Obesity and menopause

Best Practice & Research Clinical Obstetrics & Gynaecology, Journal Year: 2023, Volume and Issue: 88, P. 102348 - 102348

Published: May 6, 2023

The global obesity pandemic continues to rise, with figures from the World Health Organization showing that 13% of world's adult population was obese in 2016. Obesity has significant implications, an increased risk cardiovascular diseases, diabetes mellitus, metabolic syndrome, and several malignancies. menopausal transition is associated obesity, a gynecoid android body shape, abdominal visceral fat, which further worsens cardiometabolic risks. Whether this consequence menopause, age, genetics, or environmental factors long been debated. Increasing life expectancy means women spend part their lives menopause. As such, understanding complex interplay menopause important providing right advice/management. We review current evidence on focusing implications during impact effect available treatments morbidities.

Language: Английский

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The association between metabolic syndrome and gallstone disease: A cross-sectional study from the PERSIAN Guilan cohort study

Endocrine and Metabolic Science, Journal Year: 2025, Volume and Issue: unknown, P. 100221 - 100221

Published: Jan. 1, 2025

Language: Английский

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MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

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Changed Endocrinology in Postmenopausal Women: A Comprehensive View

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 29, 2023

Menopause, when menstrual cycles stop, is brought on by a decline in the level of hormones progesterone and oestrogen synthesised ovaries. Menopause an unavoidable stage female's lifecycle, but because experiences differ for every woman, several women require health care aid to manage their problems. The physiological variations that take place at various periods reproducing age, along with kind timing menopause, are components frequently associated greater threat cardiometabolic illness. most researched associations between menopause reduced levels ovarian estrogen synthesis excessive amounts androgen during onset menopause. Although testosterone oestrogens have differing effects adipocyte physiology, it debatable how important emergence metabolic disorders following control differentiation brain as well potential roles endocrine disruptors chemicals reviewed this systematic review subject. In general, had frequency syndrome compared men. Female metabolism was significantly impacted overt hyperthyroidism subclinical hypothyroidism. Osteoporosis another medical condition menopausal may experience. Estrogen deprivation main contributor osteoporosis women. regular cycle bone turnover disrupted decrease secretion, which boosts osteoclastic resorption activity while decreasing osteoblastic activity. entire article assesses provides information all changes woman's life after

Language: Английский

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Mitochondrial UCP1: Potential thermogenic mechanistic switch for the treatment of obesity and neurodegenerative diseases using natural and epigenetic drug candidates

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155672 - 155672

Published: May 4, 2024

Language: Английский

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Acute effects of pre-exercise high and low glycaemic index meals and exercise timings on substrate metabolism and appetite in postmenopausal women

European Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract Background Postmenopausal women are often reported to exhibit increased susceptibility metabolic disorders. Although the consumption of low glycaemic index (LGI) foods before exercise known enhance fat oxidation during exercise, optimal timing has not been evaluated. We investigated effects pre-exercise meals with different GI values and timings on substrate metabolism appetite in postmenopausal women. Methods Fifteen completed four trials a random manner. Participants consumed energy-matched high (HGI) or LGI meal at 0900 rested until 1000 (60 min-HGI -LGI trials) 1100 (120 trials). Then, participants performed 30-min walk 50% estimated maximum oxygen uptake 1300. Expired air, blood samples, ratings food reward subjective were collected. Results No differences observed among ( P = 0.66). The area under curve 3-hydroxybutyrate was higher 120 min-LGI trial compared 60 0.01) after exercise. Relative preference for high-fat post-exercise 1-hour between trials. Conclusions These findings indicate that did influence However, longer interval subsequent may be effective enhancing hepatic fatty acid oxidation.

