Hydroxychloroquine as an Adjunct Therapy for Diabetes in Pregnancy DOI Open Access
Nurul Iftida Basri, Padma Murthi, Rahana Abd Rahman

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9681 - 9681

Published: Sept. 6, 2024

This review discusses the pathophysiology of diabetes in pregnancy relation to placental function. We potential use hydroxychloroquine improving outcomes affected by diabetes. The focuses on mechanism action and its effects There are several pathways which mediates effects: through inflammasome complex, inflammatory cytokines, oxidative stress, modulatory effects, antihyperglycemic effects. As a safe drug be used pregnancy, it is worth exploring possible as an adjunct treatment current therapy pregnancy.

Language: Английский

Estrogen regulation of the nucleus accumbens as a gateway to understanding menopause associated metabolic dysfunction DOI Creative Commons
Cheryl S. Rosenfeld, Victoria J. Vieira‐Potter

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 23, 2025

Language: Английский

Citations

0
Factors Associated with Abnormal Uterine Bleeding in Perimenopausal Women DOI Creative Commons

Radenko Ivanović,

Bojan Joksimović,

Vladimir Čančar

et al.

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 51(2)

Published: Feb. 18, 2024

Background: Abnormal uterine bleeding (AUB) is one of the most common health problems encountered in women perimenopausal age group. The aim this study was to investigate characteristics functional AUB women, and identify predictors occurrence women. Methods: This a cross-sectional that included 45 with complaints admitted gynecology ward University Hospital Foča, without who underwent gynecological examination Primary Health Center Bosnia Herzegovina. We had normal ultrasound finding obvious genital or cervical lesions, were not on hormonal therapy. existence determined basis clinical by gynecologist existing medical documentation. A logistic regression model used assess possible relationship between risk factors for its occurrence. Results: mean patient 48.38 ± 2.40 years. There no significant difference age, frequency physical activity, previous use oral contraceptives two groups patients divided presence perimenopause. showed (p = 0.008), high values body mass index (BMI) 0.001), consumption alcohol cigarettes daily hypertension 0.046) represented associated Conclusions: During routine exams approaching menopause, gynecologists should emphasize harms smoking use, as well significance non-pharmacological pharmacological methods treatment obesity hypertension.

Language: Английский

Citations

3
Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause DOI

Celine Camon,

Michael Garratt, Stephanie M. Correa

et al.

Nature Aging, Journal Year: 2024, Volume and Issue: 4(12), P. 1731 - 1744

Published: Dec. 13, 2024

Language: Английский

Citations

3
Systematic metabolomic studies identified adult adiposity biomarkers with acetylglycine associated with fat loss in vivo DOI Creative Commons

Kuan‐Jui Su,

Xingying Chen, Rui Gong

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: April 14, 2023

Obesity is associated with various adverse health outcomes. Body fat (BF) distribution recognized as an important factor of negative consequences obesity. Although metabolomics studies, mainly focused on body mass index (BMI) and waist circumference, have explored the biological mechanisms involved in development obesity, these proxy composite measures are not accurate cannot reflect BF distribution, thus may hinder assessment metabolic alterations differential risk disorders among individuals presenting adiposity differently throughout body. Thus, exact relations between metabolites remain to be elucidated. Here, we aim examine associations pathways traits which distribution. We performed systematic untargeted serum metabolite profiling dual-energy X-ray absorptiometry (DXA) whole scan for 517 Chinese women. jointly analyzed DXA-derived four phenotypes detect cross-phenotype prioritize metabolomic factors. Topology-based pathway analysis was used identify BF-related processes. Finally, relationships identified candidate different sex ethnicity through two independent cohorts. Acetylglycine, top distinguished finding, validated its obesity resistance effect

Language: Английский

Citations

7
Effects of 12 Weeks of Daily Melatonin Administration on Inflammatory Markers and Adipose Tissue Mass of Rats under Hypoestrogenism DOI Creative Commons
Taciane Maria Melges Pejon, Guilherme Borges Pereira, Cynthia Aparecida de Castro

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(5), P. 740 - 740

Published: April 29, 2024

: The hormonal state of hypoestrogenism is associated with the accumulation white adipose tissue, which can induce an increase in pro-inflammatory markers, leading to progressive health complications. Melatonin act on tissue mass, promoting its reduction and influencing inflammation, reducing IL-6 releasing IL-10, pro- anti-inflammatory respectively. However, role melatonin regarding such parameters under context remains unknown. aim this study was determine effect 12 weeks mass circulating levels IL-6, TGF-β-1, leukotriene C4 (LTC4).

Language: Английский

Citations

2
In-silico analysis predicts disruption of normal angiogenesis as a causative factor in osteoporosis pathogenesis DOI Creative Commons
Remya James,

Koushik Narayan Subramanyam,

Febby Payva

et al.

