Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2529 - 2529
Published: Nov. 5, 2024
Non-communicable
diseases
(NCDs)
are
the
leading
cause
of
morbidity
and
mortality
worldwide.
These
conditions
have
numerous
health
consequences
significantly
impact
patients'
lifestyles.
Effective
long-term
treatment
is
essential
since
NCDs
irreversible.
Therefore,
primary
healthcare
must
be
both
exclusive
highest
quality,
ensuring
comprehensive
care.
The
goal
should
to
improve
quality
life
with
a
focus
on
patients,
families,
communities,
as
most
these
can
prevented
controlled,
although
not
cured.
Several
factors
been
linked
individual
health,
including
social,
cultural,
economic
aspects,
lifestyle,
certain
environmental
factors,
work,
that
positive
or
negative
effects.
More
variables
may
contribute
onset
NCDs,
which
defined
by
their
chronic
nature,
propensity
for
prolongation,
generally
slow
rate
progression.
Examples
include
hypertension,
type
2
diabetes
(T2D),
dyslipidemia,
fatty
liver
disease
metabolic
dysfunction.
has
associated
an
imbalance
in
microbial
niches,
such
gut,
hosts
billions
microorganisms
performing
multiple
functions,
production
metabolites
like
bile
acids
(BAs),
short-chain
(SCFAs),
trimethylamine
N-oxide
(TMAO).
lifestyle
changes
personal
habits
gut
microbiota
(GM),
potentially
preventing
metabolism.
highly
prevalent
worldwide,
prompting
increased
attention
strategies
modifying
intestinal
(IM).
Approaches
probiotics,
prebiotics,
synbiotics,
fecal
transplantation
(FMT)
demonstrated
improvements
individuals
conditions.
Additionally,
adoption
healthy
IM
help
prevent
related
main
aim
this
review
analyze
understand
importance
intervention
prevention
non-communicable
diseases.
R3:A1.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(2), P. 269 - 269
Published: Jan. 16, 2024
Nutrition
is
one
of
the
most
influential
environmental
factors
in
both
taxonomical
shifts
gut
microbiota
as
well
development
type
2
diabetes
mellitus
(T2DM).
Emerging
evidence
has
shown
that
effects
nutrition
on
these
parameters
not
mutually
exclusive
and
changes
related
metabolites
such
short-chain
fatty
acids
(SCFAs)
branched-chain
amino
(BCAAs)
may
influence
systemic
inflammation
signaling
pathways
contribute
to
pathophysiological
processes
associated
with
T2DM.
With
this
background,
our
review
highlights
macronutrients,
carbohydrates,
proteins,
lipids,
micronutrients,
vitamins,
minerals,
T2DM,
specifically
through
their
alterations
they
produce.
Additionally,
we
describe
influences
common
food
groups,
which
incorporate
varying
combinations
macronutrients
metabolic
context
mellitus.
Overall,
first
line
modifiable
therapies
management
T2DM
a
better
understanding
mechanisms
by
its
pathophysiology
provides
opportunities
for
optimizing
dietary
interventions.
Foods,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3886 - 3886
Published: Dec. 1, 2024
Foodborne
pathogens
are
microorganisms
that
cause
illness
through
contamination,
presenting
significant
risks
to
public
health
and
food
safety.
This
review
explores
the
metabolites
produced
by
these
pathogens,
including
toxins
secondary
metabolites,
their
implications
for
human
health,
particularly
concerning
cancer
risk.
We
examine
various
such
as
Salmonella
sp.,
Campylobacter
Escherichia
coli,
Listeria
monocytogenes,
detailing
specific
of
concern
carcinogenic
mechanisms.
study
discusses
analytical
techniques
detecting
chromatography,
spectrometry,
immunoassays,
along
with
challenges
associated
detection.
covers
effective
control
strategies,
processing
techniques,
sanitation
practices,
regulatory
measures,
emerging
technologies
in
pathogen
control.
manuscript
considers
broader
highlighting
importance
robust
policies,
awareness,
education.
identifies
research
gaps
innovative
approaches,
recommending
advancements
detection
methods,
preventive
policy
improvements
better
manage
foodborne
metabolites.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(2), P. 127 - 127
Published: Feb. 13, 2025
Numerous
recent
studies
have
suggested
that
the
composition
of
intestinal
microbiota
can
trigger
metabolic
disorders,
such
as
diabetes,
prediabetes,
obesity,
syndrome,
sarcopenia,
dyslipidemia,
hyperhomocysteinemia,
and
non-alcoholic
fatty
liver
disease.
Since
then,
considerable
effort
has
been
made
to
understand
link
between
well
role
probiotics
in
modulation
microbiota.
The
aim
this
review
was
summarize
reviews
individual
articles
on
state
art
regarding
ideal
therapy
with
prebiotics
order
obtain
reversion
dysbiosis
(alteration
microbiota)
eubiosis
during
diseases,
diseases.
This
includes
245
eligible
studies.
In
conclusion,
a
condition
dysbiosis,
or
general,
alteration
microbiota,
could
be
implicated
development
disorders
through
different
mechanisms,
mainly
linked
release
pro-inflammatory
factors.
Several
already
demonstrated
potential
using
treatment
condition,
detecting
significant
improvements
specific
symptoms
These
findings
reinforce
hypothesis
lead
generalized
inflammatory
picture
negative
consequences
organs
systems.
Moreover,
confirms
beneficial
effects
diseases
are
promising,
but
more
research
is
needed
determine
optimal
probiotic
strains,
doses,
administration
forms
for
conditions.
Hellenic Journal of Cardiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Trimethylamine
N-oxide
(TMAO)
has
been
associated
with
atherosclerosis
and
poor
outcome.