Language: Английский

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Integrated multiomic profiling of tail adipose tissue highlights novel genes, lipids, and metabolites involved in tail fat deposition in sheep

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 3, 2025

Tail fat is important for fat-tailed or fat-rumped sheep to survive in harsh environments. However, the molecular mechanism underlying tail deposition remains unclear. In this study, we comprehensively characterized transcriptome, untargeted lipidome, and targeted metabolome profiles of adipose tissues from Large-tailed Han (long sheep) Hu (short sheep). We identified 183 differentially expressed genes (DEGs), 55 differential lipids (DLs) 17 metabolites (DMs) tails sheep. Among DEGs selected (Q values ≤ 0.05 and│Log2(FC)│≥ 0.5), 18 DEGs, such as UCP3, ELOVL7 GDF10, were directly associated with lipid metabolism via Gene Ontology (GO) analysis. Some genes, PPP3R1A, ADRA1, DSLC46A2, reportedly metabolism. A fold change ≥ 1.2 0.83 a P-value < set default threshold select DLs DMs. DLs, 36 phosphatidylcholines 9 phosphatidylethanolamines. The top six greatest differences content LPE (20:4) (up), PC (42:10) (42:8) (16:1/16:1) (down), (29:0) (32:2) (down). DMs related tricarboxylic acid cycle, D-glucose, cis-aconitic citric abundant enriched mainly ferroptosis, extracellular matrix (ECM)-receptor interaction, cGMP-PKG, calcium signaling pathways cardiomyopathy cycle. This study obtained lipidome long short tails. findings suggested that ELOVL7, UCP3 ECM-receptor interaction contributed difference deposition, biosynthesis cycle may affect results enhance our understanding tail.

Language: Английский

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Age-Dependent or Disease-Associated Changes in Organ Systems and the Effect of Medical Exercise Therapy

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 59 - 86

Published: Jan. 1, 2025

Language: Английский

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Epigenetic Alterations in Ovarian Function and Their Impact on Assisted Reproductive Technologies: A Systematic Review

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 730 - 730

Published: March 17, 2025

Background: Epigenetic modifications have an important role in controlling ovarian function, modulating response and implantation success Assisted Reproductive Technologies (ART). The alterations, such as DNA methylation non-coding RNA control, been identified key variables regulating physiology reproductive outcomes. This systematic review investigates the significance of epigenetic pathways with emphasis on their effect ART rates. Methods: A thorough search PubMed, Scopus, EMBASE databases was performed to find articles published between 2015 2024 that investigated connection changes function patients. Studies examined miRNA expression, methylation, histone follicular fluid, granulosa cells, embryos were included. study followed PRISMA recommendations guarantee scientific rigor repeatability. data combined into a markers linked aging, reserve, success. Results: total 15 studies satisfied inclusion criteria, substantial relationships found distinct function. Changes expression patterns fluid cells associated oocyte maturation, potential. Women low reserve polycystic ovary syndrome (PCOS) different patterns. MiR-27a-3p miR-15a-5p shown be involved cell malfunction poor response, whereas global hypomethylation aging results. Conclusions: alterations affect via control hormone signaling, development, Further is needed determine practical applicability biomarkers predicting effectiveness enhancing patient treatment procedures.

Language: Английский

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Influence of Intermittent Fasting on Body Composition, Physical Performance, and the Orexinergic System in Postmenopausal Women: A Pilot Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1121 - 1121

Published: March 24, 2025

Objective: This study aims to evaluate the effects of different nutritional strategies, specifically intermittent fasting (IF) combined with high-intensity interval training (HIIT) versus a low-calorie diet (LCD), on body composition, physical performance, and orexinergic system in postmenopausal women. Methods: A randomized controlled trial involving thirty women (mean age 57.50 ± 6.50 years) was conducted over eight weeks, comparing two dietary approaches alongside an 8-week HIIT program. Body composition assessed using bioelectrical impedance analysis (BIA) dual-energy X-ray absorptiometry (DEXA). Performance metrics included handgrip strength 6-min walking test (6MWT). Salivary samples were analyzed for Orexin-A (OX-A) levels pre- post-intervention. Results: Significant improvements health metrics, such as heart rate (HR) endurance, found, mean HR changes showing significant difference (F = 5.943, p 0.033) between groups at T1. reflected metabolic regulation shifts relation other variables, change from baseline post-intervention values T1 10,931, 0.033). Flexibility (sit reach) significantly improved by 6% (p < 0.05), well VO2 max (10%, both highlighted key predictors overall outcomes. Additionally, Cohen's d analyses indicated that exhibited notable differences LCD group -0.90, suggesting large effect size compared control group. Conclusions: The combination IF is effective strategy enhancing performance women, potentially mediated system. Further research warranted explore long-term underlying mechanisms.

Language: Английский

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