Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

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Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 27, 2025

Abstract Circadian rhythm is ubiquitous in nature. clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, regulate variety of physiological pathological processes, including bone cartilage metabolism. Deletion the core gene leads to alterations, while phenotypes are not consistent. Studies have shown that multiple signaling pathways involved process regulating metabolism, but exact regulatory mechanisms remain unclear. This paper reviews by which regulates bone/cartilage upstream factors control , current knockout mouse models for research. We hope provide new insights prevention treatment diseases related circadian rhythms.

Language: Английский

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Association of low-sodium salt intervention with osteoporosis: A cross-sectional study based on the SSaSS study

Archives of Osteoporosis, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 28, 2025

Language: Английский

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Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

The circadian clock is an endogenous timekeeping system that regulates various physiological and behavioral processes. Recently, it has been shown the timing of physical activity food intake can significantly influence metabolic muscle health. Some recent clinical evidence practiced in late afternoon be more effective terms performance strength. Preclinical studies have highlighted explanation for this effect lies different daily expression genes clock-controlled involved development hypertrophy. In conjunction with scientific advances understanding molecular mechanisms regulate rhythms trophy, chrono-nutrition gained resonance become a promising field, aimed at regulation body metabolism. Clinical preclinical protein consumption specific time points during day, or precisely after exercise, activate signaling pathways synthesis and, thus, favor skeletal mass as well mitochondrial biogenesis, thereby improving cell energy production function. On other hand, some carbohydrates immediately exercise increases insulin secretion, which facilitates glucose uptake by cells to replenish glycogen. This review summarizes current literature concerning chrono-exercise health, focusing on involving mass, strength, Understanding intricate relationship between rhythms, nutrition, metabolism essential optimizing nutritional strategies prevent treat wasting. addition, tailoring carbohydrate individual needs improve maintenance, growth, performance.

Language: Английский

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Rhythms in Remodeling: Posttranslational Regulation of Bone by the Circadian Clock

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 705 - 705

Published: March 13, 2025

The circadian clock is a fundamental timekeeping system that regulates rhythmic biological processes in response to environmental light–dark cycles. In mammals, core genes (CLOCK, BMAL1, PER, and CRY) orchestrate these rhythms through transcriptional–translational feedback loops, influencing various physiological functions, including bone remodeling. Bone homeostasis relies on the coordinated activities of osteoblasts, osteoclasts, osteocytes, with increasing evidence highlighting role regulation maintaining skeletal integrity. Disruptions are linked disorders such as osteoporosis. Posttranslational modifications (PTMs), phosphorylation, acetylation, ubiquitination, serve crucial regulators both mechanisms metabolism. However, specific PTMs integrating timing remodeling remains underexplored. This review examines intersection biology, elucidating their impact cell function homeostasis. Understanding interactions may uncover novel therapeutic targets for diseases associated disruptions.

Language: Английский

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Circadian rest-activity rhythms and multimorbidity and mortality risks among menopausal women: a trajectory analysis of a UK Biobank cohort

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 7, 2025

Menopausal women undergo substantial physiological changes that can impact their overall health. We examined relationships between circadian rest-activity rhythms (CRARs) and multimorbidity progression in this population. used UK Biobank data, involving 10,138 participants, who were initially free of chronic conditions. primarily focused on the relative amplitude (RA) CRARs, tracking incident first conditions (FCC), multimorbidity, all-cause mortality. Multimorbidity was indicated by presence any 2/35 during follow-up period. a multi-state model to assess RA trajectory, encompassing transition from health an FCC, consequent ultimately mortality, parallel with sensitivity analyses ensure results stability reliability. During mean 8.13-year period, we identified 855 cases recorded 88 deaths. In model, lower associated increased risk FCC onset [hazard ratio (HR): 1.18, 95% confidence interval (CI): 1.07-1.31] also development (HR: 1.34, CI: 1.12-1.61), even after adjusting for several confounding factors. Among menopausal women, rhythm disturbance transitioning single condition, as well condition multimorbidity.

