Association between dietary trace minerals and pelvic inflammatory disease: data from the 2015–2018 National Health and Nutrition Examination Surveys

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 27, 2023

Objective Pelvic inflammatory disease (PID) is a prevalent gynecological disorder. Dietary trace minerals play an important role in combating many chronic diseases including PID. However, it unknown whether dietary and PID are related. This study aimed to examine the relationship between (copper, iron, selenium, zinc) Methods Data of women participants from National Health Nutrition Examination Survey (NHANES) 2015–2018 were enrolled this cross-sectional investigation. Univariate multivariate linear regression analyses performed, restricted cubic spline (RCS) applied visualize those relationships. Results In total, 2,694 ages 20 59 years participated two NHANES cycles. univariate analyses, significant negative was identified copper intake [odds ratio (OR) = 0.40, 95% confidence interval (CI): 0.24–0.67, p < 0.01] but not with iron (OR 0.96, CI: 0.90–1.03, 0.25), selenium 1.0, 0.99–1.0, 0.23), zinc 0.94, 0.86–1.03, 0.17) intake. Following adjustment for age race (model 1), robust correlation found 0.23, CI 0.09–0.61, 0.01), as indicated by fully adjusted model 2 0.29, 0.09–0.90, 0.03). Simultaneously, trend across quintile subgroups ( trends <0.05), suggesting relationship. Furthermore, RCS analysis demonstrated (overall 0.01, non-linear 0.09). Conclusion Decreased intakes linked additional research needed investigate due constraints design.

Language: Английский

---

Association of coffee and caffeine consumption with risk and prognosis of endometrial cancer and its subgroups: a Mendelian randomization

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 14, 2023

Background Previous studies have not established potential causal associations between coffee and caffeine consumption in endometrial cancer (EC) its subgroups. Therefore, we used a two-sample MR method to assess the association EC risk. We also evaluated these genetically predicted exposures prognosis. Materials methods This study 12 two independent single-nucleotide polymorphisms (SNPs) associated with as instrumental variables at genome-wide significance level of p < 5 × 10 –8 . The Association Consortium (ECAC) performed (GWAS) analysis 12,906 cases 108,979 controls. FinnGen GWAS 1,967 167,189 primary technique employed was inverse-variance weighted, followed by weighted median, MR-Egger regression, robust adjusted profile score methods. pleiotropy residual sum, Outlier test, regression pleiotropic variants. conducted sensitivity through leave-one-out method. Results Genetically subgroups ECAC, consistent consortium. After excluding eight SNPs confounding factors, analyses, delivering results. observed that correlated As confirmed analysis, selected determined most do significantly impact likelihood developing EC. Conclusion Our indicated no convincing evidence supports causing or impacting More are needed validate

Language: Английский

---

Relationship between human papillomavirus and serum vitamin D levels: a systematic review

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 13, 2024

Abstract Background Human papillomavirus (HPV) is one of the most prevalent sexually transmitted diseases worldwide. The present review was conducted to accumulate evidence on relationship between cervicovaginal human infection and serum vitamin D status. Methods Electronic databases including Web Science, Embase, Scopus, PubMed were searched by different combinations keywords related “human papillomavirus” “vitamin D”, obtained from Mesh Emtree with AND, OR operators without any time restriction until December 24, 2022. Selection articles based inclusion exclusion criteria. Newcastle-Ottawa Scale used for quality assessment. Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) checklist applied reporting. Results In total, 276 citations retrieved. After removing duplicates, non-related articles, full texts 7 reviewed 11168 participants. Three studies reported that there a positive deficiency while three did not. One study showed significant association higher stores short-term high-risk persistence. Conclusions findings no firm level infection, although possible could not be discarded. Further investigations are needed reach sound evidence.

Language: Английский

---

Galangin promotes apoptosis by upregulating the pro-apoptotic gene BAX in triple-negative breast cancer

Journal of the Egyptian National Cancer Institute, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 20, 2024

Abstract Background Triple-negative breast cancer (TNBC) is one of the most aggressive and formidable subtypes cancer, devoid targeted therapy frequently leading to unfavorable prognoses significant side effects. The demand for creative effective treatment options has prompted current study investigate potential natural chemicals as therapeutic agents. This intends examine efficacy Galangin, a naturally occurring flavonoid, in treating triple-negative cancer. Methods research utilizes dual methodology, combining silico network pharmacology with vitro experimental methods. proved crucial finding gene targets cellular signaling pathways influenced by Galangin To corroborate these computational predictions, variety studies were conducted, including MTT assay, wound scratch apoptosis reactive oxygen species mitochondrial membrane assessment, RT-PCR. Results Fifteen prevalent genes identified, demonstrating involvement proliferation, regulation, cell migration, MAPK cascade cycle regulation. predominant implicated ten principal MAPK1, MAPK8, MAPK14, IL6, which observed be linked pathway, perhaps serving critical channel through may facilitate oral In experiments demonstrated anti-proliferative effects, late-stage apoptosis, anti-migratory characteristics, antioxidant activity, upregulation pro-apoptotic BAX gene. Conclusion study’s results demonstrate that possesses considerable effects on TNBC cells, underscoring its viable drug. These findings development more precisely focused approaches TNBC, providing optimism enhanced outcomes patients suffering from this challenging disease.

Language: Английский

---

Study of Serum Copper and Zinc Levels and Serum Cu/Zn Ratio among Polish Women with Endometrial Cancer

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 144 - 144

Published: Dec. 31, 2023

Background: Micronutrients are important components for the homeostasis of human body. The studies available in literature subject on their impact risk population diseases, including malignant neoplasms, ambiguous. In this paper, relationship between Cu and Zn serum levels occurrence endometrial cancer have been analyzed. Methods: 306 patients (153 test group 153 control group) matched age were analyzed levels. Microelements determined sera collected during hospitalization by means an inductively coupled plasma mass spectrometry. addition, Cu/Zn ratio included study was Univariable multivariable analyzes used to examine factors under incidence cancer. Results: Lower elements observed compared with (Cu: 959.39 μg/L vs. 1176.42 μg/L, p < 0.001; Zn: 707.05 901.67 0.001). A statistically significant Zn. lowest level had a significantly higher reference tertile (OR 8.54; Similarly, tertile, greater 15.0; Conclusion: results suggest association lower

Language: Английский

---