A decreased observed high moderate low phosphorus 2: HRhigh vitD, mod Ca, P: 0.77, CI: 0.59–1.00). No dose–response analyses observed.ConclusionThe combination intake. highlights importance examining effect complementary nutrients assessment. Future research should focus on wider context nutritional patterns.

Language: Английский

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