Language: Английский

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Recovery effect of self‐myofascial release treatment using different type of a foam rollers

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 9, 2024

Abstract Among athletes, foam rolling is popular technique of myofascial release aimed to support recovery processes and counteract delayed onset muscle soreness. However, there no consensus on the optimal parameters roller texture used in procedure. The study determine whether using rollers with different textures hardness (smooth/soft, grooved/mid, serrated/hard) affects post-exertional restitution rate level perceived DOMS (Delayed Onset Muscle Soreness) after intense anaerobic exercise. involved 60 healthy physically active men randomly divided into three experimental groups one control group (passive rest)—each consisting 15 individuals: STH—rolling a smooth roller; G—rolling grooved TP—rolling serrated Pass—passive rest group. After performing exercise test (one-minute high-intensity squat), blood lactate (LA), creatine kinase (CK) pain perception (VAS Scale) were monitored. analysis average LA concentration 30 min post-exercise showed statistical difference for all compared passive group: STH (p < 0.001), G TP = 0.035). No statistically significant differences found between CK measurement results individual assessments. Statistically VAS values observed 0.013) 0.006) Pass at 48 h, as well 0.003); 0.001); 0.001) 72 h. Based data, strong influence (η 2 0.578) time quadriceps variable was noted. research confirm effectiveness supporting immediate prolonged recovery. conducted studies indicate significantly better pace procedure lasting least 120 s. tool did not matter such duration treatment.

Language: Английский

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Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release

Membranes, Journal Year: 2023, Volume and Issue: 13(3), P. 282 - 282

Published: Feb. 27, 2023

Melatonin is the hormone that focuses attention of researchers in medical, pharmaceutical, materials, and membranes fields due to its multiple biomedical implications. The variety techniques methods for controlled release melatonin linked multitude applications, among which sports medicine occupies a special place. This paper presents preparation characterization composite based on chitosan (Chi) sulfonated ethylene-propylene-diene terpolymer (sEPDM). were obtained by vacuum evaporation from an 8% sEPDM solution toluene (w/w), was dispersed ultrasonic field (sEPDM:Chi = 1:1, w/w). For comparative evaluation membranes' performances, melatonin-chitosan-sulfonated (Mel:Chi:sEPDM 0.5:0.5:1.0, w/w/w) test membrane made. prepared morphologically structurally characterized scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive analysis (EDAX), thermal (TG, DSC), coupled with chromatography analysis, contact angle measurements, but also point view performance process transport dedicated environments (aqueous solutions pH salinity). can amounts between 0.4 mg/cm2·per day (sEPDM), 1.6 mg/ cm2·per (Chi/sEPDM), 1.25 (Mel/Chi/SEPDM).

Language: Английский

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Regulation of metabolism by circadian rhythms: Support from time-restricted eating, intestinal microbiota & omics analysis

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122814 - 122814

Published: June 8, 2024

Circadian oscillatory system plays a key role in coordinating the metabolism of most organisms. Perturbation genetic effects and misalignment circadian rhythms result dysfunction signs metabolic disorders. The eating-fasting cycle can act on peripheral clocks, bypassing photoperiod. Therefore, time-restricted eating (TRE) improve health by adjusting rhythms, process achieved through reprogramming genomes programs at different tissue levels or remodeling intestinal microbiota, with omics technology allowing visualization regulatory processes. Here, we review recent advances regulation metabolism, focus potential application TRE for rescuing disorders contribution microbiota between, summarize significance technology.

Language: Английский

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Unveiling the role of melatonin‐related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment

Experimental Physiology, Journal Year: 2024, Volume and Issue: 110(2), P. 261 - 276

Published: Nov. 29, 2024

Osteoporosis (OP) is a prevalent bone disease characterized by reduced density and quality, increasing fragility fracture risk. Osteoclast (OC) activity circadian rhythm play role in the pathogenesis of OP. Melatonin regulator that affects metabolism, but its molecular mechanism has not been studied detail. This study aimed to identify relationship between melatonin-related genes OP through bioinformatics methods verify it experimentally.We analysed microarray data from GSE35959 dataset, identifying differentially expressed patients. Circadian rhythm-related intersect with these genes, highlighting CSNK1D central gene. Functional enrichment, correlation protein-protein interaction analyses were conducted. Experimental validation involved vitro differentiation assays using RAW264.7 cells vivo studies an ovariectomy-induced rat model evaluate osteoclastogenesis effect on Differential expression analysis revealed 272 significant identified as melatonin interplay. showed involvement OC inflammatory pathways. experiments confirmed upregulation during differentiation, small interfering RNA-mediated knockdown marker TRAP+ cell formation. vivo, associated loss rats. Melatonin-related promotes development These findings suggest potential therapeutic target for OP, offering insights into new treatment strategies integrating regulation.

Language: Английский

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