BMC Genomic Data, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 8, 2024

Angiogenesis-osteogenesis coupling is critical for proper functioning and maintaining the health of bones. Any disruption in this coupling, associated with aging disease, might lead to loss bone mass. Osteoporosis (OP) a debilitating metabolic disorder that affects microarchitecture bones, gradually leading fracture. Computational analysis revealed normal angiogenesis disrupted during progression OP, especially postmenopausal osteoporosis (PMOP). The genes OP PMOP were retrieved from DisGeNET database. Hub gene molecular pathway enrichment performed via Cytoscape plugins STRING, MCODE, CytoHubba, ClueGO web-based tool Enrichr. Twenty-eight (28) hub identified, eight which transcription factors (HIF1A, JUN, TP53, ESR1, MYC, PPARG, RUNX2 SOX9). Analysis SNPs gnomAD, I-Mutant2.0, MUpro, ConSurf COACH servers substitution F201L IL6 as most deleterious. protein was modeled SWISS-MODEL server analyzed YASARA FoldX plugin. A positive ΔΔG (1.936) mutant indicates mutated structure less stable than wild-type is. Thirteen genes, including enriched pathways found be profoundly involved angiogenesis/endothelial function immune signaling. Mechanical loading bones through weight-bearing exercises can activate osteoblasts mechanotransduction increased formation. present study suggests mechanical preventive strategy PMOP, by status maintained. This silico could used understand etiology develop novel therapeutic approaches.

Language: Английский

Citations

1
Knockdown of Esr1 from DRD1-Rich Brain Regions Affects Adipose Tissue Metabolism: Potential Crosstalk between Nucleus Accumbens and Adipose Tissue DOI Open Access

Dusti A. Shay,

Rebecca J. Welly,

Jiude Mao

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6130 - 6130

Published: June 1, 2024

Declining estrogen (E2) leads to physical inactivity and adipose tissue (AT) dysfunction. Mechanisms are not fully understood, but E2's effects on dopamine (DA) activity in the nucleus accumbens (NAc) brain region may mediate changes mood voluntary (PA). Our prior work revealed that loss of E2 robustly affected NAc DA-related gene expression, pattern correlated with sedentary behavior visceral fat. The current study used a new transgenic mouse model (D1ERKO) determine whether abolishment receptor alpha (ERα) signaling within DA-rich regions affects PA AT metabolism. Adult male female wild-type (WT) D1ERKO (KD) mice were assessed for body composition, energy intake (EE), spontaneous (SPA), expenditure (EE); underwent glucose tolerance testing; blood biochemistry. Perigonadal white (PGAT), brown (BAT), genes proteins associated DA, signaling, metabolism; sections also uncoupling protein (UCP1). KD had greater lean mass EE (genotype effects) visible change BAT phenotype characterized by increased UCP1 staining lipid depletion, an effect seen only among females. Female higher Oprm1 transcript levels PGAT UCP1. This group tended have improved (p = 0.07). suppression Esr1 does appear affect PA, yet it directly lead novel targets improve metabolic dysfunction following loss, possibly targeting NAc.

Language: Английский

Citations

1
Selected Psychosocial Factors, Nutritional Behavior, and the Analysis of Concentrations of Selected Vitamins in Patients with Cardiovascular Diseases DOI Open Access
Anna K. Główka, Magdalena Kowalówka, Paweł Burchardt

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1866 - 1866

Published: June 14, 2024

Cardiovascular diseases (CVD) are the leading cause of death worldwide, influenced by interaction factors, including age, sex, genetic conditions, overweight/obesity, hypertension, an abnormal lipid profile, vitamin deficiencies, diabetes, and psychological factors. This study aimed to assess relationships between psychosocial nutritional factors in a group 61 patients with CVD (i.e., atherosclerosis, ischemic heart disease, myocardial infarction) their possible impact on course disease. The plasma concentrations vitamins A, E, D, β-carotene were determined using validated HPLC-MS/MS, while profile was analyzed enzymatically. Psychosocial behaviors assessed author-designed questionnaires. Over 50% had 25-OH-D3 retinol >85% exhibited significant deficiencies α-tocopherol β-carotene. showed no specific relationship any particular CVD. Dietary behavior minimally impacted biochemical parameters except for higher fruit vegetable intake. negative selected quality life noticed. To increase effectiveness prevention treatment CVD, need interdisciplinary cooperation observed doctors, psychologists, specialists human nutrition seems be justified.

Language: Английский

Citations

1
Effect of ovariectomy and high-fat diet on the expression of estrogen receptors and adipose tissue metabolism in wistar rats DOI
Thiago Henrique Caldeira de Oliveira, Gleisy Kelly Neves Gonçalves

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 592, P. 112327 - 112327

Published: July 10, 2024

Language: Английский

Citations

1
The psychological side of menopause: evidence from the comorbidity network of menopausal, anxiety, and depressive symptoms DOI

Jie Wen,

Wei Wang, Kexin Liu

et al.

Menopause The Journal of The North American Menopause Society, Journal Year: 2024, Volume and Issue: 31(10), P. 897 - 904

Published: July 30, 2024

Numerous studies have uncovered a correlation between menopausal, anxiety, and depressive symptoms. How these symptoms interrelate influence each other, however, remains unclear. This study aimed to identify the associations using network analysis.

Language: Английский

Citations

1