We
evaluated
the
prognostic
impact
of
intra-hospital
TMAO
variation
on
patient
Blood
samples
from
149
patients
acute
myocardial
infarction
(AMI)
were
taken
admission
discharge.
Plasma
was
determined
by
HPLC-MS.
The
endpoint
a
composite
three-point
MACE
(major
adverse
cardiovascular
events)
including
all-cause
mortality,
re-infarction
or
heart
failure
(HF)
development.
Median
concentration
significantly
higher
than
discharge,
(respectively,
7.81
[3.47
–
19.98]
vs
3.45
[2.3
4.78]
μM,p<0.001).
After
estimating
μM
cut-off
analysis
continuous
hazard
ratio,
we
divided
our
cohort
into
two
groups.
first
group
included
75
(50.3%)
whose
levels
remained
below
decreased
under
(low-low/high-low;
LL/HL),
while
second
74
(49.7%)
high
increased
above
during
hospitalisation
(high-high/low-high;
HH/LH).
During
median
30-month
follow-up,
21.5%
experienced
endpoint.
At
Kaplan-Meier
analysis,
trend
increasing
risk
observed
in
HH/LH
(p=0.05).
multivariable
Cox
had
more
times
follow-up
LL/HL
(HR=2.15
[95%
CI,
1.03
-
4.5],
p=0.04).
Other
independent
predictors
older
age
worse
left
ventricular
systolic
function.
In
AMI,
permanently
are
long-term
follow-up.
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 143 - 143
Published: Dec. 31, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
major
contributor
to
liver-related
morbidity,
cardiovascular
disease,
and
metabolic
complications.
Lifestyle
interventions,
including
diet
exercise,
are
first
line
in
treating
MASLD.
Dietary
approaches
such
as
the
low-glycemic-index
Mediterranean
diet,
ketogenic
intermittent
fasting,
high
fiber
diets
have
demonstrated
potential
addressing
dysfunction
underlying
this
condition.
The
development
progression
of
MASLD
closely
associated
with
taxonomic
shifts
gut
microbial
communities,
relationship
well-documented
literature.
Given
importance
primary
treatment
for
MASLD,
it
important
understand
how
microbiota
their
byproducts
mediate
favorable
outcomes
induced
by
healthy
dietary
patterns.
Conversely,
changes
conferred
unhealthy
patterns
Western
may
induce
dysbiosis
influence
through
promoting
hepatic
inflammation,
up-regulating
lipogenesis,
dysregulating
bile
acid
metabolism,
increasing
insulin
resistance,
causing
oxidative
damage
hepatocytes.
Although
emerging
evidence
has
identified
links
between
microbiota,
significant
gaps
remain
understanding
specific
roles,
metabolite
pathways,
host
interactions,
causal
relationships.
Therefore,
review
aims
provide
mechanistic
insights
into
role
microbiota-mediated
processes
analysis
both
contribution
pathophysiology.
By
better
elucidating
interplay
nutrients,
processes,
onset
work
identify
new
opportunities
targeted
interventions
treat
efficiently.
Diabetology,
Journal Year:
2025,
Volume and Issue:
6(1), P. 4 - 4
Published: Jan. 3, 2025
Metabolic
syndrome
(MetS)
is
a
major
health
issue
defined
by
central
obesity
and
at
least
two
more
of
the
following
factors:
high
triglycerides,
low
high-density
lipoprotein
(HDL)
cholesterol,
blood
pressure,
fasting
glucose.
Managing
MetS
involves
lifestyle
changes,
with
adherence
to
Mediterranean
diet
(MeDi)
playing
crucial
role.
MeDi,
emphasizing
consumption
whole
grains,
fruits,
vegetables,
legumes,
nuts,
olive
oil,
has
been
linked
reduced
risk
type
2
diabetes
improved
glucoregulation.
A
randomized
controlled
trial
showed
that
low-carb
MeDi
resulted
in
30%
lower
relative
developing
compared
low-fat
diet.
Additionally,
meta-analytic
data
highlighted
strong
inverse
relationship
between
incidence
diabetes.
Furthermore,
MeDi’s
anti-inflammatory
properties
help
manage
obesity-related
low-grade
chronic
inflammation,
for
weight
management
improvement
quality
life.
The
lipid
profiles,
reductions
low-density
total
an
increase
HDL
cholesterol
were
also
found
be
adherence.
However,
despite
its
benefits,
varies
widely,
often
being
moderate
many
populations.
Improving
through
physician
advice
patient
education
maximizing
potential
prevent
diabetes-related
complications.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: March 6, 2025
Atherosclerotic
cardiovascular
diseases
(ASCVDs)
remain
a
leading
cause
of
mortality,
with
early
cholesterol
control
being
pivotal
in
mitigating
long-term
risk.
Recent
findings
suggest
that
intermittent
hyperlipidemia,
characterized
by
oscillatory
exposure,
uniquely
accelerates
atherosclerosis
compared
to
continuous
high-fat
diets.
This
review
synthesizes
emerging
evidence
on
hyperlipidemia's
impact
atherogenesis,
emphasizing
macrophage
dysfunction,
autophagy
impairment,
and
efferocytosis
deficits.
We
also
discuss
critical
gaps,
including
sex-specific
differences,
gut-microbiota
interactions,
the
influence
maternal
hypercholesterolemia.
Notably,
recent
insights
into
IL-1β-dependent
neutrophil
reprogramming
under
diets
reveal
novel
inflammatory
mechanisms
driving
plaque
destabilization.
Addressing
these
gaps
will
advance
our
understanding
atherogenesis
guide
development
innovative
prevention
strategies
therapeutic
interventions.
