Micro- and Macronutrients in Endometrial Cancer—From Metallomic Analysis to Improvements in Treatment Strategies DOI Open Access
Gabriela Hunek, Julita Zembala, Jacek Januszewski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9918 - 9918

Published: Sept. 14, 2024

Endometrial cancer is reported to be one of the most prevalent cancers female reproductive organs worldwide, with increasing incidence and mortality rates over past decade. Early diagnosis critical for effective treatment. Recently, there has been a growing focus on role nutrition micronutrient macronutrient status in patients gynecologic cancers, including endometrial cancer. In following paper, we have conducted an in-depth narrative literature review aim evaluating results metallomic studies specifically concerning micro- The main objective paper was analyze regarding nutritional describe chosen elements onset progression carcinogenesis. Further, focused evaluation usage described potential treatment abovementioned cancer, as well possible prevention considering proper supplementation healthy individuals. Calcium proposed reduce risk although some offer conflicting evidence. Deficiencies phosphorus, selenium, zinc inversely associated risk, suggesting they may play protective role, whereas excessive levels iron, copper, cadmium positively correlated increased risk. However, molecular mechanisms by which these affect carcinogenesis are not fully understood, current findings often contradictory. Further research needed clarify relationships evaluate interventions

Language: Английский

MAMMALIAN COPPER HOMEOSTASIS: PHYSIOLOGIC ROLES AND MOLECULAR MECHANISMS DOI
Svetlana Lutsenko, Shubhrajit Roy, Peter Tsvetkov

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 441 - 491

Published: Aug. 22, 2024

In the past decade, evidence for numerous roles of copper (Cu) in mammalian physiology has grown exponentially. The discoveries Cu involvement cell signaling, autophagy, motility, differentiation, and regulated death (cuproptosis) have markedly extended list already known functions Cu, such as a cofactor essential metabolic enzymes, protein structural component, regulator trafficking. Novel unexpected transporting proteins enzymes been identified, new disorders homeostasis described. Significant progress made mechanistic studies two classic metabolism, Menkes disease Wilson’s disease, which paved way novel approaches to their treatment. discovery cuproptosis role metastatic growth increased interest targeting homeostatic pathways treat cancer. this review, we summarize established concepts field discuss how decade expand modify these concepts. brain metabolism functional speciation recently discovered attracted significant attention are highlighted review.

Language: Английский

Citations

12
Serum Levels of Zinc and Copper in Patients with Endometrial Cancer: a Systematic Review and Meta-analysis DOI
Vaibhav Chaudhary,

Bhavya Sharma,

Sweta Kumari

et al.

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0
Micro- and Macronutrients in Endometrial Cancer—From Metallomic Analysis to Improvements in Treatment Strategies DOI Open Access
Gabriela Hunek, Julita Zembala, Jacek Januszewski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9918 - 9918

Published: Sept. 14, 2024

Endometrial cancer is reported to be one of the most prevalent cancers female reproductive organs worldwide, with increasing incidence and mortality rates over past decade. Early diagnosis critical for effective treatment. Recently, there has been a growing focus on role nutrition micronutrient macronutrient status in patients gynecologic cancers, including endometrial cancer. In following paper, we have conducted an in-depth narrative literature review aim evaluating results metallomic studies specifically concerning micro- The main objective paper was analyze regarding nutritional describe chosen elements onset progression carcinogenesis. Further, focused evaluation usage described potential treatment abovementioned cancer, as well possible prevention considering proper supplementation healthy individuals. Calcium proposed reduce risk although some offer conflicting evidence. Deficiencies phosphorus, selenium, zinc inversely associated risk, suggesting they may play protective role, whereas excessive levels iron, copper, cadmium positively correlated increased risk. However, molecular mechanisms by which these affect carcinogenesis are not fully understood, current findings often contradictory. Further research needed clarify relationships evaluate interventions

Language: Английский

Citations

2