Exploring the Biophysical Mechanisms of Taurine's Effect on Myeloperoxidase Enzymatic Kinetics in Pre-Diabetic and Type 2 Diabetic Patients DOI Creative Commons

Suha A. Muneam,

Nada. A. Muneam,

N. Mihad

et al.

Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research , Journal Year: 2023, Volume and Issue: 9(4), P. 331 - 341

Published: Dec. 1, 2023

Background: investigate the enzymatic activity of Myeloperoxidase (MPO) in pre-diabetic and diabetic individuals explore modulation this by taurine supplementation, considering its potential anti-oxidative properties emerging evidence role glucose metabolism.Methods: This casecontrol study was done at Iraqi University College Medicine.It used advanced spectroscopic techniques kinetic modeling to measure amount MPO sera people who were healthy, prediabetic, diabetic.The Lineweaver-Burk plot derived from Michaelis-Menten equation ascertain Km Vmax MPO.Taurine inhibition assays also performed understand effect on kinetics.Results: The data showed that increased significantly control group group.This line with rising HbA1c levels BMI, suggesting a link between activity, glycemic control, obesity.The gender distribution no significant deviation, observed metabolic alterations are not biased. Conclusion:The pronounced elevation underscores enzyme's significance diseases.The results mean more research needs be how taurine, which is known have anti-inflammatory antioxidant properties, could improve possibly restore homeostasis, opening new way treat type 2 diabetes.

Language: Английский

Diagnosis and Management of Simple and Complicated Meconium Ileus in Cystic Fibrosis, a Systematic Review DOI Creative Commons

Mădălina Andreea Donos,

Gabriela Ghiga, Laura Mihaela Trandafir

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1179 - 1179

Published: June 4, 2024

The early management of neonates with meconium ileus (MI) and cystic fibrosis (CF) is highly variable across countries not standardized. We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews Meta-analyses statement. protocol was registered in PROSPERO (CRD42024522838). Studies from three providers academic search engines were checked inclusion criteria, using following terms: AND OR mucoviscidosis. Regarding patient population studied, criteria defined our predefined PICOT framework: studies on simple or complicated which confirmed have conservatively managed surgically treated. Results: A total 566 publications last 10 years verified by authors this find most recent relevant data, only 8 met criteria. Prenatally diagnosed pseudocysts, bowel dilation, ascites ultrasound are predictors neonatal surgery risk factor negative 12-month clinical outcomes MI-CF newborns. For MI, conservative treatment hypertonic solutions enemas can be effective more than 25% cases. If repeated fail disimpact bowels, Bishop–Koop stoma safe option. No comprehensive research has been so far determine ideal surgical MI. found that reported types stomas performed another study comparing patients depending management; conclusions contradictory especially since number cases analyzed each small. Between 18% 38% MI will require reoperation various complications mortality rate varies between 0% 8%. Conclusion: This reveals lack strong data support decisions, unequivocally shows care infants standardized, suggests great need international collaborative studies.

Language: Английский

Citations

4
Effect of different conditions on the germination of coix seed and its characteristics analysis DOI Creative Commons

Lidan Dong,

Yun Yang,

Yongcai Zhao

et al.

Food Chemistry X, Journal Year: 2024, Volume and Issue: 22, P. 101332 - 101332

Published: March 28, 2024

Coix seed (CS) has high nutritional value, but the deep processing of CS is relatively limited. Sprouting can significantly improve laying foundation for efficient consumption or further processing. The optimal conditions germination are a soaking temperature 36 °C 10 h and 29 24 h. Under these conditions, final rate reached 90%. Additionally, content γ-aminobutyric acid was 21.205 mg/100 g; soluble protein, free amino acids, acid, other essential substances increased in CS. Especially after germination, (GABA) by 7.8 times compared with GABA ungerminated Therefore, value flavor germinated better than those ones, which establishs solid its application developing various products such as compound health drinks, coix yogurt, others.

Language: Английский

Citations

3
The Role of Natural Extracts in the Management of Infantile Hemangiomas and Vascular Tumors DOI Creative Commons
Iulia Cristina Roca, Elena Cojocaru, Daniela Rusu

et al.

Pediatric Health Medicine and Therapeutics, Journal Year: 2024, Volume and Issue: Volume 15, P. 1 - 16

Published: Jan. 1, 2024

Abstract: Hemangiomas are vascular tumors resulting from the proliferation of endothelial-like cells; they most common childhood tumors, affecting approximately 5– 10% newborns and infants. Besides hemangiomas, which definitely benign despite their overgrowth potential, there other like hemangioendotheliomas, may display intermediate characteristics between hemangiomas highly malignant angiosarcomas. Standard therapy be constricted by serious adverse effects, high cost, or traumatic influence. Diet is a major resource for health preservation, disease prevention, treatment. The therapeutic property edible berries, marine products, medicinal plants have long been known used in traditional medicine; plant-based nutrition can prevent development progression diseases associated with extensive neo-vascularization. purpose our review to highlight those natural treatments that hemangioma tumor patients receive future, both benefit families. We performed according Preferred Reporting Items Systematic Reviews Metanalysis Statement. Web Science, PubMed, EMBASE engines study, searched association naturopathic treatment/plant extract/plants published articles. found extracts fruits cost-effective safe as well forms cancer. In any case, more vitro vivo studies needed confirm proposed signaling pathways validate improvement parameters after products administration. era molecularly targeted personalized medicine approaching naturally occurring substances very useful tools treatment prevention. Plant extract strong specificity pertinence, non- toxic few side become an emerging cancer Keywords: abnormalities, plants, plant extract,

Language: Английский

Citations

2
Triangle correlations of lung microbiome, host physiology and gut microbiome in a rat model of idiopathic pulmonary fibrosis DOI Creative Commons

Sihan Hou,

Xueer Wang, Jiarui Guo

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 20, 2024

Changes in lung and gut microbial communities have been associated with idiopathic pulmonary fibrosis (IPF). This study aimed to investigate correlations between changes the host physiological indices an IPF model, exploring potential mechanisms of lung-gut axis pathogenesis. model rats were established via trans-tracheal injection bleomycin, assessments hematological indices, serum cytokines, histopathology, microbiome alterations. Significant differences structure composition observed compared controls, 14 7 genera showing significant abundance changes. Further analysis revealed 20 genera. Notably, 11 pairs correlated linked same IPF-related such as hydroxyproline, mean corpuscular volume (MCV), red cell distribution width-standard deviation (RDW-SD). We identified 24 instances where a genus each index, forming "lung genus—index—gut genus" relationships. Mediation showed that like MCV, RDW-SD mediated 10 (e.g., Cetobacterium, Clostridium XVIII ) Allobaculum. first describes gut-lung interactions fibrosis. suggests pathways underlying genus—host index—gut "gut index—lung correlations, thus providing clues further elucidate "gut-lung axis"

Language: Английский

Citations

0
Diabetic Pneumopathy- A Novel Diabetes-associated Complication: Pathophysiology, the Underlying Mechanism and Combination Medication DOI
Jyotsana Dwivedi, Pranay Wal, Biswajit Dash

et al.

Endocrine Metabolic & Immune Disorders - Drug Targets, Journal Year: 2023, Volume and Issue: 24(9), P. 1027 - 1052

Published: Oct. 11, 2023

The "diabetic lung" has been identified as a possible target organ in diabetes, with abnormalities ventilation control, bronchomotor tone, lung volume, pulmonary diffusing capacity, and neuroadrenergic bronchial innervation.

Language: Английский

Citations

1
Exploring the Biophysical Mechanisms of Taurine's Effect on Myeloperoxidase Enzymatic Kinetics in Pre-Diabetic and Type 2 Diabetic Patients DOI Creative Commons

Suha A. Muneam,

Nada. A. Muneam,

N. Mihad

et al.

Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research , Journal Year: 2023, Volume and Issue: 9(4), P. 331 - 341

Published: Dec. 1, 2023

Background: investigate the enzymatic activity of Myeloperoxidase (MPO) in pre-diabetic and diabetic individuals explore modulation this by taurine supplementation, considering its potential anti-oxidative properties emerging evidence role glucose metabolism.Methods: This casecontrol study was done at Iraqi University College Medicine.It used advanced spectroscopic techniques kinetic modeling to measure amount MPO sera people who were healthy, prediabetic, diabetic.The Lineweaver-Burk plot derived from Michaelis-Menten equation ascertain Km Vmax MPO.Taurine inhibition assays also performed understand effect on kinetics.Results: The data showed that increased significantly control group group.This line with rising HbA1c levels BMI, suggesting a link between activity, glycemic control, obesity.The gender distribution no significant deviation, observed metabolic alterations are not biased. Conclusion:The pronounced elevation underscores enzyme's significance diseases.The results mean more research needs be how taurine, which is known have anti-inflammatory antioxidant properties, could improve possibly restore homeostasis, opening new way treat type 2 diabetes.

Language: Английский

Citations

0